Affiliation: University of California
Barr I, Weitz S, Atkin T, Hsu P, Karayiorgou M, Gogos J, et al
. Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chem Biol. 2015;22:793-802 pubmed publisher
..Co(III)PPIX is effective at concentrations as low as 0.2Â Î¼M and is not degraded by heme degradation enzymes, making it useful as a research tool and a potential therapeutic. ..
Shoffner G, Wang R, Podell E, Cech T, Guo F. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure. 2018;: pubmed publisher
..In crystallo selection provides opportunities to improve crystals of RNAs or RNA-ligand complexes. Our results also suggest that mutants may be rationally designed for crystallization by "walking" a bulge along the RNA chain. ..
Quick Cleveland J, Jacob J, Weitz S, Shoffner G, Senturia R, Guo F. The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Rep. 2014;7:1994-2005 pubmed publisher
..Our study reveals a unique protein-RNA interaction central to pri-miRNA recognition. We propose a unifying model in which two DGCR8 dimers clamp a pri-miRNA hairpin using their Rheds. ..