Gyetko M, Sud S, Kendall T, Fuller J, Newstead M, Standiford T. Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J Immunol. 2000;165:1513-9 pubmed
..aeruginosa. This is the first report of a requirement for uPAR during cellular recruitment in vivo against a clinically relevant pathogen. ..
Gyetko M, Sud S, Chen G, Fuller J, Chensue S, Toews G. Urokinase-type plasminogen activator is required for the generation of a type 1 immune response to pulmonary Cryptococcus neoformans infection. J Immunol. 2002;168:801-9 pubmed
..This study provides novel evidence that uPA is a critical modulator of immune responses and of immune cell effector functions in vivo. ..
Gyetko M, Aizenberg D, Mayo Bond L. Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro. J Leukoc Biol. 2004;76:648-56 pubmed
..We conclude that the uPA/uPAR system modulates several of the crucial steps in neutrophil activation that result in bacterial killing and effective innate host defense. ..