Research Topics
Species | Bill GurleySummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
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Publications
Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevanceBill J Gurley
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA
Planta Med 78:1490-514. 2012..g., Hypericum perforatum). In addition, several external factors unrelated to phytochemical pharmacology can augment the drug interaction potential of botanical supplements...
Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokineticsBill J Gurley
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Medicine, General Clinical Research Center, Little Rock, AR 72205, USA
Mol Nutr Food Res 52:772-9. 2008..05). Echinacea supplementation did not affect digoxin pharmacokinetics. Clinically significant P-gp-mediated herb-drug interactions are more likely to occur with St. John's wort than with Echinacea...- Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and EchinaceaBill J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Mol Nutr Food Res 52:755-63. 2008..Accordingly, adverse herb-drug interactions may result with concomitant ingestion of goldenseal supplements and drugs that are CYP2D6 substrates... 
Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivoB J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Clin Pharmacol Ther 83:61-9. 2008..6+/-26.9 vs 71.2+/-50.5 ng/ml). MDZ disposition was not affected by kava kava supplementation. These findings suggest that significant herb-drug interactions may result from the concomitant ingestion of goldenseal and CYP3A substrates...- Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humansBill J Gurley
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, AR 72205, USA
Drug Metab Dispos 35:240-5. 2007.... - Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humansBill J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
Clin Pharmacol Ther 72:276-87. 2002..Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of St John's wort, garlic oil, Panax ginseng, and Ginkgo biloba affected CYP1A2, CYP2D6, CYP2E1, or CYP3A4 activity... - Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humansBill J Gurley
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Drug Metab Dispos 34:69-74. 2006.... - Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo bilobaBill J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Drugs Aging 22:525-39. 2005.... - Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycinBill Gurley
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522-3, Little Rock, 72205, USA
J Clin Pharmacol 46:201-13. 2006..Unlike those observed for rifampin and clarithromycin, midazolam pharmacokinetics was unaffected by milk thistle or black cohosh. Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo... - In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmettoBill J Gurley
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, 72205, USA
Clin Pharmacol Ther 76:428-40. 2004..Although the effects of E purpurea on CYP activity were minor, further study into the interaction potential of this botanical is merited... - In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypesBill J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 522, Little Rock, AR 72205, USA
Clin Pharmacol Ther 77:415-26. 2005.... - Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteersPaul O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
Pharmacotherapy 24:460-7. 2004.... - Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juicePaul O Gubbins
College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7122, USA
Eur J Clin Pharmacol 64:293-301. 2008..To explore whether sex-related differences in intestinal itraconazole metabolism exist in healthy adults using grapefruit juice (GFJ) as a selective enteric cytochrome P450 3A4 (CYP3A4) inhibitor... - Sirolimus-induced thrombotic microangiopathy in a renal transplant recipientGary W Barone
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA
Am J Kidney Dis 42:202-6. 2003..With recent animal data showing that sirolmus can be nephrotoxic in a renal ischemic-reperfusion model (similar to what happens with a renal transplant), the authors speculate on a mechanism for this adverse reaction... - Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteersStephanie F Gardner
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W. Markham #522, Little Rock, AR 72205, USA
Am J Cardiol 91:1510-3, A9. 2003 - Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serumPrem K Gupta
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Pharm Biomed Anal 49:1021-6. 2009..The method was further validated by determination of serum pharmacokinetics of hydrastine and berberine after administration of a single oral dose of goldenseal extract containing 77 mg of hydrastine and 132 mg of berberine... - Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplementsAnne A Grippo
Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA
Ann Pharmacother 41:1375-82. 2007..Because botanical and dietary supplements are plant products and need not be processed or purified due to their FDA classification as foods, they may contain unexpected phytoestrogens, such as flavonoids... - Metal content of ephedra-containing dietary supplements and select botanicalsAnne A Grippo
Department of Chemistry and Physics, Arkansas State University, PO Box 599, State University, AR 72467, USA
Am J Health Syst Pharm 63:635-44. 2006..The metal content of dietary supplements, including 13 ephedra-containing supplements, was studied...
Research Grants
- Clinical Assessment of Herb-Drug InteractionsBill Gurley; Fiscal Year: 2005..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..