PATRICE GUYENET

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Regulation of sympathetic tone and arterial pressure by the rostral ventrolateral medulla after depletion of C1 cells in rats
    P G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Ann N Y Acad Sci 940:259-69. 2001
  2. pmc Chemoreception and asphyxia-induced arousal
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States Electronic address
    Respir Physiol Neurobiol 188:333-43. 2013
  3. pmc C1 neurons: the body's EMTs
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Am J Physiol Regul Integr Comp Physiol 305:R187-204. 2013
  4. pmc The respiratory chemoreception conundrum: light at the end of the tunnel?
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Brain Res 1511:126-37. 2013
  5. pmc Optogenetic stimulation of c1 and retrotrapezoid nucleus neurons causes sleep state-dependent cardiorespiratory stimulation and arousal in rats
    Stephen B G Abbott
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 61:835-41. 2013
  6. doi request reprint The retrotrapezoid nucleus and breathing
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Adv Exp Med Biol 758:115-22. 2012
  7. pmc C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats
    S B Abbott
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    J Physiol 590:2897-915. 2012
  8. pmc The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia Health System, PO Box 800735, 1300 Jefferson Park Ave, Charlottesville, VA 22908 0735, USA
    J Appl Physiol (1985) 105:404-16. 2008
  9. ncbi request reprint Opioid signalling in the rat rostral ventrolateral medulla
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Clin Exp Pharmacol Physiol 29:238-42. 2002
  10. ncbi request reprint Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3806-16. 2002

Research Grants

  1. Functional neuroanatomy of the pre-Botzinger complex
    PATRICE GUYENET; Fiscal Year: 2006
  2. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2007
  3. Retrotrapezoid nucleus and central chemoreception
    PATRICE GUYENET; Fiscal Year: 2007
  4. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2009
  5. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2010
  6. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
  7. Retrotrapezoid nucleus and central chemoreception
    Patrice G Guyenet; Fiscal Year: 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Regulation of sympathetic tone and arterial pressure by the rostral ventrolateral medulla after depletion of C1 cells in rats
    P G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Ann N Y Acad Sci 940:259-69. 2001
    ..However, the deficits caused by treatment with anti-D beta H-SAP indicate that BS C1 neurons play a crucial role in several sympathoexcitatory responses mediated by the RVLM...
  2. pmc Chemoreception and asphyxia-induced arousal
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States Electronic address
    Respir Physiol Neurobiol 188:333-43. 2013
    ....
  3. pmc C1 neurons: the body's EMTs
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Am J Physiol Regul Integr Comp Physiol 305:R187-204. 2013
    ....
  4. pmc The respiratory chemoreception conundrum: light at the end of the tunnel?
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Brain Res 1511:126-37. 2013
    ..A small portion of this evidence is presented as background. This article is part of a Special Issue entitled Optogenetics (7th BRES)...
  5. pmc Optogenetic stimulation of c1 and retrotrapezoid nucleus neurons causes sleep state-dependent cardiorespiratory stimulation and arousal in rats
    Stephen B G Abbott
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 61:835-41. 2013
    ..These neurons, which are powerfully activated by chemoreceptor stimulation, may contribute to the sleep disruption associated with obstructive sleep apnea...
  6. doi request reprint The retrotrapezoid nucleus and breathing
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Adv Exp Med Biol 758:115-22. 2012
    ..In short, RTN Phox2b-VGLUT2 neurons are a major nodal point of the CNS network that regulates pCO(2) via breathing and these cells are probable central chemoreceptors...
  7. pmc C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats
    S B Abbott
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    J Physiol 590:2897-915. 2012
    ..In conclusion, low-frequency stimulation of C1 neurons activates pontine noradrenergic neurons and sympathetic nerve discharge, possibly via the release of glutamate from monosynaptic C1 inputs...
  8. pmc The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia Health System, PO Box 800735, 1300 Jefferson Park Ave, Charlottesville, VA 22908 0735, USA
    J Appl Physiol (1985) 105:404-16. 2008
    ..The working hypothesis could explain the breathing deficits experienced by CCHS patients...
  9. ncbi request reprint Opioid signalling in the rat rostral ventrolateral medulla
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Clin Exp Pharmacol Physiol 29:238-42. 2002
    ....
  10. ncbi request reprint Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3806-16. 2002
    ..In summary, NK1R-expressing cells of the VRG are a heterogeneous group of predominantly glutamatergic neurons that include subpopulations of respiratory premotor neurons...
  11. pmc Central respiratory chemoreception
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 518:3883-906. 2010
    ..Their contribution to central respiratory chemoreception may be behavior dependent or vary according to the state of vigilance...
  12. pmc Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    J Appl Physiol (1985) 108:995-1002. 2010
    ..In the case of SNA, these sites include the nucleus of the solitary tract, the ventrolateral medulla, and the preganglionic neurons...
  13. ncbi request reprint Pre-Bötzinger neurons with preinspiratory discharges "in vivo" express NK1 receptors in the rat
    P G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    J Neurophysiol 86:438-46. 2001
    ....
  14. pmc Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats
    Ana C Takakura
    University of Virginia Health System, PO Box 800735, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0735, USA
    J Physiol 586:2975-91. 2008
    ..The loss of an even greater percentage of these cells would presumably be required to produce significant breathing deficits in the awake state...
  15. ncbi request reprint Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia Health System, PO Box 800735, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0735, USA
    Exp Physiol 90:247-53; discussion 253-7. 2005
    ....
  16. ncbi request reprint Regulation of ventral surface chemoreceptors by the central respiratory pattern generator
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 25:8938-47. 2005
    ..In vivo, RTN neurons receive respiratory synchronous inhibitory inputs that may serve as feedback and impart these neurons with their characteristic respiratory modulation...
  17. ncbi request reprint The sympathetic control of blood pressure
    Patrice G Guyenet
    Department of Pharmacology, Health Sciences Center, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nat Rev Neurosci 7:335-46. 2006
    ..This review examines how the sympathetic tone to cardiovascular organs is generated, and discusses how elevated sympathetic tone can contribute to hypertension...
  18. ncbi request reprint The retrotrapezoid nucleus and central chemoreception
    Patrice G Guyenet
    University of Virginia, Department of Pharmacology, USA
    Adv Exp Med Biol 605:327-32. 2008
    ..In this review, we describe the properties of a cluster of pH-responsive neurons located in the retrotrapezoid region of the medulla oblongata and analyze whether these cells qualify as central respiratory chemoreceptors...
  19. pmc Retrotrapezoid nucleus and parafacial respiratory group
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Respir Physiol Neurobiol 173:244-55. 2010
    ..ccRTN neurons are activated by acidification via an intrinsic mechanism or via ATP released by glia. In summary, throughout life, ccRTN neurons seem to be a critical hub for the regulation of CO(2) via breathing...
  20. pmc Retrotrapezoid nucleus and central chemoreception
    Patrice G Guyenet
    University of Virginia Health System, P O Box 800735, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0735, USA
    J Physiol 586:2043-8. 2008
    ....
  21. ncbi request reprint Neural structures that mediate sympathoexcitation during hypoxia
    P G Guyenet
    Department of Pharmacology, University of Virginia Health System, 1300 Jefferson Park Avenue, PO Box 800735, Charlottesville, VA 22908, USA
    Respir Physiol 121:147-62. 2000
    ..The literature is also examined in the context of cerebral ischemia, the Cushing response and the genesis of certain forms of hypertension...
  22. pmc Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Respir Physiol Neurobiol 168:59-68. 2009
    ..Finally, we argue that the RTN neurons are the adult form of the parafacial respiratory group in neonate rats...
  23. ncbi request reprint Neurokinin-1 receptor-immunoreactive neurons of the ventral respiratory group in the rat
    H Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 434:128-46. 2001
    ..The data suggest that most NK1R-ir neurons of the pre-BötC region are excitatory. Furthermore, the more rostral NK1R-ir cells are propriomedullary, whereas some of the caudal ones project to the spinal cord...
  24. ncbi request reprint Alpha 2-adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral medulla
    A M Allen
    Department of Pharmacology, University of Virginia, Charlottesville 22908
    Am J Physiol 265:R1065-75. 1993
    ....
  25. ncbi request reprint Distribution of glutamic acid decarboxylase mRNA-containing neurons in rat medulla projecting to thoracic spinal cord in relation to monoaminergic brainstem neurons
    R L Stornetta
    Department of Pharmacology, University of Virginia, Charlottesville 22908, USA
    J Comp Neurol 407:367-80. 1999
    ..This population included bulbospinal neurons. In conclusion, GABAergic neurons with projections to the thoracic spinal cord exist in a restricted number of medullary nuclei from which inhibitory sympathetic control may originate...
  26. ncbi request reprint Preproenkephalin mRNA is expressed by C1 and non-C1 barosensitive bulbospinal neurons in the rostral ventrolateral medulla of the rat
    R L Stornetta
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908 0735, USA
    J Comp Neurol 435:111-26. 2001
    ..BSBS RVLM neurons most likely provide a major ENK input to sympathetic preganglionic neurons and PPE mRNA is the first identified positive phenotype of the non-C1 BSBS RVLM neurons...
  27. ncbi request reprint Location and electrophysiological characterization of rostral medullary adrenergic neurons that contain neuropeptide Y mRNA in rat medulla
    R L Stornetta
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 415:482-500. 1999
    ..NPY-positive C(1) neurons are barosensitive, have unmyelinated axons, and have a very low rate of discharge. Most bulbospinal C(1) cells with a putative sympathoexcitatory role do not make NPY...
  28. ncbi request reprint Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system
    D L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Comp Neurol 401:163-86. 1998
    ..The observed distribution of A2A-AR immunoreactivity throughout the neuraxis is consistent with the receptors' role in modulating dopaminergic neurotransmission and central control of cardiovascular function...
  29. ncbi request reprint Atipamezole-precipitated clonidine withdrawal induces c-Fos expression in rat central nervous system
    R L Stornetta
    Department of Pharmacology, University of Virginia, Health Sciences Center, Charlottesville 22908, USA
    Brain Res 764:81-92. 1997
    ..The intensity of the withdrawal syndrome indicates that chronic exposure to alpha2-adrenergic receptor agonists produces strong dependence...
  30. ncbi request reprint Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
    D L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Comp Neurol 372:135-65. 1996
    ..In general, the pattern of alpha 2C-LI throughout the neuraxis is consistent with previously published reports of the distribution of receptor mRNA detected by hybridization histochemistry...
  31. ncbi request reprint Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats
    D Huangfu
    Department of Pharmacology, University of Virginia, Charlottesville 22908, USA
    Am J Physiol 268:R1429-41. 1995
    ....
  32. ncbi request reprint Central noradrenergic neurons: the autonomic connection
    P G Guyenet
    University of Virginia School of Medicine, Department of Pharmacology, Charlottesville
    Prog Brain Res 88:365-80. 1991
    ..The question of whether the C1 "adrenergic" cells of the rostral medulla oblongata actually use noradrenaline as a neurotransmitter is also briefly addressed...
  33. ncbi request reprint Rostral ventrolateral medullary neurons projecting to locus coeruleus have cardiorespiratory inputs
    D Huangfu
    University of Virginia School of Medicine, Department of Pharmacology, Charlottesville 22908
    Brain Res 598:67-75. 1992
    ..This study suggests that much of the information conveyed by the RVLM to LC could be of a mixed cardiorespiratory nature...
  34. ncbi request reprint Mechanism of the hypotensive action of anandamide in anesthetized rats
    K Varga
    Department of Pharmacology and Toxicology, Virginia, Commonwealth University, Medical College of Virginia, Richmond 23298, USA
    Hypertension 28:682-6. 1996
    ....
  35. pmc Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents
    Roy Kanbar
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    J Physiol 589:903-17. 2011
    ..A5 neurons respond weakly to hypercapnia in vivo or to changes in pH in slices suggesting that their ability to sense local variations in brain pH or Pco₂ is limited...
  36. ncbi request reprint GABAergic and glycinergic presympathetic neurons of rat medulla oblongata identified by retrograde transport of pseudorabies virus and in situ hybridization
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 479:257-70. 2004
    ..Over half of these PS neurons may release both transmitters. The physiological role of this medullary inhibitory input remains to be explored...
  37. ncbi request reprint Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism
    Daniel K Mulkey
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:14128-38. 2007
    ..Thus, RTN neurons presumably contribute to the respiratory stimulation caused by serotonergic neurons, but serotonin seems without effect on the cellular mechanism by which RTN neurons detect pH...
  38. ncbi request reprint Fos expression by glutamatergic neurons of the solitary tract nucleus after phenylephrine-induced hypertension in rats
    Matthew Weston
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 460:525-41. 2003
    ..At least 29% of the Fos-ir glutamatergic neurons of NTS project to the vicinity of the VLM GABAergic interneurons that are presumed to mediate the sympathetic baroreflex...
  39. doi request reprint Botzinger expiratory-augmenting neurons and the parafacial respiratory group
    Michal G Fortuna
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 28:2506-15. 2008
    ....
  40. ncbi request reprint Baro-activated neurons with pulse-modulated activity in the rat caudal ventrolateral medulla express GAD67 mRNA
    Ann M Schreihofer
    Department of Pharmacology, University of Virginia Health System, Charlotttesville, Virginia 22908 0735, USA
    J Neurophysiol 89:1265-77. 2003
    ..In addition, baro-activated GABAergic CVLM neurons appear to integrate several types of inputs and provide inhibition to multiple targets...
  41. ncbi request reprint A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    J Comp Neurol 455:499-512. 2003
    ..A subgroup of these cells contains high levels of SST and NK1R immunoreactivity in their somata. These glutamatergic interneurons identify a narrow region of the RVLM that appears to be coextensive with the pre-BötC of adult rats...
  42. ncbi request reprint Inspiratory augmenting bulbospinal neurons express both glutamatergic and enkephalinergic phenotypes
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908 0735, USA
    J Comp Neurol 455:113-24. 2003
    ..We conclude that most of the phrenic inspiratory premotor neurons of the rVRG are glutamatergic neurons that may also release enkephalins...
  43. ncbi request reprint Decompensated hemorrhage activates serotonergic neurons in the subependymal parapyramidal region of the rat medulla
    Nicole M Pelaez
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908 0735, USA
    Am J Physiol Regul Integr Comp Physiol 283:R688-97. 2002
    ..SEPPN neuronal activation may also contribute to HISI or could mediate defensive thermoregulatory mechanisms triggered by hemorrhage-induced hypothermia...
  44. ncbi request reprint Respiratory control by ventral surface chemoreceptor neurons in rats
    Daniel K Mulkey
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Neurosci 7:1360-9. 2004
    ..Their pH sensitivity is intrinsic and involves a background K(+) current. In short, the CO(2)-sensitive neurons of the RTN are good candidates for the long sought-after VMS chemoreceptors...
  45. ncbi request reprint The baroreflex and beyond: control of sympathetic vasomotor tone by GABAergic neurons in the ventrolateral medulla
    Ann M Schreihofer
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia, USA
    Clin Exp Pharmacol Physiol 29:514-21. 2002
    ..This baroreceptor-independent, GABAergic inhibition of presympathetic RVLM neurons may play an important role in determining the long-term level of sympathetic vasomotor tone and AP...
  46. ncbi request reprint Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons
    Hong Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3755-64. 2002
    ..In conclusion, NK1R-expressing cells of the rostral ventrolateral medulla control both respiratory rhythm and blood pressure. However, there is no evidence yet that these two functions are regulated by the same NK1R-expressing neurons...
  47. ncbi request reprint Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance
    Christopher P Washburn
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    J Neurosci 22:1256-65. 2002
    ....
  48. ncbi request reprint Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908 0735, USA
    J Comp Neurol 444:207-20. 2002
    ..The data suggest that these neurons may be glutamatergic and that the C1 adrenergic phenotype is one of several secondary phenotypes that are differentially expressed by subgroups of these cells...
  49. ncbi request reprint Vesicular glutamate transporter DNPI/VGLUT2 mRNA is present in C1 and several other groups of brainstem catecholaminergic neurons
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908 0735, USA
    J Comp Neurol 444:191-206. 2002
    ..Based on the present evidence, the noradrenergic cell groups of the pons (A5 and A6) do not contain either known vesicular glutamate transporter and are most likely not glutamatergic...
  50. ncbi request reprint Neurokinin-1 receptor-expressing cells regulate depressor region of rat ventrolateral medulla
    Hong Wang
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 285:H2757-69. 2003
    ....
  51. ncbi request reprint Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2
    Diane L Rosin
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 465:593-603. 2003
    ..These findings, showing that many of the orexin neurons are glutamatergic, are consistent with the neuroexcitatory effects of orexin but suggest that another neurochemical phenotype may define the remaining subset of orexin neurons...
  52. ncbi request reprint Detection of amino acid and peptide transmitters in physiologically identified brainstem cardiorespiratory neurons
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States
    Auton Neurosci 114:1-10. 2004
    ....
  53. ncbi request reprint Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats
    Matthew C Weston
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 473:73-85. 2004
    ..The serotonergic neurons of the ML, though known to be activated by CO(2), probably do not contribute to central chemoreception, given that they innervate sympathetic efferents and project at best very lightly to the VRC...
  54. ncbi request reprint Coexpression of vesicular glutamate transporter-3 and gamma-aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia, Charlottesville, 22908, USA
    J Comp Neurol 492:477-94. 2005
    ..These data suggest that medullary raphe VGLUT3 neurons could inhibit sympathetic outflow and that their spinal targets include both preganglionic neurons and GABAergic interneurons...
  55. pmc Novel two-rhythm generator theory of breathing in mammals
    Patrice G Guyenet
    University of Virginia, Department of Pharmacology, Charlottesville, USA
    J Physiol 570:207. 2006
  56. pmc Water deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medulla
    Sean D Stocker
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 494:673-85. 2006
    ..One mechanism by which water deprivation may increase the sympathetic outflow is activation of a glutamatergic pathway from the PVH to the RVLM...
  57. pmc Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats
    Ana Carolina Thomaz Takakura
    Department of Pharmacology, University of Virginia Health System, Charlottesville, 22908 0735, USA
    J Physiol 572:503-23. 2006
    ..RTN neurons probably contribute a portion of the chemical drive to breathe...
  58. ncbi request reprint Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA
    Christopher P Washburn
    Department of Pharmacology, University of Virginia, Health Sciences Center, 1300 Jefferson Park Avenue P O Box 800735, Charlottesville, VA 22908 0735, USA
    Respir Physiol Neurobiol 138:19-35. 2003
    ..TASK channels presumably mediate excitatory effects of numerous transmitters on these neurons and may contribute to their pH-sensitivity...
  59. ncbi request reprint Purinergic P2 receptors modulate excitability but do not mediate pH sensitivity of RTN respiratory chemoreceptors
    Daniel K Mulkey
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 26:7230-3. 2006
    ..Therefore, we conclude that purinergic signaling can modulate RTN neuron activity but does not mediate the pH sensing intrinsic to these central respiratory chemoreceptors...
  60. ncbi request reprint Transneuronal mapping of the CNS network controlling sympathetic outflow to the rat thymus
    R Nicholas Trotter
    Department of Microbiology, University of Virginia, PO Box 800734, Charlottesville, VA 22908, USA
    Auton Neurosci 131:9-20. 2007
    ..None of the infected animals exhibited labeling of the dorsal motor nucleus of the vagus. In summary, this study provides the first anatomic map of CNS neurons involved in control of sympathetic outflow to the thymus...
  61. pmc Central chemoreceptors and sympathetic vasomotor outflow
    Thiago S Moreira
    Department of Pharmacology, University of Virginia, Charlottesville, VA, 22908, USA
    J Physiol 577:369-86. 2006
    ..Activation of the central respiratory network reduces the overall sympathetic response to CO(2), presumably by activating barosensitive CVLM neurons and inhibiting RTN chemoreceptors...
  62. ncbi request reprint Afferent and efferent connections of the rat retrotrapezoid nucleus
    Diane L Rosin
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 499:64-89. 2006
    ....
  63. ncbi request reprint Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 26:10305-14. 2006
    ..The presence of Phox2b in this circuit and its apparent absence from the respiratory CPG could explain why Phox2b mutations disrupt breathing automaticity during sleep without causing major impairment of respiration during waking...
  64. pmc Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors
    Thiago S Moreira
    Department of Pharmacology, University of Virginia Health System, PO Box 800735, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0735, USA
    J Physiol 580:285-300. 2007
    ..In conclusion, RTN chemoreceptors receive an inhibitory input from myelinated lung stretch receptors, presumably SARs. The lung input to RTN may be di-synaptic with inhibitory pump cells as sole interneurons...
  65. ncbi request reprint GABAergic pump cells of solitary tract nucleus innervate retrotrapezoid nucleus chemoreceptors
    Ana C Takakura
    Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908 0735, USA
    J Neurophysiol 98:374-81. 2007
    ..We demonstrate that a GABAergic subset of these pump cells innervates the RTN region. We conclude that these inhibitory neurons probably contact RTN chemoreceptors and mediate their inhibition by lung inflation...
  66. ncbi request reprint Activation of 5-hydroxytryptamine type 3 receptor-expressing C-fiber vagal afferents inhibits retrotrapezoid nucleus chemoreceptors in rats
    Thiago S Moreira
    Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908 0735, USA
    J Neurophysiol 98:3627-37. 2007
    ..The apnea triggered by activation of cardiopulmonary C-fiber afferents may be due in part to a reduction of the activity of RTN chemoreceptors...
  67. ncbi request reprint TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity
    Daniel K Mulkey
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:14049-58. 2007
    ..Furthermore, they indicate that a non-TASK K+ current contributes to chemosensitivity of RTN neurons, which are profoundly pH-sensitive and capable of driving respiratory output in response to local pH changes in vivo...

Research Grants20

  1. Functional neuroanatomy of the pre-Botzinger complex
    PATRICE GUYENET; Fiscal Year: 2006
    ..abstract_text> ..
  2. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2007
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  3. Retrotrapezoid nucleus and central chemoreception
    PATRICE GUYENET; Fiscal Year: 2007
    ..In short, this research has two objectives: first to increase current understanding of the cellular mechanisms responsible for central respiratory chemoreception and second, to help understand the causes of CCHS. ..
  4. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2009
    ....
  5. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2010
    ....
  6. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  7. Retrotrapezoid nucleus and central chemoreception
    Patrice G Guyenet; Fiscal Year: 2010
    ..In short, this research has two objectives: first to increase current understanding of the cellular mechanisms responsible for central respiratory chemoreception and second, to help understand the causes of CCHS. ..