John G Gums

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Optimal pharmacological therapy for community-acquired pneumonia: the role of dual antibacterial therapy
    Benjamin J Epstein
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, Florida 32601, USA
    Drugs 65:1949-71. 2005
  2. pmc Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 10:47. 2012
  3. ncbi request reprint Oseltamivir and influenza-related complications, hospitalization and healthcare expenditure in healthy adults and children
    John G Gums
    Department of Pharmacy Practice, University of Florida, Gainesville, Florida 32601, USA
    Expert Opin Pharmacother 9:151-61. 2008
  4. ncbi request reprint Differences between ceftriaxone and cefotaxime: microbiological inconsistencies
    John G Gums
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32601, USA
    Ann Pharmacother 42:71-9. 2008
  5. pmc Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study
    Yan Gong
    Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, 32610, USA
    Circ Cardiovasc Genet 5:686-91. 2012
  6. pmc G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension
    Alexander G Vandell
    Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida College of Pharmacy, 1600 SW Archer Rd, Room PG 22, Box 100486, Gainesville, FL 32610 0486, USA
    Hypertension 60:957-64. 2012
  7. pmc Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
    Julio D Duarte
    Center for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 10:56. 2012
  8. pmc Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals
    Myphuong T Le
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    PLoS ONE 8:e52062. 2013
  9. pmc Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics
    Caitrin W McDonough
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, Florida 32610 0486, USA
    J Hypertens 31:698-704. 2013
  10. pmc Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients
    Maximilian T Lobmeyer
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    Pharmacogenet Genomics 21:42-9. 2011

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Optimal pharmacological therapy for community-acquired pneumonia: the role of dual antibacterial therapy
    Benjamin J Epstein
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, Florida 32601, USA
    Drugs 65:1949-71. 2005
    ..In light of the available evidence, dual therapy should be strongly considered in all patients with severe CAP, especially when complicated by pneumococcal bacteraemia...
  2. pmc Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 10:47. 2012
    ....
  3. ncbi request reprint Oseltamivir and influenza-related complications, hospitalization and healthcare expenditure in healthy adults and children
    John G Gums
    Department of Pharmacy Practice, University of Florida, Gainesville, Florida 32601, USA
    Expert Opin Pharmacother 9:151-61. 2008
    ..To assess influenza-related secondary complications and healthcare use and costs in patients prescribed oseltamivir for influenza...
  4. ncbi request reprint Differences between ceftriaxone and cefotaxime: microbiological inconsistencies
    John G Gums
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32601, USA
    Ann Pharmacother 42:71-9. 2008
    ..To review data to determine why pneumococcal isolates appear to be increasingly resistant to cefotaxime, historically regarded as having the same in vitro susceptibility to ceftriaxone, and what this observation might imply clinically...
  5. pmc Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study
    Yan Gong
    Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, 32610, USA
    Circ Cardiovasc Genet 5:686-91. 2012
    ..Our hypothesis is that the loci/SNPs associated with BP/hypertension are also associated with BP response to antihypertensive drugs...
  6. pmc G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension
    Alexander G Vandell
    Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida College of Pharmacy, 1600 SW Archer Rd, Room PG 22, Box 100486, Gainesville, FL 32610 0486, USA
    Hypertension 60:957-64. 2012
    ..The associations with GRK4 variant alleles were stronger in patients who were also ADRB1 389R homozygotes, suggesting a potential interaction between these 2 genes...
  7. pmc Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
    Julio D Duarte
    Center for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 10:56. 2012
    ..This study aimed to determine the role of variation in these regulatory genes on blood pressure response to HCTZ, and secondarily, untreated blood pressure...
  8. pmc Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals
    Myphuong T Le
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    PLoS ONE 8:e52062. 2013
    ....
  9. pmc Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics
    Caitrin W McDonough
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, Florida 32610 0486, USA
    J Hypertens 31:698-704. 2013
    ..We sought to further evaluate associations between NEDD4L polymorphisms, blood pressure response and cardiovascular outcomes with thiazide diuretics and β-blockers...
  10. pmc Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients
    Maximilian T Lobmeyer
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    Pharmacogenet Genomics 21:42-9. 2011
    ....
  11. pmc Lack of correlation between thiazide-induced hyperglycemia and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study
    Steven M Smith
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    Pharmacotherapy 29:1157-65. 2009
    ..To determine whether changes in serum glucose, serum potassium, and plasma insulin levels are correlated in a cohort of hypertensive patients...
  12. pmc Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study
    Caitrin W McDonough
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, Florida, United States of America
    PLoS ONE 8:e76984. 2013
    ..0279). In conclusion, we identified multiple gene regions associated with atenolol induced HDL-C change that were consistent across race groups, several with functional implications or prior associations with HDL-C. ..
  13. pmc PROX1 Gene Variant is Associated with Fasting Glucose Change After Antihypertensive Treatment
    Yan Gong
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, Florida
    Pharmacotherapy 34:123-30. 2014
    ....
  14. pmc Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension
    Mohamed Shafiu
    College of Pharmacy and Center for Pharmacogenomics, University of Florida, Gainesville, Fla, USA mshafiu rapadocs com
    Kidney Blood Press Res 35:477-82. 2012
    ..URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects...
  15. pmc Lack of association between polymorphisms in STK39, a putative thiazide response gene, and blood pressure response to hydrochlorothiazide
    Julio D Duarte
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida 32610, USA
    Pharmacogenet Genomics 20:516-9. 2010
    ..These data suggest that common variants in STK39 likely do not have a clinically relevant role in blood pressure response to HCTZ in hypertensives...
  16. doi request reprint Ceftobiprole: an extended-spectrum anti-methicillin-resistant Staphylococcus aureus cephalosporin
    Shawn D Anderson
    Departments of Pharmacy Practice and Family Medicine, University of Florida, Gainesville, FL 32601, USA
    Ann Pharmacother 42:806-16. 2008
    ..To summarize and evaluate the literature concerning ceftobiprole...
  17. pmc Baseline predictors of central aortic blood pressure: a PEAR substudy
    Rebecca F Rosenwasser
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA Electronic address
    J Am Soc Hypertens 8:152-8. 2014
    ..These relationships should be considered in future studies to improve assessment of BP to reduce cardiovascular risk and mortality. ..
  18. ncbi request reprint Antivirals for influenza: strategies for use in pediatrics
    Steven M Smith
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    Paediatr Drugs 12:285-99. 2010
    ....
  19. ncbi request reprint Assessing the impact of antimicrobial resistance
    John G Gums
    Departments of Pharmacy Practice and Family Medicine, University of Florida, 625 Southwest Fourth Avenue, Gainesville, FL 32601, USA
    Am J Health Syst Pharm 59:S4-6. 2002
    ..Analysis of susceptibility and resistance patterns of specific microorganisms is necessary to gain further insight into the causes of antimicrobial resistance and ways to reduce it...
  20. ncbi request reprint Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders
    Steven M Smith
    University of Florida, Colleges of Pharmacy and Medicine, Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, Gainesville, FL 32610 0486, USA
    Expert Opin Drug Metab Toxicol 5:813-22. 2009
    ..Fexofenadine is one of several second-generation H(1)-antihistamines approved for the treatment of various allergic disorders; however, it shows numerous unique properties that make it an optimal choice for many patients...
  21. ncbi request reprint Tezosentan in the treatment of acute heart failure
    John M Tovar
    Departments of Pharmacy Practice and Family Medicine, University of Florida, Gainesville, FL, USA
    Ann Pharmacother 37:1877-83. 2003
    ..To evaluate the pharmacology, pharmacokinetics, clinical efficacy, and tolerability of tezosentan, a new intravenous endothelin (ET)-1 receptor antagonist...
  22. ncbi request reprint Monitoring pulmonary function in asthma and COPD: point-of-care testing
    John M Tovar
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32601, USA
    Ann Pharmacother 38:126-33. 2004
    ..To provide pharmacists and other healthcare providers with a better understanding of new monitoring technologies for asthma and chronic obstructive pulmonary disease (COPD) available to clinics and pharmacies...
  23. ncbi request reprint Magnesium in cardiovascular and other disorders
    John G Gums
    Department of Pharmacy Practice and Community Health and Family Medicine, University of Florida, Gainesville, FL 32601, USA
    Am J Health Syst Pharm 61:1569-76. 2004
    ..The physiological role and metabolism of magnesium, the causes of magnesium deficiency, clinical data on the benefits of magnesium supplementation, and the management of magnesium deficiency are discussed...
  24. ncbi request reprint The changing face of antibiotic prescribing: the mutant selection window
    Benjamin J Epstein
    Internal Medicine Resident, North Florida South Georgia Veterans Affairs Health System, Gainesville, FL, USA
    Ann Pharmacother 38:1675-82. 2004
    ..To describe the mutant selection window, discuss supporting evidence and limitations, and suggest potential applications for clinical practice...
  25. pmc Impact of abdominal obesity on incidence of adverse metabolic effects associated with antihypertensive medications
    Rhonda M Cooper-Dehoff
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, 1600 SW Archer Rd, Box 100486, Gainesville, FL 32610 0486, USA
    Hypertension 55:61-8. 2010
    ..19 [95% CI: 1.35 to 7.52]). Development of adverse metabolic effect, including new-onset diabetes mellitus associated with short-term exposure to hydrochlorothiazide and atenolol was more common in those with abdominal obesity...
  26. ncbi request reprint Can the renin-angiotensin system protect against stroke? A focus on angiotensin II receptor blockers
    Benjamin J Epstein
    Department of Pharmacy Practice, College of Pharmacy, College of Medicine, University of Florida, Gainesville, Florida, USA
    Pharmacotherapy 25:531-9. 2005
    ....
  27. ncbi request reprint Antimicrobial resistance in 11 hospitals in Puerto Rico: results of an antimicrobial resistance management (ARM) program
    John G Gums
    University of Florida, Gainesville, Florida 32601, USA
    P R Health Sci J 26:181-9. 2007
    ....
  28. ncbi request reprint Newer agents for the management of overactive bladder
    Benjamin J Epstein
    University of Florida, Gainesville, Florida, USA
    Am Fam Physician 74:2061-8. 2006
    ..Important pharmacokinetic differences among the agents (e.g., route of elimination) allow for selection of an appropriate agent based on individual factors such as cost and tolerability...
  29. doi request reprint Dabigatran etexilate: a novel oral thrombin inhibitor for thromboembolic disease
    Jessica A Bovio
    University of Florida, Gainesville, FL, USA
    Ann Pharmacother 45:603-14. 2011
    ....
  30. ncbi request reprint NCCLS perspectives in changing susceptibility breakpoints for antimicrobial drugs
    John G Gums
    College of Pharmacy and Medicine, Departments of Pharmacy Practice and Community Health and Family Medicine, University of Florida, Gainesville, Florida, USA
    Int J Antimicrob Agents 22:S3-13; discussion S25-6. 2003
    ..The excellent pharmacokinetic and pharmacodynamic properties of these agents are believed to contribute to their good activity in the clinic...
  31. ncbi request reprint Angiotensin receptor blockers versus ACE inhibitors: prevention of death and myocardial infarction in high-risk populations
    Benjamin J Epstein
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, 625 SW 4th Avenue, Gainesville, FL 32601 6430, USA
    Ann Pharmacother 39:470-80. 2005
    ....
  32. ncbi request reprint Formation of a primary care pharmacist practice-based research network
    Lori M Dickerson
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29406, USA
    Am J Health Syst Pharm 64:2044-9. 2007
    ....
  33. ncbi request reprint Redefining appropriate use of antibiotics
    John G Gums
    Am Fam Physician 69:35, 39-40. 2004