Ruben Gur

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state
    Ruben C Gur
    Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Cereb Cortex 19:375-82. 2009
  2. ncbi Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21
    Ruben C Gur
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
    Neuropsychology 26:251-65. 2012
  3. ncbi General and specific responsiveness of the amygdala during explicit emotion recognition in females and males
    Birgit Derntl
    MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria
    BMC Neurosci 10:91. 2009
  4. ncbi Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative battery
    Ruben C Gur
    Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Neuropsychol 25:1029-41. 2011
  5. ncbi A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation
    Ruben C Gur
    Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
    J Neurosci Methods 187:254-62. 2010
  6. ncbi Regional structural characterization of the brain of schizophrenia patients
    Paul Yushkevich
    Department of Radiology, 3600 Market Street, Suite 370, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Acad Radiol 12:1250-61. 2005
  7. ncbi Identifying sub-populations via unsupervised cluster analysis on multi-edge similarity graphs
    Madhura Ingalhalikar
    Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
    Med Image Comput Comput Assist Interv 15:254-61. 2012
  8. ncbi Working memory deficits predict short-term smoking resumption following brief abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 106:61-4. 2010
  9. ncbi Characterization of brain plasticity in schizophrenia using template deformation
    Abraham Dubb
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Radiol 12:3-9. 2005
  10. ncbi DTI based diagnostic prediction of a disease via pattern classification
    Madhura Ingalhalikar
    Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
    Med Image Comput Comput Assist Interv 13:558-65. 2010

Research Grants

  1. Adapting Experimental Cognitive and Affective Tasks for Schizophrenia
    Ruben C Gur; Fiscal Year: 2010
  2. The Neurobiology of Affective Dysfunction in Schizophrenia
    Ruben Gur; Fiscal Year: 2007
  3. AFFECTIVE DYSFUNCTION IN SCHIZOPHERNIA
    Ruben Gur; Fiscal Year: 2005
  4. The Neurobiology of Affective Dysfunction in Schizophrenia
    Ruben C Gur; Fiscal Year: 2010

Detail Information

Publications15

  1. ncbi Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state
    Ruben C Gur
    Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Cereb Cortex 19:375-82. 2009
    ..Whether greater left hemispheric hyperperfusion reflects lateral dominance needs further examination...
  2. ncbi Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21
    Ruben C Gur
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
    Neuropsychology 26:251-65. 2012
    ..Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies...
  3. ncbi General and specific responsiveness of the amygdala during explicit emotion recognition in females and males
    Birgit Derntl
    MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria
    BMC Neurosci 10:91. 2009
    ..Stimuli were color photographs of emotional Caucasian and African American faces...
  4. ncbi Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative battery
    Ruben C Gur
    Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Neuropsychol 25:1029-41. 2011
    ..The study illustrates what will hopefully become a major component of the work of clinical and research neuropsychologists as invaluable participants in the dawning age of Big Science neuropsychological genomics...
  5. ncbi A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation
    Ruben C Gur
    Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
    J Neurosci Methods 187:254-62. 2010
    ..These results encourage the use of this battery in studies needing an efficient assessment of major neurocognitive domains such as multi-site genetic studies and clinical trials...
  6. ncbi Regional structural characterization of the brain of schizophrenia patients
    Paul Yushkevich
    Department of Radiology, 3600 Market Street, Suite 370, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Acad Radiol 12:1250-61. 2005
    ..We study morphologic characteristics and age-related changes in patients with schizophrenia to investigate whether abnormal neurodevelopment and brain structure have a role in the pathophysiological course of this disease...
  7. ncbi Identifying sub-populations via unsupervised cluster analysis on multi-edge similarity graphs
    Madhura Ingalhalikar
    Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
    Med Image Comput Comput Assist Interv 15:254-61. 2012
    ..The two classes in ASD agree with underlying diagnostic labels with 92% accuracy and the SCZ clustering agrees with 78% accuracy, indicating a greater heterogeneity in the SCZ population...
  8. ncbi Working memory deficits predict short-term smoking resumption following brief abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 106:61-4. 2010
    ....
  9. ncbi Characterization of brain plasticity in schizophrenia using template deformation
    Abraham Dubb
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Radiol 12:3-9. 2005
    ..Abnormal neurodevelopment may play a role in the pathophysiology of schizophrenia. We used deformation-based morphometry to examine voxel-wise age-related changes in patients with schizophrenia compared with healthy brains...
  10. ncbi DTI based diagnostic prediction of a disease via pattern classification
    Madhura Ingalhalikar
    Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
    Med Image Comput Comput Assist Interv 13:558-65. 2010
    ..58% classification accuracy was obtained. The abnormality scores clearly separate the groups and the high classification accuracy indicates the prospect of using the scores as a diagnostic and prognostic marker...
  11. ncbi Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 150:560-9. 2009
    ..047, OR = 1.46). Our analyses suggest several associations at PAH, with consistent evidence for rs1522305. Further analyses, including additional variations and environmental influences such as phenylalanine exposure are warranted...
  12. ncbi Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women
    C Neill Epperson
    University of Pennsylvania, Department of Psychiatry, USA
    Psychoneuroendocrinology 37:372-82. 2012
    ..These results provide preliminary evidence that serotonergic effects directly mediate the impact of estrogen on brain activation during working memory and affective processing...
  13. ncbi Neuroimaging, genetics and the treatment of nicotine addiction
    Riju Ray
    Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 193:159-69. 2008
    ..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment...
  14. ncbi The effects of geometric distortion correction on motion realignment in fMRI
    Mark A Elliott
    Department of Radiology, University of Pennsylvania, B1 Stellar Chance Labs, Philadelphia, PA 19104, USA
    Acad Radiol 11:1005-10. 2004
    ..This masking, when applied to subsequent images in the fMRI time series, can clip the effects of motion, resulting in inaccurate estimation and correction of motion-based changes in the images...
  15. ncbi Characterization of sexual dimorphism in the human corpus callosum
    Abraham Dubb
    Department of Bioengineering, Psychiatry, and Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
    Neuroimage 20:512-9. 2003
    ..Our results demonstrate significant morphologic differences in the corpus callosum between genders and a possible sex difference in the neuro-developmental cycle...

Research Grants12

  1. Adapting Experimental Cognitive and Affective Tasks for Schizophrenia
    Ruben C Gur; Fiscal Year: 2010
    ..We will evaluate a dataset from an existing battery to fine tune available measures and adapt new tasks to augment the battery. ..
  2. The Neurobiology of Affective Dysfunction in Schizophrenia
    Ruben Gur; Fiscal Year: 2007
    ..We expect the results to shed light on mechanisms for affective dysfunction in schizophrenia that can lead to improved identification of vulnerability and treatment. ..
  3. AFFECTIVE DYSFUNCTION IN SCHIZOPHERNIA
    Ruben Gur; Fiscal Year: 2005
    ..The longitudinal design will allow assessment of the stability of the neurobehavioral measures and their relation, at intake, to course of illness. ..
  4. The Neurobiology of Affective Dysfunction in Schizophrenia
    Ruben C Gur; Fiscal Year: 2010
    ..We expect the results to shed light on mechanisms for affective dysfunction in schizophrenia that can lead to improved identification of vulnerability and treatment. ..