Research Topics
Genomes and GenesSpecies | Raquel GurSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Functional magnetic resonance imaging in schizophreniaRaquel E Gur
Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Medical Center, 10th Floor, Gates Building, Philadelphia, PA 19104, USA
Dialogues Clin Neurosci 12:333-43. 2010..The methodology can help bridge integration with neuropharmacologic and genomic investigations...
Limbic activation associated with misidentification of fearful faces and flat affect in schizophreniaRaquel E Gur
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 64:1356-66. 2007..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction...
Neuropsychiatric aspects of schizophreniaRaquel E Gur
Departments of Psychiatry, Neurology, and Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
CNS Neurosci Ther 17:45-51. 2011..The methodology can help bridge integration with neuropharmacologic, genomic, and neurorehabilitation investigations...- RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sampleKonasale M Prasad
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Schizophr Bull 36:983-90. 2010..02) and face memory speed (P = .03). RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample... - Organization of semantic category exemplars in schizophreniaStephen T Moelter
University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
Schizophr Res 78:209-17. 2005..Results suggest that performance differences on semantic tasks with limited retrieval demands in schizophrenia relate to difficulties utilizing higher-order categorization strategies... - Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidolJeffrey A Lieberman
Department of Psychiatry, University of North Carolina School of Medicine, NC 27599 7160, USA
Am J Psychiatry 160:1396-404. 2003..This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial... - Self-face recognition and theory of mind in patients with schizophrenia and first-degree relativesFarzin Irani
Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
Schizophr Res 88:151-60. 2006.... - Regional structural characterization of the brain of schizophrenia patientsPaul Yushkevich
Department of Radiology, 3600 Market Street, Suite 370, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Acad Radiol 12:1250-61. 2005..We study morphologic characteristics and age-related changes in patients with schizophrenia to investigate whether abnormal neurodevelopment and brain structure have a role in the pathophysiological course of this disease... - Physiologic impairment of olfactory stimulus processing in schizophreniaBruce I Turetsky
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 53:403-11. 2003..Understanding the nature of these physiologic olfactory impairments could offer clues to the basic neuropathology of this disorder... - Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of SchizophreniaHenry A Nasrallah
Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
J Clin Psychiatry 70:4-46. 2009..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research... - Symptom and demographic profiles in first-episode schizophreniaEdward I Gelber
Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Schizophr Res 67:185-94. 2004..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients... - Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010.... - Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicineFarzin Irani
Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 29:960-8. 2004..Thus, the study provides impetus for future work in this area... - Computerized measurement of facial expression of emotions in schizophreniaChristopher Alvino
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, 3600 Market, Suite 380, Philadelphia, PA 19104, United States
J Neurosci Methods 163:350-61. 2007..These results encourage the use of such deformation based expression quantification measures for research in clinical applications that require the automated measurement of facial affect... - Antipsychotic drug effects on brain morphology in first-episode psychosisJeffrey A Lieberman
Departments of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Arch Gen Psychiatry 62:361-70. 2005..This raises the possibility that antipsychotics might alter such pathomorphologic progression in early-stage schizophrenia... - Unirhinal olfactory function in schizophrenia patients and first-degree relativesDavid R Roalf
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Neuropsychiatry Clin Neurosci 18:389-96. 2006.... - A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophreniaRaquel E Gur
Department of Psychiatry, Schizophrenia Research Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 55:512-7. 2004..The correlations with symptom severity suggest that neuroanatomic abnormalities in OAR reflect compensatory brain changes... - Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies... - The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP componentsPatrick M Connolly
Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Neurochem Res 29:1179-88. 2004..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems... - Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potentialChristina R Maxwell
Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 29:739-46. 2004..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not... - Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification studyYong Fan
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Biol Psychiatry 63:118-24. 2008..This study investigates whether such endophenotypic patterns are found in FM via similar image analysis approaches... - Brain activation during facial emotion processingRuben C Gur
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
Neuroimage 16:651-62. 2002..These results support the central role of the amygdala in emotion processing, and indicate its sensitivity to the task relevance of the emotional display... - Age-related differences in brain activation during emotional face processingFaith M Gunning-Dixon
Department of Psychiatry and Radiology, Section of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurobiol Aging 24:285-95. 2003..The results of this study suggest that older adults may rely on different cortical networks to perceive emotional facial expressions than do their younger counterparts... - Neuropsychological profiles delineate distinct profiles of schizophrenia, an interaction between memory and executive function, and uneven distribution of clinical subtypesS Kristian Hill
Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, USA
J Clin Exp Neuropsychol 24:765-80. 2002..This suggests greater correspondence than previously postulated between systems responsible for clinical symptomatology and those moderating neurocognitive dysfunction... - Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia... - Brain activation during eye gaze discrimination in stable schizophreniaChristian G Kohler
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Schizophr Res 99:286-93. 2008..Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls... - Automated video-based facial expression analysis of neuropsychiatric disordersPeng Wang
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Neurosci Methods 168:224-38. 2008..Such results can pave the way for a video-based method for quantitative analysis of facial expressions in clinical research of disorders that cause affective deficits... - Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI studyRuben C Gur
Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Brain Mapp 28:263-74. 2007..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences... - No effect of donepezil on neurocognition and social cognition in young persons with stable schizophreniaChristian G Kohler
Schizophrenia Research Center, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA
Cogn Neuropsychiatry 12:412-21. 2007..Cognitive dysfunction is common in schizophrenia and linked with psychosocial dysfunction. We examined the possible effect of a 16-week trial of donepezil on cognition in young persons with stable schizophrenia... - Affect recognition deficits in schizophrenia: neural substrates and psychopharmacological implicationsAmy E Pinkham
University of Pennsylvania Medical Center, Department of Psychiatry, 10th Floor Gates Building, Philadelphia, PA 19104, USA
Expert Rev Neurother 7:807-16. 2007..Both serotonergic and anxiolytic GABAergic agents that modulate activation of the limbic system offer promising avenues for remediation efforts... - Deconstructing psychosis with human brain imagingRaquel E Gur
Department of Psychiatry, University of Pennsylvania 10 Gates, 3400 Spruce Philadelphia, PA 19104, USA
Schizophr Bull 33:921-31. 2007.... - The other-race effect in face processing among African American and Caucasian individuals with schizophreniaAmy E Pinkham
Department of Neuropsychiatry, University of Pennsylvania, 10th Floor, Gates Pavilion, Philadelphia 19104, USA
Am J Psychiatry 165:639-45. 2008..The authors sought to measure the "other-race effect" in schizophrenia, which could account for previous findings and provide information about sensitivity to such social cues in patients... - Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default stateRuben C Gur
Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Cereb Cortex 19:375-82. 2009..Whether greater left hemispheric hyperperfusion reflects lateral dominance needs further examination... - Abnormal superior temporal connectivity during fear perception in schizophreniaDavid I Leitman
Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Schizophr Bull 34:673-8. 2008..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions... - Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's diseaseThomas McBride
Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
Schizophr Res 55:217-27. 2002..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile... - Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasksJ Daniel Ragland
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Neuropsychology 16:370-9. 2002..Results support fractal n-back validity and indicate substantial overlap in working memory functions of dorsal and ventral PFC... - Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophreniaDavid I Leitman
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Soc Cogn Affect Neurosci 6:66-73. 2011..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal... - Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophreniaTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:418-26. 2010..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia... - Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patientsMonica E Calkins
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:459-72. 2010.... - Frontolimbic responses to emotional face memory: the neural correlates of first impressionsTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hum Brain Mapp 30:3748-58. 2009..The results indicate that a network of frontolimbic regions may provide emotional bias signals during facial recognition... - The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment... - Profile of auditory information-processing deficits in schizophreniaBruce I Turetsky
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Psychiatry Res 165:27-37. 2009..Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia... - Static posed and evoked facial expressions of emotions in schizophreniaChristian G Kohler
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Schizophr Res 105:49-60. 2008..This study examined static facial expressions of emotions for evidence of flattened and inappropriate affect in persons with stable schizophrenia... - Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophreniaRaquel E Gur
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Am J Psychiatry 164:813-9. 2007..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort... - Development of an abbreviated schizophrenia quality of life scale using a new methodWarren B Bilker
Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
Neuropsychopharmacology 28:773-7. 2003..This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments... - Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaChang Gyu Hahn
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:824-8. 2006..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia... - Levels-of-processing effect on internal source monitoring in schizophreniaJ Daniel Ragland
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Psychol Med 36:641-8. 2006..The current study investigates whether providing semantic organizational strategies can also normalize patients' internal source-monitoring performance... - Flat affect in schizophrenia: relation to emotion processing and neurocognitive measuresRaquel E Gur
Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
Schizophr Bull 32:279-87. 2006..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness... - Emotion-discrimination deficits in mild Alzheimer diseaseChristian G Kohler
Department of Psychiatry, Univ of Pennsylvania, Philadelphia, PA, USA
Am J Geriatr Psychiatry 13:926-33. 2005..Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers... - Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relativesMonica E Calkins
University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Psychiatry 162:1963-6. 2005..Biological relatives of patients have similar deficits, suggesting genetic susceptibility. Because the impairment may reflect generalized object memory deficits, the authors evaluated both face and visual object recognition... - Differences in facial expressions of four universal emotionsChristian G Kohler
Neuropsychiatry, Department of Psychiatry, 10th Floor Gates Bldg, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Psychiatry Res 128:235-44. 2004..Comparisons are made with previous studies that used different facial stimuli... - Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophreniaSteven J Siegel
Division of Neuropsychiatry, Laboratory of Molecular Neuropsychopharmacolgy, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Gates Building 10th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neuropsychopharmacology 26:817-23. 2002..Surgically-implantable formulations are a viable approach to provide long-term delivery of antipsychotic medications to patients with psychotic disorders... - Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophreniaJ Daniel Ragland
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 161:1004-15. 2004..Neuropsychological studies have demonstrated verbal episodic memory deficits in schizophrenia during word encoding and retrieval. This study examined neural substrates of memory in an analysis that controlled for successful retrieval... - Phenylthiocarbamide perception in patients with schizophrenia and first-degree family membersPaul J Moberg
Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Psychiatry 162:788-90. 2005..The authors examined PTC sensitivity in schizophrenia patients and their non-ill relatives to determine whether this represented a vulnerability marker... - Assessment of adolescents at risk for psychosisKarin Borgmann-Winter
Schizophrenia Research Center and Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 8:313-21. 2006..This battery may assist in unraveling the complex presentation of prodromal symptoms during the adolescent developmental period... - Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophreniaBruce I Turetsky
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
Arch Gen Psychiatry 60:1193-200. 2003..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established... - Alterations of fronto-temporal connectivity during word encoding in schizophreniaDaniel H Wolf
University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
Psychiatry Res 154:221-32. 2007..The results suggest that reduced temporal-DLPFC connectivity in schizophrenia could underlie encoding deficits, and increased temporal-VLPFC connectivity may represent an ineffective compensatory effort... - Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophreniaRaquel E Gur
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:2029-36. 2003..These results suggest that some effects of olanzapine may impact both symptoms and cognitive performance... - Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imagingRaquel E Gur
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Psychiatry 164:442-9. 2007..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging... - COMPARE: classification of morphological patterns using adaptive regional elementsYong Fan
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 26:93-105. 2007..8% for female subjects and 90.8% for male subjects), but also good stability with respect to the number of features selected and the size of SVM kernel used... - Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performancePaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Schizophr Res 90:221-8. 2007..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles... - The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypesRaquel E Gur
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:49-68. 2007.... - Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measuresPaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Exp Neuropsychol 28:1444-61. 2006.... - Relationship between clock-drawing and neuropsychological and functional status in elderly institutionalized patients with schizophreniaNatasha Lowery
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Geriatr Psychiatry 11:621-8. 2003..The authors sought to examine the usefulness of the clock-drawing test (CDT) as a measure of general cognitive and adaptive functioning in elderly patients with schizophrenia... - Levels-of-processing effect on word recognition in schizophreniaJ Daniel Ragland
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 54:1154-61. 2003..Memory remediation efforts may therefore be most successful if they focus on teaching patients to form organizational strategies during initial encoding... - Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophreniaPaul J Moberg
Brain Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Psychiatry 161:2314-6. 2004.... - Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samplesMichael E Talkowski
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Med Genet B Neuropsychiatr Genet 150:560-9. 2009..047, OR = 1.46). Our analyses suggest several associations at PAH, with consistent evidence for rs1522305. Further analyses, including additional variations and environmental influences such as phenylalanine exposure are warranted... - Characterization of brain plasticity in schizophrenia using template deformationAbraham Dubb
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Acad Radiol 12:3-9. 2005..Abnormal neurodevelopment may play a role in the pathophysiology of schizophrenia. We used deformation-based morphometry to examine voxel-wise age-related changes in patients with schizophrenia compared with healthy brains...
Research Grants
- Schizophrenia Liability Genes among African AmericansRaquel Gur; Fiscal Year: 2006..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
- Genetics of Endophenotypes and SchizophreniaRaquel Gur; Fiscal Year: 2007..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
- 2/4-Collaboration to Advance Negative Symptom Assessment In SchizophreniaRaquel E Gur; Fiscal Year: 2010..This state-of-the art instrument will play a central role in the NIMH initiative to stimulate the development of new treatments aimed at reducing the disability associated with negative symptoms. ..
- 3/4-A Genomic Approach to SchizophreniaRaquel E Gur; Fiscal Year: 2010..Our goal is to use state-of-the-art genomic tools to detect these mutations anywhere in the genome, and to identify genes that are more often impacted by structural mutations in persons with schizophrenia compared to healthy controls. ..
- 4/5-The Genetics of Endophenotypes and SchizophreniaRaquel E Gur; Fiscal Year: 2010..Once we understand the genetic architecture of these abnormalities, new medications that aim to improve the functioning and quality of life of schizophrenia patients can be developed. ..
- A Neurobehavioral Family Study of SchizophreniaRaquel Gur; Fiscal Year: 2005..All collected data will become part of the NIMH-sponsored archival database for schizophrenia. ..
- NEUROBEHAVIORAL STUDY OF SCHIZOPHRENIARaquel Gur; Fiscal Year: 1990..We will valuate the potential of MRS for measuring local metabolic parameters in schizophrenics and controls...
- AFFECTIVE DYSFUNCTION IN SCHIZOPHERNIARaquel Gur; Fiscal Year: 2001..The longitudinal design will allow assessment of the stability of the neurobehavioral measures and their relation, at intake, to course of illness. ..
- A Neurobehavioral Family Study of SchizophreniaRaquel E Gur; Fiscal Year: 2010..The goal of the Multiplex Multigenerational Investigation of the schizophrenia consortium is to integrate neurobehavioral and neuroimaging methods in high-risk families that will yield the data needed for progress in the field. ..