Nalin Gupta

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Open fetal surgery for myelomeningocele
    Nalin Gupta
    Departments of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    J Neurosurg Pediatr 9:265-73. 2012
  2. pmc Imaging of ependymomas: MRI and CT
    E L Yuh
    Neuroradiology Section, Department of Radiology, University of California, San Francisco, San Francisco, USA
    Childs Nerv Syst 25:1203-13. 2009
  3. ncbi request reprint Long-term outcomes in patients with treated childhood hydrocephalus
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco 94102, USA
    J Neurosurg 106:334-9. 2007
  4. ncbi request reprint Choroid plexus tumors in children
    Nalin Gupta
    Division of Pediatric Neurosurgery, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 14:621-31. 2003
  5. ncbi request reprint A modification of the Mayfield horseshoe headrest allowing pin fixation and cranial immobilization in infants and young children
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 58:ONS-E181; discussion ONS-E181. 2006
  6. ncbi request reprint Brain mapping for hemispheric tumors in children
    Nalin Gupta
    Department of Neurosurgery, University of California San Francisco, 94143, USA
    Pediatr Neurosurg 38:302-6. 2003
  7. doi request reprint A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas
    Tene A Cage
    Department of Neurological Surgery, University of California San Francisco, CA 94143, USA
    J Neurosurg Pediatr 11:673-81. 2013
  8. pmc An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing
    Yasuyuki Aoki
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0112, USA
    J Neurooncol 108:29-35. 2012
  9. ncbi request reprint CC chemokine receptor-2A is frequently overexpressed in glioblastoma
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA
    J Neurooncol 86:153-63. 2008
  10. doi request reprint Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment
    Rintaro Hashizume
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0520, USA
    J Neurooncol 110:305-13. 2012

Detail Information

Publications74

  1. doi request reprint Open fetal surgery for myelomeningocele
    Nalin Gupta
    Departments of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    J Neurosurg Pediatr 9:265-73. 2012
    ..This review will summarize the evaluation and treatment of patients undergoing fetal repair for myelomeningocele at one institution...
  2. pmc Imaging of ependymomas: MRI and CT
    E L Yuh
    Neuroradiology Section, Department of Radiology, University of California, San Francisco, San Francisco, USA
    Childs Nerv Syst 25:1203-13. 2009
    ..Finally, salient imaging features obtained in the postoperative period to evaluate completeness of surgical resection, and thereafter for long-term surveillance for disease recurrence, are reviewed...
  3. ncbi request reprint Long-term outcomes in patients with treated childhood hydrocephalus
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco 94102, USA
    J Neurosurg 106:334-9. 2007
    ..The goal in this study was to determine the long-term effects of childhood hydrocephalus...
  4. ncbi request reprint Choroid plexus tumors in children
    Nalin Gupta
    Division of Pediatric Neurosurgery, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 14:621-31. 2003
    ..Although adjunctive therapy for carcinoma includes chemotherapy or radiation, the long-term survival for carcinoma remains poor...
  5. ncbi request reprint A modification of the Mayfield horseshoe headrest allowing pin fixation and cranial immobilization in infants and young children
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 58:ONS-E181; discussion ONS-E181. 2006
    ..However, these techniques are associated with complications in infants and young children. A simple modification of a commonly used cranial fixation system allows rigid, safe immobilization of the head in infants and children...
  6. ncbi request reprint Brain mapping for hemispheric tumors in children
    Nalin Gupta
    Department of Neurosurgery, University of California San Francisco, 94143, USA
    Pediatr Neurosurg 38:302-6. 2003
    ..Incorporation of functional information in surgical planning should lead to safer surgical procedures with improvements in patient outcome...
  7. doi request reprint A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas
    Tene A Cage
    Department of Neurological Surgery, University of California San Francisco, CA 94143, USA
    J Neurosurg Pediatr 11:673-81. 2013
    ....
  8. pmc An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing
    Yasuyuki Aoki
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0112, USA
    J Neurooncol 108:29-35. 2012
    ..Our results demonstrate the feasibility of using an orthotopic brainstem tumor model in athymic mice, and for application to testing therapeutic agents in treating DIPG...
  9. ncbi request reprint CC chemokine receptor-2A is frequently overexpressed in glioblastoma
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA
    J Neurooncol 86:153-63. 2008
    ..Inhibition of MCP-1 synthesis suppressed migration of CCR2A-overexpressed glioma cells. Our data suggest that CCR2A might be associated with the pathobiology of GBM such as host response to treatment and tumor cell migration...
  10. doi request reprint Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment
    Rintaro Hashizume
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0520, USA
    J Neurooncol 110:305-13. 2012
    ..The hTERT modified cells are tumorigenic in athymic rodents, and produce brainstem tumors that recapitulate the infiltrative growth of brainstem gliomas in patients...
  11. doi request reprint High-grade gliomas in children
    Tene A Cage
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 23:515-23. 2012
    ..This article reviews clinical, diagnostic, and pathologic features of HGG and current treatments and potential future therapies specific to pediatric patients with HGGs...
  12. pmc Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update
    Kavita K Mishra
    Department of Radiation Oncology, University of California, San Francisco, 1600 Divisadero, San Francisco, CA 94143, USA
    J Neurooncol 100:121-7. 2010
    ..2% and 15-year PFS of 23.4%. No survival benefit is demonstrated for greater extent of resection. Age is a significant prognostic factor for progression and survival...
  13. doi request reprint A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma
    Aaron J Clark
    Department of Neurological Surgery, Pediatric Neurosurgery, University of California, San Francisco, San Francisco, CA 94143 0112, USA
    Childs Nerv Syst 29:231-8. 2013
    ..Treatment strategies range from aggressive resection to planned limited resection combined with adjuvant therapies. Currently there is no consensus for standard of care for pediatric craniopharyngioma...
  14. pmc Expression of miR-124 inhibits growth of medulloblastoma cells
    Joachim Silber
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neuro Oncol 15:83-90. 2013
    ..Further testing of miR-124 will help define the ultimate therapeutic potential of preclinical models of medulloblastoma in conjunction with various delivery strategies for treatment...
  15. pmc The superiority of conservative resection and adjuvant radiation for craniopharyngiomas
    Adam Schoenfeld
    Department of Radiation Oncology, University of California, San Francisco UCSF, San Francisco, CA 94143 1708, USA
    J Neurooncol 108:133-9. 2012
    ..014). In conclusion, for patients with craniopharyngioma, STR + RT may provide superior clinical outcome, achieving better disease control than STR and limiting side effects associated with aggressive surgical resection...
  16. pmc A human brainstem glioma xenograft model enabled for bioluminescence imaging
    Rintaro Hashizume
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, 505 Parnassus Ave, Room M779, San Francisco, CA 94143 0112, USA
    J Neurooncol 96:151-9. 2010
    ..This model is well suited for pre-clinical testing of therapeutics that are being considered for treatment of patients with brainstem tumors...
  17. doi request reprint Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumors
    Sean M McBride
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
    Int J Radiat Oncol Biol Phys 72:1319-23. 2008
    ..To review a historical cohort of pediatric patients with supratentorial primitive neuroectodermal tumors (sPNET), to clarify the role of radiation in the treatment of these tumors...
  18. doi request reprint Surgical outcomes in choroid plexus papillomas: an institutional experience
    Michael Safaee
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    J Neurooncol 113:117-25. 2013
    ..This modern experience at a tertiary care center performed exclusively during the MRI-era demonstrates that CPPs can be safely removed with minimal morbidity and good tumor control...
  19. doi request reprint Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy
    Sunanda Pejavar
    Department of Radiation Oncology, University of California, San Francisco and UCSF Benioff Children s Hospital, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94115 1708, USA
    J Neurooncol 106:367-75. 2012
    ..Our findings suggest the benefit of RT even in the presence of GTR. Future prospective studies with larger sample number are needed to validate our findings...
  20. doi request reprint Gross total resection improves overall survival in children with choroid plexus carcinoma
    Matthew Z Sun
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94117, USA
    J Neurooncol 116:179-85. 2014
    ..027), the effect did not meet our criteria for significance in our multivariate Cox model (p = 0.120). GTR improved OS of pediatric CPC and is recommended if it can be safely performed. ..
  21. doi request reprint Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas
    Michael Safaee
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94117, USA
    Childs Nerv Syst 29:2057-64. 2013
    ..We sought to investigate potential associations between extent of resection and histologic grade on progression-free survival (PFS) and overall survival (OS)...
  22. doi request reprint Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children
    Tene A Cage
    Department of Neurological Surgery, Pediatric Neurosurgery, University of California, San Francisco, 505 Parnassus Ave, Room M779, San Francisco, CA 94143 0112, USA
    Childs Nerv Syst 29:1313-9. 2013
    ..We have reviewed the results of biopsy for DIPGs in children at a single institution and compared our results to those available in the literature to elucidate the utility of biopsy for DIPGs...
  23. doi request reprint Prognosis by tumor location for pediatric spinal cord ependymomas
    Michael C Oh
    Departments of Neurological Surgery, University of California, San Francisco, CA 94117, USA
    J Neurosurg Pediatr 11:282-8. 2013
    ..A comprehensive literature review was performed to determine whether a tumor location along the spinal cord is prognostically significant in children undergoing surgery for spinal cord ependymomas...
  24. doi request reprint Minimally invasive tethered cord release in adults: a comparison of open and mini-open approaches
    Matthew B Potts
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 29:E7. 2010
    ..The authors present a comparison of open versus minimally invasive surgery to treat adult tethered cord syndrome...
  25. pmc PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome
    Sabine Mueller
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Neuro Oncol 14:1146-52. 2012
    ..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors...
  26. doi request reprint Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 10:293-301. 2012
    ..Currently, there is controversy regarding the extent, timing, and modality of treatment for pediatric craniopharyngioma...
  27. ncbi request reprint Complications of lumboperitoneal shunts
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 60:1045-8; discussion 1049. 2007
    ..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems...
  28. doi request reprint Microscopic endonasal transsphenoidal pituitary adenomectomy in the pediatric population
    Phiroz E Tarapore
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg Pediatr 7:501-9. 2011
    ..The authors of this report describe their 10-year experience in managing pituitary adenomas via the microscopic endonasal transsphenoidal approach in a pediatric population...
  29. doi request reprint Pediatric intracranial aneurysms
    Brian J Jian
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 21:491-501. 2010
    ..The patient population, clinical presentation, complications, and trends in treatments are discussed in this article...
  30. ncbi request reprint Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA
    J Neurooncol 86:133-41. 2008
    ....
  31. doi request reprint Multiple intracranial aneurysms and moyamoya disease associated with microcephalic osteodysplastic primordial dwarfism type II: surgical considerations
    James S Waldron
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 4:439-44. 2009
    ....
  32. doi request reprint Effects of temporal lobectomy on consciousness-impairing and consciousness-sparing seizures in children
    Dario J Englot
    UCSF Epilepsy Center, San Francisco, CA, USA
    Childs Nerv Syst 29:1915-22. 2013
    ..Seizures which impair consciousness are associated with increased morbidity compared to consciousness-sparing seizures...
  33. pmc The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    Kui Ming Chan
    Department of Biochemistry and Molecular Biology, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 27:985-90. 2013
    ..These results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis...
  34. pmc Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas
    Jane R Engler
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43339. 2012
    ..These studies support a role for the immune response, particularly the microglia/macrophage response, in the biology of an important subset of GBM. Identification of this subset may be important for future therapeutic stratification...
  35. pmc Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing
    Rintaro Hashizume
    Brain Tumor Research Center, Department of Neurological Surgery, University ofCalifornia, San Diego, CA, USA
    Neuro Oncol 12:366-76. 2010
    ....
  36. doi request reprint Prevalence of congenital hydrocephalus in California, 1991-2000
    Susy Jeng
    Division of Child Neurology, University of California at San Francisco, San Francisco, California 94143 0137, USA
    Pediatr Neurol 45:67-71. 2011
    ..5, 95% CI 1.4-1.6), and male sex (OR 1.2, 95% CI 1.1-1.3). Asians had a decreased risk for congenital hydrocephalus (OR 0.7, 95% CI 0.6-0.8) when compared to whites. Thirteen percent of affected neonates died before hospital discharge...
  37. ncbi request reprint In utero surgery for hydrocephalus
    Cornelia S von Koch
    Department of Neurological Surgery, University of California San Francisco, Room M 779, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143 0112, USA
    Childs Nerv Syst 19:574-86. 2003
    ..Neonatal hydrocephalus is one of the most common congenital anomalies affecting the nervous system...
  38. doi request reprint Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: a multi-institutional study
    Tarik Tihan
    Department of Pathology, University of California San Francisco, San Francisco, CA, USA
    Am J Surg Pathol 36:43-55. 2012
    ..This finding has significant implications given its role in oncogen-induced senescence and possible influence on treatment decisions of subtotally resected tumors...
  39. ncbi request reprint Spinal cord mapping as an adjunct for resection of intramedullary tumors: surgical technique with case illustrations
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, Room M 779, San Francisco, CA 94143 9112, USA
    Neurosurgery 51:1199-206; discussion 1206-7. 2002
    ..We used both antidromically elicited SSEPs for planning the myelotomy site and direct mapping of spinal cord tracts during tumor resection to reduce the risk of neurological deficits and increase the extent of tumor resection...
  40. ncbi request reprint Ventriculoperitoneal shunt complications in California: 1990 to 2000
    Yvonne Wu
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143 0137, USA
    Neurosurgery 61:557-62; discussion 562-3. 2007
    ..We examined demographic factors and VP shunt complications in a population-based retrospective cohort study of all nonfederal California hospital admissions between 1990 and 2000...
  41. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
    ..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain...
  42. pmc Human neurobrucellosis with intracerebral granuloma caused by a marine mammal Brucella spp
    Annette H Sohn
    University of California, San Francisco, San Francisco, California, USA
    Emerg Infect Dis 9:485-8. 2003
    ..The identification of these isolates as marine mammal strains was based on omp2a sequence and amplification of the region flanking bp26...
  43. pmc Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA 94143, USA
    BMC Cancer 6:97. 2006
    ....
  44. doi request reprint Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients
    Edward F Chang
    Northern California Comprehensive Epilepsy Center, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg Pediatr 5:123-30. 2010
    ..The authors' aim was to identify factors that predict seizure control following excision...
  45. ncbi request reprint Diagnosis of Chiari III malformation by second trimester fetal MRI with postnatal MRI and CT correlation
    Alice B Smith
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Pediatr Radiol 37:1035-8. 2007
    ..Postnatal MRI and CT confirmed the fetal MRI findings and demonstrate the utility of fetal MRI in the early evaluation of songraphically detected posterior fossa abnormalities...
  46. doi request reprint Distinct patterns of human medulloblastoma dissemination in the developing chick embryo nervous system
    Tene A Cage
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0112, USA
    Clin Exp Metastasis 29:371-80. 2012
    ..This work supports an avian-human xenograft as a successful model to study patterns of MB dissemination. Our model provides a basis for manipulating cell signaling mechanisms to understand critical targets involved in MB dissemination...
  47. pmc Chiari type I malformation in a pediatric population
    Leslie A Aitken
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94117 0137, USA
    Pediatr Neurol 40:449-54. 2009
    ..Larger and longer-term studies are needed to determine the prognosis and optimal treatment of pediatric Chiari I...
  48. doi request reprint Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005
    Melike Pekmezci
    Department of Pathology, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 67:1341-9; discussion 1349. 2010
    ..Craniopharyngiomas are rare epithelial tumors that are presumed to arise from the remnants of Rathke's pouch...
  49. ncbi request reprint The effects of detethering on the urodynamics profile in children with a tethered cord
    Michael H Hsieh
    Departments of Urology Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 105:391-5. 2006
    ..The authors of this study sought to determine the effects of detethering on the urodynamic profile of children with a tethered cord...
  50. pmc Radially branched deployment for more efficient cell transplantation at the scale of the human brain
    Matthew T Silvestrini
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 91:92-103. 2013
    ..This technical deficiency may limit the successful clinical translation of cell transplantation...
  51. doi request reprint Neural stem cell engraftment and myelination in the human brain
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Transl Med 4:155ra137. 2012
    ..These phase 1 findings indicate a favorable safety profile for HuCNS-SCs in subjects with PMD. The MRI results suggest durable cell engraftment and donor-derived myelin in the transplanted host white matter...
  52. ncbi request reprint Intracranial dermoid cyst mimicking hemorrhage. Case report and review of the literature
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco 94143, USA
    J Neurosurg 105:311-4. 2006
    ..The authors describe their experience and review the literature, emphasizing that a dermoid cyst may have unusual radiographic characteristics indicative of hemorrhage and may contain areas of hemorrhage on histological examination...
  53. ncbi request reprint Superior outcomes in children compared with adults after microsurgical resection of brain arteriovenous malformations
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 105:82-7. 2006
    ....
  54. ncbi request reprint In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes
    Diana L Farmer
    Departments of Surgery and Neurosurgery and the Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
    Arch Surg 138:872-8. 2003
    ..Experimental work raises the possibility that in utero repair of myelomeningocele (MMC) may improve lower extremity, bladder, and bowel function, ameliorate the Arnold-Chiari malformation, and decrease the need for postnatal shunting...
  55. pmc The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas
    Kavita K Mishra
    Brain Tumor Research Center and Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 8:166-74. 2006
    ..We were unable to demonstrate a benefit for administering radiation as part of initial treatment. An outcome benefit was seen with greater extent of resection...
  56. pmc Corridors of migrating neurons in the human brain and their decline during infancy
    Nader Sanai
    Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nature 478:382-6. 2011
    ..Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates...
  57. ncbi request reprint Telomerase inhibitors for the treatment of brain tumors and the potential of intranasal delivery
    Rintaro Hashizume
    University of California San Francisco, Hellen Diller Family Cancer Research Center, Mission Bay, 1450 3rd Street, HD 200, San Francisco, CA 94158 0520, USA
    Curr Opin Mol Ther 12:168-75. 2010
    ..The IND of telomerase inhibitors represents a new therapeutic approach that appears to selectively kill tumor cells, without inducing toxic effects in the surrounding healthy brain tissue...
  58. doi request reprint Transpedicular corpectomy with posterior expandable cage placement for L1 burst fracture
    Dean Chou
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0350, USA
    J Clin Neurosci 16:1069-72. 2009
    ..We describe our surgical procedure in this technical note...
  59. pmc Diagnosis influences response of cerebral near infrared spectroscopy to intracranial hypertension in children
    Maria T Zuluaga
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
    Pediatr Crit Care Med 11:514-22. 2010
    ....
  60. ncbi request reprint Time trends and demographics of deaths from congenital hydrocephalus in children in the United States: National Center for Health Statistics data, 1979 to 1998
    John H Chi
    Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
    J Neurosurg 103:113-8. 2005
    ..The authors' analysis sought to rectify this situation...
  61. doi request reprint High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations
    Shannon Fogh
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    J Neurosurg 117:115-9. 2012
    ....
  62. ncbi request reprint Airbag deployment and improperly restrained children: a lethal combination
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, San Francisco Injury Center, University of California San Francisco, San Francisco, California, USA
    J Trauma 59:729-33. 2005
    ..We also reviewed the relevant literature and provide information useful for caregivers and health care professionals in hopes of reducing future injuries...
  63. ncbi request reprint Diffusion-weighted MR imaging abnormalities in pediatric patients with surgically-treated intracranial mass lesions
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, San Francisco School of Medicine, University of California, San Francisco, CA 94143 0112, USA
    J Neurooncol 79:203-9. 2006
    ..The purpose of this study was to investigate the occurrence of these postoperative abnormalities in pediatric patients with intracranial mass lesions...
  64. ncbi request reprint Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:982-93; discussion 982-93. 2005
    ..In this study, we hypothesized that changes in the intraoperative MEPs during tumor resection correlate with postoperative motor function deficits...
  65. ncbi request reprint Pediatric intramedullary spinal cord tumors
    Kurtis I Auguste
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 17:51-61. 2006
  66. ncbi request reprint Neurocutaneous melanosis presenting with hydrocephalus. Case report and review of the literature
    Frank L Acosta
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 102:96-100. 2005
    ..Our case illustrates to the neurosurgeon the importance of recognizing the likelihood of underlying pathological conditions of the central nervous system in a child with cutaneous melanocytic nevi...
  67. ncbi request reprint Magnetic resonance neurography in children with birth-related brachial plexus injury
    Alice B Smith
    Department of Neuroradiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Pediatr Radiol 38:159-63. 2008
    ..Clinical examination and electrodiagnostic studies have been used in the evaluation of birth-related brachial plexus injury. These are limited in their demonstration of anatomic detail and severity of injury...
  68. doi request reprint Minimally invasive decompression of a suboccipital osseous prominence causing rotational vertebral artery occlusion. Case report
    Daniel C Lu
    Departments of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 4:191-5. 2009
    ..Successful decompression of the VA was performed via a minimally invasive 22-mm tubular retractor. This is the first reported case report of a minimally invasive decompression of the VA between the skull base and C-1...
  69. ncbi request reprint Radiation-induced atypical meningioma with rapid growth in a 13-year-old girl. Case report
    Marcus L Ware
    Department of Neurological Surgery Division of Pediatric Neurosurgery and Brain Tumor Research Center, University of California, San Francisco Medical Center, San Francisco, California 94143 0112, USA
    J Neurosurg 100:488-91. 2004
    ..This tumor was resected and the patient's symptoms improved. This case illustrates the importance of continued close follow up after cranial irradiation in the pediatric population...
  70. ncbi request reprint Cystic schwannoma of the anterior tentorial hiatus. Case report and review of the literature
    Rose Du
    Department of Neurosurgery, University of California at San Francisco, San Francisco, Calif 94143 0112, USA
    Pediatr Neurosurg 38:167-73. 2003
    ..Postoperatively, the patient remained neurologically intact. The clinical presentation and treatment of schwannomas arising in this location are discussed...
  71. ncbi request reprint Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis
    Nikolai N Khodarev
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Int J Cancer 109:214-9. 2004
    ..These findings may have important implications for the treatment of glioblastoma tumors and other human cancers...
  72. ncbi request reprint Occult tethered cord syndrome: a survey of practice patterns
    Paul Steinbok
    Division of Neurosurgery, British Columbia s Children s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosurg 104:309-13. 2006
    ....
  73. ncbi request reprint Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells
    Nikolai N Khodarev
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    J Cell Sci 116:1013-22. 2003
    ..We suggest that tumour cells release growth factors that induce endothelial cells to express specific ligands and their cognate receptors coordinately...
  74. ncbi request reprint Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy
    Eduard B Dinca
    Neuroscience Graduate Program, Mayo Clinic, Rochester, Minnesota, USA
    J Neurosurg 107:610-6. 2007
    ..In the current study we have applied BLI to the analysis of clinically relevant issues involving use of the DNA methylating agent temozolomide (TMZ) in a mouse model...

Research Grants2

  1. Macrophage and Microglial Activation in Glioma-Associated Inflammation
    Nalin Gupta; Fiscal Year: 2007
    The goal of this project is to provide the applicant, Nalin Gupta, with the necessary expertise to develop an independent research career at the University of California San Francisco by building on his previous experience and training...