ORLANDO M GUTIERREZ

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Dietary Patterns and Risk of Death and Progression to ESRD in Individuals With CKD: A Cohort Study
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL Electronic address
    Am J Kidney Dis 64:204-13. 2014
  2. pmc Association between urinary albumin excretion and coronary heart disease in black vs white adults
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    JAMA 310:706-14. 2013
  3. pmc Fibroblast growth factor 23, Klotho, and disordered mineral metabolism in chronic kidney disease: unraveling the intricate tapestry of events and implications for therapy
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine and Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    J Ren Nutr 23:250-4. 2013
  4. pmc Sodium- and phosphorus-based food additives: persistent but surmountable hurdles in the management of nutrition in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Adv Chronic Kidney Dis 20:150-6. 2013
  5. pmc Racial differences in albuminuria, kidney function, and risk of stroke
    ORLANDO M GUTIERREZ
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Neurology 79:1686-92. 2012
  6. pmc Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    J Ren Nutr 22:480-9. 2012
  7. doi request reprint Increased serum phosphate and adverse clinical outcomes: unraveling mechanisms of disease
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Curr Opin Nephrol Hypertens 20:224-8. 2011
  8. pmc (1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Clin J Am Soc Nephrol 7:139-45. 2012
  9. pmc Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, and Department of Epidemiology, University of Alabama at Birmingham, AL, USA
    Clin J Am Soc Nephrol 6:2871-8. 2011
  10. doi request reprint Recent insights into racial differences in bone and mineral metabolism
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Curr Opin Endocrinol Diabetes Obes 18:347-51. 2011

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Dietary Patterns and Risk of Death and Progression to ESRD in Individuals With CKD: A Cohort Study
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL Electronic address
    Am J Kidney Dis 64:204-13. 2014
    ..Nutrition is linked strongly with health outcomes in chronic kidney disease (CKD). However, few studies have examined relationships between dietary patterns and health outcomes in persons with CKD...
  2. pmc Association between urinary albumin excretion and coronary heart disease in black vs white adults
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    JAMA 310:706-14. 2013
    ..Whether similar associations extend to coronary heart disease (CHD) is unclear...
  3. pmc Fibroblast growth factor 23, Klotho, and disordered mineral metabolism in chronic kidney disease: unraveling the intricate tapestry of events and implications for therapy
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine and Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    J Ren Nutr 23:250-4. 2013
    ..These findings ultimately support the notion that addressing root causes of disturbances of FGF23 and Klotho, such as phosphorus excess, should remain the main focus in managing mineral metabolism in CKD...
  4. pmc Sodium- and phosphorus-based food additives: persistent but surmountable hurdles in the management of nutrition in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Adv Chronic Kidney Dis 20:150-6. 2013
    ..To overcome these barriers, coordinated efforts will be needed to demonstrate that high intake of these additives is not safe for public consumption and as such should be subject to greater regulatory scrutiny...
  5. pmc Racial differences in albuminuria, kidney function, and risk of stroke
    ORLANDO M GUTIERREZ
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Neurology 79:1686-92. 2012
    ..The objective of this study was to examine the joint associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion with incident stroke in a large national cohort study...
  6. pmc Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    J Ren Nutr 22:480-9. 2012
    ..Accordingly, we hypothesized that excess intake of these foods accounts for a relationship between lower socioeconomic status and higher serum phosphorus concentration...
  7. doi request reprint Increased serum phosphate and adverse clinical outcomes: unraveling mechanisms of disease
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Curr Opin Nephrol Hypertens 20:224-8. 2011
    ..Recent epidemiologic studies have focused on identifying potential mechanisms of these associations as well as risk factors for increased serum phosphate in the general population...
  8. pmc (1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Clin J Am Soc Nephrol 7:139-45. 2012
    ..The extent to which this was due to a direct stimulatory effect of PTH versus an indirect effect of increasing 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels was unclear...
  9. pmc Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, and Department of Epidemiology, University of Alabama at Birmingham, AL, USA
    Clin J Am Soc Nephrol 6:2871-8. 2011
    ..Elevated FGF23 concentrations are associated with cardiovascular disease events and mortality across a broad range of kidney function, but the predictors of FGF23 concentrations in the general population are unclear...
  10. doi request reprint Recent insights into racial differences in bone and mineral metabolism
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Curr Opin Endocrinol Diabetes Obes 18:347-51. 2011
    ..This study reviews recent insights into racial differences in bone from 2010 to 2011...
  11. pmc Prevalence of apparent treatment-resistant hypertension among individuals with CKD
    Rikki M Tanner
    Department of Epidemiology, University of Alabama, Birmingham, Alabama, USA
    Clin J Am Soc Nephrol 8:1583-90. 2013
    ....
  12. ncbi request reprint Incident ESRD and treatment-resistant hypertension: the reasons for geographic and racial differences in stroke (REGARDS) study
    Rikki M Tanner
    University of Alabama at Birmingham, Birmingham, AL
    Am J Kidney Dis 63:781-8. 2014
    ..Although hypertension is a risk factor for end-stage renal disease (ESRD), few data are available for the association between treatment-resistant hypertension and ESRD risk...
  13. doi request reprint Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions
    Tamara Isakova
    Division of Nephrology and Hypertension, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Ren Nutr 21:295-302. 2011
    ..We evaluated the relationship between calcidiol (25D), calcitriol (1,25D), inflammation, and albuminuria in Study of Early Evaluation of Kidney Disease, a multicenter CKD cohort...
  14. pmc Cardiovascular risk factors in CKD associate with both ESRD and mortality
    Paul Muntner
    Department of Epidemiology, University of Alabama, 1665 University Boulevard, Suite 230J, Birmingham, AL 35294, USA
    J Am Soc Nephrol 24:1159-65. 2013
    ....
  15. pmc Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease
    Patricia Wahl
    Division of Nephrology and Hypertension, Department of Medicine, University ofMiami Miller School of Medicine, Miami, Florida, USA
    Diabetes Care 35:994-1001. 2012
    ..Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status...
  16. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
    ....
  17. pmc Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Clin J Am Soc Nephrol 8:1009-18. 2013
    ..Reducing dietary phosphate intake or absorption may decrease FGF23 levels, but data on the combined effects of dietary phosphate restriction and phosphate binders in CKD are limited...
  18. pmc Geographic variation in CKD prevalence and ESRD incidence in the United States: results from the reasons for geographic and racial differences in stroke (REGARDS) study
    Rikki M Tanner
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Kidney Dis 61:395-403. 2013
    ..It is not known whether geographic differences in the prevalence of chronic kidney disease exist and are associated with end-stage renal disease (ESRD) incidence rates across the United States...
  19. pmc Racial differences in postprandial mineral ion handling in health and in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 25:3970-7. 2010
    ..The aim of this study was to examine racial differences in postprandial urinary mineral ion excretion in health and in CKD...
  20. pmc Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 79:1370-8. 2011
    ..Hence, FGF23 measurements may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels...
  21. pmc Fibroblast growth factor 23, high-sensitivity cardiac troponin, and left ventricular hypertrophy in CKD
    Kelsey Smith
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Kidney Dis 61:67-73. 2013
    ..We investigated the association of FGF-23 and hs-cTnI (high-sensitivity cardiac troponin I) and hs-cTnT (high-sensitivity cardiac troponin T) levels in CKD and examined the role of LVH in this association...
  22. pmc Low socioeconomic status associates with higher serum phosphate irrespective of race
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1953-60. 2010
    ....
  23. ncbi request reprint Vitamin D deficiency and anemia in early chronic kidney disease
    Neha M Patel
    Division of Nephrology and Hypertension, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Kidney Int 77:715-20. 2010
    ..Our study shows that 25D and 1,25D deficiency are independently associated with decreased hemoglobin levels and anemia in chronic kidney disease. Whether this association is causal requires further study...
  24. pmc Associations of dietary phosphorus intake, urinary phosphate excretion, and fibroblast growth factor 23 with vascular stiffness in chronic kidney disease
    Jessica Houston
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Ren Nutr 23:12-20. 2013
    ....
  25. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  26. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  27. pmc Dietary patterns are associated with incident stroke and contribute to excess risk of stroke in black Americans
    Suzanne E Judd
    From the Department of Biostatistics S E J, G H, School of Public Health S E J, O M G, G H, V J H, Division of Nephrology, Department of Medicine O M G, Department of Epidemiology O M G, V J H, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine J L L, Division of Preventive Medicine, Department of Medicine, School of Medicine J M S, University of Alabama at Birmingham Program in Gastronomy, Culinary Arts, and Wine Studies, Boston University, MA P K N and Department of Neurology, School of Medicine, University of Cincinnati, OH B M K
    Stroke 44:3305-11. 2013
    ..Black Americans and residents of the Southeastern United States are at increased risk of stroke. Diet is one of many potential factors proposed that might explain these racial and regional disparities...
  28. ncbi request reprint Risk for recurrent coronary heart disease and all-cause mortality among individuals with chronic kidney disease compared with diabetes mellitus, metabolic syndrome, and cigarette smokers
    Usman Baber
    Department of Epidemiology, University of Alabama at Birmingham, 1665 University Blvd, Ryals Public Health Building, Suite 230J, Birmingham, AL 35294 0022, USA
    Am Heart J 166:373-380.e2. 2013
    ..Whether chronic kidney disease (CKD) confers a similar risk for recurrent CHD events is unknown...
  29. pmc Impact of poverty on serum phosphate concentrations in the Third National Health and Nutrition Examination Survey
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Ren Nutr 21:140-8. 2011
    ..We examined the impact of socioeconomic status on dietary phosphorus intake and serum phosphate concentrations in the general population...
  30. pmc Healthy behaviors, risk factor control and awareness of chronic kidney disease
    Delphine S Tuot
    Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
    Am J Nephrol 37:135-43. 2013
    ..We examined whether CKD self-recognition is associated with healthy behaviors and achieving risk-reduction targets known to decrease risk of cardiovascular morbidity and CKD progression...
  31. pmc Diuretics, calciuria and secondary hyperparathyroidism in the Chronic Renal Insufficiency Cohort
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:1258-65. 2011
    ..Diuretics are widely used to control volume status and blood pressure in CKD patients but are also known to have important effects on renal calcium handling, which we hypothesized could alter the risk of secondary hyperparathyroidism...
  32. pmc High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III
    Alex R Chang
    Division of Nephrology, Geisinger Health System, Danville, PA ARC the Welch Center for Prevention, Epidemiology, and Clinical Research ARC, ML, LJA, and MEG and Divisions of Nephrology ARC and MEG and General Internal Medicine LJA, Johns Hopkins University, Baltimore, MD and the Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL OMG
    Am J Clin Nutr 99:320-7. 2014
    ..Elevated serum phosphorus is associated with all-cause mortality, but little is known about risk associated with dietary phosphorus intake...
  33. pmc Age-specific associations of reduced estimated glomerular filtration rate with concurrent chronic kidney disease complications
    C Barrett Bowling
    Birmingham Atlanta Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Birmingham, Alabama, USA
    Clin J Am Soc Nephrol 6:2822-8. 2011
    ..It has been suggested that moderate reductions in estimated GFR (eGFR) among older adults may not reflect chronic kidney disease (CKD)...
  34. pmc Blood pressure indexes and end-stage renal disease risk in adults with chronic kidney disease
    Emmy K Bell
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Hypertens 25:789-96. 2012
    ..Few studies have compared different blood pressure (BP) indexes for end-stage renal disease (ESRD) risk among individuals with chronic kidney disease...
  35. ncbi request reprint Fibroblast growth factor 23 and disordered vitamin D metabolism in chronic kidney disease: updating the "trade-off" hypothesis
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin J Am Soc Nephrol 5:1710-6. 2010
    ....
  36. pmc Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    Tamara Isakova
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:584-91. 2011
    ..Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD...
  37. pmc The connection between dietary phosphorus, cardiovascular disease, and mortality: where we stand and what we need to know
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, School of Medicine and Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL
    Adv Nutr 4:723-9. 2013
    ....
  38. pmc FGF23 induces left ventricular hypertrophy
    Christian Faul
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Clin Invest 121:4393-408. 2011
    ..These results unveil a klotho-independent, causal role for FGF23 in the pathogenesis of LVH and suggest that chronically elevated FGF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD...
  39. pmc Metabolic Subtypes and Risk of Mortality in Normal Weight, Overweight, and Obese Individuals with CKD
    Lynae J Hanks
    Departments of Medicine, Nutrition Sciences, Epidemiology, and, Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, Department of Preventive Medicine, Loyola University, Maywood, Illinois, Departments of Epidemiology and Medicine, Emory University, Atlanta, Georgia
    Clin J Am Soc Nephrol 8:2064-71. 2013
    ..Higher body mass index (BMI) is paradoxically associated with lower mortality in persons with CKD, but whether cardiometabolic abnormalities modulate this association is unclear...
  40. doi request reprint A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease
    Tamara Isakova
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 76:705-16. 2009
    ....
  41. pmc Contribution of food additives to sodium and phosphorus content of diets rich in processed foods
    Anna Carrigan
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    J Ren Nutr 24:13-9, 19e1. 2014
    ..Phosphorus-based food additives increase the total phosphorus content of processed foods. However, the extent to which these additives augment total phosphorus intake per day is unclear...
  42. pmc Fibroblast growth factor 23, vitamin D, and health disparities among African Americans with chronic kidney disease
    Nakshatra Saxena
    Division of Nephrology, Department of Medicine, and Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
    Semin Nephrol 33:448-56. 2013
    ..This review critically assesses ongoing controversies surrounding the relationship between vitamin D and racial disparities in chronic kidney disease outcomes, and how FGF23 may help to clarify the picture. ..
  43. ncbi request reprint N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  44. doi request reprint Dietary phosphorus restriction in advanced chronic kidney disease: merits, challenges, and emerging strategies
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Semin Dial 23:401-6. 2010
    ..Controlling serum phosphate levels is among the most challenging aspects of day-to-day dialysis care but integration of sensible dietary interventions will likely improve phosphorus control...