Genomes and Genes


Feng Guo


Affiliation: University of California
Country: USA


  1. Barr I, Weitz S, Atkin T, Hsu P, Karayiorgou M, Gogos J, et al. Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chem Biol. 2015;22:793-802 pubmed publisher
    ..Co(III)PPIX is effective at concentrations as low as 0.2 μM and is not degraded by heme degradation enzymes, making it useful as a research tool and a potential therapeutic. ..
  2. Shoffner G, Wang R, Podell E, Cech T, Guo F. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure. 2018;: pubmed publisher
    ..In crystallo selection provides opportunities to improve crystals of RNAs or RNA-ligand complexes. Our results also suggest that mutants may be rationally designed for crystallization by "walking" a bulge along the RNA chain. ..
  3. Quick Cleveland J, Jacob J, Weitz S, Shoffner G, Senturia R, Guo F. The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Rep. 2014;7:1994-2005 pubmed publisher
    ..Our study reveals a unique protein-RNA interaction central to pri-miRNA recognition. We propose a unifying model in which two DGCR8 dimers clamp a pri-miRNA hairpin using their Rheds. ..