Genomes and Genes
C B Gundersen
Affiliation: University of California
- Cysteine string proteins are associated with cortical granules of Xenopus laevis oocytesC B Gundersen
Department of Molecular and Medical Pharmacology and The Crump Institute for Biological Imaging, UCLA School of Medicine, Los Angeles, CA 90095, USA
Cell Tissue Res 303:211-9. 2001..Moreover, because of the relative ease of manipulating cells as large as Xenopus oocytes, this system harbors considerable promise as a model for studying the role of csps and other proteins in exocytotic events...
- Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesisCameron B Gundersen
Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
J Theor Biol 332:149-60. 2013..The relative simplicity of this model and its amenability to empirical testing provide a useful template for future investigations of the molecular events underlying the exocytotic cascade. ..
- Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brainCameron B Gundersen
the Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Brain Res 1332:1-11. 2010..Collectively, the enrichment of CSP-beta in synaptosomes and the association of CSP-beta with synaptic vesicles suggest that CSP-beta, like CSP-alpha, may be an important component of the regulated secretory machinery in mouse brain...
- A Xenopus cysteine string protein with a cysteine residue in the J domainA Mastrogiacomo
Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90095, USA
Biochim Biophys Acta 1401:239-41. 1998..Xcsp mRNA appears as a 4.6 kb species on Northern analysis, and immunoblot of Xenopus brain membranes reveals a single, 35 kDa Xcsp that can be deacylated, like other csps...
- Attenuated influx of calcium ions at nerve endings of csp and shibire mutant DrosophilaJ A Umbach
Department of Molecular and Medical Pharmacology and The Crump Institute for Biological Imaging, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Neurosci 18:3233-40. 1998..Thus, using two completely independent Drosophila mutants, we demonstrate that synaptic vesicles and csps are vital for the function of presynaptic Ca channels...
- Intrinsic membrane association of Drosophila cysteine string proteinsA Mastrogiacomo
Department of Molecular and Medical Pharmacology and Crump Institute for Biological Imaging, UCLA School of Medicine, Los Angeles, CA 90095, USA
FEBS Lett 436:85-91. 1998..Thus, we conclude that under physiological conditions csps are integral membrane proteins of secretory organelles, and that the cysteine string domain plays a vital role in the membrane association of these proteins...
- Evidence that cysteine string proteins regulate an early step in the Ca2+-dependent secretion of neurotransmitter at Drosophila neuromuscular junctionsJ A Umbach
Department of Molecular and Medical Pharmacology and The Crump Institute for Biological Imaging, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Neurosci 17:7203-9. 1997..In part, because of previous work showing that csps are important for the functional expression of N-type Ca channels in frog oocytes, we favor the idea that csps participate in a regulatory interaction involving presynaptic Ca channels...
- Electrospray-ionization mass spectrometry of intact intrinsic membrane proteinsJ P Whitelegge
Center for Molecular and Medical Sciences Mass Spectrometry, Department of Chemistry and Biochemistry, University of California, Los Angeles 90095 1569, USA
Protein Sci 7:1423-30. 1998..The apparent retention of structure by bacteriorhodopsin during the analysis raises the potential of obtaining tertiary structure information using more developed ESI-MS experiments...
- The nucleotide and deduced amino acid sequence of a rat cysteine string proteinA Mastrogiacomo
Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90024, USA
Brain Res Mol Brain Res 28:12-8. 1995..Moreover, like its Torpedo (fish) counterpart, it is extensively fatty acylated. It will be of considerable interest to ascertain the functional correlates of these cross-species similarities of cysteine string proteins...
- The DnaJ-like cysteine string protein and exocytotic neurotransmitter releaseE Buchner
Lehrstuhl fur Genetik, Biozentrum der Universitat, Wurzburg, Germany
Trends Neurosci 20:223-7. 1997..Here we try to integrate these observations into speculative functional models on the role of this new protein family in synaptic vesicle exocytosis...
- Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter releaseM Saitoe
Institute for Behavioral Sciences, Gunma University School of Medicine, Maebashi, Gunma 371 8511, Japan
Science 293:514-7. 2001..Thus, spontaneous vesicle exocytosis appears to be tightly linked to the clustering of glutamate receptors during development...
- Presynaptic dysfunction in Drosophila csp mutantsJ A Umbach
Department of Molecular and Medical Pharmacology School of Medicine, University of California, Los Angeles 90024
Neuron 13:899-907. 1994..This disruption explains the cellular basis of the temperature-sensitive paralysis of these organisms...