Barry M Gumbiner

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    PLoS ONE 4:e8411. 2009
  2. pmc Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Cell Biol 174:301-13. 2006
  3. pmc Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
    Alice S T Wong
    Dept of Cell Biology, School of Medicine, University of Virginia, PO Box 800732, Charlottesville, VA 22903, USA
    J Cell Biol 161:1191-203. 2003
  4. ncbi request reprint Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
  5. pmc Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes
    Cara J Gottardi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 167:339-49. 2004
  6. ncbi request reprint Structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:32128-37. 2007
  7. pmc Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion
    Yuliya I Petrova
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Biol Cell 23:2092-108. 2012
  8. pmc Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network
    Paul Skoglund
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Development 135:2435-44. 2008
  9. pmc E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
    Nam Gyun Kim
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:11930-5. 2011
  10. pmc Axial protocadherin (AXPC) regulates cell fate during notochordal morphogenesis
    Michael D Yoder
    Department of Cell Biology, School of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Dev Dyn 240:2495-504. 2011

Research Grants

  1. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry M Gumbiner; Fiscal Year: 2010
  2. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2009
  3. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2007
  4. CATENIN AND CADHERIN SIGNALING IN DEVELOPMENT AND CANCER
    Barry Gumbiner; Fiscal Year: 2007
  5. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2006
  6. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2005
  7. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2004
  8. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2003
  9. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2002
  10. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2001

Collaborators

Detail Information

Publications29

  1. pmc A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    PLoS ONE 4:e8411. 2009
    ..Paraxial protocadherin (PAPC) and fibronectin leucine-rich domain transmembrane protein-3 (FLRT3) are induced by TGFbeta signaling in Xenopus embryos and both regulate morphogenesis by inhibiting C-cadherin mediated cell adhesion...
  2. pmc Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Cell Biol 174:301-13. 2006
    ..Thus, spatial regulation of classical cadherin adhesive function by local expression of a protocadherin is a novel mechanism for controlling cell sorting and tissue morphogenesis...
  3. pmc Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
    Alice S T Wong
    Dept of Cell Biology, School of Medicine, University of Virginia, PO Box 800732, Charlottesville, VA 22903, USA
    J Cell Biol 161:1191-203. 2003
    ..However, alteration in the beta-catenin/TCF transcriptional regulation of target genes is not required for the invasion suppressor activity of E-cadherin, suggesting the involvement of other beta-catenin-binding proteins...
  4. ncbi request reprint Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
    ..Signal-transduction pathways impinge on the catenins (cytoplasmic cadherin-associated proteins), which transduce changes across the membrane to alter the state of the cadherin adhesive bond...
  5. pmc Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes
    Cara J Gottardi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 167:339-49. 2004
    ..This model explains how cells can control whether beta-catenin is used independently in cell adhesion and nuclear signaling, or competitively so that the two processes are coordinated and interrelated...
  6. ncbi request reprint Structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:32128-37. 2007
    ..Therefore, protein oligomerization and/or protein interactions via the extracellular and transmembrane domains of PAPC are required for its cell sorting function...
  7. pmc Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion
    Yuliya I Petrova
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Biol Cell 23:2092-108. 2012
    ....
  8. pmc Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network
    Paul Skoglund
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Development 135:2435-44. 2008
    ..These findings bridge the gap between a molecular-scale motor protein and tissue-scale embryonic morphogenesis...
  9. pmc E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
    Nam Gyun Kim
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:11930-5. 2011
    ..Therefore, Our results indicate that, in addition to its role in cell-cell adhesion, E-cadherin-mediated cell-cell contact directly regulates the Hippo signaling pathway to control cell proliferation...
  10. pmc Axial protocadherin (AXPC) regulates cell fate during notochordal morphogenesis
    Michael D Yoder
    Department of Cell Biology, School of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Dev Dyn 240:2495-504. 2011
    ..The results presented here show that AXPC functions in notochord morphogenesis by directing cell-fate decisions rather than cell-cell adhesion...
  11. pmc The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
    Yi Qin
    Center for Cell Signaling, Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 171:1061-71. 2005
    ..These results suggest that Scrib stabilizes the coupling between E-cadherin and the catenins and are consistent with the idea that mammalian Scrib could behave as a tumor suppressor by regulating epithelial cell adhesion and migration...
  12. pmc Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1
    Run Fan
    University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 110:2569-74. 2013
    ..These findings show that an important activity of mitogenic signaling pathways is to inactivate the growth-inhibitory Hippo pathway and provide a mechanism for antagonism between contact inhibition and growth factor action...
  13. ncbi request reprint Cadherin conformations associated with dimerization and adhesion
    Hitomi Tsuiji
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    J Biol Chem 282:12871-82. 2007
    ..Thus, the EC2-EC5 domains either reflect, or are involved in, cadherin dimerization and organization at the cell surface...
  14. pmc Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, PO Box 800732, Charlottesville, VA 22908, USA
    Dev Biol 366:232-43. 2012
    ..These findings suggest that the de-epithelialization step of the neural crest EMT by cadherin-6B/BMPRII involves regulation of actin dynamics via LIMK/cofilin...
  15. ncbi request reprint Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions
    Cara J Gottardi
    Department of Cell Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908 0732, USA
    Am J Physiol Cell Physiol 286:C747-56. 2004
    ....
  16. ncbi request reprint Coordinate gene regulation by two different catenins
    Barry M Gumbiner
    Department of Cell Biology, School of Medicine, University of Virginia, Post Office Box 800732, Charlottesville, Virginia 22908, USA
    Dev Cell 8:795-6. 2005
    ..These findings raise the exciting possibility that these two related proteins function in parallel to mediate cadherin-associated regulation of gene expression...
  17. pmc E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions
    Michael Perrais
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    Mol Biol Cell 18:2013-25. 2007
    ..Thus, E-cadherin homophilic binding independent of other cell contacts directly transduces growth inhibition by a beta-catenin-dependent mechanism that inhibits selective signaling functions of growth factor receptors...
  18. pmc Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Development 137:2691-701. 2010
    ..Thus, the overall EMT of neural crest cells occurs via two distinct steps: a cadherin 6B and BMP signaling-mediated de-epithelialization, and a subsequent delamination through the basement membrane...
  19. pmc Regulation of protein stability by GSK3 mediated phosphorylation
    Chong Xu
    Graduate Program of Molecular, Cellular and Developmental Biology, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 8:4032-9. 2009
    ..We propose that GSK3 phosphorylation dependent proteolysis is a widespread mechanism that the cell employs to regulate a variety of cell processes in response to signals...
  20. pmc Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein
    Sreekala Mahadevaiyer
    Department of Cell Biology, University of Virginia Health Sciences Center, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Biochim Biophys Acta 1773:120-30. 2007
    ....
  21. pmc Identification of targets of the Wnt pathway destruction complex in addition to beta-catenin
    Nam Gyun Kim
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 106:5165-70. 2009
    ..Thus, we propose that Wnt/GSK3/destruction complex signaling regulates multiple target proteins to control a broad range of cellular activities in addition to beta-catenin-mediated transcription activation...
  22. ncbi request reprint Crosstalk between different adhesion molecules
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, P O Box 800732, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 18:572-8. 2006
    ..Furthermore, protocadherins can interact with extracellular matrix proteins or function by regulating classical cadherins...
  23. pmc The Hippo-YAP signaling pathway and contact inhibition of growth
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Sci 127:709-17. 2014
    ..This Commentary is focused on the biological significance of Hippo-YAP signaling and how upstream regulatory modules of the pathway interact to produce biological outcomes. ..
  24. pmc Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength
    Arthur C Huen
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Biol 159:1005-17. 2002
    ..These data provide direct in vitro evidence that IF-membrane attachments regulate adhesive strength and suggest furthermore that actin- and IF-based junctions act synergistically to strengthen adhesion...
  25. ncbi request reprint C-cadherin ectodomain structure and implications for cell adhesion mechanisms
    Titus J Boggon
    Department of Biochemistry, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 296:1308-13. 2002
    ....
  26. pmc Cadherin-mediated cell sorting not determined by binding or adhesion specificity
    Carien M Niessen
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 156:389-399. 2002
    ..These results show that cadherins are far more promiscuous in their adhesive-binding capacity than had been expected and that the ability to sort out must be determined by mechanisms other than simple adhesive-binding specificity...
  27. pmc The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, P O Box 32, 1230 York Avenue, New York, NY 10021, USA
    Dev Biol 312:90-102. 2007
    ..We conclude that the maternal Wnt pathway generates the Nieuwkoop center in vitro and the organizer in vivo by activating a common set of genes, without the need of an intermediary signaling step...
  28. ncbi request reprint Translocation of beta-catenin into the nucleus independent of interactions with FG-rich nucleoporins
    Eun Kyung Suh
    Neuroscience Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Exp Cell Res 290:447-56. 2003
    ..Transport is blocked by a soluble form of the C-cadherin cytoplasmic domain, suggesting that masking of the nuclear targeting signal may be a mechanism of regulating beta-catenin subcellular localization...
  29. ncbi request reprint Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo
    Alin Vonica
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Biol 250:112-27. 2002
    ..Since Brachyury is considered to have a major role in mesoderm formation, it is possible that Wnts might play a role in mesoderm specification, in addition to patterning...

Research Grants18

  1. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry M Gumbiner; Fiscal Year: 2010
    ..Moreover, we are developing methods to detect and control the functional state of cadherins on the cell, which have the potential to be used as diagnostic or therapeutic approaches for the treatment of many diseases, including cancer. ..
  2. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2009
    ..Moreover, we are developing methods to detect and control the functional state of cadherins on the cell, which have the potential to be used as diagnostic or therapeutic approaches for the treatment of many diseases, including cancer. ..
  3. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2007
    ..abstract_text> ..
  4. CATENIN AND CADHERIN SIGNALING IN DEVELOPMENT AND CANCER
    Barry Gumbiner; Fiscal Year: 2007
    ..These experiments should help us understand the mechanisms of p-catenin-mediated signaling and provide insights into the relationships between cell adhesion, tissue morphogenesis, and tumor growth. ..
  5. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2006
    ..abstract_text> ..
  6. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2005
    ..abstract_text> ..
  7. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2004
    ..abstract_text> ..
  8. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2003
    ..abstract_text> ..
  9. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2002
    ..abstract_text> ..
  10. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2001
    ..abstract_text> ..
  11. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2000
    ..abstract_text> ..
  12. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 1999
    ..The findings will have implications for understanding changes in the adhesive behavior of cells during tumor progression in morphogenetic defects associated with human congenital diseases. ..
  13. BIOCHEMISTRY AND REGULATION OF CADHERIN ACTIVITY
    Barry Gumbiner; Fiscal Year: 2009
    ..Moreover, we are developing methods to detect and control the functional state of cadherins on the cell, which have the potential to be used as diagnostic or therapeutic approaches for the treatment of many diseases, including cancer. ..