Affiliation: University of California
Copeland J, Bosdet I, Freeman J, Guo M, Gorski S, Hay B. echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Dev Biol. 2007;7:82 pubmed
..Characterization of likely echinus null alleles and genetic interactions suggests that echinus acts at a novel point(s) to regulate interommatidial cell sorting and/or cell death in the fly eye. ..
Guo M, Hong E, Fernandes J, Zipursky S, Hay B. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum Mol Genet. 2003;12:2669-78 pubmed
..We have used these flies to carry out a screen for mutations that suppress gamma-secretase activity and have identified a small chromosomal region that contains a gene or genes whose products may promote gamma-secretase activity. ..
Yun J, Puri R, Yang H, Lizzio M, Wu C, Sheng Z, et al
. MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. elife. 2014;3:e01958 pubmed publisher
..The MUL1 pathway compensates for loss of PINK1/parkin in both Drosophila and mammals and is a promising therapeutic target for PD.DOI: http://dx.doi.org/10.7554/eLife.01958.001. ..
Dodson M, Leung L, Lone M, Lizzio M, Guo M. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis Model Mech. 2014;7:1351-63 pubmed publisher
..Collectively, our data provides compelling evidence of a vital role for lrrk in lysosomal function and endolysosomal membrane transport in vivo, and suggests a link between lrrk and retromer-mediated endosomal recycling. ..