MARGARET GYETKO

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Urokinase-deficient mice fail to generate a type 2 immune response following schistosomal antigen challenge
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Veterans Affairs Ann Arbor Healthcare System and University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Infect Immun 72:461-7. 2004
  2. ncbi request reprint Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, 3916 Taubman Center Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    J Leukoc Biol 76:648-56. 2004
  3. ncbi request reprint Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection
    M R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 165:1513-9. 2000
  4. ncbi request reprint Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA
    M R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 167:5539-42. 2001
  5. ncbi request reprint Urokinase-type plasminogen activator is required for the generation of a type 1 immune response to pulmonary Cryptococcus neoformans infection
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 168:801-9. 2002
  6. ncbi request reprint Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast
    M Gharaee-Kermani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical School, 2215 Fuller Road, 11 R, Ann Arbor, MI 48105, USA
    Curr Med Chem 16:1400-17. 2009
  7. pmc Urokinase-type plasminogen activator in inflammatory cell recruitment and host defense against Pneumocystis carinii in mice
    J M Beck
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0360, USA
    Infect Immun 67:879-84. 1999
  8. pmc Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model
    M R Gyetko
    Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 97:1818-26. 1996
  9. ncbi request reprint Urokinase is required for T lymphocyte proliferation and activation in vitro
    M R Gyetko
    Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, USA
    J Lab Clin Med 133:274-88. 1999
  10. ncbi request reprint The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy
    Mehrnaz Gharaee-Kermani
    University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2215 Fuller Road, 11R, Ann Arbor, MI 48105, USA
    Expert Opin Investig Drugs 17:905-16. 2008

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Urokinase-deficient mice fail to generate a type 2 immune response following schistosomal antigen challenge
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Veterans Affairs Ann Arbor Healthcare System and University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Infect Immun 72:461-7. 2004
    ..These findings, in conjunction with our previous work, demonstrate that mice deficient in uPA have profoundly impaired immunity involving both T1 and T2 polarization and are largely immunologically unresponsive...
  2. ncbi request reprint Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, 3916 Taubman Center Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    J Leukoc Biol 76:648-56. 2004
    ..We conclude that the uPA/uPAR system modulates several of the crucial steps in neutrophil activation that result in bacterial killing and effective innate host defense...
  3. ncbi request reprint Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection
    M R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 165:1513-9. 2000
    ..aeruginosa. This is the first report of a requirement for uPAR during cellular recruitment in vivo against a clinically relevant pathogen...
  4. ncbi request reprint Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA
    M R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 167:5539-42. 2001
    ..Markedly fewer uPAR(-/-) compared with WT lymphoblasts were recruited to the lung. These findings suggest that uPAR may be a novel target for immune modulation in T lymphocyte-mediated disorders...
  5. ncbi request reprint Urokinase-type plasminogen activator is required for the generation of a type 1 immune response to pulmonary Cryptococcus neoformans infection
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 168:801-9. 2002
    ..This study provides novel evidence that uPA is a critical modulator of immune responses and of immune cell effector functions in vivo...
  6. ncbi request reprint Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast
    M Gharaee-Kermani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical School, 2215 Fuller Road, 11 R, Ann Arbor, MI 48105, USA
    Curr Med Chem 16:1400-17. 2009
    ..This review will focus on the critical role of TGFbeta on AECs EMT and myofibroblasts in the development of fibrosis...
  7. pmc Urokinase-type plasminogen activator in inflammatory cell recruitment and host defense against Pneumocystis carinii in mice
    J M Beck
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0360, USA
    Infect Immun 67:879-84. 1999
    ..Therefore, uPA is an important participant in the network of inflammatory events required for the clearance of P. carinii, confirming an important role for this molecule in pulmonary host defense against opportunistic pathogens...
  8. pmc Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model
    M R Gyetko
    Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 97:1818-26. 1996
    ..001). We have demonstrated that uPA is required for a pulmonary inflammatory response to C. neoformans. Lack of uPA results in inadequate cellular recruitment, uncontrolled infection, and death...
  9. ncbi request reprint Urokinase is required for T lymphocyte proliferation and activation in vitro
    M R Gyetko
    Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, USA
    J Lab Clin Med 133:274-88. 1999
    ..These findings suggest that the inability of uPA-/- mice to combat Cryptococcus neoformans infection may be caused by the impairment of T lymphocyte immune responses in the absence of uPA...
  10. ncbi request reprint The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy
    Mehrnaz Gharaee-Kermani
    University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2215 Fuller Road, 11R, Ann Arbor, MI 48105, USA
    Expert Opin Investig Drugs 17:905-16. 2008
    ..The balance between the activating enzyme uPA, and its inhibitor PAI-1, is a critical determinant of the amount of scar development that follows...
  11. ncbi request reprint Current and emerging drugs for idiopathic pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2215 Fuller Road, 11R, Ann Arbor, MI 48105, USA
    Expert Opin Emerg Drugs 12:627-46. 2007
    ..This article examines the body of evidence supporting present therapies and reviews the newer agents being tested in patients with idiopathic pulmonary fibrosis...
  12. ncbi request reprint New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy
    Mehrnaz Gharaee-Kermani
    Division of Pulmonary Medicine and Critical Care, Department of Internal Medicine, University of Michigan Medical School, 2215 Fuller Rd VAMC 11R, Ann Arbor, Michigan 48105, USA
    Pharm Res 24:819-41. 2007
    ..This article reviews the new concepts in the pathogenesis, current and future treatment options of pulmonary fibrosis, and the recent advances regarding the roles of stem cells in lung tissue repair, regeneration, and remodeling...
  13. ncbi request reprint Mactinin treatment promotes wound-healing-associated inflammation in urokinase knockout mice
    Sharon D Luikart
    Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Wound Repair Regen 14:123-8. 2006
    ..The results suggest that impaired wound healing in urokinase-deficient mice can be restored by administration of mactinin...
  14. ncbi request reprint Induction of p53 by urokinase in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 280:28133-41. 2005
    ..This pathway could regulate pathophysiologic alterations of p53 expression in the setting of lung inflammation or neoplasia...
  15. ncbi request reprint Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator
    Andrei L Kindzelskii
    Department of Ophthalmology and Visual Sciences and Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Histochem Cell Biol 121:299-310. 2004
    ..demonstrated its usefulness in real-time studies of cell migration, and (4). showed that the uPA/uPAR system is an important contributor to focal pericellular proteolysis...
  16. ncbi request reprint Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
    ....
  17. ncbi request reprint Urokinase is required for the formation of mactinin, an alpha-actinin fragment that promotes monocyte/macrophage maturation
    Sharon Luikart
    Veterans Affairs Medical Center, Minneapolis, MN, USA
    Biochim Biophys Acta 1591:99-107. 2002
    ..These findings support the role of urokinase in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions...

Research Grants1

  1. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
    ..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..