Research Topics
| Gultekin GulsenSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animalsGultekin Gulsen
Tu and Yuen Center for Functional Onco Imaging, 164 Irvine Hall, University of California, Irvine, California 92697, USA
Technol Cancer Res Treat 5:351-63. 2006..ENU induced tumor model is used to test the performance of the system in vivo...
TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse modelJing Liu
Department of Pediatrics, Division of Human Genetics, University of California, Irvine, USA
BMC Dev Biol 11:65. 2011..Although many studies have shown that a dysregulation of TBX3 expression may contribute to cancer progression, no direct evidence shows TBX3 causes breast cancer...- Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumorsGultekin Gulsen
John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
Technol Cancer Res Treat 1:497-505. 2002.... - Design and implementation of a multifrequency near-infrared diffuse optical tomography systemGultekin Gulsen
University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
J Biomed Opt 11:014020. 2006..It is shown that the multifrequency reconstruction approach provides superior image quality compared to the single frequency counterpart... - Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor modelSean Merritt
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
Appl Opt 42:2951-9. 2003..15 M/microM). Tissue hemoglobin oxygen saturation (StO2) also showed a large variation between tissue types: viable tissue had an optically measured StO2 value of 61 +/- 5%, whereas StO2 determined for necrotic tissue was 43 +/- 6%... - In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistrationDavid J Cuccia
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
Appl Opt 42:2940-50. 2003..In contrast, MB behaves as a small-molecular-weight contrast agent that leaks rapidly from the vasculature into the extravascular, extracellular space, and is sensitive to blood flow and the arterial input function... 
Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT): experimental validation with a dynamic phantomMehmet Burcin Unlu
Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92617, USA
Phys Med Biol 54:6739-55. 2009..g. choosing the diameter of the inclusion 20% smaller increased the peak enhancement 60% but changed the injection and dilution rates only less than 10%...- Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imagingMehmet Burcin Unlu
University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
J Biomed Opt 13:060501. 2008..The absorption enhancements in the ROIs were calculated. An enhancement of the ICG was observed in the viable region. On the contrary, there was a lower enhancement in the nonviable region... - Diffuse optical tomographic reconstruction using multifrequency dataMehmet Burcin Unlu
University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
J Biomed Opt 11:054008. 2006..2. The use of two-frequency data is sufficient to improve the quantitative accuracy compared with the single frequency reconstruction with appropriate selection of these frequencies... - Dual-contrast dynamic MRI-DOT for small animal imagingDavid Thayer
Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, CA 92692, USA
Technol Cancer Res Treat 9:61-70. 2010.... - Fully linear reconstruction method for fluorescence yield and lifetime through inverse complex-source formulation: simulation studiesHao Gao
Department of Mathematics, University of California, Irvine, California 926197, USA
Opt Lett 35:1899-901. 2010..In addition, the colocalization constraint due to the unique feature of fluorescence imaging is imposed to enhance algorithm performance. The algorithms are tested with simulated data... - Quantitative fluorescence tomography with functional and structural a priori informationYuting Lin
Center for Functional Onco Imaging, University of California, Irvine, Irvine, California 92697, USA
Appl Opt 48:1328-36. 2009..On the other hand, the true fluorophore concentration could be recovered when both functional and structural a priori information is utilized to guide and constrain the FT reconstruction algorithm... - Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomographyYuting Lin
University of California, Irvine, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
J Biomed Opt 16:106015. 2011..The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized... - A simulation study of the variability of indocyanine green kinetics and using structural a priori information in dynamic contrast enhanced diffuse optical tomography (DCE-DOT)Mehmet Burcin Unlu
Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
Phys Med Biol 53:3189-200. 2008..As a result, although the recovered peak concentration was still case dependent, the variability of the shape of the kinetic curve was reduced... - Effects of the time dependence of a bioluminescent source on the tomographic reconstructionMehmet Burcin Unlu
Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
Appl Opt 47:799-806. 2008.... - A gantry-based tri-modality system for bioluminescence tomographyHan Yan
Tu and Yuen Center for Functional Onco Imaging and Department of Radiological Sciences, University of California, Irvine, California 92697, USA
Rev Sci Instrum 83:043708. 2012..5 mm diameter bioluminescence inclusion can be localized accurately with the functional a priori information while its source strength can be recovered more accurately using both structural and the functional a priori information... - Temperature-modulated fluorescence tomography based on both concentration and lifetime contrastYuting Lin
University of California, Department of Radiological Sciences, Tu and Yuen Center for Functional Onco Imaging, Irvine, CA 92697, USA
J Biomed Opt 17:056007. 2012..The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast... - A double end-cap birdcage RF coil for small animal whole body imagingGultekin Gulsen
John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, California, USA
J Magn Reson 156:309-12. 2002..Furthermore, if one wishes to obtain the same homogeneity within a given volume, a double end-cap would have less than half of the length of the single end-cap coil leading to a superior S/N performance... - Optimal analysis method for dynamic contrast-enhanced diffuse optical tomographyMichael Ghijsen
Department of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
Int J Biomed Imaging 2011:426503. 2011..Hence, implementation of a combined MRI-DOT system to image ICG enhancement can potentially be a promising tool for breast cancer imaging... - Automatic tuned MRI RF coil for multinuclear imaging of small animals at 3TL Tugan Muftuler
John Tu and Thomas Yuen Center for Functional Onco-Imaging, College of Medicine, University of California, Irvine 92697, USA
J Magn Reson 155:39-44. 2002..Good matching and tuning were obtained at both resonance frequencies. The tuning and matching of the coil were changed from one resonance frequency to the other within 60 s...
Research Grants
- Polarization Sensitive OCT for Detection of MelanomaGultekin Gulsen; Fiscal Year: 2003..Thus this research will have the potential to improve patient care and reduce the human and economical cost of melanoma. ..
- Development of A Multi-Modality System for Onco-ImagingGultekin Gulsen; Fiscal Year: 2007..If successful, the outcome of our effort will offer a sophisticated tool that could provide high sensitivity and high specificity in the detection and characterization of tumors. ..
- Tomographic Molecular Imaging for Breast CancerGultekin Gulsen; Fiscal Year: 2010....