Research Topics
| A A Leslie GunatilakaSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosumBharat P Bashyal
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA
J Nat Prod 68:724-8. 2005..Only globosumones A (1) and B (2) were found to be moderately active...
Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrenceA A Leslie Gunatilaka
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, Tucson, 85706 6800, USA
J Nat Prod 69:509-26. 2006..Some significant biological and ecological implications of their occurrence are also reviewed...
Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran DesertE M Kithsiri Wijeratne
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
J Nat Prod 71:218-22. 2008..When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines...- Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analoguesE M Kithsiri Wijeratne
SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
J Nat Prod 75:361-9. 2012.... - Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159Yuquan Xu
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706 6800, USA
J Nat Prod 70:1467-71. 2007..Replacement of one, two, or all three N-methyl-L-phenylalanine residues of beauvericin with N-methyl-L-3-fluorophenylalanine moieties (beauvericins H(1-3), compounds 5-7) increased cytotoxicity without affecting antihaptotactic activity... - Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversiiShuhao Wang
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
Chem Biol 15:1328-38. 2008..chiversii radicicol locus yields dechloro-radicicol (monocillin I). Inactivation of a cytochrome P450 epoxidase furnishes pochonin D, a deepoxy-dihydro radicicol analog... - Maximizing chemical diversity of fungal metabolites: biogenetically related Heptaketides of the endolichenic fungus Corynespora sp. (1)E M Kithsiri Wijeratne
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
J Nat Prod 73:1156-9. 2010..The structures of all new compounds were determined by interpretation of their spectroscopic data and chemical interconversions... - Smardaesidins A-G, isopimarane and 20-nor-isopimarane diterpenoids from Smardaea sp., a fungal endophyte of the moss Ceratodon purpureusXiao Ning Wang
SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, United States
J Nat Prod 74:2052-61. 2011..More importantly, sphaeropsidin A (8) showed cell-type selectivity in the cytotoxicity assay and inhibited migration of metastatic breast adenocarcinoma (MDA-MB-231) cells at subcytotoxic concentrations... - Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporumJixun Zhan
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706 6800, USA
J Nat Prod 70:227-32. 2007..Interestingly, 6-deoxybikaverin (7) was completely devoid of activity, suggesting the requirement of the C-6 hydroxy group of bikaverin for its cytotoxic activity... - Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1)Ya ming Xu
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, AZ 85706 6800, USA
J Nat Prod 70:2045-8. 2007..All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M... - Heptaketides from Corynespora sp. inhabiting the cavern beard lichen, Usnea cavernosa: first report of metabolites of an endolichenic fungusPriyani A Paranagama
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
J Nat Prod 70:1700-5. 2007..Dehydroherbarin (5) inhibited migration of both cell lines at concentrations not toxic to these cell lines. This is the first report of metabolites from an endolichenic fungus... - A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activityE M Kithsiri Wijeratne
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA
Bioorg Med Chem 14:7917-23. 2006.... - 2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somniferaYa ming Xu
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706, USA
Bioorg Med Chem 17:2210-4. 2009.... - Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversiiPriyani A Paranagama
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, AZ 85706 6800, USA
J Nat Prod 70:1939-45. 2007..Compounds 1- 7 and 12 were evaluated for their potential to inhibit Hsp90 and antiproliferative activity toward the cancer cell lines NCI-H460, MCF-7, and SF-268. Only compounds 6, 7, and 8 exhibited significant activity in both assays... - Biomimetic conversion of (-)-fusoxypyridone and (-)-oxysporidinone to (-)-sambutoxin: further evidence for the structure of the tricyclic pyridone alkaloid, (-)-fusoxypyridoneE M Kithsiri Wijeratne
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
Bioorg Med Chem Lett 21:2327-9. 2011..Oxidation of 4 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) yielded a hitherto unknown sambutoxin analogue, (-)-4,2'-anhydrosambutoxin (5)... - Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassianaYuquan Xu
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
Chem Biol 15:898-907. 2008..Comparative infection assays with a BbBEAS knockout B. bassiana strain against three insect hosts revealed that beauvericin plays a highly significant but not indispensable role in virulence... - Microbial transformations of aryltetralone and aryltetralin lignans by Cunninghamella echinulata and Beauveria bassianaGisele B Messiano
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, United States
J Nat Prod 73:1933-7. 2010..The structures of all new compounds were established by detailed analysis of their spectroscopic data... - Characterization of the Biosynthetic Genes for 10,11-Dehydrocurvularin, a Heat Shock Response-Modulating Anticancer Fungal Polyketide from Aspergillus terreusYuquan Xu
Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA
Appl Environ Microbiol 79:2038-47. 2013.... - Combinatorial mutasynthesis of scrambled beauvericins, cyclooligomer depsipeptide cell migration inhibitors from Beauveria bassianaYuquan Xu
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Rd, Tucson, AZ 85706 6800, USA
Chembiochem 10:345-54. 2009..The effects of the introduced structural changes on the antiproliferative and cell migration inhibitory activities of these analogues were evaluated... - Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandifloraBharat P Bashyal
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA
J Nat Prod 69:1820-2. 2006..All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity... - Biomimetic synthesis of xuxuarines Ealpha and Ebeta: structure revision of Rzedowskia bistriterpenoidsNeil E Jacobsen
Department of Chemistry, College of Arts and Sciences, The University of Arizona, Tucson, AZ 85721, USA
Bioorg Med Chem 16:1884-9. 2008..Complete 1H, and 13C NMR spectral assignments of xuxuarines Ealpha and Ebeta have been made by the application of 1D and 2D NMR techniques... - Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensisJixun Zhan
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706 6800, USA
Phytochemistry 68:368-72. 2007.... - Microbial metabolism of 1-aminoanthracene by Beauveria bassianaJixun Zhan
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706 6800, USA
Bioorg Med Chem 16:5085-9. 2008..Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation... - Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierreiSong Gao
Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
J Nat Prod 74:852-6. 2011..Pierreiones A (1) and B (2) demonstrated solid tumor selectivity with minimal cytotoxicity, while pierreione C (3) exhibited no activity... - Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desertThomas J Turbyville
SW Center for Natural Products Research and Commercialization, University of Arizona, Tucson, Arizona 85706-6800, USA
J Nat Prod 69:178-84. 2006..Isolation of radicicol and monocillin I in this study provides evidence that we have developed an effective strategy for discovering natural product-based Hsp90 inhibitors with potential anticancer activity... - Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159Jixun Zhan
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706-6800, USA
J Nat Prod 69:1525-7. 2006..The efficiency of these conversions suggests that microbial biotransformation reactions offer an attractive alternative to chemical 4'-O-methyl-glucosylation of amino- and hydroxyanthraquinones... - Unusual withanolides from aeroponically grown Withania somniferaYa ming Xu
SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
Phytochemistry 72:518-22. 2011..Reaction of withaferin A with uracil afforded 1 and its epimer, 3β-(uracil-1-yl)-2,3-dihydrowithaferin A (4). The structures of these compounds were elucidated on the basis of their high resolution mass and NMR spectroscopic data... - Microbial transformation of curvularinJixun Zhan
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706-6800, USA
J Nat Prod 68:1271-3. 2005..bassiana ATCC 7159 without any added substrate suggested that hydroxylase, glucosyl transferase, and methylase are constitutive enzymes of this organism... - Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran DesertGuang-Xiong Zhou
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA
J Nat Prod 67:328-32. 2004..All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity... - Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPESLinda C Meade-Tollin
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA
J Nat Prod 67:2-4. 2004.... - Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plantsJian He
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
J Nat Prod 67:1985-91. 2004..Compounds 4 and 5 displayed considerable cytotoxicity, whereas 1, 6, 9, and 14 were found to be moderately active, with 6 and 9 exhibiting selective cytotoxicity against cancer cell lines compared with the normal fibroblast cells... - Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran DesertE M Kithsiri Wijeratne
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA
J Nat Prod 66:1567-73. 2003..A pathway for the biosynthetic origin of asterredione (1) from asterriquinone D (7) is proposed... - 1H and 13C NMR signal assignments of a novel Baeyer-Villiger originated diterpene lactoneHenriete S Vieira
, , Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, CEP 31270-901, Belo Horizonte, MG, Brazil
Magn Reson Chem 44:146-50. 2006..The complete 1H and 13C NMR assignment is presented for this novel compound that showed discrete in vitro antibacterial activity... - Efficient purification of the biosurfactant viscosin from Pseudomonas libanensis strain M9-3 and its physicochemical and biological propertiesHarvinder S Saini
Department of Microbiology, Guru Nanak Dev University, Amritsar 143005, Punjab, India
J Nat Prod 71:1011-5. 2008..Viscosin inhibited migration of the metastatic prostate cancer cell line, PC-3M, without visible toxicity. These properties suggest the potential of viscosin in environmental and biomedical applications... - A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitorCatherine A McLellan
FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
Plant Physiol 145:174-82. 2007..Finally, cocultivation of P. quadriseptata with Arabidopsis enhanced plant heat stress tolerance. These data demonstrate that HSP90-inhibitory compounds produced by fungi can influence plant growth and responses to the environment...
Research Grants
- Anticancer Agents from Plant- and Lichen-Associated Fungi of the Sonoran DesertLeslie Gunatilaka; Fiscal Year: 2010....
- Anticancer Agents from Endophytic Fungi of Desert PlantsLeslie Gunatilaka; Fiscal Year: 2006....
- Anticancer Agents from Plant- and Lichen-Associated Fungi of the Sonoran DesertLeslie Gunatilaka; Fiscal Year: 2009....