Research Topics
| Eric S HaagSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Using Caenorhabditis to explore the evolution of the germ lineEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Adv Exp Med Biol 757:405-25. 2013..The biological roles of germline RBPs are thus highly context-dependent, and the inference of archetypal roles from isolated models in different phyla may therefore be premature...
A toolkit for rapid gene mapping in the nematode Caenorhabditis briggsaeDaniel C Koboldt
Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
BMC Genomics 11:236. 2010..These studies rely on the availability of forward genetic tools such as mutants and mapping markers...
Dial-a-mutant: web-based knockout collections for model organismsEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Biol Cell 99:343-7. 2007..These tools greatly enhance the ability of non-specialists to conduct studies of gene function in vivo in these model species...- Caenorhabditis evolution: if they all look alike, you aren't looking hard enoughEric S Haag
Department of Biology, Building 144, University of Maryland, College Park, MD 20742, USA
Trends Genet 23:101-4. 2007..Here, we summarize the main findings of the meeting, which marks the formal birth of a research community dedicated to Caenorhabditis species evolution... - Compensatory vs. pseudocompensatory evolution in molecular and developmental interactionsEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Genetica 129:45-55. 2007..Future empirical work in this area should focus on comparing the details of intra- and intergenic interactions in closely related organisms... - Compensatory evolution of interacting gene products through multifunctional intermediatesEric S Haag
Department of Biology, University of Maryland, College Park 20742, USA
Evolution 59:1620-32. 2005..These results suggest that population size, the source of adaptive benefit, and the structural details of heteromeric gene product complexes interact to influence the path by which intergenic incompatibility evolves... - L'enfant terrible at 30: the maturation of evolutionary developmental biologyEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Development 138:2633-7. 2011..It revealed maturation on several fronts, including increased experimental rigor, the softening of dichotomies that were crucial to its founding and growth, and its growing relevance to both basic and biomedical biology... - Sex determination across evolution: connecting the dotsEric S Haag
Department of Biology and Program in Behavior, Evolution, Ecology and Systematics, University of Maryland, College Park, Maryland, United States of America
PLoS Biol 3:e21. 2005 - Independent recruitments of a translational regulator in the evolution of self-fertile nematodesAlana V Beadell
Department of Biology, University of Maryland, College Park, MD 20742, USA
Proc Natl Acad Sci U S A 108:19672-7. 2011..We conclude that, as with transcription factors, spatially localized translational regulators play important roles in the evolution of anatomical novelties... - Context-dependent function of a conserved translational regulatory moduleQinwen Liu
Department of Biology, University of Maryland, College Park, MD 20742, USA
Development 139:1509-21. 2012..Finally, we document non-redundant roles for Cbr-puf-2 in embryonic and early larval development, the latter role being essential. Thus, recently duplicated PUF paralogs have already acquired distinct functions... - A sensitized genetic background reveals evolution near the terminus of the Caenorhabditis germline sex determination pathwayRobin Cook Hill
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 11:333-42. 2009..These results represent another way in which C. briggsae germline sex determination is incongruent with that of the outwardly similar C. elegans... - Genetic flexibility in the convergent evolution of hermaphroditism in Caenorhabditis nematodesRobin Cook Hill
Department of Biology, University of Maryland, College Park, 20742, USA
Dev Cell 10:531-8. 2006..These findings are consistent with convergent evolution of hermaphroditism, which is marked by considerable developmental genetic flexibility... - Causes and consequences of the evolution of reproductive mode in Caenorhabditis nematodesCristel G Thomas
Department of Biology, University of Maryland, College Park, MD 20742, USA
Trends Genet 28:213-20. 2012..We also discuss the consequences of selfing, which leads to a rapid loss of variation and relaxation of natural and sexual selection on mating-related traits, and may ultimately put selfing lineages at a higher risk of extinction... - Caenorhabditis briggsae recombinant inbred line genotypes reveal inter-strain incompatibility and the evolution of recombinationJoseph A Ross
Department of Biology, University of Maryland, College Park, Maryland, USA
PLoS Genet 7:e1002174. 2011.... - Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodesGavin C Woodruff
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Genetics 186:997-1012. 2010..In the near future, this hybrid system will likely be fruitful for understanding the genetics of reproductive isolation in Caenorhabditis... - Chapter 3. Caenorhabditis nematodes as a model for the adaptive evolution of germ cellsEric S Haag
Department of Biology, University of Maryland, College Park, MD, USA
Curr Top Dev Biol 86:43-66. 2009..Recent studies that employ comparative genetic methods in this rapidly maturing system are discussed, and likely areas for future progress are identified... - Intraspecific variation in fem-3 and tra-2, two rapidly coevolving nematode sex-determining genesEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Gene 349:35-42. 2005..The FEM-3-binding domain of TRA-2 is less polymorphic than FEM-3. Amino acids neither polymorphic nor conserved between species are candidates for residues mediating species-specific interaction of FEM-3 with its binding partners... - Evolution and development: anchors away!Eric S Haag
Department of Biology, University of Maryland, College Park, MD, USA
Curr Biol 17:R172-4. 2007..A new study reveals what may be the very earliest stages of this process by experimentally modifying key vulval signaling pathways in different species of Caenorhabditis, and carefully quantifying the results... - Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2Eric S Haag
Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
Curr Biol 12:2035-41. 2002..Extrapolation of this result to larger phylogenetic scales helps explain the dissimilarity of the sex determination systems across phyla... - Simplification and desexualization of gene expression in self-fertile nematodesCristel G Thomas
Department of Biology, University of Maryland, College Park, MD 20742, USA
Curr Biol 22:2167-72. 2012..These changes may result from the combination of relaxed sexual selection and a recently reported genetic mechanism favoring genome shrinkage in partial selfers... - Germline imprinting: battle of the sexes or battle of the X's?Eric S Haag
Department of Biology, Building 144, University of Maryland, College Park, MD 20742, USA
Dev Cell 6:157-8. 2004..Writing in Nature Genetics, Bean et al. report a parallel between male germline X inactivation in nematodes and a fungal gene-silencing mechanism that alters the way we view the evolution of both phenomena... - Meeting review: the microevolution of developmentEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 5:1-2. 2003 - Echinoderm rudiments, rudimentary bilaterians, and the origin of the chordate CNSEric S Haag
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 7:280-1. 2005 - Comparative genetics of sex determination: masculinizing mutations in Caenorhabditis briggsaeDanielle F Kelleher
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 178:1415-29. 2008..Beyond these immediate results, this collection of mutations provides an essential foundation for further comparative genetic analysis of the Caenorhabditis sex determination pathway... - Evolution of ribonuclease inhibitor by exon duplicationMarcia C Haigis
Mol Biol Evol 19:959-63. 2002
Research Grants
- THERMODYNAMICS AND STRUCTURE OF POLYMERIZING ACTINSANDRA GREER; Fiscal Year: 2001..abstract_text> ..
- Comparative Genetic Analysis of Hermaphroditism in CaenorhabditisEric S Haag; Fiscal Year: 2010..Finally, since these rapidly evolving features are essential for nematode reproduction, they may eventually make excellent targets for parasite-specific anti-helminthic drugs. ..
- Comparative Genetic Analysis of Hermaphroditism in CaenorhabditisERIC HAAG; Fiscal Year: 2009..Finally, since these rapidly evolving features are essential for nematode reproduction, they may eventually make excellent targets for parasite-specific anti-helminthic drugs. ..