ORLANDO M GUTIERREZ

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey
    O M Gutierrez
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, 1120 NW 14th Street, CRB, C 221, Room 815, Miami, FL 33136, USA
    Osteoporos Int 22:1745-53. 2011
  2. pmc Racial differences in postprandial mineral ion handling in health and in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 25:3970-7. 2010
  3. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
  4. doi Fibroblast growth factor 23 and disordered vitamin D metabolism in chronic kidney disease: updating the "trade-off" hypothesis
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin J Am Soc Nephrol 5:1710-6. 2010
  5. pmc Low socioeconomic status associates with higher serum phosphate irrespective of race
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1953-60. 2010
  6. doi N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
  7. pmc Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease
    Patricia Wahl
    Division of Nephrology and Hypertension, Department of Medicine, University ofMiami Miller School of Medicine, Miami, Florida, USA
    Diabetes Care 35:994-1001. 2012
  8. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
  9. doi Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions
    Tamara Isakova
    Division of Nephrology and Hypertension, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Ren Nutr 21:295-302. 2011
  10. pmc Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Clin J Am Soc Nephrol 8:1009-18. 2013

Detail Information

Publications35

  1. pmc Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey
    O M Gutierrez
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, 1120 NW 14th Street, CRB, C 221, Room 815, Miami, FL 33136, USA
    Osteoporos Int 22:1745-53. 2011
    ....
  2. pmc Racial differences in postprandial mineral ion handling in health and in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 25:3970-7. 2010
    ..The aim of this study was to examine racial differences in postprandial urinary mineral ion excretion in health and in CKD...
  3. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  4. doi Fibroblast growth factor 23 and disordered vitamin D metabolism in chronic kidney disease: updating the "trade-off" hypothesis
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin J Am Soc Nephrol 5:1710-6. 2010
    ....
  5. pmc Low socioeconomic status associates with higher serum phosphate irrespective of race
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1953-60. 2010
    ....
  6. doi N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  7. pmc Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease
    Patricia Wahl
    Division of Nephrology and Hypertension, Department of Medicine, University ofMiami Miller School of Medicine, Miami, Florida, USA
    Diabetes Care 35:994-1001. 2012
    ..Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status...
  8. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
    ....
  9. doi Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions
    Tamara Isakova
    Division of Nephrology and Hypertension, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Ren Nutr 21:295-302. 2011
    ..We evaluated the relationship between calcidiol (25D), calcitriol (1,25D), inflammation, and albuminuria in Study of Early Evaluation of Kidney Disease, a multicenter CKD cohort...
  10. pmc Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Clin J Am Soc Nephrol 8:1009-18. 2013
    ..Reducing dietary phosphate intake or absorption may decrease FGF23 levels, but data on the combined effects of dietary phosphate restriction and phosphate binders in CKD are limited...
  11. pmc Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 79:1370-8. 2011
    ..Hence, FGF23 measurements may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels...
  12. pmc Fibroblast growth factor 23, high-sensitivity cardiac troponin, and left ventricular hypertrophy in CKD
    Kelsey Smith
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Kidney Dis 61:67-73. 2013
    ..We investigated the association of FGF-23 and hs-cTnI (high-sensitivity cardiac troponin I) and hs-cTnT (high-sensitivity cardiac troponin T) levels in CKD and examined the role of LVH in this association...
  13. pmc Phosphorus binders and survival on hemodialysis
    Tamara Isakova
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:388-96. 2009
    ..Although confirmatory studies are needed in the dialysis setting, future placebo-controlled, randomized trials of phosphorus binders might focus on predialysis patients with chronic kidney disease and normal serum phosphate levels...
  14. pmc Associations of dietary phosphorus intake, urinary phosphate excretion, and fibroblast growth factor 23 with vascular stiffness in chronic kidney disease
    Jessica Houston
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Ren Nutr 23:12-20. 2013
    ....
  15. doi Vitamin D deficiency and anemia in early chronic kidney disease
    Neha M Patel
    Division of Nephrology and Hypertension, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Kidney Int 77:715-20. 2010
    ..Our study shows that 25D and 1,25D deficiency are independently associated with decreased hemoglobin levels and anemia in chronic kidney disease. Whether this association is causal requires further study...
  16. pmc Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, and Department of Epidemiology, University of Alabama at Birmingham, AL, USA
    Clin J Am Soc Nephrol 6:2871-8. 2011
    ..Elevated FGF23 concentrations are associated with cardiovascular disease events and mortality across a broad range of kidney function, but the predictors of FGF23 concentrations in the general population are unclear...
  17. pmc Impact of poverty on serum phosphate concentrations in the Third National Health and Nutrition Examination Survey
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Ren Nutr 21:140-8. 2011
    ..We examined the impact of socioeconomic status on dietary phosphorus intake and serum phosphate concentrations in the general population...
  18. pmc Plasma gelsolin and circulating actin correlate with hemodialysis mortality
    Po Shun Lee
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:1140-8. 2009
    ..9 to 33.5). Worsening renal function correlated with pGSN decline in 53 subjects with CKD not on dialysis. In summary, low pGSN and detectable circulating actin identify chronic hemodialysis patients at highest risk for 1-yr mortality...
  19. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  20. pmc Association between urinary albumin excretion and coronary heart disease in black vs white adults
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    JAMA 310:706-14. 2013
    ..Whether similar associations extend to coronary heart disease (CHD) is unclear...
  21. pmc (1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Clin J Am Soc Nephrol 7:139-45. 2012
    ..The extent to which this was due to a direct stimulatory effect of PTH versus an indirect effect of increasing 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels was unclear...
  22. pmc Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    J Ren Nutr 22:480-9. 2012
    ..Accordingly, we hypothesized that excess intake of these foods accounts for a relationship between lower socioeconomic status and higher serum phosphorus concentration...
  23. doi Recent insights into racial differences in bone and mineral metabolism
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Curr Opin Endocrinol Diabetes Obes 18:347-51. 2011
    ..This study reviews recent insights into racial differences in bone from 2010 to 2011...
  24. pmc Diuretics, calciuria and secondary hyperparathyroidism in the Chronic Renal Insufficiency Cohort
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:1258-65. 2011
    ..Diuretics are widely used to control volume status and blood pressure in CKD patients but are also known to have important effects on renal calcium handling, which we hypothesized could alter the risk of secondary hyperparathyroidism...
  25. pmc Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    Tamara Isakova
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:584-91. 2011
    ..Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD...
  26. pmc Healthy behaviors, risk factor control and awareness of chronic kidney disease
    Delphine S Tuot
    Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
    Am J Nephrol 37:135-43. 2013
    ..To encourage adoption of healthy behaviors, a better understanding of barriers to participation in CKD-healthy behaviors is needed...
  27. doi A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease
    Tamara Isakova
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 76:705-16. 2009
    ....
  28. pmc FGF23 induces left ventricular hypertrophy
    Christian Faul
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Clin Invest 121:4393-408. 2011
    ..These results unveil a klotho-independent, causal role for FGF23 in the pathogenesis of LVH and suggest that chronically elevated FGF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD...
  29. pmc Prevalence of apparent treatment-resistant hypertension among individuals with CKD
    Rikki M Tanner
    Department of Epidemiology, University of Alabama, Birmingham, Alabama, USA
    Clin J Am Soc Nephrol 8:1583-90. 2013
    ....
  30. pmc Blood pressure indexes and end-stage renal disease risk in adults with chronic kidney disease
    Emmy K Bell
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Hypertens 25:789-96. 2012
    ..Few studies have compared different blood pressure (BP) indexes for end-stage renal disease (ESRD) risk among individuals with chronic kidney disease...
  31. doi Increased serum phosphate and adverse clinical outcomes: unraveling mechanisms of disease
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Curr Opin Nephrol Hypertens 20:224-8. 2011
    ..Recent epidemiologic studies have focused on identifying potential mechanisms of these associations as well as risk factors for increased serum phosphate in the general population...
  32. ncbi Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    Orlando Gutierrez
    Department of Medicine Internal Medicine Residency Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Am Soc Nephrol 16:2205-15. 2005
    ..Increased FGF-23 may contribute to maintaining normal serum phosphate levels in the face of advancing CKD but may worsen calcitriol deficiency and thus may be a central factor in the early pathogenesis of SHPT...
  33. doi Dietary phosphorus restriction in advanced chronic kidney disease: merits, challenges, and emerging strategies
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Semin Dial 23:401-6. 2010
    ..Controlling serum phosphate levels is among the most challenging aspects of day-to-day dialysis care but integration of sensible dietary interventions will likely improve phosphorus control...
  34. pmc Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active
    Takashi Shimada
    Endocrine Unit, Thier 10, 50 Blossum Street, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:578-85. 2010
    ..Conclusions: Our results provide strong evidence for the conclusion that virtually all circulating FGF23 in dialysis patients is intact and biologically active...
  35. pmc Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD
    Tamara Isakova
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Soc Nephrol 19:615-23. 2008
    ....