C Guthrie

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF)
    G Chanfreau
    Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA 94143 0448
    Science 274:1511-4. 1996
  2. pmc Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase
    A L Kistler
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143 0448, USA
    Genes Dev 15:42-9. 2001
  3. pmc Conservation in budding yeast of a kinase specific for SR splicing factors
    C W Siebel
    Department of Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, CA 94143 0448, USA
    Proc Natl Acad Sci U S A 96:5440-5. 1999
  4. pmc An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport
    A de Bruyn Kops
    Department of Biochemistry and Biophysics, UCSF Medical School, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    EMBO J 20:4183-93. 2001
  5. ncbi request reprint A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles
    P L Raghunathan
    University of California, San Francisco, School of Medicine, Department of Biochemistry and Biophysics, San Francisco, CA 94143 0448, USA
    Science 279:857-60. 1998
  6. ncbi request reprint Mechanical devices of the spliceosome: motors, clocks, springs, and things
    J P Staley
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cell 92:315-26. 1998

Collaborators

  • A de Bruyn Kops
  • A L Kistler
  • C W Siebel
  • J P Staley
  • P L Raghunathan
  • G Chanfreau
  • X D Fu
  • L Feng
  • S M Noble

Detail Information

Publications6

  1. ncbi request reprint Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF)
    G Chanfreau
    Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA 94143 0448
    Science 274:1511-4. 1996
    ..These results demonstrate a structural and functional conservation of the yeast and mammalian 3'-end processing machineries despite a lack of conservation of the cis sequences...
  2. pmc Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase
    A L Kistler
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143 0448, USA
    Genes Dev 15:42-9. 2001
    ..We propose that Sub2 functionally interacts with Mud2 both before and after PS formation. In the absence of Mud2, Sub2 function becomes dispensable...
  3. pmc Conservation in budding yeast of a kinase specific for SR splicing factors
    C W Siebel
    Department of Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, CA 94143 0448, USA
    Proc Natl Acad Sci U S A 96:5440-5. 1999
    ..The unexpected discovery of an SR protein kinase in budding yeast provides a foundation for genetic dissection of the biological functions of SR proteins and their kinases...
  4. pmc An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport
    A de Bruyn Kops
    Department of Biochemistry and Biophysics, UCSF Medical School, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    EMBO J 20:4183-93. 2001
    ..We hypothesize that Brr6p is located adjacent to the nuclear pore and interacts functionally with the pore and transport machinery...
  5. ncbi request reprint A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles
    P L Raghunathan
    University of California, San Francisco, School of Medicine, Department of Biochemistry and Biophysics, San Francisco, CA 94143 0448, USA
    Science 279:857-60. 1998
    ..Addition of purified Prp24 protein regenerates duplex U4/U6 snRNPs for new rounds of splicing. The reannealing reaction catalyzed by Prp24 proceeds more efficiently with snRNPs than with deproteinized snRNAs...
  6. ncbi request reprint Mechanical devices of the spliceosome: motors, clocks, springs, and things
    J P Staley
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cell 92:315-26. 1998