Phalguni Gupta

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The CD8 Antiviral Factor (CAF) can suppress HIV-1 transcription from the Long Terminal Repeat (LTR) promoter in the absence of elements upstream of the CATATAA box
    Varsha Shridhar
    Pittsburgh Retrovirology Laboratory, Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, 426, Parran Hall, 130, DeSoto Street, Pittsburgh 15261, USA
    Virol J 11:130. 2014
  2. pmc Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32539. 2012
  3. pmc Origin and dynamics of HIV-1 subtype C infection in India
    Chengli Shen
    Department of Infectious Diseases and Microbiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e25956. 2011
  4. pmc Antiviral activity of retrocyclin RC-101, a candidate microbicide against cell-associated HIV-1
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 29:391-6. 2013
  5. pmc Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Acquir Immune Defic Syndr 60:455-61. 2012
  6. ncbi request reprint High incidence and prevalence of HIV-1 infection in high risk population in Calcutta, India
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J STD AIDS 14:463-8. 2003
  7. pmc Noncytotoxic suppression of human immunodeficiency virus type 1 transcription by exosomes secreted from CD8+ T cells
    Ashwin Tumne
    Department of Infectious Diseases and Microbiology, Pittsburgh Retrovirus Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:4354-64. 2009
  8. doi request reprint Biological properties of HIV-1 subtype B' isolates from infected Chinese blood donors at different disease stages
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Virology 384:161-8. 2009
  9. pmc Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Virology 401:190-6. 2010
  10. ncbi request reprint High replication fitness and transmission efficiency of HIV-1 subtype C from India: Implications for subtype C predominance
    Milka A Rodriguez
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 426 Parran Hall, GSPH, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Virology 385:416-24. 2009

Research Grants

  1. ORIGIN AND DYNAMICS OF HIV-1 IN SEMEN
    Phalguni Gupta; Fiscal Year: 2000
  2. HIV IN SEMEN FROM INFECTED SUBJECTS FROM INDIA
    Phalguni Gupta; Fiscal Year: 2006
  3. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2006
  4. PITT AIDS RESEARCH TRAINING PROGRAM
    Phalguni Gupta; Fiscal Year: 2007
  5. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2007
  6. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2009
  7. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2010
  8. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2006
  9. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2003
  10. ASSESSMENT OF CD8 SUPPRESSION OF HIV/SIV TO VACCINES
    Phalguni Gupta; Fiscal Year: 2000

Collaborators

Detail Information

Publications47

  1. ncbi request reprint The CD8 Antiviral Factor (CAF) can suppress HIV-1 transcription from the Long Terminal Repeat (LTR) promoter in the absence of elements upstream of the CATATAA box
    Varsha Shridhar
    Pittsburgh Retrovirology Laboratory, Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, 426, Parran Hall, 130, DeSoto Street, Pittsburgh 15261, USA
    Virol J 11:130. 2014
    ..However, the region on the LTR upon which CAF acts is unknown. Our objective was to determine the region on the LTR upon which CAF acts to suppress HIV-1 transcription...
  2. pmc Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32539. 2012
    ..Although there are different strains of HIV-1 in a chronically infected individual, only one or limited virus strains are successfully transmitted to a new individual. The reason for this "transmission bottleneck" is as yet unknown...
  3. pmc Origin and dynamics of HIV-1 subtype C infection in India
    Chengli Shen
    Department of Infectious Diseases and Microbiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e25956. 2011
    ..To investigate the geographical origin and evolution dynamics of HIV-1 subtype C infection in India...
  4. pmc Antiviral activity of retrocyclin RC-101, a candidate microbicide against cell-associated HIV-1
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 29:391-6. 2013
    ....
  5. pmc Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Acquir Immune Defic Syndr 60:455-61. 2012
    ..Cervical tissue-based organ cultures have been used successfully to evaluate microbicides for toxicity and antiviral activity. The antimicrobial peptide retrocyclin RC-101 has been shown to have potent anti-HIV activity in cell culture...
  6. ncbi request reprint High incidence and prevalence of HIV-1 infection in high risk population in Calcutta, India
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J STD AIDS 14:463-8. 2003
    ..Such a high annual seroincidence rate makes this population well suited for studies of HIV-1 prevention, including vaccine trials...
  7. pmc Noncytotoxic suppression of human immunodeficiency virus type 1 transcription by exosomes secreted from CD8+ T cells
    Ashwin Tumne
    Department of Infectious Diseases and Microbiology, Pittsburgh Retrovirus Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:4354-64. 2009
    ..Our results, for the first time, indicate the existence of an antiviral membrane-bound factor consistent with the hallmarks defining noncytotoxic CD8(+) T-cell suppression of HIV-1...
  8. doi request reprint Biological properties of HIV-1 subtype B' isolates from infected Chinese blood donors at different disease stages
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Virology 384:161-8. 2009
    ..This study has provided valuable information on the biological properties of circulating HIV-1 strains among Chinese FBDs to better understand their viral characteristics and design more appropriate vaccine candidates for FBDs...
  9. pmc Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Virology 401:190-6. 2010
    ..Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects...
  10. ncbi request reprint High replication fitness and transmission efficiency of HIV-1 subtype C from India: Implications for subtype C predominance
    Milka A Rodriguez
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 426 Parran Hall, GSPH, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Virology 385:416-24. 2009
    ..These data provide a model to explain the asymmetric distribution of subtype C over other subtypes in India...
  11. ncbi request reprint Estimation of the predictive role of plasma viral load on CD4 decline in HIV-1 subtype C-infected subjects in India
    Ming Ding
    Department of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Acquir Immune Defic Syndr 50:119-25. 2009
    ..Because of high expenses of commercially available viral load assays, the role of viral load in disease progression has not been evaluated in HIV-1 subtype C-infected patients in India...
  12. ncbi request reprint Lack of differences in HIV-1 nef functional domains in infected chinese blood donors at different stages of disease
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 23:1150-4. 2007
    ....
  13. doi request reprint Study of HIV-1 transmission across cervical mucosa to tonsil tissue cells using an organ culture
    Jackeline Soto-Rivera
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Reprod Immunol 69:52-63. 2013
    ..The purpose of the study is to develop a model to study early HIV-1 transmission events that occur after crossing the cervical mucosa into regional lymph nodes...
  14. ncbi request reprint Genetic and functional characterization of the LTR of HIV-1 subtypes A and C circulating in India
    Milka A Rodriguez
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 23:1428-33. 2007
    ..To our knowledge, this is the first study characterizing the genetic structure and functional attributes of subtype A LTRs from India...
  15. doi request reprint Chromosomal engineering of Clostridium perfringens using group II introns
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 435:217-28. 2008
    ..perfringens genes. The usefulness of this system has now been demonstrated by specifically inactivating four different C. perfringens toxin genes...
  16. ncbi request reprint Construction and characterization of an infectious molecular clone of HIV-1 subtype A of Indian origin
    Milka A Rodriguez
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 426 Parran Hall, 130 DeSoto Street, PA 15261, USA
    Virology 345:328-36. 2006
    ..This infectious clone of HIV-1 can be useful to study the molecular mechanism of dominance of subtype C in India...
  17. ncbi request reprint Induction of strong anti-HIV cellular immunity by a combination of Clostridium perfringens expressing HIV gag and virus like particles
    Poonam Pegu
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Curr HIV Res 9:613-22. 2011
    ..Such cellular immune response was found to be mediated by both CD8(+) and CD4(+) T cells. Such a strong mucosal immune response could be very useful in developing a mucosal vaccine against HIV-1...
  18. ncbi request reprint Persistent HIV type 1 infection in semen and blood compartments in patients after long-term potent antiretroviral therapy
    Jodi K Craigo
    Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 20:1196-209. 2004
    ..This together with our previous studies (Gupta P, et al.: J Infect Dis 2000;182:79-87) suggest that the genital and blood compartments likely serve as distinct reservoirs harboring latent HIV-1 during prolonged drug therapy...
  19. ncbi request reprint Induction of SIV p27-specific multifunctional T cells in the gut following prime-boost immunization with Clostridium perfringens and adenovirus vaccines expressing SIV p27
    Ruth A Helmus
    Molecular Virology and Microbiology Graduate Program, Molecular Genetics and Biochemistry Department, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Curr HIV Res 8:101-12. 2010
    ..These results indicate that priming gut tissue with Cp-p27 can enhance the gut mucosal cellular immune response generated via systemic immunization with Ad-p27...
  20. pmc Disruption of a toxin gene by introduction of a foreign gene into the chromosome of Clostridium perfringens using targetron-induced mutagenesis
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 430 Parran Hall, GSPH, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Plasmid 58:182-9. 2007
    ..Upon oral feeding of the mutant bacteria to mice, intact p27 protein was detected in the lower GI tract. The re-engineered C. perfringens provides a biosafe efficient oral vehicle to deliver antigen to the gastrointestinal tract...
  21. ncbi request reprint Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model
    Sameera Sayeed
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Microbiol 67:15-30. 2008
    ..These results indicate that CPB is both required and sufficient for CN3685-induced enteric pathology, supporting a key role for this toxin in type C intestinal pathogenesis...
  22. ncbi request reprint Use of frozen-thawed cervical tissues in the organ culture system to measure anti-HIV activities of candidate microbicides
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 22:419-24. 2006
    ....
  23. pmc DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS Pathog 2:e70. 2006
    ..Transmission of HIV-1 from B cells to T cells through this DC-SIGN pathway could be important in the pathogenesis of HIV-1 infection...
  24. pmc Differential functional phenotypes of two primary HIV-1 strains resulting from homologous point mutations in the LLP domains of the envelope gp41 intracytoplasmic domain
    Jason T Newman
    Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, PA 15261, USA
    Virology 367:102-16. 2007
    ..This comparison of homologous point mutations in two different strains of HIV supports the role of LLPs as determinants of Env function, but reveals for the first time the influence of virus strain on LLP mutant phenotypes...
  25. pmc Effect of early anti-retroviral therapy on the pathogenic changes in mucosal tissues of SIV infected rhesus macaques
    Jessica Malzahn
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Virol J 9:269. 2012
    ..The effect of early ART on SIV replication and infection-related pathogenic changes in mucosal tissues of the infected monkeys was examined...
  26. doi request reprint Molecular characterization of the HIV type 1 vpr gene in infected Chinese former blood/plasma donors at different stages of diseases
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 24:661-6. 2008
    ..These results show that vpr may not play an important role in HIV-1 pathogenesis in different stages of Chinese patients and may have important implications in developing vpr-related treatments suitable for HIV-1-infected PBDs...
  27. pmc An optimized sensitive method for quantitation of DNA/RNA viruses in heparinized and cryopreserved plasma
    Ming Ding
    Graduate School of Public Health, Pittsburgh, PA, United States
    J Virol Methods 176:1-8. 2011
    ..This method could be used to extract nucleic acids from archived, heparinized plasma for PCR based quantitation of target molecules...
  28. ncbi request reprint Characterization of the gp120 of circulating HIV type 1 in a group of infected Chinese blood/plasma donors with asymptomatic and symptomatic stages of the disease
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 22:1167-71. 2006
    ....
  29. ncbi request reprint Activation of HIV type 1 specific cytotoxic T lymphocytes from semen by HIV type 1 antigen-presenting dendritic cells and IL-12
    Xiao li Huang
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 22:93-8. 2006
    ..The DC-T cell system can serve as a model for immunotherapy of HIV-1 infection in the local genital tract as well as systemic blood circulation...
  30. ncbi request reprint Subcompartmentalization of HIV-1 quasispecies between seminal cells and seminal plasma indicates their origin in distinct genital tissues
    Shirish Paranjpe
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    AIDS Res Hum Retroviruses 18:1271-80. 2002
    ..These findings provide for the first time evidence of subcompartmentalization of HIV-1 in male genital organs and suggest that intervention strategies such as vasectomy may not prevent sexual transmission...
  31. doi request reprint Development of a liposome microbicide formulation for vaginal delivery of octylglycerol for HIV prevention
    Lin Wang
    Magee Womens Research Institute, Pittsburgh, PA, USA
    Drug Dev Ind Pharm 38:995-1007. 2012
    ..Furthermore, minimal toxicity was observed to lactobacilli in vitro or in vivo safety testing. The OG liposome formulation offers a promising microbicide product with efficacy against HSV, HIV and N. gonorrhoeae...
  32. pmc Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 76:9868-76. 2002
    ....
  33. pmc Antibody neutralization escape mediated by point mutations in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41
    Vandana Kalia
    University of Pittsburgh, Department of Molecular Genetics and Biochemistry, School of Medicine, W1144 BST, Pittsburgh, PA 15261, USA
    J Virol 79:2097-107. 2005
    ....
  34. doi request reprint Transmission and evolution of hepatitis C virus in HCV seroconverters in HIV infected subjects
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Virology 449:339-49. 2014
    ..Our results suggest that HCV transmission and evolution in HIV-infected subjects may not be influenced by host CD4 cell count at the time of infection. ..
  35. pmc Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorpora
    Vandana Kalia
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 77:3634-46. 2003
    ..Altogether, these results demonstrate for the first time that the highly conserved LLP domains perform critical but distinct functions in Env incorporation and fusogenicity...
  36. ncbi request reprint Effects of physiological fluids on physical-chemical characteristics and activity of topical vaginal microbicide products
    Alexandra B Sassi
    Department of Pharmaceutics, Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
    J Pharm Sci 97:3123-39. 2008
    ..These in vitro assessments can identify the potential for changes in product's physical-chemical characteristics in vivo which may result in diminished product performance...
  37. pmc ADAR1 is a novel multi targeted anti-HIV-1 cellular protein
    Nabanita Biswas
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Virology 422:265-77. 2012
    ..Furthermore, ADAR1 induced mutations in the env gene inhibited viral infectivity...
  38. pmc Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide
    Alexandra B Sassi
    Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA, 15213, USA
    AIDS Res Ther 8:27. 2011
    ..abstract:..
  39. ncbi request reprint Use of a Clostridium perfringens vector to express high levels of SIV p27 protein for the development of an oral SIV vaccine
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, School of Medicine, University of Pittsburgh, PA 15261, USA
    Virology 329:226-33. 2004
    ..perfringens expressing SIV p27 antigen. In addition, uptake of C. perfringens was able to induce maturation of mouse DCs. These results support the potential use of C. perfringens as an oral SIV/HIV vaccine vector...
  40. pmc Construction of an alpha toxin gene knockout mutant of Clostridium perfringens type A by use of a mobile group II intron
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Appl Environ Microbiol 71:7542-7. 2005
    ..Advantages of this technology, such as site specificity, relatively high frequency of insertion, and introduction of no antibiotic resistance genes into the chromosome, could facilitate construction of other C. perfringens mutants...
  41. ncbi request reprint Measurement of anti-HIV activity of marketed vaginal products and excipients using a PBMC-based in vitro assay
    Lisa Cencia Rohan
    Department of Pharmaceutical Sciences, School of Pharmacy, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Sex Transm Dis 31:143-8. 2004
    ..Although a number of in vitro methods have been developed for testing anti-HIV activity of microbicides, most of these methods have not been used for testing microbicides as a gel or cream...
  42. ncbi request reprint Baboon bone-marrow xenotransplant in a patient with advanced HIV disease: case report and 8-year follow-up
    Marian G Michaels
    University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Transplantation 78:1582-9. 2004
    ..The aims of this pilot study were to evaluate the safety of the procedure and develop an approach to prevent and monitor for xenozoonoses...
  43. pmc Induction of anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) and CD4(+) T-cell reactivity by dendritic cells loaded with HIV-1 X4-infected apoptotic cells
    Xiao Qing Zhao
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 76:3007-14. 2002
    ..This may be an important mechanism of HIV-1 immunogenicity and provides a strategy for immunotherapy of HIV-1-infected patients on combination antiretroviral therapy...
  44. pmc Dendritic Cells Restore CD8+ T Cell Reactivity to Autologous HIV-1
    Kellie N Smith
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Virol 88:9976-90. 2014
    ..These data underscore the potential efficacy of DC immunotherapy that aims to awaken a dormant, autologous, HIV-1-specific CD8(+) T cell response...
  45. pmc The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct
    Amy L Cole
    Department of Molecular Biology and Microbiology, Biomolecular Science Center, Burnett College of Biomedical Sciences at University of Central Florida, Orlando, FL 32816, USA
    Immunology 121:140-5. 2007
    ..Collectively, these data support the potential development of RC-101 as a topical microbicide to prevent HIV-1 infection and transmission...
  46. ncbi request reprint Azurin, Plasmodium falciparum malaria and HIV/AIDS: inhibition of parasitic and viral growth by Azurin
    Anita Chaudhari
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cell Cycle 5:1642-8. 2006
    ..8-azurin and Laz makes these proteins, or peptides derived from them, potential therapeutic agents in the treatment of malaria, HIV-1 infections or coinfections with both P. falciparum and HIV-1...
  47. ncbi request reprint Adherence to antiretroviral therapy and persistence of HIV RNA in semen
    Paulo F Barroso
    Infectious Diseases Sevice, Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 32:435-40. 2003
    ..Although antiretroviral therapy (ART) reduces HIV seminal shedding, little is known about the relationship between adherence to ART and HIV suppression in semen...

Research Grants22

  1. ORIGIN AND DYNAMICS OF HIV-1 IN SEMEN
    Phalguni Gupta; Fiscal Year: 2000
    ..The information from the proposed study will be extremely useful in the understanding of transmission and eradication of HIV following therapy. ..
  2. HIV IN SEMEN FROM INFECTED SUBJECTS FROM INDIA
    Phalguni Gupta; Fiscal Year: 2006
    ..Semen and blood plasma and mononuclear cells samples collected through our collaborative study in India will be used in this project. ..
  3. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2006
    ..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..
  4. PITT AIDS RESEARCH TRAINING PROGRAM
    Phalguni Gupta; Fiscal Year: 2007
    ..b>Phalguni Gupta, with the help of a steering committee composed of senior and junior training faculty...
  5. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2007
    ..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..
  6. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2009
    ..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..
  7. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2010
    ..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..
  8. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2006
    ..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
  9. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2003
    ....
  10. ASSESSMENT OF CD8 SUPPRESSION OF HIV/SIV TO VACCINES
    Phalguni Gupta; Fiscal Year: 2000
    ..The information generated from this project will be extremely useful in determining the utility of the suppressive activity in evaluating efficacy of a vaccine. ..
  11. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2000
    ....
  12. ORIGIN AND DYNAMICS OF HIV-1 IN SEMEN
    Phalguni Gupta; Fiscal Year: 2001
    ..The information from the proposed study will be extremely useful in the understanding of transmission and eradication of HIV following therapy. ..
  13. ASSESSMENT OF CD8 SUPPRESSION OF HIV/SIV TO VACCINES
    Phalguni Gupta; Fiscal Year: 2001
    ..The information generated from this project will be extremely useful in determining the utility of the suppressive activity in evaluating efficacy of a vaccine. ..
  14. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2001
    ....
  15. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2001
    ....
  16. ORIGIN AND DYNAMICS OF HIV-1 IN SEMEN
    Phalguni Gupta; Fiscal Year: 2002
    ..The information from the proposed study will be extremely useful in the understanding of transmission and eradication of HIV following therapy. ..
  17. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2002
    ....
  18. ASSESSMENT OF CD8 SUPPRESSION OF HIV/SIV TO VACCINES
    Phalguni Gupta; Fiscal Year: 2002
    ..The information generated from this project will be extremely useful in determining the utility of the suppressive activity in evaluating efficacy of a vaccine. ..
  19. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2010
    ..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..