James R Gum

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint MUC17, a novel membrane-tethered mucin
    James R Gum
    Gastrointestinal Research Laboratory 151M2, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
    Biochem Biophys Res Commun 291:466-75. 2002
  2. ncbi request reprint Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
    Eun Taek Park
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Cancer 122:1253-60. 2008
  3. ncbi request reprint Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1
    Ryota Hokari
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Physiol Gastrointest Liver Physiol 289:G949-59. 2005
  4. ncbi request reprint Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon
    James R Gum
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cancer Res 2:504-13. 2004
  5. ncbi request reprint Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus
    James R Gum
    Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 278:49600-9. 2003
  6. ncbi request reprint N-glycosylation is required for the surface localization of MUC17 mucin
    Jenny J L Ho
    Gastrointestinal Research Laboratory 151 M2, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Oncol 23:585-92. 2003
  7. ncbi request reprint Expression of connective tissue growth factor in pancreatic cancer cell lines
    Sungwon Kwon
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, CA 94132, USA
    Int J Oncol 31:693-703. 2007
  8. ncbi request reprint HATH1 expression in mucinous cancers of the colorectum and related lesions
    Eun Taek Park
    Gastrointestinal Research Laboratory, Department of Medicine, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    Clin Cancer Res 12:5403-10. 2006
  9. ncbi request reprint Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry
    Jonathan P Terdiman
    Department of Medicine, University of California, San Francisco 94143, USA
    Gastroenterology 122:940-7. 2002
  10. ncbi request reprint Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B
    Hae Wan Lee
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 277:32624-31. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint MUC17, a novel membrane-tethered mucin
    James R Gum
    Gastrointestinal Research Laboratory 151M2, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
    Biochem Biophys Res Commun 291:466-75. 2002
    ..Thus, these membrane mucins reside together in a gene cluster, but are expressed in different tissues and are likely to have different functions as well...
  2. ncbi request reprint Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
    Eun Taek Park
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Cancer 122:1253-60. 2008
    ..In addition, the expression of both SOX2 and MUC5AC in serrated polyps supports the hypothesis that these polyps may be predominant precursors of mucinous and signet ring cell carcinomas of the colorectum...
  3. ncbi request reprint Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1
    Ryota Hokari
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Physiol Gastrointest Liver Physiol 289:G949-59. 2005
    ..These findings are relevant to the normal biology of the colonic mucosa as well as to the development of VIP as a therapeutic agent for treatment of inflammatory bowel disease...
  4. ncbi request reprint Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon
    James R Gum
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cancer Res 2:504-13. 2004
    ..ITFTag tumors closely resemble human small cell carcinomas of the colon, suggesting the possibility that these tumors might be derived from the enteroendocrine cell lineage as well...
  5. ncbi request reprint Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus
    James R Gum
    Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 278:49600-9. 2003
    ..It remains to be determined whether other members of the 7q22 membrane mucin gene family have amino-terminal domains similar to MUC3A and MUC3B...
  6. ncbi request reprint N-glycosylation is required for the surface localization of MUC17 mucin
    Jenny J L Ho
    Gastrointestinal Research Laboratory 151 M2, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Oncol 23:585-92. 2003
    ..Both tunicamycin and brefeldin A, an inhibitor of protein transport, reduced surface localization. In summary, our results indicate that the surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status...
  7. ncbi request reprint Expression of connective tissue growth factor in pancreatic cancer cell lines
    Sungwon Kwon
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, CA 94132, USA
    Int J Oncol 31:693-703. 2007
    ..Since activating Ras mutations occur in the earliest stages of pancreatic cancer, CTGF may be induced independent of Smad4 in pancreatic cancer cells...
  8. ncbi request reprint HATH1 expression in mucinous cancers of the colorectum and related lesions
    Eun Taek Park
    Gastrointestinal Research Laboratory, Department of Medicine, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    Clin Cancer Res 12:5403-10. 2006
    ..The aim of this study was to assess the possible role of HATH1 in the development of mucinous cancers and signet ring carcinomas...
  9. ncbi request reprint Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry
    Jonathan P Terdiman
    Department of Medicine, University of California, San Francisco 94143, USA
    Gastroenterology 122:940-7. 2002
    ..We sought to compare rates of genetically defined HNPCC among individuals with early onset CRC drawn from a high-risk clinic and a population-based cancer registry...
  10. ncbi request reprint Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B
    Hae Wan Lee
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 277:32624-31. 2002
    ....
  11. ncbi request reprint Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia
    Hee Ug Park
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Pancreas 26:e48-54. 2003
    ..Altered levels and patterns of mucin gene expression have been reported to occur in epithelial cancers...
  12. pmc Chemoprevention of colonic polyps with balsalazide: an exploratory, double-blind, placebo-controlled study
    Jonathan P Terdiman
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Dig Dis Sci 54:2488-96. 2009
    ..Preclinical data suggest that 5-aminosalicylates also may have a chemopreventive effect...
  13. ncbi request reprint Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription
    Hirofumi Jono
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 277:45547-57. 2002
    ....
  14. ncbi request reprint The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment
    Klaus Godl
    Department of Medical Biochemistry, Goteborg University, Gothenburg, Sweden
    J Biol Chem 277:47248-56. 2002
    ....
  15. pmc The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells
    Martin E Lidell
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, 413 90 Gothenburg, Sweden
    Biochem J 372:335-45. 2003
    ..This suggests that the information for sorting the MUC2 mucin into the regulated secretory pathway in cells having this ability is present in parts other than the C-terminus of MUC2...
  16. ncbi request reprint The complete genomic organization of the human MUC6 and MUC2 mucin genes
    Karine Rousseau
    Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, NW1 2HE London, UK
    Genomics 83:936-9. 2004
    ..The gene structures agreed partially but not completely with predictions from gene prediction programs...