Pankaj Gupta

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance)
    Pankaj Gupta
    University of Minnesota, Minneapolis, MN, USA
    Invest New Drugs 31:1311-20. 2013
  2. pmc Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells
    Chendong Pan
    Associate Professor of Medicine, University of Minnesota Medical School, Hematology Oncology Section 111E, VA Medical Center, One Veterans Dr, Minneapolis, MN 55417
    Blood 106:1956-64. 2005
  3. ncbi request reprint Impairment of the activity of glycosaminoglycan-binding cytokines by functionally abnormal heparan sulfates: a novel mechanism underlying disease pathophysiology
    Pankaj Gupta
    Veterans Affairs Medical Center, Hematology Oncology Transplantation Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    ScientificWorldJournal 6:452-6. 2006
  4. ncbi request reprint Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I)
    Zhenhong Nan
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Transplant 21:1577-93. 2012
  5. doi request reprint Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I
    Daniel A Wolf
    Department of Genetics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Neurobiol Dis 43:123-33. 2011
  6. doi request reprint Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity
    Shaukat A Khan
    Hematology and Oncology Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Am J Physiol Cell Physiol 294:C1387-97. 2008
  7. pmc Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, University of Minnesota, Minneapolis, 55455, USA
    Mol Ther 17:1136-44. 2009
  8. pmc Elevated granulocyte colony-stimulating factor, non-infectious leukocytosis and fevers in a patient with multiple myeloma
    Meghan M Sebasky
    University of Minnesota Medical Center, Minneapolis, MN, USA
    J Gen Intern Med 23:2134-5. 2008
  9. pmc Morphine promotes renal pathology in sickle mice
    Marc L Weber
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Int J Nephrol Renovasc Dis 5:109-18. 2012
  10. ncbi request reprint The microenvironment of AFT024 cells maintains primitive human hematopoiesis by counteracting contact mediated inhibition of proliferation
    Michael Punzel
    Department of Medicine, Division of Hematology and Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA
    Cell Commun Adhes 9:149-59. 2002

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance)
    Pankaj Gupta
    University of Minnesota, Minneapolis, MN, USA
    Invest New Drugs 31:1311-20. 2013
    ..Conclusions: Vatalanib induces improvement in blood counts in a small proportion of MDS patients. Clinical applicability is limited by side effects. ..
  2. pmc Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells
    Chendong Pan
    Associate Professor of Medicine, University of Minnesota Medical School, Hematology Oncology Section 111E, VA Medical Center, One Veterans Dr, Minneapolis, MN 55417
    Blood 106:1956-64. 2005
    ..Similar mechanisms may operate in the pathogenesis of other diseases where structurally abnormal GAGs accumulate...
  3. ncbi request reprint Impairment of the activity of glycosaminoglycan-binding cytokines by functionally abnormal heparan sulfates: a novel mechanism underlying disease pathophysiology
    Pankaj Gupta
    Veterans Affairs Medical Center, Hematology Oncology Transplantation Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    ScientificWorldJournal 6:452-6. 2006
  4. ncbi request reprint Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I)
    Zhenhong Nan
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Transplant 21:1577-93. 2012
    ....
  5. doi request reprint Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I
    Daniel A Wolf
    Department of Genetics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Neurobiol Dis 43:123-33. 2011
    ..The results suggest the potential of improved outcome for MPSs and other neurological diseases when a high level of gene expression can be achieved by direct, early administration of vector to the CNS...
  6. doi request reprint Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity
    Shaukat A Khan
    Hematology and Oncology Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Am J Physiol Cell Physiol 294:C1387-97. 2008
    ....
  7. pmc Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system
    Elena L Aronovich
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, University of Minnesota, Minneapolis, 55455, USA
    Mol Ther 17:1136-44. 2009
    ....
  8. pmc Elevated granulocyte colony-stimulating factor, non-infectious leukocytosis and fevers in a patient with multiple myeloma
    Meghan M Sebasky
    University of Minnesota Medical Center, Minneapolis, MN, USA
    J Gen Intern Med 23:2134-5. 2008
    ..We report the case of a 56-year-old male with multiple myeloma in whom recurrent fevers and leukocytosis delayed potentially effective chemotherapy due to concern for active infection...
  9. pmc Morphine promotes renal pathology in sickle mice
    Marc L Weber
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Int J Nephrol Renovasc Dis 5:109-18. 2012
    ..These results suggest that clinically relevant doses of morphine induce renal pathology and that OR antagonists may be effective for ameliorating morphine-induced renal disease...
  10. ncbi request reprint The microenvironment of AFT024 cells maintains primitive human hematopoiesis by counteracting contact mediated inhibition of proliferation
    Michael Punzel
    Department of Medicine, Division of Hematology and Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA
    Cell Commun Adhes 9:149-59. 2002
    ..In conclusion, AFT024 cells produce factor(s), that counteract contact induced growth inhibition of primitive human hematopoietic progenitors, leading to expansion of these cells in contact with the microenvironment...
  11. pmc Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy
    Mayra F Garcia-Rivera
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA
    Brain Res Bull 74:429-38. 2007
    ....
  12. pmc Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids
    Divyanshoo R Kohli
    Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Blood 116:456-65. 2010
    ..Importantly, cannabinoids attenuate pain in mice expressing HbS...
  13. pmc Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation
    Sharon D Luikart
    Hematology Oncology Section 111E, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    BMC Cell Biol 10:60. 2009
    ..We therefore sought to determine the mechanism by which mactinin stimulates monocytes...
  14. doi request reprint Expression and phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 in B-cell lymphomas and reactive lymphoid tissues
    Dhatri Kodali
    Hematology Oncology Section, Departments of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota, USA
    Arch Pathol Lab Med 135:365-71. 2011
    ..eIF-4F activity is controlled by a repressor binding protein (4E-BP1), which promotes translation when phosphorylated...
  15. ncbi request reprint MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:917-33. 2008
    ....
  16. doi request reprint Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:314-29. 2008
    ....
  17. pmc Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:297-313. 2008
    ....
  18. doi request reprint Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva
    Pankaj Gupta
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 215:827-36. 2008
    ..This approach highlights a potential new combinatorial strategy, which may prove beneficial for NSCLC patients with acquired resistance to EGFR inhibitors...
  19. ncbi request reprint BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis
    Pankaj Gupta
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Res 66:8182-91. 2006
    ....
  20. pmc Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer
    Luni Emdad
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 208:298-306. 2006
    ..The present studies support the use of IR in combination with mda-7/IL-24 as a means of augmenting the therapeutic benefit of this gene in ovarian cancer, particularly in the context of tumors displaying resistance to radiation therapy...
  21. ncbi request reprint Mechanisms of acute myocardial infarction study (MAMIS)
    Ram B Singh
    Medical Hospital and Research Center, Moradabad, India
    Biomed Pharmacother 58:S111-5. 2004
    ....
  22. ncbi request reprint MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Cancer Biol Ther 3:739-51. 2004
    ....
  23. ncbi request reprint Identification of an MIP-1alpha -binding heparan sulfate oligosaccharide that supports long-term in vitro maintenance of human LTC-ICs
    Sally E Stringer
    Paterson Institute for Cancer Research, Manchester, United Kingdom
    Blood 101:2243-5. 2003
    ..This oligosaccharide had the structure required for MIP-1alpha binding, which we have recently described. The present study defines the minimum size and structural features of LTC-IC supportive HS...

Research Grants6

  1. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ....
  2. Correction of Hurler syndrome by multipotent stem cells
    Pankaj Gupta; Fiscal Year: 2007
    ..If MAPC transplantation is of benefit in the Hurler model, similar strategies may be developed for treating diverse neurodegenerative disorders. ..