George A Gutman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels
    George A Gutman
    Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697, USA
    Pharmacol Rev 55:583-6. 2003
  2. ncbi request reprint International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
    George A Gutman
    Department of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA
    Pharmacol Rev 57:473-508. 2005
  3. ncbi request reprint Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, 291 Irvine Hall, Medical School, University of California Irvine, Irvine, CA 92697 4561, USA
    Mol Pharmacol 67:1369-81. 2005
  4. pmc K+ channels as targets for specific immunomodulation
    K George Chandy
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Trends Pharmacol Sci 25:280-9. 2004
  5. pmc Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 103:17414-9. 2006
  6. ncbi request reprint SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels
    Aaron Kolski-Andreaco
    Department of Physiology and Biophysics, University of California Irvine, Irvine, California 92697, USA
    J Biol Chem 279:6893-904. 2004
  7. pmc Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia
    Vikram G Shakkottai
    Department of Physiology and Biophysics, University of California Irvine, 92697, USA
    J Clin Invest 113:582-90. 2004
  8. pmc The sense of place in the immune system
    Michael D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Nat Immunol 7:329-32. 2006
  9. pmc Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression
    Gwendolyn M Jang
    Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
    Gene 408:133-45. 2008
  10. ncbi request reprint Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA
    Gwendolyn M Jang
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 279:47419-30. 2004

Collaborators

Detail Information

Publications12

  1. ncbi request reprint International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels
    George A Gutman
    Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697, USA
    Pharmacol Rev 55:583-6. 2003
    ..The complete Compendium, including data tables for each member of the potassium channel family can be found at http://www.iuphar-db.org/iuphar-ic/...
  2. ncbi request reprint International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
    George A Gutman
    Department of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA
    Pharmacol Rev 57:473-508. 2005
  3. ncbi request reprint Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, 291 Irvine Hall, Medical School, University of California Irvine, Irvine, CA 92697 4561, USA
    Mol Pharmacol 67:1369-81. 2005
    ..ShK(L5) prevents and treats experimental autoimmune encephalomyelitis and suppresses delayed type hypersensitivity in rats. ShK(L5) might prove useful for therapy of autoimmune disorders...
  4. pmc K+ channels as targets for specific immunomodulation
    K George Chandy
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Trends Pharmacol Sci 25:280-9. 2004
    ..3 and IKCa1 channels, and provide a rationale for the potential therapeutic use of these inhibitors in immunological disorders...
  5. pmc Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 103:17414-9. 2006
    ..Repeated dosing with Kv1.3 inhibitors in rats has not revealed systemic toxicity. Further development of Kv1.3 blockers for autoimmune disease therapy is warranted...
  6. ncbi request reprint SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels
    Aaron Kolski-Andreaco
    Department of Physiology and Biophysics, University of California Irvine, Irvine, California 92697, USA
    J Biol Chem 279:6893-904. 2004
    ....
  7. pmc Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia
    Vikram G Shakkottai
    Department of Physiology and Biophysics, University of California Irvine, 92697, USA
    J Clin Invest 113:582-90. 2004
    ..This dominant-inhibitory strategy may help define the in vivo role of SK channels in other neuronal pathways...
  8. pmc The sense of place in the immune system
    Michael D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Nat Immunol 7:329-32. 2006
    ....
  9. pmc Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression
    Gwendolyn M Jang
    Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
    Gene 408:133-45. 2008
    ..Our results suggest that the relative strengths of the polyadenylation signals are major determinants of overall Kv1.4 mRNA abundance in cells...
  10. ncbi request reprint Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA
    Gwendolyn M Jang
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 279:47419-30. 2004
    ..Therefore, these findings indicate that Kv1.4 expression is mediated through a complex interplay between many distinct RNA regions...
  11. ncbi request reprint A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    J Biol Chem 278:9928-37. 2003
    ..3 up-regulation. ShK-F6CA might be useful for rapid and quantitative detection of Kv1.3(high) expressing cells in normal and diseased tissues, and to visualize the distribution of functional channels in intact cells...
  12. ncbi request reprint International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels
    Aguan D Wei
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacol Rev 57:463-72. 2005