Eric S Haag

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi request reprint Using Caenorhabditis to explore the evolution of the germ line
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Adv Exp Med Biol 757:405-25. 2013
  2. pmc A toolkit for rapid gene mapping in the nematode Caenorhabditis briggsae
    Daniel C Koboldt
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    BMC Genomics 11:236. 2010
  3. ncbi request reprint Caenorhabditis evolution: if they all look alike, you aren't looking hard enough
    Eric S Haag
    Department of Biology, Building 144, University of Maryland, College Park, MD 20742, USA
    Trends Genet 23:101-4. 2007
  4. ncbi request reprint Compensatory vs. pseudocompensatory evolution in molecular and developmental interactions
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Genetica 129:45-55. 2007
  5. ncbi request reprint Compensatory evolution of interacting gene products through multifunctional intermediates
    Eric S Haag
    Department of Biology, University of Maryland, College Park 20742, USA
    Evolution 59:1620-32. 2005
  6. ncbi request reprint Dial-a-mutant: web-based knockout collections for model organisms
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Biol Cell 99:343-7. 2007
  7. doi request reprint L'enfant terrible at 30: the maturation of evolutionary developmental biology
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Development 138:2633-7. 2011
  8. pmc Sex determination across evolution: connecting the dots
    Eric S Haag
    Department of Biology and Program in Behavior, Evolution, Ecology and Systematics, University of Maryland, College Park, Maryland, United States of America
    PLoS Biol 3:e21. 2005
  9. pmc Independent recruitments of a translational regulator in the evolution of self-fertile nematodes
    Alana V Beadell
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 108:19672-7. 2011
  10. pmc Context-dependent function of a conserved translational regulatory module
    Qinwen Liu
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Development 139:1509-21. 2012

Collaborators

Detail Information

Publications25

  1. doi request reprint Using Caenorhabditis to explore the evolution of the germ line
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Adv Exp Med Biol 757:405-25. 2013
    ..The biological roles of germline RBPs are thus highly context-dependent, and the inference of archetypal roles from isolated models in different phyla may therefore be premature...
  2. pmc A toolkit for rapid gene mapping in the nematode Caenorhabditis briggsae
    Daniel C Koboldt
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    BMC Genomics 11:236. 2010
    ..These studies rely on the availability of forward genetic tools such as mutants and mapping markers...
  3. ncbi request reprint Caenorhabditis evolution: if they all look alike, you aren't looking hard enough
    Eric S Haag
    Department of Biology, Building 144, University of Maryland, College Park, MD 20742, USA
    Trends Genet 23:101-4. 2007
    ..Here, we summarize the main findings of the meeting, which marks the formal birth of a research community dedicated to Caenorhabditis species evolution...
  4. ncbi request reprint Compensatory vs. pseudocompensatory evolution in molecular and developmental interactions
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Genetica 129:45-55. 2007
    ..Future empirical work in this area should focus on comparing the details of intra- and intergenic interactions in closely related organisms...
  5. ncbi request reprint Compensatory evolution of interacting gene products through multifunctional intermediates
    Eric S Haag
    Department of Biology, University of Maryland, College Park 20742, USA
    Evolution 59:1620-32. 2005
    ..These results suggest that population size, the source of adaptive benefit, and the structural details of heteromeric gene product complexes interact to influence the path by which intergenic incompatibility evolves...
  6. ncbi request reprint Dial-a-mutant: web-based knockout collections for model organisms
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Biol Cell 99:343-7. 2007
    ..These tools greatly enhance the ability of non-specialists to conduct studies of gene function in vivo in these model species...
  7. doi request reprint L'enfant terrible at 30: the maturation of evolutionary developmental biology
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Development 138:2633-7. 2011
    ..It revealed maturation on several fronts, including increased experimental rigor, the softening of dichotomies that were crucial to its founding and growth, and its growing relevance to both basic and biomedical biology...
  8. pmc Sex determination across evolution: connecting the dots
    Eric S Haag
    Department of Biology and Program in Behavior, Evolution, Ecology and Systematics, University of Maryland, College Park, Maryland, United States of America
    PLoS Biol 3:e21. 2005
  9. pmc Independent recruitments of a translational regulator in the evolution of self-fertile nematodes
    Alana V Beadell
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 108:19672-7. 2011
    ..We conclude that, as with transcription factors, spatially localized translational regulators play important roles in the evolution of anatomical novelties...
  10. pmc Context-dependent function of a conserved translational regulatory module
    Qinwen Liu
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Development 139:1509-21. 2012
    ..Finally, we document non-redundant roles for Cbr-puf-2 in embryonic and early larval development, the latter role being essential. Thus, recently duplicated PUF paralogs have already acquired distinct functions...
  11. pmc A sensitized genetic background reveals evolution near the terminus of the Caenorhabditis germline sex determination pathway
    Robin Cook Hill
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 11:333-42. 2009
    ..These results represent another way in which C. briggsae germline sex determination is incongruent with that of the outwardly similar C. elegans...
  12. pmc Simplification and desexualization of gene expression in self-fertile nematodes
    Cristel G Thomas
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Biol 22:2167-72. 2012
    ..These changes may result from the combination of relaxed sexual selection and a recently reported genetic mechanism favoring genome shrinkage in partial selfers...
  13. ncbi request reprint Genetic flexibility in the convergent evolution of hermaphroditism in Caenorhabditis nematodes
    Robin Cook Hill
    Department of Biology, University of Maryland, College Park, 20742, USA
    Dev Cell 10:531-8. 2006
    ..These findings are consistent with convergent evolution of hermaphroditism, which is marked by considerable developmental genetic flexibility...
  14. pmc Causes and consequences of the evolution of reproductive mode in Caenorhabditis nematodes
    Cristel G Thomas
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Trends Genet 28:213-20. 2012
    ..We also discuss the consequences of selfing, which leads to a rapid loss of variation and relaxation of natural and sexual selection on mating-related traits, and may ultimately put selfing lineages at a higher risk of extinction...
  15. pmc Caenorhabditis briggsae recombinant inbred line genotypes reveal inter-strain incompatibility and the evolution of recombination
    Joseph A Ross
    Department of Biology, University of Maryland, College Park, Maryland, USA
    PLoS Genet 7:e1002174. 2011
    ....
  16. pmc Chapter 3. Caenorhabditis nematodes as a model for the adaptive evolution of germ cells
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD, USA
    Curr Top Dev Biol 86:43-66. 2009
    ..Recent studies that employ comparative genetic methods in this rapidly maturing system are discussed, and likely areas for future progress are identified...
  17. pmc Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes
    Gavin C Woodruff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Genetics 186:997-1012. 2010
    ..In the near future, this hybrid system will likely be fruitful for understanding the genetics of reproductive isolation in Caenorhabditis...
  18. ncbi request reprint Evolution and development: anchors away!
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD, USA
    Curr Biol 17:R172-4. 2007
    ..A new study reveals what may be the very earliest stages of this process by experimentally modifying key vulval signaling pathways in different species of Caenorhabditis, and carefully quantifying the results...
  19. ncbi request reprint Intraspecific variation in fem-3 and tra-2, two rapidly coevolving nematode sex-determining genes
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Gene 349:35-42. 2005
    ..The FEM-3-binding domain of TRA-2 is less polymorphic than FEM-3. Amino acids neither polymorphic nor conserved between species are candidates for residues mediating species-specific interaction of FEM-3 with its binding partners...
  20. ncbi request reprint Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2
    Eric S Haag
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Curr Biol 12:2035-41. 2002
    ..Extrapolation of this result to larger phylogenetic scales helps explain the dissimilarity of the sex determination systems across phyla...
  21. ncbi request reprint Germline imprinting: battle of the sexes or battle of the X's?
    Eric S Haag
    Department of Biology, Building 144, University of Maryland, College Park, MD 20742, USA
    Dev Cell 6:157-8. 2004
    ..Writing in Nature Genetics, Bean et al. report a parallel between male germline X inactivation in nematodes and a fungal gene-silencing mechanism that alters the way we view the evolution of both phenomena...
  22. ncbi request reprint Meeting review: the microevolution of development
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 5:1-2. 2003
  23. ncbi request reprint Echinoderm rudiments, rudimentary bilaterians, and the origin of the chordate CNS
    Eric S Haag
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 7:280-1. 2005
  24. pmc Comparative genetics of sex determination: masculinizing mutations in Caenorhabditis briggsae
    Danielle F Kelleher
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 178:1415-29. 2008
    ..Beyond these immediate results, this collection of mutations provides an essential foundation for further comparative genetic analysis of the Caenorhabditis sex determination pathway...
  25. ncbi request reprint Evolution of ribonuclease inhibitor by exon duplication
    Marcia C Haigis
    Mol Biol Evol 19:959-63. 2002

Research Grants9

  1. THERMODYNAMICS AND STRUCTURE OF POLYMERIZING ACTIN
    SANDRA GREER; Fiscal Year: 2001
    ..abstract_text> ..
  2. Comparative Genetic Analysis of Hermaphroditism in Caenorhabditis
    Eric S Haag; Fiscal Year: 2010
    ..Finally, since these rapidly evolving features are essential for nematode reproduction, they may eventually make excellent targets for parasite-specific anti-helminthic drugs. ..
  3. Comparative Genetic Analysis of Hermaphroditism in Caenorhabditis
    ERIC HAAG; Fiscal Year: 2009
    ..Finally, since these rapidly evolving features are essential for nematode reproduction, they may eventually make excellent targets for parasite-specific anti-helminthic drugs. ..