Young S Gwak

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, TX 77555, USA
    Exp Neurol 234:362-72. 2012
  2. pmc Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat
    Y S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Neuroscience 161:895-903. 2009
  3. ncbi request reprint Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Exp Neurol 195:236-43. 2005
  4. pmc GABA and central neuropathic pain following spinal cord injury
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Neuropharmacology 60:799-808. 2011
  5. doi request reprint Bilateral hyperexcitability of thalamic VPL neurons following unilateral spinal injury in rats
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    J Physiol Sci 60:59-66. 2010
  6. ncbi request reprint Spinal AMPA receptor inhibition attenuates mechanical allodynia and neuronal hyperexcitability following spinal cord injury in rats
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    J Neurosci Res 85:2352-9. 2007
  7. pmc Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Pain 138:410-22. 2008
  8. pmc Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury
    Young S Gwak
    Department of Neuroscience, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Exp Neurol 220:154-61. 2009
  9. pmc Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury
    Eric D Crown
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Pain 153:710-21. 2012
  10. ncbi request reprint Reactive oxygen species contribute to neuropathic pain and locomotor dysfunction via activation of CamKII in remote segments following spinal cord contusion injury in rats
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, TX 77555 1043, USA
    Pain 154:1699-708. 2013

Collaborators

Detail Information

Publications18

  1. pmc Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, TX 77555, USA
    Exp Neurol 234:362-72. 2012
    ..Our work in the context of work by others in SCI models demonstrates that dysfunctional glia, a condition called "gliopathy", is a key contributor in the underlying cellular mechanisms contributing to neuropathic pain...
  2. pmc Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat
    Y S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Neuroscience 161:895-903. 2009
    ..05) that was prevented in a dose-related manner by PPF. In conclusion, our present data support astrocytic and microglial activation that contributes to below-level central neuropathic pain following spinal cord injury...
  3. ncbi request reprint Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Exp Neurol 195:236-43. 2005
    ..Thus, permanent alterations in dorsal horn receptor expression may play important roles in transmission of nociceptive responses in the spinal cord following SCI...
  4. pmc GABA and central neuropathic pain following spinal cord injury
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Neuropharmacology 60:799-808. 2011
    ..This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'...
  5. doi request reprint Bilateral hyperexcitability of thalamic VPL neurons following unilateral spinal injury in rats
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    J Physiol Sci 60:59-66. 2010
    ..In addition, both sides of the thalamic VPL regions showed higher incidences of WDR neurons. In conclusion, our data demonstrate that spinal unilateral injury induces bilaterally increased evoked activity in thalamic VPL neurons...
  6. ncbi request reprint Spinal AMPA receptor inhibition attenuates mechanical allodynia and neuronal hyperexcitability following spinal cord injury in rats
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    J Neurosci Res 85:2352-9. 2007
    ..In conclusion, our study demonstrates that the AMPA receptor plays an important role in behaviors related to the maintenance of central neuropathic pain below the level of spinal cord injury...
  7. pmc Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Pain 138:410-22. 2008
    ..05). In conclusion, our present data demonstrate that propentofylline modulates glia activation and GABAergic inhibitory tone by modulation of GAD(65) protein expression following spinal cord injury...
  8. pmc Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury
    Young S Gwak
    Department of Neuroscience, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Exp Neurol 220:154-61. 2009
    ..05). In conclusion, our present data demonstrate that activated neuronal and microglial, but not astrocytic, p-38alpha MAPK contributes to the maintenance of neuronal hyperexcitability in caudal regions following spinal cord injury...
  9. pmc Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury
    Eric D Crown
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Pain 153:710-21. 2012
    ..Furthermore, targeting key signaling proteins is a novel, useful therapeutic strategy for treating chronic central neuropathic pain...
  10. ncbi request reprint Reactive oxygen species contribute to neuropathic pain and locomotor dysfunction via activation of CamKII in remote segments following spinal cord contusion injury in rats
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, TX 77555 1043, USA
    Pain 154:1699-708. 2013
    ..05). In conclusion, the present data suggest that overproduction of ROS contribute to sensory and motor abnormalities in remote segments below the lesion after thoracic SCI...
  11. pmc Ionotropic glutamate receptors contribute to maintained neuronal hyperexcitability following spinal cord injury in rats
    Joong Woo Leem
    Department of Physiology, Brain Research Institute, and BK21 Project for Medical Science, Yonsei University College of Medicine, C P O Box 8044, Seoul, 120 752, Republic of Korea
    Exp Neurol 224:321-4. 2010
    ....
  12. ncbi request reprint Effect of age at time of spinal cord injury on behavioral outcomes in rat
    Young Seob Gwak
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
    J Neurotrauma 21:983-93. 2004
    ..Additionally, our data suggest that age at the time of injury may be one risk factor in predicting the development of CCP after SCI in people...
  13. ncbi request reprint Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and BK21 Project for Medical Science, Yonsei University College of Medicine, CPO Box 8044, Seoul 120 752, South Korea
    Neurosci Lett 336:117-20. 2003
    ..These results indicate that anti-NGF prevents the development of abnormal somatosensory behavior and suggest a potential pre-emptive analgesic treatment for central pain...
  14. doi request reprint An electrophysiological method for quantifying neuropathic pain behaviors in rats: measurement of hindlimb withdrawal EMG magnitude
    Hee Young Kim
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    J Physiol Sci 59:473-6. 2009
    ..Our current data suggest that measurement of electrophysiological EMG magnitudes enables more reliable and objective assessment for quantifying nocifensive behaviors related to neuropathic pain...
  15. pmc Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury
    Eric D Crown
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Exp Neurol 213:257-67. 2008
    ..Taken together, these novel data are the first to demonstrate causality that increased activation of p38 MAPK in multiple cell types play an important role in the maintenance of at-level CNP following spinal cord injury...
  16. ncbi request reprint Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat
    Young Seob Gwak
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Neurosci Lett 362:232-5. 2004
    ..These results support age-dependent behavioral outcomes after SCI...
  17. ncbi request reprint Activation of spinal GABA receptors attenuates chronic central neuropathic pain after spinal cord injury
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
    J Neurotrauma 23:1111-24. 2006
    ....
  18. ncbi request reprint Antinociceptive effects of heterotopic electroacupuncture in formalin-induced pain
    Jae Hyo Kim
    Department of Meridian and Acupoints, Wonkwang University College of Oriental Medicine, Iksan 570 749, Korea
    Am J Chin Med 34:565-74. 2006
    ..Therefore, EA induced pre-emptive antinociception via the extra-segmental inhibition of the formalin-induced pain, suggesting that EA to heterotopic acupoints is a useful treatment for inflammatory pain...