Gultekin Gulsen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals
    Gultekin Gulsen
    Tu and Yuen Center for Functional Onco Imaging, 164 Irvine Hall, University of California, Irvine, California 92697, USA
    Technol Cancer Res Treat 5:351-63. 2006
  2. pmc TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model
    Jing Liu
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, USA
    BMC Dev Biol 11:65. 2011
  3. ncbi request reprint Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumors
    Gultekin Gulsen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
    Technol Cancer Res Treat 1:497-505. 2002
  4. ncbi request reprint Design and implementation of a multifrequency near-infrared diffuse optical tomography system
    Gultekin Gulsen
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:014020. 2006
  5. ncbi request reprint Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model
    Sean Merritt
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Appl Opt 42:2951-9. 2003
  6. ncbi request reprint In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration
    David J Cuccia
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Appl Opt 42:2940-50. 2003
  7. doi request reprint Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT): experimental validation with a dynamic phantom
    Mehmet Burcin Unlu
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92617, USA
    Phys Med Biol 54:6739-55. 2009
  8. pmc Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging
    Mehmet Burcin Unlu
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 13:060501. 2008
  9. ncbi request reprint Dual-contrast dynamic MRI-DOT for small animal imaging
    David Thayer
    Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, CA 92692, USA
    Technol Cancer Res Treat 9:61-70. 2010
  10. ncbi request reprint Diffuse optical tomographic reconstruction using multifrequency data
    Mehmet Burcin Unlu
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:054008. 2006

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals
    Gultekin Gulsen
    Tu and Yuen Center for Functional Onco Imaging, 164 Irvine Hall, University of California, Irvine, California 92697, USA
    Technol Cancer Res Treat 5:351-63. 2006
    ..ENU induced tumor model is used to test the performance of the system in vivo...
  2. pmc TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model
    Jing Liu
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, USA
    BMC Dev Biol 11:65. 2011
    ..Although many studies have shown that a dysregulation of TBX3 expression may contribute to cancer progression, no direct evidence shows TBX3 causes breast cancer...
  3. ncbi request reprint Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumors
    Gultekin Gulsen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
    Technol Cancer Res Treat 1:497-505. 2002
    ....
  4. ncbi request reprint Design and implementation of a multifrequency near-infrared diffuse optical tomography system
    Gultekin Gulsen
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:014020. 2006
    ..It is shown that the multifrequency reconstruction approach provides superior image quality compared to the single frequency counterpart...
  5. ncbi request reprint Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model
    Sean Merritt
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Appl Opt 42:2951-9. 2003
    ..15 M/microM). Tissue hemoglobin oxygen saturation (StO2) also showed a large variation between tissue types: viable tissue had an optically measured StO2 value of 61 +/- 5%, whereas StO2 determined for necrotic tissue was 43 +/- 6%...
  6. ncbi request reprint In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration
    David J Cuccia
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Appl Opt 42:2940-50. 2003
    ..In contrast, MB behaves as a small-molecular-weight contrast agent that leaks rapidly from the vasculature into the extravascular, extracellular space, and is sensitive to blood flow and the arterial input function...
  7. doi request reprint Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT): experimental validation with a dynamic phantom
    Mehmet Burcin Unlu
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92617, USA
    Phys Med Biol 54:6739-55. 2009
    ..g. choosing the diameter of the inclusion 20% smaller increased the peak enhancement 60% but changed the injection and dilution rates only less than 10%...
  8. pmc Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging
    Mehmet Burcin Unlu
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 13:060501. 2008
    ..The absorption enhancements in the ROIs were calculated. An enhancement of the ICG was observed in the viable region. On the contrary, there was a lower enhancement in the nonviable region...
  9. ncbi request reprint Dual-contrast dynamic MRI-DOT for small animal imaging
    David Thayer
    Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, CA 92692, USA
    Technol Cancer Res Treat 9:61-70. 2010
    ....
  10. ncbi request reprint Diffuse optical tomographic reconstruction using multifrequency data
    Mehmet Burcin Unlu
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:054008. 2006
    ..2. The use of two-frequency data is sufficient to improve the quantitative accuracy compared with the single frequency reconstruction with appropriate selection of these frequencies...
  11. doi request reprint Fully linear reconstruction method for fluorescence yield and lifetime through inverse complex-source formulation: simulation studies
    Hao Gao
    Department of Mathematics, University of California, Irvine, California 926197, USA
    Opt Lett 35:1899-901. 2010
    ..In addition, the colocalization constraint due to the unique feature of fluorescence imaging is imposed to enhance algorithm performance. The algorithms are tested with simulated data...
  12. pmc Quantitative fluorescence tomography with functional and structural a priori information
    Yuting Lin
    Center for Functional Onco Imaging, University of California, Irvine, Irvine, California 92697, USA
    Appl Opt 48:1328-36. 2009
    ..On the other hand, the true fluorophore concentration could be recovered when both functional and structural a priori information is utilized to guide and constrain the FT reconstruction algorithm...
  13. pmc In vivo validation of quantitative frequency domain fluorescence tomography
    Yuting Lin
    University of California, Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, 164 Irvine Hall, Irvine, California 92697, USA
    J Biomed Opt 17:126021. 2012
    ..2-mm diameter indocyanine green inclusion located 15 mm deep inside a rat can be recovered with less than a 5% error when functional a priori information from DOT and structural a priori information from MRI are utilized...
  14. pmc Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography
    Yuting Lin
    University of California, Irvine, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 16:106015. 2011
    ..The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized...
  15. pmc A simulation study of the variability of indocyanine green kinetics and using structural a priori information in dynamic contrast enhanced diffuse optical tomography (DCE-DOT)
    Mehmet Burcin Unlu
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    Phys Med Biol 53:3189-200. 2008
    ..As a result, although the recovered peak concentration was still case dependent, the variability of the shape of the kinetic curve was reduced...
  16. ncbi request reprint Effects of the time dependence of a bioluminescent source on the tomographic reconstruction
    Mehmet Burcin Unlu
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Appl Opt 47:799-806. 2008
    ....
  17. pmc Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast
    Yuting Lin
    University of California, Department of Radiological Sciences, Tu and Yuen Center for Functional Onco Imaging, Irvine, CA 92697, USA
    J Biomed Opt 17:056007. 2012
    ..The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast...
  18. pmc A gantry-based tri-modality system for bioluminescence tomography
    Han Yan
    Tu and Yuen Center for Functional Onco Imaging and Department of Radiological Sciences, University of California, Irvine, California 92697, USA
    Rev Sci Instrum 83:043708. 2012
    ..5 mm diameter bioluminescence inclusion can be localized accurately with the functional a priori information while its source strength can be recovered more accurately using both structural and the functional a priori information...
  19. ncbi request reprint A double end-cap birdcage RF coil for small animal whole body imaging
    Gultekin Gulsen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, California, USA
    J Magn Reson 156:309-12. 2002
    ..Furthermore, if one wishes to obtain the same homogeneity within a given volume, a double end-cap would have less than half of the length of the single end-cap coil leading to a superior S/N performance...
  20. doi request reprint Photo-magnetic imaging: resolving optical contrast at MRI resolution
    Yuting Lin
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, CA, USA
    Phys Med Biol 58:3551-62. 2013
    ..However, these two objects are not only effectively resolved with PMI, but their true concentrations are also recovered successfully...
  21. pmc Optimal analysis method for dynamic contrast-enhanced diffuse optical tomography
    Michael Ghijsen
    Department of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    Int J Biomed Imaging 2011:426503. 2011
    ..Hence, implementation of a combined MRI-DOT system to image ICG enhancement can potentially be a promising tool for breast cancer imaging...
  22. ncbi request reprint Automatic tuned MRI RF coil for multinuclear imaging of small animals at 3T
    L Tugan Muftuler
    John Tu and Thomas Yuen Center for Functional Onco Imaging, College of Medicine, University of California, Irvine 92697, USA
    J Magn Reson 155:39-44. 2002
    ..Good matching and tuning were obtained at both resonance frequencies. The tuning and matching of the coil were changed from one resonance frequency to the other within 60 s...

Research Grants6

  1. Polarization Sensitive OCT for Detection of Melanoma
    Gultekin Gulsen; Fiscal Year: 2003
    ..Thus this research will have the potential to improve patient care and reduce the human and economical cost of melanoma. ..
  2. Development of A Multi-Modality System for Onco-Imaging
    Gultekin Gulsen; Fiscal Year: 2007
    ..If successful, the outcome of our effort will offer a sophisticated tool that could provide high sensitivity and high specificity in the detection and characterization of tumors. ..
  3. Tomographic Molecular Imaging for Breast Cancer
    Gultekin Gulsen; Fiscal Year: 2010
    ....