John F Guzowski

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268
    J F Guzowski
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 21:5089-98. 2001
  2. ncbi request reprint Imaging neural activity with temporal and cellular resolution using FISH
    J F Guzowski
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, Tucson, AZ 85724, USA
    Curr Opin Neurobiol 11:579-84. 2001
  3. ncbi request reprint Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches
    John F Guzowski
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson 85724 5115, USA
    Hippocampus 12:86-104. 2002
  4. ncbi request reprint Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles
    Almira Vazdarjanova
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 24:6489-96. 2004
  5. ncbi request reprint Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks
    Almira Vazdarjanova
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 22:10067-71. 2002
  6. ncbi request reprint 3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridization
    Monica K Chawla
    Neural Systems, Memory, and Aging Division, Life Sciences North Bldg, Rm 384, University of Arizona, Tucson, AZ 85724, USA
    J Neurosci Methods 139:13-24. 2004
  7. pmc Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution
    Vicki L Sutherland
    Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, United States
    J Neurosci Methods 160:144-8. 2007
  8. ncbi request reprint Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain
    Almira Vazdarjanova
    Synapses and Cognitive Neuroscience Center and Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Comp Neurol 498:317-29. 2006
  9. pmc Networks of neurons, networks of genes: an integrated view of memory consolidation
    Teiko Miyashita
    Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 89:269-84. 2008
  10. ncbi request reprint Using immediate-early genes to map hippocampal subregional functions
    Stepan Kubik
    Department of Neurobiology and Behavior Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
    Learn Mem 14:758-70. 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268
    J F Guzowski
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 21:5089-98. 2001
    ..Thus, although the expression of Arc, zif268, and c-fos exhibited many similarities, Arc was most responsive to differences in behavioral task demands...
  2. ncbi request reprint Imaging neural activity with temporal and cellular resolution using FISH
    J F Guzowski
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, Tucson, AZ 85724, USA
    Curr Opin Neurobiol 11:579-84. 2001
    ..Thus, this technique provides information about when individual neurons are activated and allows the visualization, within a single brain, of different neuronal populations engaged by two distinct experiences...
  3. ncbi request reprint Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches
    John F Guzowski
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson 85724 5115, USA
    Hippocampus 12:86-104. 2002
    ..Further investigation into the expression and function of IEGs using catFISH and antisense approaches will likely increase understanding of the molecular and cellular bases of information processing involving the hippocampus...
  4. ncbi request reprint Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles
    Almira Vazdarjanova
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 24:6489-96. 2004
    ..Taken together, these findings suggest that CA3 and CA1 neuronal ensembles perform distinct, yet complementary, functions in the processing of spatial and contextual information...
  5. ncbi request reprint Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks
    Almira Vazdarjanova
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 22:10067-71. 2002
    ....
  6. ncbi request reprint 3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridization
    Monica K Chawla
    Neural Systems, Memory, and Aging Division, Life Sciences North Bldg, Rm 384, University of Arizona, Tucson, AZ 85724, USA
    J Neurosci Methods 139:13-24. 2004
    ..5% concordance with multi-expert consensus). The high degree of reliability and accuracy suggests that the software will generalize well to multiple brain areas and eventually to large-scale brain analysis...
  7. pmc Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution
    Vicki L Sutherland
    Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, United States
    J Neurosci Methods 160:144-8. 2007
    ....
  8. ncbi request reprint Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain
    Almira Vazdarjanova
    Synapses and Cognitive Neuroscience Center and Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Comp Neurol 498:317-29. 2006
    ....
  9. pmc Networks of neurons, networks of genes: an integrated view of memory consolidation
    Teiko Miyashita
    Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 89:269-84. 2008
    ..Such an updating process may well recruit and use many of the plasticity mechanisms necessary for the initial encoding of memory...
  10. ncbi request reprint Using immediate-early genes to map hippocampal subregional functions
    Stepan Kubik
    Department of Neurobiology and Behavior Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
    Learn Mem 14:758-70. 2007
    ..In closing, we provide a framework for how cutting-edge IEG imaging and intervention techniques will likely contribute to better understanding of the specific functions of CA3 and other hippocampal subregions...
  11. pmc Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons
    John F Guzowski
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 103:1077-82. 2006
    ..This state-dependence of neuronal transcriptional coupling provides a mechanism of metaplasticity and may regulate capacity for synaptic modification in neural networks...
  12. pmc Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus
    Christa K McIntyre
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, 218 Bonney Research Laboratory, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 102:10718-23. 2005
    ....
  13. ncbi request reprint Ensemble dynamics of hippocampal regions CA3 and CA1
    John F Guzowski
    Department of Neurosciences, University of New Mexico HSC, Albuquerque, NM 87131, USA
    Neuron 44:581-4. 2004
    ..The results provide converging evidence that CA3 is capable of performing nonlinear transformations of sensory input patterns, whereas CA1 may represent changes in input in a more linear fashion...
  14. ncbi request reprint Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    J Neurochem 88:434-42. 2004
    ..Presumably, pharmacological agents blocking the Abeta-related inhibition of gene expression will have benefit in AD...
  15. ncbi request reprint Mapping behaviorally relevant neural circuits with immediate-early gene expression
    John F Guzowski
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 5223, USA
    Curr Opin Neurobiol 15:599-606. 2005
    ....
  16. ncbi request reprint Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression
    Daniele Bottai
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 22:167-75. 2002
    ..These coordinate transcriptional events rapidly convert a constitutive gene to an IEG and regulate the expression of functionally different Homer 1 proteins...
  17. ncbi request reprint A hybrid 3D watershed algorithm incorporating gradient cues and object models for automatic segmentation of nuclei in confocal image stacks
    Gang Lin
    Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    Cytometry A 56:23-36. 2003
    ..A common source of segmentation error is tight clustering of nuclei. There is a compelling need to minimize these errors for constructing highly automated scoring systems...
  18. pmc A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    Learn Mem 14:433-45. 2007
    ..Moreover, these data demonstrate that different LTP induction paradigms do not have identical molecular consequences, which may account for certain discrepancies between previous studies...
  19. ncbi request reprint Neuronal competition and selection during memory formation
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Science 316:457-60. 2007
    ..Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning...
  20. ncbi request reprint Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory
    Bonnie R Fletcher
    Fishberg Department of Neuroscience and Alfred B and Gudrun J Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hippocampus 17:227-34. 2007
    ..The conclusion from these data is that cholinergic deafferentation alone cannot account for the spatial learning deficits or impaired behavioral induction of Arc transcription produced by fornix lesions...
  21. ncbi request reprint Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons
    Lawrence C R Tafoya
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Neurosci 26:7826-38. 2006
    ....
  22. pmc Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval
    Wei Ping Zhang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    Learn Mem 12:239-47. 2005
    ....
  23. pmc Hypothesis: suppression of memory protein formation underlies anesthetic-induced amnesia
    Michael T Alkire
    Department of Anesthesiology and Perioperative Care, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA
    Anesthesiology 109:768-70. 2008