Raquel Gur

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Functional magnetic resonance imaging in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Medical Center, 10th Floor, Gates Building, Philadelphia, PA 19104, USA
    Dialogues Clin Neurosci 12:333-43. 2010
  2. ncbi Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 64:1356-66. 2007
  3. doi Neuropsychiatric aspects of schizophrenia
    Raquel E Gur
    Departments of Psychiatry, Neurology, and Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    CNS Neurosci Ther 17:45-51. 2011
  4. pmc RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Bull 36:983-90. 2010
  5. ncbi Organization of semantic category exemplars in schizophrenia
    Stephen T Moelter
    University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
    Schizophr Res 78:209-17. 2005
  6. ncbi Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol
    Jeffrey A Lieberman
    Department of Psychiatry, University of North Carolina School of Medicine, NC 27599 7160, USA
    Am J Psychiatry 160:1396-404. 2003
  7. ncbi Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives
    Farzin Irani
    Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    Schizophr Res 88:151-60. 2006
  8. ncbi Regional structural characterization of the brain of schizophrenia patients
    Paul Yushkevich
    Department of Radiology, 3600 Market Street, Suite 370, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Acad Radiol 12:1250-61. 2005
  9. ncbi Physiologic impairment of olfactory stimulus processing in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 53:403-11. 2003
  10. ncbi Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009

Collaborators

Detail Information

Publications68

  1. pmc Functional magnetic resonance imaging in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Medical Center, 10th Floor, Gates Building, Philadelphia, PA 19104, USA
    Dialogues Clin Neurosci 12:333-43. 2010
    ..The methodology can help bridge integration with neuropharmacologic and genomic investigations...
  2. ncbi Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 64:1356-66. 2007
    ..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction...
  3. doi Neuropsychiatric aspects of schizophrenia
    Raquel E Gur
    Departments of Psychiatry, Neurology, and Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    CNS Neurosci Ther 17:45-51. 2011
    ..The methodology can help bridge integration with neuropharmacologic, genomic, and neurorehabilitation investigations...
  4. pmc RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Bull 36:983-90. 2010
    ..02) and face memory speed (P = .03). RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample...
  5. ncbi Organization of semantic category exemplars in schizophrenia
    Stephen T Moelter
    University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
    Schizophr Res 78:209-17. 2005
    ..Results suggest that performance differences on semantic tasks with limited retrieval demands in schizophrenia relate to difficulties utilizing higher-order categorization strategies...
  6. ncbi Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol
    Jeffrey A Lieberman
    Department of Psychiatry, University of North Carolina School of Medicine, NC 27599 7160, USA
    Am J Psychiatry 160:1396-404. 2003
    ..This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial...
  7. ncbi Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives
    Farzin Irani
    Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    Schizophr Res 88:151-60. 2006
    ....
  8. ncbi Regional structural characterization of the brain of schizophrenia patients
    Paul Yushkevich
    Department of Radiology, 3600 Market Street, Suite 370, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Acad Radiol 12:1250-61. 2005
    ..We study morphologic characteristics and age-related changes in patients with schizophrenia to investigate whether abnormal neurodevelopment and brain structure have a role in the pathophysiological course of this disease...
  9. ncbi Physiologic impairment of olfactory stimulus processing in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 53:403-11. 2003
    ..Only limited efforts have been made to investigate the neurophysiologic substrate of these olfactory abnormalities. This article reports the first examination of olfactory electrophysiologic responses in patients with schizophrenia...
  10. ncbi Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009
    ..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...
  11. ncbi Symptom and demographic profiles in first-episode schizophrenia
    Edward I Gelber
    Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Schizophr Res 67:185-94. 2004
    ..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients...
  12. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  13. ncbi Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  14. pmc Computerized measurement of facial expression of emotions in schizophrenia
    Christopher Alvino
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, 3600 Market, Suite 380, Philadelphia, PA 19104, United States
    J Neurosci Methods 163:350-61. 2007
    ..These results encourage the use of such deformation based expression quantification measures for research in clinical applications that require the automated measurement of facial affect...
  15. ncbi Antipsychotic drug effects on brain morphology in first-episode psychosis
    Jeffrey A Lieberman
    Departments of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Arch Gen Psychiatry 62:361-70. 2005
    ..This raises the possibility that antipsychotics might alter such pathomorphologic progression in early-stage schizophrenia...
  16. ncbi Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
    ....
  17. ncbi A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Schizophrenia Research Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 55:512-7. 2004
    ..Although gender differences in schizophrenia are evident clinically and correlate with neuroanatomic measures, their relationship to OAR has not been examined...
  18. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  19. ncbi The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurochem Res 29:1179-88. 2004
    ..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems...
  20. ncbi Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:739-46. 2004
    ..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not...
  21. pmc Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification study
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Biol Psychiatry 63:118-24. 2008
    ..This study investigates whether such endophenotypic patterns are found in FM via similar image analysis approaches...
  22. ncbi Brain activation during facial emotion processing
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuroimage 16:651-62. 2002
    ..These results support the central role of the amygdala in emotion processing, and indicate its sensitivity to the task relevance of the emotional display...
  23. ncbi Age-related differences in brain activation during emotional face processing
    Faith M Gunning-Dixon
    Department of Psychiatry and Radiology, Section of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 24:285-95. 2003
    ..The results of this study suggest that older adults may rely on different cortical networks to perceive emotional facial expressions than do their younger counterparts...
  24. ncbi Neuropsychological profiles delineate distinct profiles of schizophrenia, an interaction between memory and executive function, and uneven distribution of clinical subtypes
    S Kristian Hill
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, USA
    J Clin Exp Neuropsychol 24:765-80. 2002
    ..This suggests greater correspondence than previously postulated between systems responsible for clinical symptomatology and those moderating neurocognitive dysfunction...
  25. ncbi Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  26. pmc Brain activation during eye gaze discrimination in stable schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 99:286-93. 2008
    ..Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls...
  27. pmc Automated video-based facial expression analysis of neuropsychiatric disorders
    Peng Wang
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neurosci Methods 168:224-38. 2008
    ..Such results can pave the way for a video-based method for quantitative analysis of facial expressions in clinical research of disorders that cause affective deficits...
  28. ncbi Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI study
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:263-74. 2007
    ..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences...
  29. ncbi No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cogn Neuropsychiatry 12:412-21. 2007
    ..Cognitive dysfunction is common in schizophrenia and linked with psychosocial dysfunction. We examined the possible effect of a 16-week trial of donepezil on cognition in young persons with stable schizophrenia...
  30. ncbi Affect recognition deficits in schizophrenia: neural substrates and psychopharmacological implications
    Amy E Pinkham
    University of Pennsylvania Medical Center, Department of Psychiatry, 10th Floor Gates Building, Philadelphia, PA 19104, USA
    Expert Rev Neurother 7:807-16. 2007
    ..Both serotonergic and anxiolytic GABAergic agents that modulate activation of the limbic system offer promising avenues for remediation efforts...
  31. pmc Deconstructing psychosis with human brain imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania 10 Gates, 3400 Spruce Philadelphia, PA 19104, USA
    Schizophr Bull 33:921-31. 2007
    ....
  32. doi The other-race effect in face processing among African American and Caucasian individuals with schizophrenia
    Amy E Pinkham
    Department of Neuropsychiatry, University of Pennsylvania, 10th Floor, Gates Pavilion, Philadelphia 19104, USA
    Am J Psychiatry 165:639-45. 2008
    ..The authors sought to measure the "other-race effect" in schizophrenia, which could account for previous findings and provide information about sensitivity to such social cues in patients...
  33. pmc Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state
    Ruben C Gur
    Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Cereb Cortex 19:375-82. 2009
    ..Whether greater left hemispheric hyperperfusion reflects lateral dominance needs further examination...
  34. pmc Abnormal superior temporal connectivity during fear perception in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Schizophr Bull 34:673-8. 2008
    ..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions...
  35. ncbi Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
    Thomas McBride
    Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Schizophr Res 55:217-27. 2002
    ..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile...
  36. ncbi Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasks
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychology 16:370-9. 2002
    ..Results support fractal n-back validity and indicate substantial overlap in working memory functions of dorsal and ventral PFC...
  37. pmc Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophrenia
    David I Leitman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Soc Cogn Affect Neurosci 6:66-73. 2011
    ..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal...
  38. doi Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
    ..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
  39. doi Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:459-72. 2010
    ....
  40. doi Frontolimbic responses to emotional face memory: the neural correlates of first impressions
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 30:3748-58. 2009
    ..The results indicate that a network of frontolimbic regions may provide emotional bias signals during facial recognition...
  41. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  42. pmc Profile of auditory information-processing deficits in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychiatry Res 165:27-37. 2009
    ..Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia...
  43. doi Static posed and evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:49-60. 2008
    ..This study examined static facial expressions of emotions for evidence of flattened and inappropriate affect in persons with stable schizophrenia...
  44. ncbi Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Psychiatry 164:813-9. 2007
    ..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort...
  45. ncbi Development of an abbreviated schizophrenia quality of life scale using a new method
    Warren B Bilker
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neuropsychopharmacology 28:773-7. 2003
    ..This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments...
  46. ncbi Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  47. ncbi Levels-of-processing effect on internal source monitoring in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychol Med 36:641-8. 2006
    ..The current study investigates whether providing semantic organizational strategies can also normalize patients' internal source-monitoring performance...
  48. pmc Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
    Schizophr Bull 32:279-87. 2006
    ..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness...
  49. ncbi Emotion-discrimination deficits in mild Alzheimer disease
    Christian G Kohler
    Department of Psychiatry, Univ of Pennsylvania, Philadelphia, PA, USA
    Am J Geriatr Psychiatry 13:926-33. 2005
    ..Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers...
  50. ncbi Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives
    Monica E Calkins
    University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1963-6. 2005
    ..Biological relatives of patients have similar deficits, suggesting genetic susceptibility. Because the impairment may reflect generalized object memory deficits, the authors evaluated both face and visual object recognition...
  51. ncbi Differences in facial expressions of four universal emotions
    Christian G Kohler
    Neuropsychiatry, Department of Psychiatry, 10th Floor Gates Bldg, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Psychiatry Res 128:235-44. 2004
    ..Comparisons are made with previous studies that used different facial stimuli...
  52. ncbi Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, Laboratory of Molecular Neuropsychopharmacolgy, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Gates Building 10th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 26:817-23. 2002
    ..Surgically-implantable formulations are a viable approach to provide long-term delivery of antipsychotic medications to patients with psychotic disorders...
  53. ncbi Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:1004-15. 2004
    ..Neuropsychological studies have demonstrated verbal episodic memory deficits in schizophrenia during word encoding and retrieval. This study examined neural substrates of memory in an analysis that controlled for successful retrieval...
  54. ncbi Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:788-90. 2005
    ..The authors examined PTC sensitivity in schizophrenia patients and their non-ill relatives to determine whether this represented a vulnerability marker...
  55. ncbi Assessment of adolescents at risk for psychosis
    Karin Borgmann-Winter
    Schizophrenia Research Center and Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 8:313-21. 2006
    ..This battery may assist in unraveling the complex presentation of prodromal symptoms during the adolescent developmental period...
  56. ncbi Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
    ..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established...
  57. pmc Alterations of fronto-temporal connectivity during word encoding in schizophrenia
    Daniel H Wolf
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
    Psychiatry Res 154:221-32. 2007
    ..The results suggest that reduced temporal-DLPFC connectivity in schizophrenia could underlie encoding deficits, and increased temporal-VLPFC connectivity may represent an ineffective compensatory effort...
  58. ncbi Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia
    Raquel E Gur
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:2029-36. 2003
    ..These results suggest that some effects of olanzapine may impact both symptoms and cognitive performance...
  59. ncbi Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  60. ncbi COMPARE: classification of morphological patterns using adaptive regional elements
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 26:93-105. 2007
    ..8% for female subjects and 90.8% for male subjects), but also good stability with respect to the number of features selected and the size of SVM kernel used...
  61. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007
    ..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles...
  62. pmc The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes
    Raquel E Gur
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:49-68. 2007
    ....
  63. ncbi Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  64. ncbi Relationship between clock-drawing and neuropsychological and functional status in elderly institutionalized patients with schizophrenia
    Natasha Lowery
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Geriatr Psychiatry 11:621-8. 2003
    ..The authors sought to examine the usefulness of the clock-drawing test (CDT) as a measure of general cognitive and adaptive functioning in elderly patients with schizophrenia...
  65. ncbi Levels-of-processing effect on word recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 54:1154-61. 2003
    ..By requiring participants to classify and encode words on either a shallow (e.g., uppercase/lowercase) or deep level (e.g., concrete/abstract), the levels-of-processing paradigm eliminates the need to generate organizational strategies...
  66. ncbi Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophrenia
    Paul J Moberg
    Brain Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:2314-6. 2004
    ....
  67. pmc Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 150:560-9. 2009
    ..047, OR = 1.46). Our analyses suggest several associations at PAH, with consistent evidence for rs1522305. Further analyses, including additional variations and environmental influences such as phenylalanine exposure are warranted...
  68. ncbi Characterization of brain plasticity in schizophrenia using template deformation
    Abraham Dubb
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Radiol 12:3-9. 2005
    ..Abnormal neurodevelopment may play a role in the pathophysiology of schizophrenia. We used deformation-based morphometry to examine voxel-wise age-related changes in patients with schizophrenia compared with healthy brains...

Research Grants30

  1. Schizophrenia Liability Genes among African Americans
    Raquel Gur; Fiscal Year: 2006
    ..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
  2. Genetics of Endophenotypes and Schizophrenia
    Raquel Gur; Fiscal Year: 2007
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  3. 2/4-Collaboration to Advance Negative Symptom Assessment In Schizophrenia
    Raquel E Gur; Fiscal Year: 2010
    ..This state-of-the art instrument will play a central role in the NIMH initiative to stimulate the development of new treatments aimed at reducing the disability associated with negative symptoms. ..
  4. 3/4-A Genomic Approach to Schizophrenia
    Raquel E Gur; Fiscal Year: 2010
    ..Our goal is to use state-of-the-art genomic tools to detect these mutations anywhere in the genome, and to identify genes that are more often impacted by structural mutations in persons with schizophrenia compared to healthy controls. ..
  5. 4/5-The Genetics of Endophenotypes and Schizophrenia
    Raquel E Gur; Fiscal Year: 2010
    ..Once we understand the genetic architecture of these abnormalities, new medications that aim to improve the functioning and quality of life of schizophrenia patients can be developed. ..
  6. A Neurobehavioral Family Study of Schizophrenia
    Raquel Gur; Fiscal Year: 2005
    ..All collected data will become part of the NIMH-sponsored archival database for schizophrenia. ..
  7. NEUROBEHAVIORAL STUDY OF SCHIZOPHRENIA
    Raquel Gur; Fiscal Year: 1990
    ..We will valuate the potential of MRS for measuring local metabolic parameters in schizophrenics and controls...
  8. AFFECTIVE DYSFUNCTION IN SCHIZOPHERNIA
    Raquel Gur; Fiscal Year: 2001
    ..The longitudinal design will allow assessment of the stability of the neurobehavioral measures and their relation, at intake, to course of illness. ..
  9. A Neurobehavioral Family Study of Schizophrenia
    Raquel E Gur; Fiscal Year: 2010
    ..The goal of the Multiplex Multigenerational Investigation of the schizophrenia consortium is to integrate neurobehavioral and neuroimaging methods in high-risk families that will yield the data needed for progress in the field. ..