Ruben C Gur

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Computerized neurocognitive scanning: I. Methodology and validation in healthy people
    R C Gur
    Brain Behavior Laboratory, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 25:766-76. 2001
  2. ncbi request reprint Computerized neurocognitive scanning: II. The profile of schizophrenia
    R C Gur
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, The University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 25:777-88. 2001
  3. ncbi request reprint Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults
    Ruben C Gur
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania, Medical Center, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 10:72-80. 2002
  4. ncbi request reprint Brain maturation and its relevance to understanding criminal culpability of juveniles
    Ruben C Gur
    Department of Psychiatry, Neuropsychiatry Section, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 7:292-6. 2005
  5. ncbi request reprint Sex differences in temporo-limbic and frontal brain volumes of healthy adults
    Ruben C Gur
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Cereb Cortex 12:998-1003. 2002
  6. pmc A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation
    Ruben C Gur
    Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
    J Neurosci Methods 187:254-62. 2010
  7. pmc Dynamic evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:30-9. 2008
  8. doi request reprint Brain activity and emotional processing in smokers treated with varenicline
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Biol 18:732-8. 2013
  9. ncbi request reprint Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
  10. pmc Brain activation during eye gaze discrimination in stable schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 99:286-93. 2008

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Computerized neurocognitive scanning: I. Methodology and validation in healthy people
    R C Gur
    Brain Behavior Laboratory, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 25:766-76. 2001
    ..Therefore, the computerized scan has favorable reliability and construct validity and can be applied efficiently to study healthy variability related to age and gender...
  2. ncbi request reprint Computerized neurocognitive scanning: II. The profile of schizophrenia
    R C Gur
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, The University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 25:777-88. 2001
    ..We conclude that the computerized neurocognitive scan can be applied reliably in people with schizophrenia, yielding data that support its construct and criterion validity...
  3. ncbi request reprint Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults
    Ruben C Gur
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania, Medical Center, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 10:72-80. 2002
    ..Thus, the biological changes commonly attributed to "aging" do, in fact, begin much earlier in the life-cycle...
  4. ncbi request reprint Brain maturation and its relevance to understanding criminal culpability of juveniles
    Ruben C Gur
    Department of Psychiatry, Neuropsychiatry Section, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 7:292-6. 2005
    ....
  5. ncbi request reprint Sex differences in temporo-limbic and frontal brain volumes of healthy adults
    Ruben C Gur
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Cereb Cortex 12:998-1003. 2002
    ..002). The larger volume of cortex devoted to emotional modulation may relate to behavioral evidence for sex differences in emotion processing...
  6. pmc A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation
    Ruben C Gur
    Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
    J Neurosci Methods 187:254-62. 2010
    ..These results encourage the use of this battery in studies needing an efficient assessment of major neurocognitive domains such as multi-site genetic studies and clinical trials...
  7. pmc Dynamic evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:30-9. 2008
    ..In this study, we examined facial expression differences based on duration and frequencies of emotion expressions...
  8. doi request reprint Brain activity and emotional processing in smokers treated with varenicline
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Biol 18:732-8. 2013
    ..Taken together, these results suggest that observed drug effects on brain activity do not reflect affective changes but rather enhanced early processing of perceptual features of facial stimuli. ..
  9. ncbi request reprint Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
    ..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
  10. pmc Brain activation during eye gaze discrimination in stable schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 99:286-93. 2008
    ..Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls...
  11. pmc Abnormal superior temporal connectivity during fear perception in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Schizophr Bull 34:673-8. 2008
    ..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions...
  12. ncbi request reprint Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 64:1356-66. 2007
    ..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction...
  13. pmc Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophrenia
    David I Leitman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Soc Cogn Affect Neurosci 6:66-73. 2011
    ..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal...
  14. doi request reprint Not pitch perfect: sensory contributions to affective communication impairment in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Biol Psychiatry 70:611-8. 2011
    ..The neural correlates of this dysfunction are unclear. Prior study has suggested that schizophrenia vocal affect perception deficits stem from an inability to use acoustic cues, notably pitch, in decoding emotion...
  15. ncbi request reprint Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition
    J Daniel Ragland
    Department of Psychiatry, 10th Floor Gates Bldg HUP, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1840-8. 2005
    ..Patients with schizophrenia improve episodic memory accuracy when given organizational strategies through levels-of-processing paradigms. This study tested if improvement is accompanied by normalized frontotemporal function...
  16. ncbi request reprint Neurocognitive growth charting in psychosis spectrum youths
    Ruben C Gur
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Psychiatry 71:366-74. 2014
    ..We hypothesized that psychosis spectrum youths have delayed neurocognitive age relative to chronological age. We expected larger lags with increased symptom severity and in late adolescence and early adulthood...
  17. ncbi request reprint Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  18. doi request reprint Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010
    ..In rodents and humans, cognitive deficits can be reversed by treatment with the alpha4beta2 nicotinic receptor partial agonist varenicline. This neuroimaging study examined the neural mechanisms that underlie these effects...
  19. doi request reprint Static posed and evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:49-60. 2008
    ..This study examined static facial expressions of emotions for evidence of flattened and inappropriate affect in persons with stable schizophrenia...
  20. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006
    ..This study assessed the relationship between symptoms and cognitive measures at intake and functional outcome 2-8 years later (average 3 years) in first-episode and previously treated schizophrenia patients...
  21. ncbi request reprint Frontolimbic responses to emotional face memory: the neural correlates of first impressions
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 30:3748-58. 2009
    ..The results indicate that a network of frontolimbic regions may provide emotional bias signals during facial recognition...
  22. pmc Sex differences in familiality effects on neurocognitive performance in schizophrenia
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Psychiatry 73:976-84. 2013
    ..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...
  23. doi request reprint The other-race effect in face processing among African American and Caucasian individuals with schizophrenia
    Amy E Pinkham
    Department of Neuropsychiatry, University of Pennsylvania, 10th Floor, Gates Pavilion, Philadelphia 19104, USA
    Am J Psychiatry 165:639-45. 2008
    ..The authors sought to measure the "other-race effect" in schizophrenia, which could account for previous findings and provide information about sensitivity to such social cues in patients...
  24. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  25. ncbi request reprint Whole-brain morphometric study of schizophrenia revealing a spatially complex set of focal abnormalities
    Christos Davatzikos
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania Medical Center, 3600 Market Street, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 62:1218-27. 2005
    ..Frontotemporal abnormalities have been documented by using predetermined region-of-interest approaches, but deformation-based morphometry permits examination of the entire brain...
  26. pmc Neurocognitive performance stability in a multiplex multigenerational study of schizophrenia
    David R Roalf
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Schizophr Bull 39:1008-17. 2013
    ..These findings suggest that measures of mean performance and IIV of speed during a CNB may provide useful information about the genetic susceptibility in schizophrenia. ..
  27. pmc Opposing amygdala and ventral striatum connectivity during emotion identification
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Cogn 76:353-63. 2011
    ..These results indicate that activity in the amygdala and ventral striatum may be inversely related, and that both regions may provide opposing affective bias signals during emotion identification...
  28. ncbi request reprint Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:1004-15. 2004
    ..Neuropsychological studies have demonstrated verbal episodic memory deficits in schizophrenia during word encoding and retrieval. This study examined neural substrates of memory in an analysis that controlled for successful retrieval...
  29. ncbi request reprint Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives
    Farzin Irani
    Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    Schizophr Res 88:151-60. 2006
    ....
  30. pmc Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
    ..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
  31. pmc Alterations of fronto-temporal connectivity during word encoding in schizophrenia
    Daniel H Wolf
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
    Psychiatry Res 154:221-32. 2007
    ..The results suggest that reduced temporal-DLPFC connectivity in schizophrenia could underlie encoding deficits, and increased temporal-VLPFC connectivity may represent an ineffective compensatory effort...
  32. ncbi request reprint Association between facial emotion recognition and odor identification in schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, University of Pennsylvania, Department of Psychiatry, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 19:128-31. 2007
    ..Olfactory and emotion recognition abilities appear significantly linked in schizophrenia...
  33. pmc Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
    Schizophr Bull 32:279-87. 2006
    ..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness...
  34. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  35. pmc Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 61:723-9. 2012
    ..These findings provide evidence for scalable intrinsic reinforcement signals during standard cognitive tasks, and suggest a novel link between motivation and cognition during adolescent development...
  36. pmc Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21
    Ruben C Gur
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
    Neuropsychology 26:251-65. 2012
    ..Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies...
  37. pmc Computerized neurocognitive test performance in schizophrenia: a lifespan analysis
    Farzin Irani
    Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 20:41-52. 2012
    ..Favorable construct validity in younger schizophrenia patients has been reported, but not in older patients. New variables afforded by computerized assessments were used to clarify age-associated cognitive impairment across the lifespan...
  38. pmc Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge
    Daniel H Wolf
    Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 218:503-12. 2011
    ..Pharmacological modulation of emotion-processing deficits and related neural abnormalities may provide useful phenotypes for pathophysiological investigation...
  39. pmc Automated video-based facial expression analysis of neuropsychiatric disorders
    Peng Wang
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neurosci Methods 168:224-38. 2008
    ..Such results can pave the way for a video-based method for quantitative analysis of facial expressions in clinical research of disorders that cause affective deficits...
  40. ncbi request reprint Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:459-72. 2010
    ....
  41. ncbi request reprint Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Psychiatry 164:813-9. 2007
    ..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort...
  42. doi request reprint Neural circuitry for accurate identification of facial emotions
    James Loughead
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 1194:37-44. 2008
    ..Results indicate that the fusiform cortex and amygdala respond differentially in the four target conditions (happy, sad, angry and fearful) along the dimension of threat-relatedness...
  43. pmc Sensory contributions to impaired emotion processing in schizophrenia
    Pamela D Butler
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Schizophr Bull 35:1095-107. 2009
    ..These results provide evidence for a contribution of impaired early-stage visual processing in emotion recognition deficits in schizophrenia and suggest that a bottom-up approach to remediation may be effective...
  44. pmc Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification study
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Biol Psychiatry 63:118-24. 2008
    ..This study investigates whether such endophenotypic patterns are found in FM via similar image analysis approaches...
  45. ncbi request reprint Organization of semantic category exemplars in schizophrenia
    Stephen T Moelter
    University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
    Schizophr Res 78:209-17. 2005
    ..Results suggest that performance differences on semantic tasks with limited retrieval demands in schizophrenia relate to difficulties utilizing higher-order categorization strategies...
  46. pmc An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
    Neuroimage 64:240-56. 2013
    ..These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed...
  47. doi request reprint Development of abbreviated nine-item forms of the Raven's standard progressive matrices test
    Warren B Bilker
    University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Assessment 19:354-69. 2012
    ..The two 9-item forms provide a 75% administration time savings compared with the 30-item form, while achieving similar item- and test-level characteristics and equal correlations to 60-item based scores...
  48. pmc More than just tapping: index finger-tapping measures procedural learning in schizophrenia
    Felipe N Da Silva
    Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 4283, USA
    Schizophr Res 137:234-40. 2012
    ..To our knowledge, this study presents the first use of index finger-tapping to study procedural learning in individuals with schizophrenia or schizoaffective disorder (SCZ/SZA) as compared to healthy controls...
  49. ncbi request reprint A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Schizophrenia Research Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 55:512-7. 2004
    ..Although gender differences in schizophrenia are evident clinically and correlate with neuroanatomic measures, their relationship to OAR has not been examined...
  50. ncbi request reprint Telling truth from lie in individual subjects with fast event-related fMRI
    Daniel D Langleben
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 26:262-72. 2005
    ..Salience of the task cues is a potential confounding factor in the fMRI pattern attributed to deception in forced choice deception paradigms...
  51. ncbi request reprint Age-related differences in brain activation during emotional face processing
    Faith M Gunning-Dixon
    Department of Psychiatry and Radiology, Section of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 24:285-95. 2003
    ..The results of this study suggest that older adults may rely on different cortical networks to perceive emotional facial expressions than do their younger counterparts...
  52. ncbi request reprint Differences in facial expressions of four universal emotions
    Christian G Kohler
    Neuropsychiatry, Department of Psychiatry, 10th Floor Gates Bldg, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Psychiatry Res 128:235-44. 2004
    ..Comparisons are made with previous studies that used different facial stimuli...
  53. ncbi request reprint An fMRI study of facial emotion processing in patients with schizophrenia
    Raquel E Gur
    Section of Neuropsychiatry, Department of Psychiatry, Gates Bldg 10th Floor, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Psychiatry 159:1992-9. 2002
    ..The authors evaluated cerebral blood flow response in schizophrenia patients during facial emotion processing to test the hypothesis of diminished limbic activation related to emotional relevance of facial stimuli...
  54. ncbi request reprint Symptom and demographic profiles in first-episode schizophrenia
    Edward I Gelber
    Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Schizophr Res 67:185-94. 2004
    ..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients...
  55. ncbi request reprint Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI study
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:263-74. 2007
    ..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences...
  56. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  57. pmc White matter organization and neurocognitive performance variability in schizophrenia
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, United States
    Schizophr Res 143:172-8. 2013
    ..However, the neural basis of WIV has not been studied in patients with schizophrenia...
  58. pmc A meta-analysis of emotion perception and functional outcomes in schizophrenia
    Farzin Irani
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 137:203-11. 2012
    ..Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic strategy to combine results from several studies and examine synthesized effect sizes...
  59. doi request reprint The face in the crowd effect: anger superiority when using real faces and multiple identities
    Amy E Pinkham
    Department of Psychiatry, University of Pennsylvania, PA, USA
    Emotion 10:141-6. 2010
    ..These results are the first to extend the face in the crowd effect beyond homogenous crowds to more ecologically valid conditions and thus provide compelling evidence for its legitimacy as a naturalistic phenomenon...
  60. ncbi request reprint Normative data for the symbol cancellation test in young healthy adults
    Natasha Lowery
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Appl Neuropsychol 11:218-21. 2004
    ..In addition, a relation likely exists between SCT performance and age and education, but a larger sample seems warranted to reliably model the pattern...
  61. ncbi request reprint Functional magnetic resonance imaging of internal source monitoring in schizophrenia: recognition with and without recollection
    J Daniel Ragland
    Department of Psychiatry, Brain Behavior Laboratory, 3400 Spruce Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Schizophr Res 87:160-71. 2006
    ..Activation in these areas was associated with worse positive and negative symptoms, but did not correlate with performance, suggesting inefficient rather than compensatory activation...
  62. pmc Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 168:930-46. 2011
    ....
  63. pmc The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes
    Raquel E Gur
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:49-68. 2007
    ....
  64. pmc Computerized measurement of facial expression of emotions in schizophrenia
    Christopher Alvino
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, 3600 Market, Suite 380, Philadelphia, PA 19104, United States
    J Neurosci Methods 163:350-61. 2007
    ..These results encourage the use of such deformation based expression quantification measures for research in clinical applications that require the automated measurement of facial affect...
  65. ncbi request reprint Levels-of-processing effect on word recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 54:1154-61. 2003
    ..By requiring participants to classify and encode words on either a shallow (e.g., uppercase/lowercase) or deep level (e.g., concrete/abstract), the levels-of-processing paradigm eliminates the need to generate organizational strategies...
  66. ncbi request reprint Levels-of-processing effect on internal source monitoring in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychol Med 36:641-8. 2006
    ..The current study investigates whether providing semantic organizational strategies can also normalize patients' internal source-monitoring performance...
  67. ncbi request reprint The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms of repeat administration
    Matthew M Kurtz
    Department of Psychiatry, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Arch Clin Neuropsychol 19:191-201. 2004
    ..Divergent validity was established through low, nonsignificant correlations between the PCET and measures of facial emotion recognition, word and face memory, visuospatial function, and verbal reasoning...
  68. ncbi request reprint Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia
    Raquel E Gur
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:2029-36. 2003
    ..These results suggest that some effects of olanzapine may impact both symptoms and cognitive performance...
  69. ncbi request reprint Facial emotion recognition in schizophrenia: intensity effects and error pattern
    Christian G Kohler
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1768-74. 2003
    ..The authors used color photographs of emotional and neutral expressions to investigate recognition patterns of five universal emotions in schizophrenia...
  70. pmc Facial emotion recognition in schizophrenia: when and why does it go awry?
    Bruce I Turetsky
    Neurophysiology and Brain Imaging Laboratory, Department of Psychiatry 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Res 94:253-63. 2007
    ..This study examined event-related potential (ERP) responses to emotional faces in schizophrenia patients and controls to determine when, in the temporal processing stream, patient abnormalities occur...
  71. ncbi request reprint No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cogn Neuropsychiatry 12:412-21. 2007
    ..Cognitive dysfunction is common in schizophrenia and linked with psychosocial dysfunction. We examined the possible effect of a 16-week trial of donepezil on cognition in young persons with stable schizophrenia...
  72. doi request reprint Brain activation during autobiographical relationship episode narratives: a core conflictual relationship theme approach
    James W Loughead
    Department of Psychiatry, University of Pennsylvania, Gates Building, 10th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Psychother Res 20:321-36. 2010
    ..This suggests that brain systems subserving memory processes are more active when recalling relationship episodes with greater CCRT content...
  73. pmc Computerized neurocognitive profile in young people with 22q11.2 deletion syndrome compared to youths with schizophrenia and at-risk for psychosis
    Paula C Goldenberg
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 159:87-93. 2012
    ..Similar deficits have been described in the 22q11DS population using non-computerized measures, which require increased testing time...
  74. doi request reprint Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative battery
    Ruben C Gur
    Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Neuropsychol 25:1029-41. 2011
    ..The study illustrates what will hopefully become a major component of the work of clinical and research neuropsychologists as invaluable participants in the dawning age of Big Science neuropsychological genomics...
  75. ncbi request reprint Quantification of facial expressions using high-dimensional shape transformations
    Ragini Verma
    Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, 3600 Market Street, Suite 380, Philadelphia, PA 19104, USA
    J Neurosci Methods 141:61-73. 2005
    ..A model for the average expression of specific emotions was also constructed using the RVD maps. This method can be applied in basic and clinical investigations of facial affect and its neural substrates...
  76. ncbi request reprint Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives
    Monica E Calkins
    University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1963-6. 2005
    ..Biological relatives of patients have similar deficits, suggesting genetic susceptibility. Because the impairment may reflect generalized object memory deficits, the authors evaluated both face and visual object recognition...
  77. ncbi request reprint Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasks
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychology 16:370-9. 2002
    ..Results support fractal n-back validity and indicate substantial overlap in working memory functions of dorsal and ventral PFC...
  78. ncbi request reprint Emotion processing in chimeric faces: hemispheric asymmetries in expression and recognition of emotions
    Tim Indersmitten
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 23:3820-5. 2003
    ..Evoked anger is uniquely expressed more intensely and accurately on the side of the face that projects to the viewer's right hemisphere, dominant in emotion recognition...
  79. pmc Baby schema modulates the brain reward system in nulliparous women
    Melanie L Glocker
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:9115-9. 2009
    ..Our findings suggest that engagement of the mesocorticolimbic system is the neurophysiologic mechanism by which baby schema promotes human caregiving, regardless of kinship...
  80. pmc Gender difference in neural response to psychological stress
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 2:227-39. 2007
    ..Our study may represent an initial step in uncovering the neurobiological basis underlying the contrasting health consequences of psychosocial stress in men and women...
  81. ncbi request reprint COMPARE: classification of morphological patterns using adaptive regional elements
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 26:93-105. 2007
    ..8% for female subjects and 90.8% for male subjects), but also good stability with respect to the number of features selected and the size of SVM kernel used...
  82. ncbi request reprint Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  83. ncbi request reprint Brain activation during facial emotion processing
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuroimage 16:651-62. 2002
    ..These results support the central role of the amygdala in emotion processing, and indicate its sensitivity to the task relevance of the emotional display...
  84. ncbi request reprint Neuropsychological profiles delineate distinct profiles of schizophrenia, an interaction between memory and executive function, and uneven distribution of clinical subtypes
    S Kristian Hill
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, USA
    J Clin Exp Neuropsychol 24:765-80. 2002
    ..This suggests greater correspondence than previously postulated between systems responsible for clinical symptomatology and those moderating neurocognitive dysfunction...
  85. ncbi request reprint Memory-delineated subtypes of schizophrenia: relationship to clinical, neuroanatomical, and neurophysiological measures
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Neuropsychology 16:481-90. 2002
    ..Unimpaired patients had fewer negative symptoms and dorsal medial prefrontal hypermetabolism. The authors conclude that categorizing patients on the basis of memory deficits may yield neurobiologically meaningful disease subtypes...
  86. ncbi request reprint Development of an abbreviated schizophrenia quality of life scale using a new method
    Warren B Bilker
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neuropsychopharmacology 28:773-7. 2003
    ..This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments...
  87. pmc Functional magnetic resonance imaging in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Medical Center, 10th Floor, Gates Building, Philadelphia, PA 19104, USA
    Dialogues Clin Neurosci 12:333-43. 2010
    ..The methodology can help bridge integration with neuropharmacologic and genomic investigations...
  88. ncbi request reprint Affect recognition deficits in schizophrenia: neural substrates and psychopharmacological implications
    Amy E Pinkham
    University of Pennsylvania Medical Center, Department of Psychiatry, 10th Floor Gates Building, Philadelphia, PA 19104, USA
    Expert Rev Neurother 7:807-16. 2007
    ..Both serotonergic and anxiolytic GABAergic agents that modulate activation of the limbic system offer promising avenues for remediation efforts...
  89. ncbi request reprint Neural substrates for functionally discriminating self-face from personally familiar faces
    Steven M Platek
    Department of Psychology, Drexel University, and Department of Psychiatry, Brain Behavior Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 27:91-8. 2006
    ....
  90. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  91. pmc Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state
    Ruben C Gur
    Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Cereb Cortex 19:375-82. 2009
    ..Whether greater left hemispheric hyperperfusion reflects lateral dominance needs further examination...
  92. ncbi request reprint Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods
    Muktar H Aliyu
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294 2041, and Duke University Medical Center John Umstead Hospital, Butner, NC, United States
    Schizophr Res 87:32-44. 2006
    ..This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia...
  93. ncbi request reprint Amygdala activation and facial expressions: explicit emotion discrimination versus implicit emotion processing
    Ute Habel
    Department of Psychiatry and Psychotherapy, University of Aachen, Germany
    Neuropsychologia 45:2369-77. 2007
    ..A significant correlation between amygdala activation and emotion recognition, but not age discrimination performance, emphasizes the amygdala's enhanced role during conscious emotion processing...
  94. ncbi request reprint Impaired error monitoring contributes to face recognition deficit in schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Schizophr Res 85:151-61. 2006
    ..It has been proposed that social and cognitive deficits in schizophrenia may result from impaired error monitoring...
  95. ncbi request reprint Amygdala activation at 3T in response to human and avatar facial expressions of emotions
    Ewald Moser
    MR Centre of Excellence, Medical University of Vienna, Vienna, Austria
    J Neurosci Methods 161:126-33. 2007
    ..However, the finding of differences between human and avatar faces in face-sensitive regions indicates the presence of mechanisms by which human brains can differentiate between them. This mechanism merits further investigation...
  96. ncbi request reprint Perception of happy and sad facial expressions in chronic schizophrenia: evidence for two evaluative systems
    Henry Silver
    Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
    Schizophr Res 55:171-7. 2002
    ..Persons suffering from schizophrenia have impaired perception of emotional expressions, but it is not clear whether this is part of a generalized deficit in cognitive function...
  97. ncbi request reprint Working memory deficit as a core neuropsychological dysfunction in schizophrenia
    Henry Silver
    Brain Behavior Laaboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Am J Psychiatry 160:1809-16. 2003
    ..This study tested the hypothesis that impaired working memory is a core deficit underlying multiple neuropsychological deficits in schizophrenia patients...
  98. ncbi request reprint Symptoms versus neurocognitive test performance as predictors of psychosocial status in schizophrenia: a 1- and 4-year prospective study
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program, Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Bull 31:167-74. 2005
    ..The significance of these findings for the development and assessment of novel treatment interventions for schizophrenia is discussed...
  99. ncbi request reprint Anger and depression in cocaine addiction: association with the orbitofrontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
    Psychiatry Res 138:13-22. 2005
    ....
  100. ncbi request reprint Impairment in the specificity of emotion processing in schizophrenia
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Am J Psychiatry 163:442-7. 2006
    ..The authors also sought to establish whether the deficit affects sensitivity or specificity of performance...
  101. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....