Qing Guo

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint When good Cdk5 turns bad
    Qing Guo
    Department of Physiology, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK 73104, USA
    Sci Aging Knowledge Environ 2006:pe5. 2006
  2. ncbi request reprint AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4
    Qing Guo
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 279:4596-603. 2004
  3. ncbi request reprint Cyclin-dependent kinase 5--a neuronal killer?
    Qing Guo
    Department of Physiology, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK 73104, USA
    Sci Aging Knowledge Environ 2003:pe36. 2003
  4. pmc Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice
    Daniel J Payette
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Brain Res 1135:12-21. 2007
  5. ncbi request reprint PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
    Jun Xie
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:13824-32. 2005
  6. ncbi request reprint Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane
    Jun Xie
    Department of Physiology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Biol Chem 279:28266-75. 2004
  7. ncbi request reprint AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
    Jun Xie
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Neurobiol Dis 16:150-7. 2004
  8. ncbi request reprint Apoptosis antagonizing transcription factor protects renal tubule cells against oxidative damage and apoptosis induced by ischemia-reperfusion
    Jun Xie
    Department of Physiology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Am Soc Nephrol 17:3336-46. 2006
  9. ncbi request reprint RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice
    Jun Xie
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 92:59-71. 2005
  10. ncbi request reprint Par-4 is a novel mediator of renal tubule cell death in models of ischemia-reperfusion injury
    Jun Xie
    Dept of Physiology, Univ of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Am J Physiol Renal Physiol 292:F107-15. 2007

Research Grants

  1. Regulation of APP Processing by Par-4
    Qing Guo; Fiscal Year: 2007
  2. AATF and Renal Protection
    Qing Guo; Fiscal Year: 2009
  3. AATF and Renal Protection
    Qing Guo; Fiscal Year: 2010

Collaborators

  • Yan Zhou
  • Jun Xie
  • Najeeb A Shirwany
  • Yuequan Shen
  • Wei Jen Tang
  • Xuehui Chen
  • Daniel J Payette
  • Julia T Warren
  • Natalia L Zhukovskaya
  • Jian Jin
  • Zihe Rao
  • Daniel Payette
  • Keytam S Awad
  • Jan Florian
  • Andrew Bohm
  • Chester L Drum
  • Jiangang Yuan
  • Luet Lok Wong
  • Guangtao Li
  • Mark Bartlam
  • Stephen G Bell
  • Yiwei Liu
  • Jonathan P Jones
  • Alexandra Christopher
  • Sheng Ye
  • Yu Gao
  • Boqin Qiang
  • Feng Xu
  • Yixin Sun

Detail Information

Publications20

  1. ncbi request reprint When good Cdk5 turns bad
    Qing Guo
    Department of Physiology, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK 73104, USA
    Sci Aging Knowledge Environ 2006:pe5. 2006
    ..quot; The findings may have implications for the development and treatment of conditions like Alzheimer's disease...
  2. ncbi request reprint AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4
    Qing Guo
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 279:4596-603. 2004
    ..These results indicate that AATF is an endogenous antagonist of Par-4 activity and an effective inhibitor of aberrant Abeta production and secretion under apoptotic conditions...
  3. ncbi request reprint Cyclin-dependent kinase 5--a neuronal killer?
    Qing Guo
    Department of Physiology, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK 73104, USA
    Sci Aging Knowledge Environ 2003:pe36. 2003
    ....
  4. pmc Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice
    Daniel J Payette
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Brain Res 1135:12-21. 2007
    ..Since human neocortex has recently been shown to possess intrinsic cholinergic innervation, our results indicate that alterations in CHT1-mediated high affinity choline uptake in cortical neurons may contribute to Alzheimer's dementia...
  5. ncbi request reprint PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
    Jun Xie
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:13824-32. 2005
    ....
  6. ncbi request reprint Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane
    Jun Xie
    Department of Physiology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Biol Chem 279:28266-75. 2004
    ..These results suggest that Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface...
  7. ncbi request reprint AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
    Jun Xie
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Neurobiol Dis 16:150-7. 2004
    ..AATF may therefore represent a potential candidate for therapeutic intervention of neurodegeneration in both sporadic and familial forms of AD...
  8. ncbi request reprint Apoptosis antagonizing transcription factor protects renal tubule cells against oxidative damage and apoptosis induced by ischemia-reperfusion
    Jun Xie
    Department of Physiology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Am Soc Nephrol 17:3336-46. 2006
    ..These results identify AATF as a novel cytoprotective factor against oxidative and apoptotic damage in renal tubular cells. AATF may represent a potential candidate for therapeutic application in IRI...
  9. ncbi request reprint RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice
    Jun Xie
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 92:59-71. 2005
    ....
  10. ncbi request reprint Par-4 is a novel mediator of renal tubule cell death in models of ischemia-reperfusion injury
    Jun Xie
    Dept of Physiology, Univ of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Am J Physiol Renal Physiol 292:F107-15. 2007
    ..These results identify Par-4 as a novel and early mediator of renal tubule cell injury following IRI and provide a potential target for developing new therapeutic strategies for renal IRI and ARF...
  11. pmc The amyloid beta ion channel hypothesis of Alzheimer's disease
    Najeeb A Shirwany
    Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Neuropsychiatr Dis Treat 3:597-612. 2007
    ..In this review we shall critically examine this theory in light of classic and contemporary literature...
  12. pmc Regulation of intracellular calcium in cortical neurons transgenic for human Abeta40 and Abeta42 following nutritive challenge
    Najeeb A Shirwany
    Department of Physiology, University of Oklahoma Health Sciences Center Oklahoma City, OK 73014, USA
    Int J Clin Exp Med 2:149-58. 2009
    ..Overall, our results also suggest that a highly amyloidogenic Abeta species, such as Abeta42, might not necessarily be significantly more neurotoxic than a less or non-amyloidogenic Abeta species, such as Abeta40...
  13. pmc A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step
    Julia T Warren
    Biological Sciences Collegial Division, The University of Chicago, Chicago, IL 60637, USA
    J Mol Biol 374:517-27. 2007
    ..This conformational switch should be incorporated into models of either stepwise conformational transition or flexible, dynamic energetic state sampling-based transition...
  14. pmc Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently
    Qing Guo
    Ben May Department for Cancer Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    J Biol Chem 283:23836-45. 2008
    ..Thus, two structurally conserved, bacterial adenylyl cyclase toxins have evolved to utilize distinct binding surfaces and modes of activation in their interaction with CaM, a highly conserved eukaryotic signaling protein...
  15. ncbi request reprint Major conformational changes during T7RNAP transcription initiation coincide with, and are required for, promoter release
    Qing Guo
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Mol Biol 353:256-70. 2005
    ....
  16. pmc Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
    Yuequan Shen
    Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    EMBO J 24:929-41. 2005
    ..Mammalian adenylyl cyclases share no structural similarity with EF and they also use two-metal-ion catalysis, suggesting the catalytic mechanism-driven convergent evolution of two structurally diverse adenylyl cyclases...
  17. ncbi request reprint Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
    Yuequan Shen
    Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 317:309-14. 2004
    ..Therefore, this alternate binding mode of the adenosine of AMPCPP binds to EF likely playing only a minor role in ATP binding and in catalysis...
  18. ncbi request reprint Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene
    Xuehui Chen
    Laboratory of Structural Biology, Department of Biological Science and Technology and Ministry of Education Laboratory of Protein Science, Tsinghua University, Beijing 100084, China
    J Biol Chem 277:37519-26. 2002
    ..0 min(-1). Both substrates are oxidized to pentachlorophenol, which is degraded by micro-organisms. In principle, the F87W/Y96F/L244A/V247L mutant could have applications in the bioremediation of polychlorinated benzenes...
  19. ncbi request reprint Crystal structure of the catalytic domain of a human thioredoxin-like protein
    Jian Jin
    Laboratory of Structural Biology and the MOE Laboratory of Protein Science, School of Life Science and Engineering, Tsinghua University, Beijing, China
    Eur J Biochem 269:2060-8. 2002
    ....
  20. ncbi request reprint Recognition by tryptophanyl-tRNA synthetases of discriminator base on tRNATrp from three biological domains
    Qing Guo
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    J Biol Chem 277:14343-9. 2002
    ..These observations identify a tRNA(Trp) structural region near the end of acceptor stem comprising A73 and G1-C72 as a crucial domain required for effective recognition by human TrpRS...

Research Grants9

  1. Regulation of APP Processing by Par-4
    Qing Guo; Fiscal Year: 2007
    ..Inhibition of Par-4 activity by enhancing AATF expression and/or manipulating Par-4/APP interaction may provide novel therapeutic implications for Alzheimer's disease. ..
  2. AATF and Renal Protection
    Qing Guo; Fiscal Year: 2009
    ....
  3. AATF and Renal Protection
    Qing Guo; Fiscal Year: 2010
    ....