Margaret L Gulley

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Clinical implementation of RNA signatures for pharmacogenomic decision-making
    Weihua Tang
    Department of Pathology and Laboratory Medicine
    Pharmgenomics Pers Med 4:95-107. 2011
  2. pmc Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile
    Weihua Tang
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, 913 Brinkhous Bullitt Building, Chapel Hill, NC, 27599 7525, USA
    Infect Agent Cancer 7:21. 2012
  3. doi request reprint A rational approach to genetic testing for sarcoma
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Diagn Mol Pathol 18:1-10. 2009
  4. pmc Using Epstein-Barr viral load assays to diagnose, monitor, and prevent posttransplant lymphoproliferative disorder
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina, 101 Manning Dr, 913 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Clin Microbiol Rev 23:350-66. 2010
  5. ncbi request reprint Tumor origin and CD20 expression in posttransplant lymphoproliferative disorder occurring in solid organ transplant recipients: implications for immune-based therapy
    Margaret L Gulley
    Department of Pathology, University of North Carolina at Chapel Hill and the Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7525, USA
    Transplantation 76:959-64. 2003
  6. ncbi request reprint Clinical laboratory reports in molecular pathology
    Margaret L Gulley
    Department of Pathology, 913 Brinkhous Bullitt Bldg, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Arch Pathol Lab Med 131:852-63. 2007
  7. pmc Laboratory assays for Epstein-Barr virus-related disease
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Mol Diagn 10:279-92. 2008
  8. ncbi request reprint Public policy recommendations for oversight of molecular laboratory tests
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599 7525, USA
    N C Med J 68:109-11. 2007
  9. pmc Epstein-Barr virus-specific methylation of human genes in gastric cancer cells
    Julie L Ryan
    Department of Pathology and Laboratory Medicine and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Infect Agent Cancer 5:27. 2010
  10. pmc Validation of Roche LightCycler Epstein-Barr virus quantification reagents in a clinical laboratory setting
    Margaret L Gulley
    Dept of Pathology, University of North Carolina, 101 Manning Dr, 913 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Mol Diagn 8:589-97. 2006

Collaborators

Detail Information

Publications52

  1. pmc Clinical implementation of RNA signatures for pharmacogenomic decision-making
    Weihua Tang
    Department of Pathology and Laboratory Medicine
    Pharmgenomics Pers Med 4:95-107. 2011
    ..These strategies are shepherding genomic arrays into clinical settings to provide added value to patients and to the larger health care system...
  2. pmc Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile
    Weihua Tang
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, 913 Brinkhous Bullitt Building, Chapel Hill, NC, 27599 7525, USA
    Infect Agent Cancer 7:21. 2012
    ..EBV DNA is found within the malignant cells of 10% of gastric cancers. Modern molecular technology facilitates identification of virus-related biochemical effects that could assist in early diagnosis and disease management...
  3. doi request reprint A rational approach to genetic testing for sarcoma
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Diagn Mol Pathol 18:1-10. 2009
    ....
  4. pmc Using Epstein-Barr viral load assays to diagnose, monitor, and prevent posttransplant lymphoproliferative disorder
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina, 101 Manning Dr, 913 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Clin Microbiol Rev 23:350-66. 2010
    ..Restoring T cell immunity against EBV is a major strategy for overcoming PTLD, and novel EBV-directed therapies are being explored to thwart virus-driven neoplasia...
  5. ncbi request reprint Tumor origin and CD20 expression in posttransplant lymphoproliferative disorder occurring in solid organ transplant recipients: implications for immune-based therapy
    Margaret L Gulley
    Department of Pathology, University of North Carolina at Chapel Hill and the Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7525, USA
    Transplantation 76:959-64. 2003
    ..The efficacy of anti-CD20 therapy, on the other hand, depends on CD20 expression by neoplastic cells. Only limited prior data exist regarding either of these parameters...
  6. ncbi request reprint Clinical laboratory reports in molecular pathology
    Margaret L Gulley
    Department of Pathology, 913 Brinkhous Bullitt Bldg, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Arch Pathol Lab Med 131:852-63. 2007
    ..The recent introduction of array technology has added another layer of complexity involving massive parallel analysis of multiple genes, transcripts, or proteins...
  7. pmc Laboratory assays for Epstein-Barr virus-related disease
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Mol Diagn 10:279-92. 2008
    ....
  8. ncbi request reprint Public policy recommendations for oversight of molecular laboratory tests
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599 7525, USA
    N C Med J 68:109-11. 2007
  9. pmc Epstein-Barr virus-specific methylation of human genes in gastric cancer cells
    Julie L Ryan
    Department of Pathology and Laboratory Medicine and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Infect Agent Cancer 5:27. 2010
    ..abstract:..
  10. pmc Validation of Roche LightCycler Epstein-Barr virus quantification reagents in a clinical laboratory setting
    Margaret L Gulley
    Dept of Pathology, University of North Carolina, 101 Manning Dr, 913 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Mol Diagn 8:589-97. 2006
    ..In conclusion, this LightCycler EBV assay is rapid, sensitive, and linear for quantifying EBV viral load. The assay appears to be useful for measuring clinically significant EBV levels in immunodeficient patients...
  11. pmc Genetic tests to evaluate prognosis and predict therapeutic response in acute myeloid leukemia
    Margaret L Gulley
    Department of Pathology and Laboratory Medicine, 913 Brinkhous Bullitt Building, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Mol Diagn 12:3-16. 2010
    ..Acute myeloid leukemia leads the way for modern molecular medicine...
  12. pmc Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments: a novel approach to screen for the virus in paraffin-embedded tissue and plasma
    Julie L Ryan
    Department of Pathology, University of North Carolina at Chapel Hill, NC 27599 7525, USA
    J Mol Diagn 6:378-85. 2004
    ..The findings suggest that Q-PCR is an effective method of distinguishing disease-associated virus from incidental virus in paraffin-embedded tissue and in plasma samples...
  13. ncbi request reprint Epstein-Barr viral load as a marker of lymphoma in AIDS patients
    Hongxin Fan
    University of North Carolina at Chapel Hill and the Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    J Med Virol 75:59-69. 2005
    ..There was no association between EBV viral load and human immunodeficiency virus (HIV) load or CD4 count. In conclusion, EBV viral load shows promise as a tool to assist in diagnosis and management of EBV-related lymphoma patients...
  14. ncbi request reprint Analytic validation of a quantitative real-time PCR assay to measure CMV viral load in whole blood
    Leigh B Thorne
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Diagn Mol Pathol 16:73-80. 2007
    ..In summary, CMV viral load measurement targeting the polymerase gene is nearly equivalent to the antigenemia assay for detecting and monitoring active CMV infection in whole blood samples...
  15. ncbi request reprint Epstein-Barr Virus (EBV) DNA in plasma is not encapsidated in patients with EBV-related malignancies
    Julie L Ryan
    Department of Pathology, University of North Carolina at Chapel Hill, 27599, USA
    Diagn Mol Pathol 13:61-8. 2004
    ..These findings may be important in understanding how viral load relates to disease status and in predicting response to nucleoside analogs and other antiviral therapies...
  16. ncbi request reprint Laboratory markers of tumor burden in nasopharyngeal carcinoma: a comparison of viral load and serologic tests for Epstein-Barr virus
    Hongxin Fan
    Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Cancer 112:1036-41. 2004
    ..EBV viral load was more informative than was EA serology for distinguishing remission from relapsed disease. EBV DNA measurement appears to be a noninvasive way to monitor tumor burden after therapy...
  17. pmc Epstein-Barr virus lytic infection contributes to lymphoproliferative disease in a SCID mouse model
    Gregory K Hong
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 79:13993-4003. 2005
    ..These results suggest that lytic EBV gene expression contributes to EBV-associated lymphoproliferative disease, potentially through induction of paracrine B-cell growth factors...
  18. ncbi request reprint Real-time PCR measures Epstein-Barr Virus DNA in archival breast adenocarcinomas
    Leigh B Thorne
    Department of Pathology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Diagn Mol Pathol 14:29-33. 2005
    ..The low levels probably confounded our ability to localize the virus to particular cell types or to characterize viral gene expression...
  19. doi request reprint Cytomegalovirus DNA measurement in blood and plasma using Roche LightCycler CMV quantification reagents
    Weihua Tang
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Diagn Mol Pathol 17:166-73. 2008
    ..The LightCycler CMV assay is rapid, sensitive, and linear for quantifying CMV viral load, and it seems to be useful in the diagnosis and monitoring of affected patients...
  20. doi request reprint Post-transplantation lymphoproliferative disease: Epstein-Barr virus DNA levels, HLA-A3, and survival
    Stephen A Wheless
    The School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Respir Crit Care Med 178:1060-5. 2008
    ..Elevation in Epstein-Barr virus (EBV) circulating DNA has been proposed as a marker for development of post-transplant lymphoproliferative disease (PTLD), but few published data exist in the study of lung-transplant recipients...
  21. ncbi request reprint Detection of clonal IGH gene rearrangements: summary of molecular oncology surveys of the College of American Pathologists
    Marina N Nikiforova
    Department of Pathology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arch Pathol Lab Med 131:185-9. 2007
    ....
  22. pmc Atypical Epstein-Barr viral genomic structure in lymphoma tissue and lymphoid cell lines
    Weihua Tang
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Diagn Mol Pathol 22:91-101. 2013
    ....
  23. pmc Viral response to chemotherapy in endemic burkitt lymphoma
    Weihua Tang
    Departments of Pathology and Laboratory Medicine, Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Clin Cancer Res 16:2055-64. 2010
    ..We studied whether cyclophosphamide chemotherapy induces EBV to switch from latent to lytic phases of infection in a series of EBV-associated Burkitt lymphomas...
  24. ncbi request reprint Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma
    Jennifer A Morrison
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Cancer Res 64:5251-60. 2004
    ..These findings point to a divergence in pathways activated by EBV in different cellular contexts...
  25. pmc Quality assurance of RNA expression profiling in clinical laboratories
    Weihua Tang
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599 7525, USA
    J Mol Diagn 14:1-11. 2012
    ..Careful attention to the well-honed principles of laboratory medicine, along with guidance from government and professional groups on strategies to preserve RNA and manage large data sets, promotes clinical-grade assay performance...
  26. pmc Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma
    Dirk P Dittmer
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA
    Int J Cancer 123:2105-12. 2008
    ..The conceptual insights provided by our quantitative analysis should aid our understanding of mammalian episomes, as well as lead to designs to cure latent viral infection...
  27. pmc Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue
    Alexander A Benders
    Department of Pathology and Laboratory Medicine, The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599 7525, USA
    Head Neck Pathol 3:276-82. 2009
    ..There is no consistent relationship between LMP1 and either HIF-1alpha expression or degree of microvasculature. The biologic basis for the wide variation in vessel density deserves further investigation...
  28. doi request reprint UGT1A1 promoter genotype is not strongly associated with severity of coronary artery disease
    Michael J Papez
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Diagn Mol Pathol 18:226-31. 2009
    ..These findings suggest that UGT1A1 promoter genotype is not a major factor contributing to risk of CAD...
  29. doi request reprint Recommended principles and practices for validating clinical molecular pathology tests
    Lawrence Jennings
    Department of Pathology and Laboratory Medicine, Children s Memorial Hospital, Chicago, Illinois, USA
    Arch Pathol Lab Med 133:743-55. 2009
    ..Analytic and clinical performance characteristics as well as test limitations are established and documented through the process of test validation...
  30. pmc Clinical applications of BCR-ABL molecular testing in acute leukemia
    Amgad L Nashed
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    J Mol Diagn 5:63-72. 2003
    ..On the horizon are gene expression profiles that will likely provide additional information beyond what is obtainable with current clinical and laboratory approaches...
  31. ncbi request reprint No evidence of Epstein-Barr virus association with Merkel cell carcinoma
    Maren Shaw
    Department of Dermatology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC 27599 7525, USA
    J Cutan Pathol 33:624-8. 2006
    ..Additionally, Merkel cell hyperplasia is seen in the Epstein-Barr virus (EBV)-driven process oral hairy leukoplakia, and EBV is known to be involved in the pathogenesis of several other malignancies...
  32. pmc Use of adenovirus vectors expressing Epstein-Barr virus (EBV) immediate-early protein BZLF1 or BRLF1 to treat EBV-positive tumors
    Wen hai Feng
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599 7295, USA
    J Virol 76:10951-9. 2002
    ..The addition of ganciclovir did not significantly affect the antitumor effect of the BZLF1 and BRLF1 adenovirus vectors. These results suggest a potential cancer therapy against EBV-related tumors...
  33. pmc Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples
    Fathi Elloumi
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med Genomics 4:54. 2011
    ..This "normal" tissue could represent a source of non-random error or systematic bias in genomic classification...
  34. doi request reprint BRAF mutation testing in colorectal cancer
    Shree G Sharma
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA
    Arch Pathol Lab Med 134:1225-8. 2010
    ....
  35. ncbi request reprint T-cell blast crisis of chronic myelogenous leukemia manifesting as a large mediastinal tumor
    Charles C Ye
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Hum Pathol 33:770-3. 2002
    ....
  36. pmc Epstein-Barr virus lytic infection is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell lines
    Gregory K Hong
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 79:13984-92. 2005
    ..In addition, as VEGF is a pleiotropic factor with effects other than angiogenesis, lytically induced VEGF secretion may potentially contribute to viral pathogenesis...
  37. pmc Diagnosis of human congenital cytomegalovirus infection by amplification of viral DNA from dried blood spots on perinatal cards
    Lori Scanga
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599 7525, USA
    J Mol Diagn 8:240-5. 2006
    ..Further studies are warranted on patients with hearing loss or other neurological deficits to determine the percentage that is attributable to congenital HCMV infection...
  38. pmc Standard mutation nomenclature in molecular diagnostics: practical and educational challenges
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 9:1-6. 2007
    ..Our aim is to alert laboratory scientists and other health care professionals to the important issues and provide a foundation for further discussions that will ultimately lead to solutions...
  39. pmc Detection of common disease-causing mutations in mitochondrial DNA (mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes MTTL1 3243 A>G and myoclonic epilepsy associated with ragged-red fibers MTTK 8344A>G) by real-time polymer
    Hongxin Fan
    Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, 27599 7525, USA
    J Mol Diagn 8:277-81. 2006
    ..This LightCycler assay is a rapid and reliable technique for molecular diagnosis of these mitochondrial gene mutations...
  40. ncbi request reprint The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas
    Scott E Kilpatrick
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Mod Pathol 19:815-9. 2006
    ..However, when cell block material is available for immunohistochemistry, the majority of such cases are successfully subtyped...
  41. ncbi request reprint Guidelines for interpreting EBER in situ hybridization and LMP1 immunohistochemical tests for detecting Epstein-Barr virus in Hodgkin lymphoma
    Margaret L Gulley
    Department of Pathology, University of Texas Health Science Center at San Antonio, USA
    Am J Clin Pathol 117:259-67. 2002
    ..EBER and LMP1 assays in combination are more effective than either assay alone for identifying EBV-related Hodgkin lymphoma...
  42. ncbi request reprint Distribution of Epstein-Barr viral load in serum of individuals from nasopharyngeal carcinoma high-risk families in Taiwan
    Xiaohong Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
    Int J Cancer 118:780-4. 2006
    ....
  43. ncbi request reprint Epstein-Barr virus as a marker of survival after Hodgkin's lymphoma: a population-based study
    Theresa H M Keegan
    Northern California Cancer Center, 2201 Walnut Ave, Ste 300, Fremont, CA 94538 2334, USA
    J Clin Oncol 23:7604-13. 2005
    ..This study assessed survival after HL in a population-based cohort large enough to examine the joint effects of EBV with other factors including age, sex, and histologic subtype...
  44. ncbi request reprint Quantitation of CMV by real-time PCR in transfusable RBC units
    Deborah J Greenlee
    University of Texas Health Science Center at San Antonio, USA
    Transfusion 42:403-8. 2002
    ..CMV is transmissible through transfusion of blood components. The goal of this study was to measure CMV levels in RBC units using a sensitive and quantitative DNA amplification assay...
  45. ncbi request reprint Clonal evolution of lymphoblastoid cell lines
    Julie L Ryan
    Department of Dermatology, University of Rochester James P Wilmot Cancer Center, Rochester, NY, USA
    Lab Invest 86:1193-200. 2006
    ....
  46. ncbi request reprint Detection of bcl-2/J(H) translocation by polymerase chain reaction: a summary of the experience of the Molecular Oncology Survey of the College of American Pathologist
    Eric D Hsi
    Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 126:902-8. 2002
    ....
  47. pmc Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations
    Sally L Glaser
    Northern California Cancer Center, Fremont, CA 94538, USA
    Int J Cancer 123:1499-507. 2008
    ....
  48. ncbi request reprint Population-based patterns of human immunodeficiency virus-related Hodgkin lymphoma in the Greater San Francisco Bay Area, 1988-1998
    Sally L Glaser
    Northern California Cancer Center, Union City, California 94587, USA
    Cancer 98:300-9. 2003
    ....
  49. ncbi request reprint Epstein-Barr virus and breast cancer: state of the evidence for viral carcinogenesis
    Sally L Glaser
    Northern California Cancer Center, 32960 Alvarado Niles Road, Ste 600, P O Box 5033, Union City, CA 94587, USA
    Cancer Epidemiol Biomarkers Prev 13:688-97. 2004
    ..Further research is warranted, given the potential for an EBV association to inform not only breast cancer etiology but also early detection, treatment, and prevention...
  50. ncbi request reprint Inter- and intra-observer reliability of Epstein-Barr virus detection in Hodgkin lymphoma using histochemical procedures
    Sally L Glaser
    Northern California Cancer Center, 32960 Alvarado Niles Road, Suite 600, Union City, CA 94587, USA
    Leuk Lymphoma 45:489-97. 2004
    ..The variability in assay interpretation justifies caution in comparing EBV association results across HL studies and underscores the need for interpretation guidelines...
  51. pmc Lymphoid tissues from patients with infectious mononucleosis lack monoclonal B and T cells
    Julie A Plumbley
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Mol Diagn 4:37-43. 2002
    ..In this case series, no monoclonal lymphoid populations were identified in any case of IM. This finding suggests that molecular studies are useful in distinguishing IM from lymphoid neoplasms...
  52. ncbi request reprint False-negative factor V Leiden genetic testing in a patient with recurrent deep venous thrombosis
    Edward N Libby
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Am J Hematol 81:284-9. 2006
    ..There is a need for standardization of optimized fVL genetic testing methods. Further education of ordering physicians on the limitations of genetic testing is necessary...