Sudhir Gupta

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway
    Sudhanshu Agrawal
    Laboratories of Cellular and Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    J Clin Immunol 31:472-8. 2011
  2. ncbi request reprint Role of dendritic cells in innate and adaptive immune response in human aging
    Sudhir Gupta
    Programs in Primary Immunodeficiency and Human Aging, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92660, USA Electronic address
    Exp Gerontol 54:47-52. 2014
  3. pmc Impaired functions of peripheral blood monocyte subpopulations in aged humans
    Joseph Nyugen
    Division of Basic and Clinical Immunology, University of California, Med Sci I, C 240, Irvine, CA 92697, USA
    J Clin Immunol 30:806-13. 2010
  4. doi request reprint Tolerance and autoimmunity in primary immunodeficiency disease: a comprehensive review
    Sudhir Gupta
    Programs in Primary Immunodeficiency and Aging and Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies, Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California at Irvine, Irvine, CA, 92697, USA
    Clin Rev Allergy Immunol 45:162-9. 2013
  5. pmc Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans
    Sudhir Gupta
    Programs in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA
    Immun Ageing 10:3. 2013
  6. doi request reprint Primary immunodeficiencies in India: a perspective
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
    Ann N Y Acad Sci 1250:73-9. 2012
  7. doi request reprint T and B cell deficiency associated with yellow nail syndrome
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA
    Scand J Immunol 75:329-35. 2012
  8. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
  9. pmc Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from Benin
    Julie Lajoie
    Laboratoire d Immunogénétique, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Canada
    J Clin Immunol 30:90-8. 2010
  10. ncbi request reprint Central memory and effector memory subsets of human CD4(+) and CD8(+) T cells display differential sensitivity to TNF-{alpha}-induced apoptosis
    Sudhir Gupta
    Medical Sci I, C 240, University of California, Irvine, CA 92697, USA
    Ann N Y Acad Sci 1050:108-14. 2005

Research Grants

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. pmc Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway
    Sudhanshu Agrawal
    Laboratories of Cellular and Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    J Clin Immunol 31:472-8. 2011
    ..These data demonstrate that leptin activates human B cells to secrete cytokines via activation of JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathways, which may contribute to its inflammatory and immunoregulatory properties...
  2. ncbi request reprint Role of dendritic cells in innate and adaptive immune response in human aging
    Sudhir Gupta
    Programs in Primary Immunodeficiency and Human Aging, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92660, USA Electronic address
    Exp Gerontol 54:47-52. 2014
    ..In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs. ..
  3. pmc Impaired functions of peripheral blood monocyte subpopulations in aged humans
    Joseph Nyugen
    Division of Basic and Clinical Immunology, University of California, Med Sci I, C 240, Irvine, CA 92697, USA
    J Clin Immunol 30:806-13. 2010
    ....
  4. doi request reprint Tolerance and autoimmunity in primary immunodeficiency disease: a comprehensive review
    Sudhir Gupta
    Programs in Primary Immunodeficiency and Aging and Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies, Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California at Irvine, Irvine, CA, 92697, USA
    Clin Rev Allergy Immunol 45:162-9. 2013
    ..Here, we have provided a comprehensive review of the mechanisms of central and peripheral tolerance and autoimmune manifestations and mechanisms of autoimmunity in primary immunodeficiency diseases...
  5. pmc Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans
    Sudhir Gupta
    Programs in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA
    Immun Ageing 10:3. 2013
    ..These data suggest that leptin-induced B cell-derived proinflammatory cytokines may play a role in chronic inflammation associated with human aging...
  6. doi request reprint Primary immunodeficiencies in India: a perspective
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
    Ann N Y Acad Sci 1250:73-9. 2012
    ..We highlight some of the limitations and challenges in the diagnosis and therapy of PID, and more recent efforts to establish PID Centers of Excellence and a national PID registry in India...
  7. doi request reprint T and B cell deficiency associated with yellow nail syndrome
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA
    Scand J Immunol 75:329-35. 2012
    ..Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema...
  8. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
    ..However, IgA can also, when aggregated, be deleterious to the host, inducing inflammatory diseases. This Janus-like nature of IgA is mainly due to their heterogeneity in molecular forms and their interaction with IgA receptors...
  9. pmc Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from Benin
    Julie Lajoie
    Laboratoire d Immunogénétique, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Canada
    J Clin Immunol 30:90-8. 2010
    ..Understanding the genital mucosal immunity and the factors involved in linking innate to adaptive immunity is crucial for the design of efficient preventive strategies against human immunodeficiency virus (HIV)-1...
  10. ncbi request reprint Central memory and effector memory subsets of human CD4(+) and CD8(+) T cells display differential sensitivity to TNF-{alpha}-induced apoptosis
    Sudhir Gupta
    Medical Sci I, C 240, University of California, Irvine, CA 92697, USA
    Ann N Y Acad Sci 1050:108-14. 2005
    ..We also provide evidence for the molecular mechanisms underlying the differential sensitivity of naive and different sets of memory T cells to TNF-alpha-induced apoptosis...
  11. ncbi request reprint Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review)
    Sudhir Gupta
    Medical Science I, C 240, University of California, Irvine, CA 92697, USA
    Int J Oncol 22:15-20. 2003
    ..These are some of the recent discoveries in death receptor and mitochondrial pathways of apoptosis that have been reviewed in this article...
  12. ncbi request reprint A decision between life and death during TNF-alpha-induced signaling
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92697, USA
    J Clin Immunol 22:185-94. 2002
    ..Furthermore, a role of DAP kinase in TNF-induced apoptosis is discussed. Finally, the molecular basis of the effect of age on TNF-alpha-induced apoptosis in human T cells is reviewed...
  13. ncbi request reprint TNF-alpha-induced apoptosis in human naïve and memory CD8+ T cells in aged humans
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Med Sci I C 240, Irvine, CA 92697 4096, USA
    Exp Gerontol 41:69-77. 2006
    ..However, apoptosis does not appear to play a major role in increased accumulation of effector memory CD8+ T cells during human aging...
  14. ncbi request reprint Increased spontaneous, tumor necrosis factor receptor- and CD95 (Fas)-mediated apoptosis in cord blood T-cell subsets from Turner's syndrome
    S Gupta
    University of California, Irvine, USA
    Genes Immun 4:239-43. 2003
    ..This study demonstrates that increased apoptosis of T-cell subsets in Turner's syndrome occurs via the death receptor pathway and may play a role in the pathogenesis of immunological defects associated with Turner's syndrome...
  15. ncbi request reprint Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytes
    Sudhir Gupta
    Laboratories of Cellular and Molecular Immunology and Molecular Biology Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    Mech Ageing Dev 124:503-9. 2003
    ..T cells and T cell subsets from aged humans are more sensitive to TNF-alpha-induced apoptosis, which appears to be due to both an increased apoptotic signaling and decreased survival signals...
  16. ncbi request reprint Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2
    Sudhir Gupta
    Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    Mol Cancer Ther 2:711-9. 2003
    ..These data indicate that As(2)O(3) induces apoptosis in T cells by enhancing oxidative stress and that Bcl-2 appears to play a major role in As(2)O(3)-induced apoptosis...
  17. ncbi request reprint Molecular mechanisms of apoptosis in the cells of the immune system in human aging
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA
    Immunol Rev 205:114-29. 2005
    ....
  18. ncbi request reprint Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsets
    Sudhir Gupta
    Laboratories of Cellular and Molecular Immunology and Molecular Biology, Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    Int J Biochem Cell Biol 37:1034-42. 2005
    ....
  19. ncbi request reprint Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans
    S Gupta
    Cellular and Molecular Immunology and Molecular Biology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Cell Death Differ 12:177-83. 2005
    ..These data suggest a deficiency of NF-kappaB signaling pathway and a role of IKKbeta, at least in part, for increased sensitivity of lymphocytes from aged humans to TNF-alpha-induced apoptosis...
  20. ncbi request reprint A role of fas-associated death domain (FADD) in increased apoptosis in aged humans
    Sudhir Gupta
    Molecular Biology and Cellular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, Irvine, California 92697, USA
    J Clin Immunol 24:24-9. 2004
    ..These data suggest that FADD plays an important role in increased apoptosis in aged lymphocytes signaled via TNF-R...
  21. ncbi request reprint Immunological treatments for autism
    S Gupta
    Division of Basic and Clinical Immunology, Medical Sciences I, University of California, Irvine 92697, USA
    J Autism Dev Disord 30:475-9. 2000
    ..Based upon immunological abnormalities, various treatment modalities have been applied to children with autism. In this brief review, these immunological changes and various biological therapies are analyzed and summarized...
  22. ncbi request reprint Molecular steps of tumor necrosis factor receptor-mediated apoptosis
    S Gupta
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine 92697, USA
    Curr Mol Med 1:317-24. 2001
    ..A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed...
  23. ncbi request reprint Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism
    S Gupta
    Department of Medicine, University of California, Irvine 92697 4075, USA
    J Neuroimmunol 85:106-9. 1998
    ..These data suggest that an imbalance of Th1- and Th2-like cytokines in autism may play a role in the pathogenesis of autism...
  24. ncbi request reprint A possible role of multidrug resistance-associated protein (MRP) in basic fibroblast growth factor secretion by AIDS-associated Kaposi's sarcoma cells: a survival molecule?
    S Gupta
    Department of Medicine, University of California, Irvine 92697, USA
    J Clin Immunol 18:256-63. 1998
    ..Furthermore, probenecid appears to induce apoptosis in AIDS-KS cells by depriving them of the growth promoting activity of bFGF. These data suggest that MRP may play a role as a survival molecule in AIDS-KS cells...
  25. ncbi request reprint Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans
    S Gupta
    Laboratory of Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697 4069, USA
    Vaccine 18:1596-601. 2000
    ..These data suggest that increased sensitivity of lymphocytes from aged subjects to death signals may play an important role in the pathogenesis of lymphopenia and T cell deficiency associated with the aging process...
  26. ncbi request reprint Death of memory T-cell subsets in humans: changes during aging
    Sudhir Gupta
    Professor of Medicine, Pathology and Laboratory Medicine, and Microbiology and Molecular Genetics, and Chief, Division Basic and Clinical Immunology, University of California, Division of Basic and Clinical Immunology, Medical Science I, C 240, Irvine, CA 92697, USA
    Expert Rev Clin Immunol 3:637-45. 2007
    ..In this article, we briefly review different pathways of death signaling and alterations in apoptotic signaling pathways in order to understand changes in various T cells in human aging...
  27. pmc Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsets
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    J Virol 83:5442-50. 2009
    ..These data show that HHV-6 differentially influences the functions of naïve T cells and different subsets of memory CD4(+) and CD8(+) T cells, which in part may be due to differential susceptibility to HHV-6A-induced apoptosis...
  28. doi request reprint CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Medical Sciences I, Irvine, CA 92697, United States
    Exp Gerontol 43:266-74. 2008
    ..Our data suggest that increased CD95-mediated apoptosis of T(N) and T(CM) CD8+ and CD4+ T cells may play a role in their decline in human aging...
  29. ncbi request reprint Effector memory CD8+ T cells are resistant to apoptosis
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    Ann N Y Acad Sci 1109:145-50. 2007
    ..We show that both T(EM) and T(EMRA) CD8(+) T cells are resistant to apoptosis, whereas T(N) and T(CM) CD8(+) T cells are sensitive to apoptosis...
  30. ncbi request reprint Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Genes Immun 8:560-9. 2007
    ..These data demonstrate that H2O2 induces apoptosis preferentially in human naïve and central memory CD4+ and CD8+ T cells via the mitochondrial pathway by regulating intracellular GSH and the expression of Bax and VDAC...
  31. ncbi request reprint Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways
    Sudhir Gupta
    Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    Autoimmun Rev 6:476-81. 2007
    ..In this review we have discussed relative sensitivity/resistance of naïve and different subsets of memory T cells to apoptosis via different signaling pathways. Molecular basis for differential sensitivity to apoptosis is discussed...
  32. ncbi request reprint Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules
    Sudhir Gupta
    Cellular and Molecular Immunology and Molecular Biology Laboratories, Division of Basic and Clinical Immunology, Department of Medicine, Medical Sciences 1, C 240, University of California, Irvine, CA 92697, USA
    Exp Gerontol 37:293-9. 2002
    ..A role of impaired TNF-RII-mediated signaling in increased apoptosis in aged subjects is also discussed...
  33. ncbi request reprint Differential sensitivity of naïve and memory subsets of human CD8+ T cells to TNF-alpha-induced apoptosis
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    J Clin Immunol 26:193-203. 2006
    ..These data suggest that signaling molecules downstream of TNFRs may be responsible for differential sensitivity among subsets of CD8+ T cells to TNF-alpha-induced apoptosis...
  34. ncbi request reprint Characterization of naïve, memory and effector CD8+ T cells: effect of age
    Sudhir Gupta
    Division of Basic and Clinical Immunology, Medical Sciences C C 240, University of California, Irvine, CA 92697 4069, USA
    Exp Gerontol 39:545-50. 2004
    ..In this article, we have further defined naïve, central memory, effector memory, and effector CD8+ T cells in humans and their changes in aged humans...
  35. ncbi request reprint Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells
    Abdullah Baysan
    Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Int J Oncol 30:313-8. 2007
    ..Altogether, these data indicate that As2O3 induces apoptosis in B cells, regardless of Bcl-2 expression, via the mitochondrial pathway by enhancing oxidative stress...
  36. ncbi request reprint Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis
    Rama Yerramasetti
    Division of Basic and Clinical Immunology University of California, Irvine 92697, USA
    J Clin Immunol 22:37-47. 2002
    ....
  37. ncbi request reprint Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria
    Leman Yel
    Department of Medicine, University of California, Irvine, CA 92697, USA
    Int J Mol Med 16:971-7. 2005
    ..Finally, caspase-9 and caspase-3 were activated in the absence of caspase-8 activation. Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironment...
  38. pmc Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA
    Anshu Agrawal
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    J Immunol 182:1138-45. 2009
    ..This activated state of DCs may be responsible for their increased reactivity to self-Ags such as DNA, which in turn contributes to the age-associated chronic inflammation...
  39. ncbi request reprint Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    Anshu Agrawal
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    J Immunol 178:6912-22. 2007
    ..Increased phosphatase and tensin homolog may thus be responsible for the defect in AKT phosphorylation and, therefore, the altered innate immune response of DCs from elderly humans...
  40. ncbi request reprint Impaired pneumovax-23-induced monocyte-derived cytokine production in patients with common variable immunodeficiency
    Raymond Hong
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    J Clin Immunol 30:435-41. 2010
    ..pneumoniae. In humans, monocyte/macrophage-derived cytokines in response to S. pneumoniae have not been studied. Patients with CVID respond poorly to Pneumovax-23 (containing all capsular polysaccharides) vaccination...
  41. pmc Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity
    Anshu Agrawal
    Department of Medicine, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92617, USA
    Aging (Albany NY) 4:648-59. 2012
    ....
  42. ncbi request reprint Molecular mechanisms of TNF-alpha-induced apoptosis in naïve and memory T cell subsets
    Sudhir Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA
    Autoimmun Rev 5:264-8. 2006
    ..In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases...
  43. ncbi request reprint Molecular basis of rifampicin-induced inhibition of anti-CD95-induced apoptosis of peripheral blood T lymphocytes: the role of CD95 ligand and FLIPs
    Sastry Gollapudi
    Laboratory of Cellular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    J Clin Immunol 23:11-22. 2003
    ..These data suggest that rifampicin inhibits anti-CD95-mediated apoptosis in lymphocytes by modulating the expression of certain proteins that regulate apoptosis, at least in part, via glucocorticoid receptors...
  44. pmc Inflammation & autoimmunity in human ageing: dendritic cells take a center stage
    Sudhir Gupta
    Laboratories in Cellular and Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
    Indian J Med Res 138:711-6. 2013
    ..DNA from aged is hypomethylated and hypomethylation is associated with increased immunogenecity of self DNA. ..
  45. ncbi request reprint Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells
    Anshu Agrawal
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    J Leukoc Biol 81:474-82. 2007
    ..These data suggest that modulation of TH2 responses by mercury and thimerosal, in particular, is through depletion of GSH in DC...
  46. ncbi request reprint Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    Exp Gerontol 48:1285-92. 2013
    ..In summary, our data suggests that LiCl reduces inflammation in aged and young DCs via different mechanisms. Furthermore, the effect of LiCl is different on LPS and PAM3CSK4 responses. ..
  47. pmc Age-associated epigenetic modifications in human DNA increase its immunogenicity
    Anshu Agrawal
    Division of Basic and Clinical Immunology, Med Sci I C 240A, University of California, Irvine CA 92697, USA
    Aging (Albany NY) 2:93-100. 2010
    ..Increased immunogenicity of self DNA may thus be another mechanism that may contribute to the increase in age-associated chronic inflammation, autoimmunity and cancer...
  48. ncbi request reprint Biology of dendritic cells in aging
    Anshu Agrawal
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    J Clin Immunol 28:14-20. 2008
    ..We have discussed certain mechanisms responsible for the defective dendritic cell function associated with aging...
  49. ncbi request reprint Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells
    Sastry Gollapudi
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697 4069, USA
    Int J Oncol 22:597-600. 2003
    ....
  50. pmc Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Department of Medicine, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e13418. 2010
    ..The type of adaptive immune T cell response generated is dependent upon the type of PRR activated by the microbes. Dectin-1 is a C-type lectin receptor present on dendritic cells...
  51. pmc Impaired secretion of interferons by dendritic cells from aged subjects to influenza : role of histone modifications
    Sangeetha Prakash
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA, 92697, USA
    Age (Dordr) 35:1785-97. 2013
    ....
  52. ncbi request reprint Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis
    Yiping Zhang
    Department of Neurology, University of California, Irvine, California 92697 4275, USA
    J Clin Immunol 25:254-64. 2005
    ..These findings suggest a B cell axonal specific immune response in the CNS in MS...
  53. pmc Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
    Aishwarya Sridharan
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    Age (Dordr) 33:363-76. 2011
    ..In summary, our study demonstrates that advancing age has a profound effect on PDC function at multiple levels and may therefore, be responsible for the increased susceptibility to infections in the elderly...
  54. pmc Dendritic cells in human aging
    Anshu Agrawal
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, United States
    Exp Gerontol 42:421-6. 2007
    ..A role of DCs in immunosenescence and chronic inflammation associated with aging has not been investigated in detail. In this article, we will briefly review DCs biology and changes associated with human aging...
  55. doi request reprint Vaccinia virus proteins activate human dendritic cells to induce T cell responses in vitro
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Vaccine 27:88-92. 2009
    ..Overall D13L and H3L proteins are more immunogenic than D8L. Taken together data suggest that these peptides are highly immunogenic and can modulate an effective innate and adaptive response in humans in vitro...
  56. pmc Impact of aging on dendritic cell functions in humans
    Anshu Agrawal
    Division of Basic and Clinical Immunology, Med Sci I C 240A, University of California, Irvine 92697, CA, USA
    Ageing Res Rev 10:336-45. 2011
    ..Aging thus has a profound affect on DC functions. Present review summarizes the effect of advancing age on DC functions in humans in the context of both immunity and tolerance...
  57. ncbi request reprint Polyclonal B-cell expansion in the cerebrospinal fluid of patients with pseudotumor cerebri
    Reng Rong Da
    Department of Neurology, University of California, Irvine, California 92697, USA
    J Clin Immunol 24:674-82. 2004
    ..Our results suggest that both T-cell-dependent and T-cell-independent humoral immunity are present in the CSF of PTC...
  58. pmc Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells
    S Gupta
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California-Irvine, Irvine, CA 92697-4025, USA
    Mol Cell Biol 21:5846-56. 2001
    ..This latter observation is consistent with our previous observation that overstimulation of the activity of endogenous members of Ras signaling pathways, activated MEK in particular, is a prerequisite for aggressive tumorigenic growth...
  59. ncbi request reprint Chronic HIV type 1 infection down-regulates expression of DAP kinase and p19ARF-p53 checkpoint and is associated with resistance to CD95-mediated apoptosis in HUT78 T cells
    Choong H Kim
    Molecular Biology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    AIDS Res Hum Retroviruses 20:183-9. 2004
    ..These data suggest that down-regulation of DAP kinase and downstream signaling factors may be one of the mechanism that HIV-1 may employ to protect the infected host cells from cell death and to allow persistent HIV-1 replication...
  60. ncbi request reprint Cellular immunodeficiency and autoimmunity in long-term mineral oil administration
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
    Ann Allergy Asthma Immunol 92:88-91. 2004
    ..Infection, ulceration, subcutaneous nodules, and autoimmune activation are among the known adverse effects. Immunodeficiency has not been previously reported in association with mineral oil injection...
  61. ncbi request reprint Severe T- and B-cell immune deficiency associated with malignant thymoma
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
    Ann Allergy Asthma Immunol 91:501-5. 2003
    ..Typically, thymic tumors are benign, and gradually developing immunodeficiency consists of hypogammaglobulinemia with low B-cell counts and an inverted CD4+/CD8+ T-cell ratio due to excessive CD8+ T cells...
  62. ncbi request reprint Age-related alterations of gene expression patterns in human CD8+ T cells
    Jia Ning Cao
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Medical Sciences I, C 240 Irvine, CA 92697, USA
    Aging Cell 9:19-31. 2010
    ....
  63. ncbi request reprint Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway
    S Makani
    Cellular and Molecular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine 92697, USA
    Genes Immun 3:270-8. 2002
    ..These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSH...
  64. ncbi request reprint P-glycoprotein (encoded by multidrug resistance genes) is not required for interleukin-2 secretion in mice and humans
    S Gollapudi
    Molecular Biology and Cellular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697 4069, USA
    Genes Immun 1:371-9. 2000
    ..These data show that P-gp is not required for secretion of IL-2, IFN-gamma, IL-4, and IL-10 secretion in mice and IL-2 secretion in humans...
  65. ncbi request reprint Anti-P-glycoprotein antibody-induced apoptosis of activated peripheral blood lymphocytes: a possible role of P-glycoprotein in lymphocyte survival
    S Gollapud
    Department of Medicine, University of California, Irvine 92697, USA
    J Clin Immunol 21:420-30. 2001
    ..These data demonstrate that anti-P-gp mAb promotes apoptosis in activated T lymphocytes by up-regulating CD95L expression and via CD95-CD95L interactions and suggest a possible role of P-gp in lymphocyte survival...
  66. ncbi request reprint Ciprofloxacin inhibits activation of latent human immunodeficiency virus type 1 in chronically infected promonocytic U1 cells
    S Gollapudi
    Department of Medicine, University of California, Irvine 92697, USA
    AIDS Res Hum Retroviruses 14:499-504. 1998
    ..Furthermore, ciprofloxacin inhibited TNF-alpha-induced HIV expression in U1 cells. The concentrations of ciprofloxacin that inhibited HIV production are readily achievable in vivo...
  67. ncbi request reprint Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cells
    Ted Y Young
    Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
    Ann Allergy Asthma Immunol 98:389-92. 2007
    ..Autosomal dominant, autosomal recessive, and sporadic forms have been described. Coronary artery aneurysms and analysis of central (TCMs) and effector (TEMs) memory T cells have not been previously reported with this syndrome...
  68. pmc TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    J Clin Immunol 31:89-98. 2011
    ....
  69. ncbi request reprint A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humans
    Sudhir Gupta
    Department of Medicine, Division of Basic and Medical Sciences 1, C 240, University of California, Irvine, CA 92697, USA
    Mech Ageing Dev 125:99-101. 2004
    ..These data may suggest that decreased cIAP2 may play a role in increased apoptosis in aged humans. Possible mechanisms for the regulation of IAPs in aging are discussed...
  70. ncbi request reprint Clinical and immunological features in IgM deficiency
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    Int Arch Allergy Immunol 150:291-8. 2009
    ..Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment...
  71. ncbi request reprint Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts
    Nezam Haider
    University of California Irvine School of Medicine, Irvine, CA, USA
    Nat Clin Pract Cardiovasc Med 6:250-61. 2009
    ..We investigated whether activation of endogenous apoptosis inhibitors plays a part when death receptor and mitochondrial apoptotic pathways have been triggered...
  72. ncbi request reprint Molecular steps of death receptor and mitochondrial pathways of apoptosis
    S Gupta
    Department of Medicine Medical Sciences, University of California, Irvine 92697, USA
    Life Sci 69:2957-64. 2001
    ..During the past 5 years, rapid progress has been made in understanding the molecular basis of apoptosis. In this brief review, I will summarize the various molecular steps of apoptosis...
  73. ncbi request reprint HSP60, Bax, apoptosis and the heart
    S Gupta
    Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
    J Cell Mol Med 9:51-8. 2005
    ..HSP60 has also been shown to accelerate the cleavage of pro-caspase3. Thus, HSP60 has a complex role in apoptosis in the cell. Its binding to Bax under normal conditions suggests a key regulatory role in apoptosis...
  74. ncbi request reprint The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation
    B Reddy
    Department of Medicine, Marion Bessin Research Liver Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Transplantation 71:801-11. 2001
    ..Strategies to specifically antagonize CD8+ T cells or to modulate MHC class I expression in association with costimulatory blockade by CTLA4Ig may enhance the clinical feasibility of transplanting allogeneic hepatocytes...
  75. ncbi request reprint Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging
    Masayoshi Sarai
    University of California, Irvine, California
    J Am Coll Cardiol 50:2305-12. 2007
    ..The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in atherosclerotic lesions as evaluated by imaging with annexin A5...
  76. ncbi request reprint The primary vasculitides: a clinicopathologic correlation
    Navneet Narula
    Department of Pathology, University of California Medical Center, Irvine, Orange 92868, USA
    Am J Clin Pathol 124:S84-95. 2005
    ..Incorporation of antineutrophil cytoplasmic antibodies in defining the pathogenesis of vasculitis has been particularly useful in diagnosing those small vessel vasculitides that are life threatening and need immediate intervention...
  77. ncbi request reprint Mortals turn me on
    Sudhir Gupta
    School of Medicine, University of California Irvine, 101 The City Drive, Irvine, CA 92868, USA
    J Nucl Med 46:906-8. 2005
  78. ncbi request reprint Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins
    S Gupta
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Immunol 166:6104-11. 2001
    ..These findings thus support a model whereby IRF-4 function is modulated in a stage-specific manner by its interaction with developmentally restricted sets of Krüppel-type zinc finger proteins...
  79. ncbi request reprint Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR
    A E Nel
    Department of Medicine, UCLA School of Medicine 90024, USA
    J Biol Chem 270:18428-36. 1995
    ..Taken together, these results indicate that anti-CD3 induces Grb2-hSos1-PLC-gamma 1-p36/p38-ZAP70 complexes, which localize in the vicinity of TCR-zeta...
  80. pmc IFN-gamma potentiates atherosclerosis in ApoE knock-out mice
    S Gupta
    Department of Medicine, Columbia University, New York 10032, USA
    J Clin Invest 99:2752-61. 1997
    ..Therefore, therapeutic inhibition of IFN-gamma signaling may lead to the formation of more lipid-poor and stable atheromata...
  81. ncbi request reprint Paired human fibrosarcoma cell lines that possess or lack endogenous mutant N-ras alleles as experimental model for Ras signaling pathways
    S Gupta
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697-4025, USA
    Methods Enzymol 333:290-306. 2001
    ..There are dramatic effects on both the transformed and tumorigenic phenotype, depending on the cell line and mutant cDNA that is transfected...
  82. ncbi request reprint Expression of P-glycoprotein, encoded by MDR 1 gene, a metabolically active efflux pump in murine mast cells
    D Wein
    Division of Basic and Clinical Immunology, Medical Sciences I, University of California, Irvine 92717, USA
    Cancer Lett 101:241-6. 1996
    ..These data suggest the presence of a functionally active P-gp in mast cells. A possible physiologic role for P-gp in the secretion of certain mediators/cytokines from mast cells is suggested...
  83. ncbi request reprint HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis
    Li Lin
    Molecular and Cellular Cardiology, Cardiovascular Division, University of California, Davis, California 95616, USA
    Am J Physiol Heart Circ Physiol 293:H2238-47. 2007
    ..Thus abnormal trafficking of HSP60 to the cell surface may be an early trigger for myocyte loss and the progression of heart failure...
  84. ncbi request reprint Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  85. ncbi request reprint Role of protein kinase beta isozyme in multidrug resistance in murine leukemia P388/ADR cells
    S Gollapudi
    Division of Basic and Clinical Immunology, University of California, Irvine 92717, USA
    J Chemother 7:157-9. 1995
    ..Furthermore, the technique of intracellular delivery of antibodies provides a new approach to discern the role of PKC isoforms in multidrug resistance in various tumor cells...
  86. ncbi request reprint HSP60, Bax, and cardiac apoptosis
    A A Knowlton
    Cardiovascular Division, Department of Medicine, University of California, Davis 95616, USA
    Cardiovasc Toxicol 3:263-8. 2003
    ..Redistribution of cytosolic HSP60 to the plasma membrane during hypoxia appears to contribute to the initiation of the apoptotic cascade with hypoxia and reoxygenation...
  87. ncbi request reprint Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease
    A N Irani
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Ther 3:302-9. 2001
    ..These data indicate that liver repopulation with functionally intact cells can reverse pathophysiological perturbations and cure Wilson's disease...
  88. pmc Subpopulations of CD4+ (T4+) cells in homosexual/bisexual men with persistent generalized lymphadenopathy
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Clin Exp Immunol 68:1-4. 1987
    ..This study demonstrates that HIV infection results in the depletion of both subsets of T4 cells to an almost similar extent...
  89. ncbi request reprint IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells
    S Gupta
    Department of Medicine, Columbia University, New York 10032, USA
    J Immunol 163:3834-41. 1999
    ..Activation of Stat6 as well as of Stat2:Stat6 complexes by IFN-alpha in B cells may allow modulation of target genes in a cell type-specific manner...
  90. pmc Immunological and clinical profile of adult patients with selective immunoglobulin subclass deficiency: response to intravenous immunoglobulin therapy
    F Abrahamian
    Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Clin Exp Immunol 159:344-50. 2010
    ..IVIG appears to be an effective therapy...
  91. ncbi request reprint Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapy
    S Gupta
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gene Med 1:386-92. 1999
    ..Moreover, hepatocyte transplantation systems offer creative tools for defining critical mechanisms in gene regulation and survival of transduced cells...
  92. ncbi request reprint Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells
    S J Berger
    Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biochem Biophys Res Commun 288:101-5. 2001
    ..The possible role of EGCG as a chemotherapeutic agent needs to be investigated...
  93. ncbi request reprint T cells and aging, January 2002 update
    Graham Pawelec
    University of Tubingen, Center for Medical Research, ZMF, Waldhornlestr 22, D 72072 Tubingen, Germany
    Front Biosci 7:d1056-183. 2002
    ....
  94. ncbi request reprint Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home
    Uwe Nicolay
    Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    J Clin Immunol 26:65-72. 2006
    ..Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy...
  95. doi request reprint Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseases
    João Bosco Oliveira
    Molecular Immunology and Genetics Section, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Clin Immunol 28:S20-8. 2008
    ....
  96. ncbi request reprint Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases
    Hans D Ochs
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98107, USA
    J Clin Immunol 26:265-73. 2006
    ..No treatment-related serious adverse events were reported. We conclude that subcutaneous administration of 16% SCIg is a safe and effective alternative to IVIg for replacement therapy of PIDD...
  97. ncbi request reprint Heartache of fc receptors
    Sudhir Gupta
    J Am Coll Cardiol 49:1693-5. 2007
  98. pmc Neurological picture. Dengue haemorrhagic fever: an unusual cause of intracranial haemorrhage
    Jyoti Kumar
    Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
    J Neurol Neurosurg Psychiatry 78:253. 2007

Research Grants3

  1. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2002
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..
  2. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2003
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..
  3. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2004
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..