Monica L Guzman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Preferential induction of apoptosis for primary human leukemic stem cells
    Monica L Guzman
    Blood and Marrow Transplant Program, Markey Cancer Center, Division of HematologyOncology, University of Kentucky Medical Center, Lexington, KY 40536 0093 USA
    Proc Natl Acad Sci U S A 99:16220-5. 2002
  2. pmc The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    Monica L Guzman
    University of Rochester School of Medicine, 601 Elmwood Ave, Box 703, Rochester, NY 14642, USA
    Blood 105:4163-9. 2005
  3. pmc Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester, NY 14642, USA
    Blood 110:4436-44. 2007
  4. pmc Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data
    Duane C Hassane
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, NY, USA
    Blood 111:5654-62. 2008
  5. pmc Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide
    Jolanta Skalska
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 4:e8115. 2009
  6. pmc An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester, NY 14642, USA
    Blood 110:4427-35. 2007
  7. doi request reprint Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cancer Cell 15:252-4. 2009
  8. ncbi request reprint Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells
    Jonathan M Weber
    Endocrine Division, Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue Box 693 Rochester, NY 14642, USA
    Bone 39:485-93. 2006
  9. ncbi request reprint Mechanisms controlling pathogenesis and survival of leukemic stem cells
    Craig T Jordan
    Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 703, NY 14642, USA
    Oncogene 23:7178-87. 2004
  10. ncbi request reprint Cancer stem cells
    Craig T Jordan
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 355:1253-61. 2006

Collaborators

Detail Information

Publications15

  1. pmc Preferential induction of apoptosis for primary human leukemic stem cells
    Monica L Guzman
    Blood and Marrow Transplant Program, Markey Cancer Center, Division of HematologyOncology, University of Kentucky Medical Center, Lexington, KY 40536 0093 USA
    Proc Natl Acad Sci U S A 99:16220-5. 2002
    ..Further, the data begin to elucidate the molecular mechanisms that underlie LSC-specific apoptosis and suggest new directions for AML therapy...
  2. pmc The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    Monica L Guzman
    University of Rochester School of Medicine, 601 Elmwood Ave, Box 703, Rochester, NY 14642, USA
    Blood 105:4163-9. 2005
    ..On the basis of these findings, we propose that the activity of PTL triggers LSC-specific apoptosis and as such represents a potentially important new class of drugs for LSC-targeted therapy...
  3. pmc Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester, NY 14642, USA
    Blood 110:4436-44. 2007
    ..We conclude that TDZD-8 uses a unique and previously unknown mechanism to rapidly target leukemia cells, including malignant stem and progenitor populations...
  4. pmc Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data
    Duane C Hassane
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, NY, USA
    Blood 111:5654-62. 2008
    ..These findings suggest the use of multicenter collections of high-throughput data to facilitate discovery of leukemia drugs and drug targets...
  5. pmc Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide
    Jolanta Skalska
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 4:e8115. 2009
    ..Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-cancer agents would modulate exofacial protein thiols...
  6. pmc An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester, NY 14642, USA
    Blood 110:4427-35. 2007
    ..Therefore, based on the collective preclinical data, we propose that the novel compound DMAPT has the potential to target human LSCs in vivo...
  7. doi request reprint Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cancer Cell 15:252-4. 2009
    ..In the current issue of Cancer Cell, a study by Santaguida et al. provides new insights into JunB's function and the genesis of myeloid disease...
  8. ncbi request reprint Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells
    Jonathan M Weber
    Endocrine Division, Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue Box 693 Rochester, NY 14642, USA
    Bone 39:485-93. 2006
    ....
  9. ncbi request reprint Mechanisms controlling pathogenesis and survival of leukemic stem cells
    Craig T Jordan
    Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 703, NY 14642, USA
    Oncogene 23:7178-87. 2004
    ..In this review, we discuss emerging concepts in the field and describe how various molecular and cellular characteristics of leukemia cells might be exploited as a means to preferentially ablate malignant stem cells...
  10. ncbi request reprint Cancer stem cells
    Craig T Jordan
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 355:1253-61. 2006
  11. ncbi request reprint Feverfew: weeding out the root of leukaemia
    Monica L Guzman
    Expert Opin Biol Ther 5:1147-52. 2005
    ..Thus, this naturally occurring agent may provide new avenues of investigation for the treatment of leukaemia. In this article, characteristics of parthenolide are reviewed...
  12. ncbi request reprint Considerations for targeting malignant stem cells in leukemia
    Monica L Guzman
    Blood and Marrow Transplant Program, Markey Cancer Center, Division of Hematology Oncology, University of Kentucky Medical Center, Lexington, Kentucky, USA
    Cancer Control 11:97-104. 2004
    ..Like normal stem cells, these leukemic stem cells (LSCs) are able to self-renew, differentiate, and proliferate extensively. Evidence suggests that LSCs are critical for the initiation and perpetuation of leukemic disease...
  13. pmc Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels
    Ivan Topisirovic
    Institute for Research in Immunovirology and Cancer, University of Montreal, Montreal, Quebec H3T 1J4, Canada
    Mol Cell Biol 25:1100-12. 2005
    ....
  14. doi request reprint The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
    Saman Hewamana
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Blood 111:4681-9. 2008
    ..001, r(2) = 0.3), implicating Rel A in fludarabine resistance. Taken together, these data indicate that Rel A represents an excellent therapeutic target for this incurable disease...
  15. pmc Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis
    Ivan Topisirovic
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, One Gustave Levy Place, New York, NY 10029, USA
    Mol Cell Biol 23:8992-9002. 2003
    ..Thus, our findings indicate that this nuclear function of eIF4E can contribute to leukemogenesis by promoting growth and by impeding differentiation...