Research Topics
Species | John G GumsSummaryAffiliation: University of Florida Country: USA Publications
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Publications
Optimal pharmacological therapy for community-acquired pneumonia: the role of dual antibacterial therapyBenjamin J Epstein
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, Florida 32601, USA
Drugs 65:1949-71. 2005..In light of the available evidence, dual therapy should be strongly considered in all patients with severe CAP, especially when complicated by pneumococcal bacteraemia...
Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure responseStephen T Turner
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Transl Med 10:47. 2012....- Differences between ceftriaxone and cefotaxime: microbiological inconsistenciesJohn G Gums
Department of Pharmacy Practice, University of Florida, Gainesville, FL 32601, USA
Ann Pharmacother 42:71-9. 2008..To review data to determine why pneumococcal isolates appear to be increasingly resistant to cefotaxime, historically regarded as having the same in vitro susceptibility to ceftriaxone, and what this observation might imply clinically... - Oseltamivir and influenza-related complications, hospitalization and healthcare expenditure in healthy adults and childrenJohn G Gums
Department of Pharmacy Practice, University of Florida, Gainesville, Florida 32601, USA
Expert Opin Pharmacother 9:151-61. 2008..To assess influenza-related secondary complications and healthcare use and costs in patients prescribed oseltamivir for influenza... - G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertensionAlexander G Vandell
Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida College of Pharmacy, 1600 SW Archer Rd, Room PG 22, Box 100486, Gainesville, FL 32610 0486, USA
Hypertension 60:957-64. 2012..The associations with GRK4 variant alleles were stronger in patients who were also ADRB1 389R homozygotes, suggesting a potential interaction between these 2 genes... - Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazideJulio D Duarte
Center for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
J Transl Med 10:56. 2012..This study aimed to determine the role of variation in these regulatory genes on blood pressure response to HCTZ, and secondarily, untreated blood pressure... 
Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diureticsCaitrin W McDonough
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, Florida 32610 0486, USA
J Hypertens 31:698-704. 2013..We sought to further evaluate associations between NEDD4L polymorphisms, blood pressure response and cardiovascular outcomes with thiazide diuretics and β-blockers...- Lack of correlation between thiazide-induced hyperglycemia and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) studySteven M Smith
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA
Pharmacotherapy 29:1157-65. 2009..To determine whether changes in serum glucose, serum potassium, and plasma insulin levels are correlated in a cohort of hypertensive patients... - Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patientsMaximilian T Lobmeyer
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
Pharmacogenet Genomics 21:42-9. 2011.... - Hypertension susceptibility Loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses studyYan Gong
Department of Pharmacotherapy and Translational Research
Circ Cardiovasc Genet 5:686-91. 2012..Clinical Trial Registration Information- clinicaltrials.gov; Identifier: NCT00246519... - Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individualsMyphuong T Le
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA
PLoS ONE 8:e52062. 2013.... - Lack of association between polymorphisms in STK39, a putative thiazide response gene, and blood pressure response to hydrochlorothiazideJulio D Duarte
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida 32610, USA
Pharmacogenet Genomics 20:516-9. 2010..These data suggest that common variants in STK39 likely do not have a clinically relevant role in blood pressure response to HCTZ in hypertensives... - Ceftobiprole: an extended-spectrum anti-methicillin-resistant Staphylococcus aureus cephalosporinShawn D Anderson
Departments of Pharmacy Practice and Family Medicine, University of Florida, Gainesville, FL 32601, USA
Ann Pharmacother 42:806-16. 2008..To summarize and evaluate the literature concerning ceftobiprole... - Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertensionMohamed Shafiu
College of Pharmacy and Center for Pharmacogenomics, University of Florida, Gainesville, Fla, USA mshafiu rapadocs com
Kidney Blood Press Res 35:477-82. 2012..URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects... - Assessing the impact of antimicrobial resistanceJohn G Gums
Departments of Pharmacy Practice and Family Medicine, University of Florida, 625 Southwest Fourth Avenue, Gainesville, FL 32601, USA
Am J Health Syst Pharm 59:S4-6. 2002..Analysis of susceptibility and resistance patterns of specific microorganisms is necessary to gain further insight into the causes of antimicrobial resistance and ways to reduce it... - Tezosentan in the treatment of acute heart failureJohn M Tovar
Departments of Pharmacy Practice and Family Medicine, University of Florida, Gainesville, FL, USA
Ann Pharmacother 37:1877-83. 2003..To evaluate the pharmacology, pharmacokinetics, clinical efficacy, and tolerability of tezosentan, a new intravenous endothelin (ET)-1 receptor antagonist... - Monitoring pulmonary function in asthma and COPD: point-of-care testingJohn M Tovar
Department of Pharmacy Practice, University of Florida, Gainesville, FL 32601, USA
Ann Pharmacother 38:126-33. 2004..To provide pharmacists and other healthcare providers with a better understanding of new monitoring technologies for asthma and chronic obstructive pulmonary disease (COPD) available to clinics and pharmacies... - Magnesium in cardiovascular and other disordersJohn G Gums
Department of Pharmacy Practice and Community Health and Family Medicine, University of Florida, Gainesville, FL 32601, USA
Am J Health Syst Pharm 61:1569-76. 2004..The physiological role and metabolism of magnesium, the causes of magnesium deficiency, clinical data on the benefits of magnesium supplementation, and the management of magnesium deficiency are discussed... - Antivirals for influenza: strategies for use in pediatricsSteven M Smith
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA
Paediatr Drugs 12:285-99. 2010.... - Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disordersSteven M Smith
University of Florida, Colleges of Pharmacy and Medicine, Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, Gainesville, FL 32610 0486, USA
Expert Opin Drug Metab Toxicol 5:813-22. 2009..Fexofenadine is one of several second-generation H(1)-antihistamines approved for the treatment of various allergic disorders; however, it shows numerous unique properties that make it an optimal choice for many patients... - Antimicrobial resistance in 11 hospitals in Puerto Rico: results of an antimicrobial resistance management (ARM) programJohn G Gums
University of Florida, Gainesville, Florida 32601, USA
P R Health Sci J 26:181-9. 2007.... - The changing face of antibiotic prescribing: the mutant selection windowBenjamin J Epstein
Internal Medicine Resident, North Florida South Georgia Veterans Affairs Health System, Gainesville, FL, USA
Ann Pharmacother 38:1675-82. 2004..To describe the mutant selection window, discuss supporting evidence and limitations, and suggest potential applications for clinical practice... - Can the renin-angiotensin system protect against stroke? A focus on angiotensin II receptor blockersBenjamin J Epstein
Department of Pharmacy Practice, College of Pharmacy, College of Medicine, University of Florida, Gainesville, Florida, USA
Pharmacotherapy 25:531-9. 2005.... - Impact of abdominal obesity on incidence of adverse metabolic effects associated with antihypertensive medicationsRhonda M Cooper-Dehoff
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, 1600 SW Archer Rd, Box 100486, Gainesville, FL 32610 0486, USA
Hypertension 55:61-8. 2010..19 [95% CI: 1.35 to 7.52]). Development of adverse metabolic effect, including new-onset diabetes mellitus associated with short-term exposure to hydrochlorothiazide and atenolol was more common in those with abdominal obesity... - Dabigatran etexilate: a novel oral thrombin inhibitor for thromboembolic diseaseJessica A Bovio
University of Florida, Gainesville, FL, USA
Ann Pharmacother 45:603-14. 2011.... - Newer agents for the management of overactive bladderBenjamin J Epstein
University of Florida, Gainesville, Florida, USA
Am Fam Physician 74:2061-8. 2006..Important pharmacokinetic differences among the agents (e.g., route of elimination) allow for selection of an appropriate agent based on individual factors such as cost and tolerability... - NCCLS perspectives in changing susceptibility breakpoints for antimicrobial drugsJohn G Gums
College of Pharmacy and Medicine, Departments of Pharmacy Practice and Community Health and Family Medicine, University of Florida, Gainesville, Florida, USA
Int J Antimicrob Agents 22:S3-13; discussion S25-6. 2003..The excellent pharmacokinetic and pharmacodynamic properties of these agents are believed to contribute to their good activity in the clinic... - Angiotensin receptor blockers versus ACE inhibitors: prevention of death and myocardial infarction in high-risk populationsBenjamin J Epstein
Department of Pharmacy Practice, College of Pharmacy, University of Florida, 625 SW 4th Avenue, Gainesville, FL 32601 6430, USA
Ann Pharmacother 39:470-80. 2005.... - Redefining appropriate use of antibioticsJohn G Gums
Am Fam Physician 69:35, 39-40. 2004 - Formation of a primary care pharmacist practice-based research networkLori M Dickerson
Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29406, USA
Am J Health Syst Pharm 64:2044-9. 2007....