Peixuan Guo

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc The emerging field of RNA nanotechnology
    Peixuan Guo
    Nanobiomedical Center, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Nat Nanotechnol 5:833-42. 2010
  2. pmc Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics
    Dan Shu
    Nanobiomedical Center, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Nat Nanotechnol 6:658-67. 2011
  3. pmc Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging
    Jing Liu
    Nanobiomedical Center, SEEBME, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, United States
    ACS Nano 5:237-46. 2011
  4. pmc Role of channel lysines and the "push through a one-way valve" mechanism of the viral DNA packaging motor
    Huaming Fang
    Nanobiomedical Center, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, Ohio, USA
    Biophys J 102:127-35. 2012
  5. pmc Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells
    Yi Shu
    Nanobiomedical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Methods 54:204-14. 2011
  6. pmc Three reversible and controllable discrete steps of channel gating of a viral DNA packaging motor
    Jia Geng
    Nanobiomedical Center, SEEBME, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH 45267, USA
    Biomaterials 32:8234-42. 2011
  7. pmc Assembly of therapeutic pRNA-siRNA nanoparticles using bipartite approach
    Yi Shu
    Nanobiomedical Center, SEEBME, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Ther 19:1304-11. 2011
  8. doi request reprint Synthesis, conjugation, and labeling of multifunctional pRNA nanoparticles for specific delivery of siRNA, drugs, and other therapeutics to target cells
    Peixuan Guo
    Nanobiomedical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 928:197-219. 2012
  9. pmc Sequential action of ATPase, ATP, ADP, Pi and dsDNA in procapsid-free system to enlighten mechanism in viral dsDNA packaging
    Chad Schwartz
    The School of Environmental, Energy, Biological, and Medical Engineering SEEBME, Nanobiomedical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Nucleic Acids Res 40:2577-86. 2012
  10. doi request reprint Formation of lipid bilayers inside microfluidic channel array for monitoring membrane-embedded nanopores of phi29 DNA packaging nanomotor
    Joon S Shim
    College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA
    Biomed Microdevices 14:921-8. 2012

Collaborators

  • Hui Zhang
  • Feng Xiao
  • Chong H Ahn
  • Le Zhang
  • Jing Liu
  • Yi Shu
  • Dan Shu
  • Huaming Fang
  • Farzin Haque
  • Jia Geng
  • Peng Jing
  • Joon S Shim
  • Chad Schwartz
  • Mathieu Cinier
  • Pheruza Tarapore
  • Lisa Huang
  • Sejal R Fox
  • Shuk Mei Ho
  • Sherine Abdelmawla
  • Nira Ben-Johnathan
  • Jarek Meller
  • Roman Petrenko
  • Carlo Montemagno

Detail Information

Publications15

  1. pmc The emerging field of RNA nanotechnology
    Peixuan Guo
    Nanobiomedical Center, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Nat Nanotechnol 5:833-42. 2010
    ..We also offer some perspectives on the yield and cost of RNA production...
  2. pmc Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics
    Dan Shu
    Nanobiomedical Center, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Nat Nanotechnol 6:658-67. 2011
    ..We studied 25 different three-way junction motifs in biological RNA and found only one other motif that shares characteristics similar to the three-way junction of phi29 pRNA...
  3. pmc Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging
    Jing Liu
    Nanobiomedical Center, SEEBME, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, United States
    ACS Nano 5:237-46. 2011
    ..Our results demonstrate that it is practical to produce RNase-resistant, biologically active, and stable RNA for application in nanotechnology...
  4. pmc Role of channel lysines and the "push through a one-way valve" mechanism of the viral DNA packaging motor
    Huaming Fang
    Nanobiomedical Center, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, Ohio, USA
    Biophys J 102:127-35. 2012
    ..The results support our recent findings regarding the dsDNA packaging mechanism known as the "push through a one-way valve"...
  5. pmc Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells
    Yi Shu
    Nanobiomedical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Methods 54:204-14. 2011
    ..25 of conventional 2'-F siRNA, and advantageous in vivo features such as non-toxicity, non-induction of interferons or non-stimulating of cytokine response in animals will also be reviewed...
  6. pmc Three reversible and controllable discrete steps of channel gating of a viral DNA packaging motor
    Jia Geng
    Nanobiomedical Center, SEEBME, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH 45267, USA
    Biomaterials 32:8234-42. 2011
    ..The step-wise conformational change of the channel was also reversible and controllable, making it an ideal nano-valve for constructing a nanomachine with potential applications in nanobiotechnology and nanomedicine...
  7. pmc Assembly of therapeutic pRNA-siRNA nanoparticles using bipartite approach
    Yi Shu
    Nanobiomedical Center, SEEBME, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Ther 19:1304-11. 2011
    ..The pRNA nanoparticles were subsequently processed by Dicer to release the siRNA embedded within the nanoparticles. The results will pave the way toward the treatment of diseases using synthetic pRNA/siRNA chimeric nanoparticles...
  8. doi request reprint Synthesis, conjugation, and labeling of multifunctional pRNA nanoparticles for specific delivery of siRNA, drugs, and other therapeutics to target cells
    Peixuan Guo
    Nanobiomedical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 928:197-219. 2012
    ....
  9. pmc Sequential action of ATPase, ATP, ADP, Pi and dsDNA in procapsid-free system to enlighten mechanism in viral dsDNA packaging
    Chad Schwartz
    The School of Environmental, Energy, Biological, and Medical Engineering SEEBME, Nanobiomedical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Nucleic Acids Res 40:2577-86. 2012
    ..Combination of the two distinct roles of gp16 and connector renews the perception of previous dsDNA packaging energy calculations and provides insight into the discrepancy between 2 and 2.5 bp per ATP...
  10. doi request reprint Formation of lipid bilayers inside microfluidic channel array for monitoring membrane-embedded nanopores of phi29 DNA packaging nanomotor
    Joon S Shim
    College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA
    Biomed Microdevices 14:921-8. 2012
    ....
  11. pmc Assembly mechanism of the sixty-subunit nanoparticles via interaction of RNA with the reengineered protein connector of phi29 DNA-packaging motor
    Feng Xiao
    Department of Biomedical Engineering, College of Engineering College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    ACS Nano 4:3293-301. 2010
    ....
  12. pmc Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers
    Pheruza Tarapore
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
    Mol Ther 19:386-94. 2011
    ..The pRNA system, which has the capability to assemble into multivalent nanoparticles, has immense promise as a highly potent therapeutic agent...
  13. pmc Dual-channel single-molecule fluorescence resonance energy transfer to establish distance parameters for RNA nanoparticles
    Dan Shu
    Nanobiomedical Center, College of Engineering and Applied Science College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, United States
    ACS Nano 4:6843-53. 2010
    ..Distances between nucleotides in pRNA dimers were found to be different from those of the dimers bound to procapsid, suggesting a conformational change of the pRNA dimer upon binding to the procapsid...
  14. pmc One-way traffic of a viral motor channel for double-stranded DNA translocation
    Peng Jing
    Nanobiomedical Center, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Nano Lett 10:3620-7. 2010
    ....
  15. pmc Engineering RNA for targeted siRNA delivery and medical application
    Peixuan Guo
    Department of Biomedical Engineering College of Engineering College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA
    Adv Drug Deliv Rev 62:650-66. 2010
    ....