KAREN GYLYS

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Rapid annexin-V labeling in synaptosomes
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919, Factor Building, Los Angeles, CA 90095, USA
    Neurochem Int 44:125-31. 2004
  2. ncbi request reprint Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry
    K H Gylys
    UCLA School of Nursing, Los Angeles, California 90095 6919, USA
    J Neurosci Res 61:186-92. 2000
  3. ncbi request reprint Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex
    Karen Hoppens Gylys
    UCLA School of Nursing, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:8-17. 2007
  4. pmc Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    Karen Hoppens Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919 Factor Bldg, Los Angeles, CA 90095 6919, USA
    Am J Pathol 165:1809-17. 2004
  5. ncbi request reprint Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cytometry A 60:90-6. 2004
  6. pmc Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 7334, USA
    Dement Geriatr Cogn Disord 33:219-25. 2012
  7. ncbi request reprint Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095 6919, USA
    J Neurochem 84:1442-51. 2003
  8. ncbi request reprint Caspase inhibition protects nerve terminals from in vitro degradation
    Karen H Gylys
    UCLA School of Nursing, Brain Research Institute, Box 956919, Los Angeles, California 90095, USA
    Neurochem Res 27:465-72. 2002
  9. ncbi request reprint Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection
    Dorothy J Wiley
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 6919, USA
    Cancer Epidemiol Biomarkers Prev 15:915-20. 2006
  10. pmc Smoking enhances risk for new external genital warts in men
    Dorothy J Wiley
    Division of Primary Care, School of Nursing, University of California at Los Angeles UCLA, Los Angeles, California, USA
    Int J Environ Res Public Health 6:1215-34. 2009

Detail Information

Publications13

  1. ncbi request reprint Rapid annexin-V labeling in synaptosomes
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919, Factor Building, Los Angeles, CA 90095, USA
    Neurochem Int 44:125-31. 2004
    ..These data demonstrate that PS externalization and caspase activation occur rapidly in this widely used neurochemical preparation...
  2. ncbi request reprint Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry
    K H Gylys
    UCLA School of Nursing, Los Angeles, California 90095 6919, USA
    J Neurosci Res 61:186-92. 2000
    ..These results suggest that flow cytometry may be used to take advantage of the increased viability, yield, and convenience of the P-2 fraction for studies of nerve terminal function...
  3. ncbi request reprint Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex
    Karen Hoppens Gylys
    UCLA School of Nursing, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:8-17. 2007
    ..These results suggest that Abeta accumulation in synaptic terminals may underly dysfunction prior to or independent of extracellular amyloid deposition...
  4. pmc Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    Karen Hoppens Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919 Factor Bldg, Los Angeles, CA 90095 6919, USA
    Am J Pathol 165:1809-17. 2004
    ....
  5. ncbi request reprint Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cytometry A 60:90-6. 2004
    ....
  6. pmc Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 7334, USA
    Dement Geriatr Cogn Disord 33:219-25. 2012
    ..We asked if consequently, oxidation of methionine residues to methionine sulfoxide (MetO) was increased in plasma proteins of persons carrying familial AD (FAD) mutations...
  7. ncbi request reprint Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095 6919, USA
    J Neurochem 84:1442-51. 2003
    ..These results suggest that complex formation with apoE enhances internalization of soluble Abeta uptake into terminals...
  8. ncbi request reprint Caspase inhibition protects nerve terminals from in vitro degradation
    Karen H Gylys
    UCLA School of Nursing, Brain Research Institute, Box 956919, Los Angeles, California 90095, USA
    Neurochem Res 27:465-72. 2002
    ..These results indicate activation of both caspase and calpain in the P-2 fraction and suggest a role for these cysteine proteases in the in vitro degradation of nerve terminals...
  9. ncbi request reprint Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection
    Dorothy J Wiley
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 6919, USA
    Cancer Epidemiol Biomarkers Prev 15:915-20. 2006
    ..Main Outcome Measure: HPV16-L1 antibody (anti-HPV16 antibody) detected from serum using RIA or ELISA...
  10. pmc Smoking enhances risk for new external genital warts in men
    Dorothy J Wiley
    Division of Primary Care, School of Nursing, University of California at Los Angeles UCLA, Los Angeles, California, USA
    Int J Environ Res Public Health 6:1215-34. 2009
    ..Multivariate analyses showed smoking, prior episodes of EGWs, HIV infection and CD4+ T-lymphocyte count among the infected, each differentially influenced the risk for new EGWs...
  11. pmc Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, UCLA Department of Neurology, Los Angeles, CA, United States
    Neurosci Lett 487:287-92. 2011
    ..We describe biochemical, imaging, and neuropathological changes in a pedigree with a novel PSEN1 mutation. This allows us to validate the pathogenicity of this mutation and the indices used to assess AD...
  12. pmc Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research at UCLA, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 33:1-5. 2012
    ..Changes in cerebrospinal fluid (CSF) levels of 42-amino-acid β-amyloid (Aβ(42)), total tau protein (t-tau) and phosphorylated tau at residue 181 (p-tau(181)) during this state are incompletely characterized...
  13. pmc Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
    Jeffrey A Fein
    School of Nursing, University of California at Los Angeles School of Medicine, Sepulveda Veterans Administration Medical Center, Los Angeles, California 90095 6919, USA
    Am J Pathol 172:1683-92. 2008
    ..0001). These results showing overlapping Abeta and tau pathology are consistent with a model in which both synaptic loss and dysfunction are linked to a synaptic amyloid cascade within the synaptic compartment...

Research Grants2

  1. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    KAREN GYLYS; Fiscal Year: 2009
    ..These experiments will help us to understand how cholesterol may contribute to Alzheimer's pathology. ..
  2. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    Karen H Gylys; Fiscal Year: 2010
    ..These experiments will help us to understand how cholesterol may contribute to Alzheimer's pathology. ..