Bill Gurley

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. doi request reprint Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA
    Planta Med 78:1490-514. 2012
  2. pmc Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Medicine, General Clinical Research Center, Little Rock, AR 72205, USA
    Mol Nutr Food Res 52:772-9. 2008
  3. pmc Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Nutr Food Res 52:755-63. 2008
  4. ncbi request reprint Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo
    B J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Clin Pharmacol Ther 83:61-9. 2008
  5. pmc Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, AR 72205, USA
    Drug Metab Dispos 35:240-5. 2007
  6. ncbi request reprint Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Clin Pharmacol Ther 72:276-87. 2002
  7. pmc Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Drug Metab Dispos 34:69-74. 2006
  8. pmc Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Drugs Aging 22:525-39. 2005
  9. pmc Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
    Bill Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, 72205, USA
    J Clin Pharmacol 46:201-13. 2006
  10. ncbi request reprint In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, 72205, USA
    Clin Pharmacol Ther 76:428-40. 2004

Research Grants

  1. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005

Detail Information

Publications18

  1. doi request reprint Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA
    Planta Med 78:1490-514. 2012
    ..g., Hypericum perforatum). In addition, several external factors unrelated to phytochemical pharmacology can augment the drug interaction potential of botanical supplements...
  2. pmc Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Medicine, General Clinical Research Center, Little Rock, AR 72205, USA
    Mol Nutr Food Res 52:772-9. 2008
    ..05). Echinacea supplementation did not affect digoxin pharmacokinetics. Clinically significant P-gp-mediated herb-drug interactions are more likely to occur with St. John's wort than with Echinacea...
  3. pmc Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Nutr Food Res 52:755-63. 2008
    ..Accordingly, adverse herb-drug interactions may result with concomitant ingestion of goldenseal supplements and drugs that are CYP2D6 substrates...
  4. ncbi request reprint Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo
    B J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Clin Pharmacol Ther 83:61-9. 2008
    ..6+/-26.9 vs 71.2+/-50.5 ng/ml). MDZ disposition was not affected by kava kava supplementation. These findings suggest that significant herb-drug interactions may result from the concomitant ingestion of goldenseal and CYP3A substrates...
  5. pmc Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, AR 72205, USA
    Drug Metab Dispos 35:240-5. 2007
    ....
  6. ncbi request reprint Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Clin Pharmacol Ther 72:276-87. 2002
    ..Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of St John's wort, garlic oil, Panax ginseng, and Ginkgo biloba affected CYP1A2, CYP2D6, CYP2E1, or CYP3A4 activity...
  7. pmc Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Drug Metab Dispos 34:69-74. 2006
    ....
  8. pmc Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Drugs Aging 22:525-39. 2005
    ....
  9. pmc Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
    Bill Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, 72205, USA
    J Clin Pharmacol 46:201-13. 2006
    ..Unlike those observed for rifampin and clarithromycin, midazolam pharmacokinetics was unaffected by milk thistle or black cohosh. Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo...
  10. ncbi request reprint In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, 72205, USA
    Clin Pharmacol Ther 76:428-40. 2004
    ....
  11. pmc In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 522, Little Rock, AR 72205, USA
    Clin Pharmacol Ther 77:415-26. 2005
    ....
  12. ncbi request reprint Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
    Pharmacotherapy 24:460-7. 2004
    ....
  13. doi request reprint Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7122, USA
    Eur J Clin Pharmacol 64:293-301. 2008
    ..To explore whether sex-related differences in intestinal itraconazole metabolism exist in healthy adults using grapefruit juice (GFJ) as a selective enteric cytochrome P450 3A4 (CYP3A4) inhibitor...
  14. ncbi request reprint Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient
    Gary W Barone
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA
    Am J Kidney Dis 42:202-6. 2003
    ..With recent animal data showing that sirolmus can be nephrotoxic in a renal ischemic-reperfusion model (similar to what happens with a renal transplant), the authors speculate on a mechanism for this adverse reaction...
  15. ncbi request reprint Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers
    Stephanie F Gardner
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham 522, Little Rock, AR 72205, USA
    Am J Cardiol 91:1510-3, A9. 2003
  16. doi request reprint Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum
    Prem K Gupta
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Pharm Biomed Anal 49:1021-6. 2009
    ..The method was further validated by determination of serum pharmacokinetics of hydrastine and berberine after administration of a single oral dose of goldenseal extract containing 77 mg of hydrastine and 132 mg of berberine...
  17. ncbi request reprint Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements
    Anne A Grippo
    Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA
    Ann Pharmacother 41:1375-82. 2007
    ..Because botanical and dietary supplements are plant products and need not be processed or purified due to their FDA classification as foods, they may contain unexpected phytoestrogens, such as flavonoids...
  18. ncbi request reprint Metal content of ephedra-containing dietary supplements and select botanicals
    Anne A Grippo
    Department of Chemistry and Physics, Arkansas State University, PO Box 599, State University, AR 72467, USA
    Am J Health Syst Pharm 63:635-44. 2006
    ..The metal content of dietary supplements, including 13 ephedra-containing supplements, was studied...

Research Grants3

  1. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..