ANDREW GULICK

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase
    Andrew M Gulick
    Hauptman Woodward Medical Research Institute and Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203 1102, USA
    ACS Chem Biol 4:811-27. 2009
  2. ncbi request reprint The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A
    Andrew M Gulick
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203 1149, USA
    Biochemistry 42:2866-73. 2003
  3. ncbi request reprint Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states
    Andrew M Gulick
    Hauptman Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, New York 14203 1196, USA
    Biochemistry 43:8670-9. 2004
  4. pmc Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase
    Albert S Reger
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203 1102, USA
    Biochemistry 46:6536-46. 2007
  5. pmc Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase
    Albert S Reger
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203, USA
    Biochemistry 47:8016-25. 2008
  6. ncbi request reprint The 1.8 A crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa
    Eric J Drake
    Hauptman Woodward Medical Research Institute, State University of New York at Buffalo, 700 Ellicott Street, Buffalo, NY 14203, USA
    J Biol Chem 282:20425-34. 2007
  7. ncbi request reprint Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain
    Eric J Drake
    Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, USA
    Chem Biol 13:409-19. 2006
  8. ncbi request reprint Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site
    Yangzhou Wang
    Hauptman Woodward Medical Institute, 73 High Street, Buffalo, New York 14203, USA
    Biochemistry 44:7095-106. 2005
  9. pmc The 2.1 A crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substrates
    Manish B Shah
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203 1102, USA
    Proteins 77:685-98. 2009
  10. pmc Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin
    Eric J Drake
    Hauptman Woodward Medical Research Institute, Department of Structural Biology, State University of New York at Buffalo, 700 Ellicott St, Buffalo, NY 14203 1102, USA
    J Mol Biol 384:193-205. 2008

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase
    Andrew M Gulick
    Hauptman Woodward Medical Research Institute and Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203 1102, USA
    ACS Chem Biol 4:811-27. 2009
    ..Finally, the ramifications of this domain rotation in the catalytic cycle of the modular NRPS enzymes are discussed...
  2. ncbi request reprint The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A
    Andrew M Gulick
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203 1149, USA
    Biochemistry 42:2866-73. 2003
    ..Additionally, we provide a structural explanation for the recently shown control of enzyme activity by acetylation of an active site lysine...
  3. ncbi request reprint Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states
    Andrew M Gulick
    Hauptman Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, New York 14203 1196, USA
    Biochemistry 43:8670-9. 2004
    ..The structure of the 4-chlorobenzoate binding site is discussed in the context of the binding sites of other family members to gain insight into substrate specificity and evolution of new function...
  4. pmc Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase
    Albert S Reger
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203 1102, USA
    Biochemistry 46:6536-46. 2007
    ..Finally, the crystallographic structures of wild-type Acs and mutants R194A, R584A, R584E, K609A, and V386A are presented to support the biochemical analysis...
  5. pmc Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase
    Albert S Reger
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203, USA
    Biochemistry 47:8016-25. 2008
    ..2008) Biochemistry 47, 8026-8039]. The complete characterization of this enzyme allows us to provide an explanation for the use of the domain alternation strategy by these enzymes...
  6. ncbi request reprint The 1.8 A crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa
    Eric J Drake
    Hauptman Woodward Medical Research Institute, State University of New York at Buffalo, 700 Ellicott Street, Buffalo, NY 14203, USA
    J Biol Chem 282:20425-34. 2007
    ..The PA2412 deletion strain is able to use exogenously produced pyoverdine, showing that there is no defect in the uptake or utilization of the iron-pyoverdine complex...
  7. ncbi request reprint Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain
    Eric J Drake
    Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, USA
    Chem Biol 13:409-19. 2006
    ..Mutational studies on EntE support our previous hypothesis that members of the adenylate-forming family of enzymes adopt two distinct conformations to catalyze the two-step reactions...
  8. ncbi request reprint Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site
    Yangzhou Wang
    Hauptman Woodward Medical Institute, 73 High Street, Buffalo, New York 14203, USA
    Biochemistry 44:7095-106. 2005
    ..Collectively, the common and unique interactions with both the DNA bases and the backbone phosphates lead to substrate specificity and individual preference for certain DNA sites...
  9. pmc The 2.1 A crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substrates
    Manish B Shah
    Hauptman Woodward Medical Research Institute, Buffalo, New York 14203 1102, USA
    Proteins 77:685-98. 2009
    ..These insights emphasize the high sequence and structural diversity among this family in the area of the acyl-binding pocket...
  10. pmc Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin
    Eric J Drake
    Hauptman Woodward Medical Research Institute, Department of Structural Biology, State University of New York at Buffalo, 700 Ellicott St, Buffalo, NY 14203 1102, USA
    J Mol Biol 384:193-205. 2008
    ..The active site of PvcB is compared to the structures of other family members and suggests that a conformational change to order several loops will accompany the binding of ligands...
  11. pmc Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis
    Eric J Drake
    Hauptman Woodward Institute and Department of Structural Biology, University at Buffalo, Buffalo, NY 14203 1102, USA
    Biochemistry 49:9292-305. 2010
    ..Structures of rationally designed bisubstrate inhibitors are also presented...
  12. ncbi request reprint Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli
    Jesse A Sundlov
    Hauptman Woodward Medical Research Institute, Buffalo, NY, USA
    Acta Crystallogr D Biol Crystallogr 62:734-40. 2006
    ..Analysis of the structure in light of recent structural and bioinformatic analysis of other members of the SCOR family provides insight into the residues involved in cofactor and substrate binding...
  13. pmc Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis
    Rui Wu
    Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Biochemistry 47:8026-39. 2008
    ..On the basis of our findings we propose a catalytic mechanism that centers on a small group of key residues (some of which serve in more than one role) and that includes several residues that function in domain alternation...
  14. ncbi request reprint Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range
    Rui Wu
    Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Biochemistry 46:14487-99. 2007
    ..The combination of structural and kinetic analyses of the constructed mutants proved to be an effective approach to engineering the ligase for novel substrates...
  15. ncbi request reprint Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase
    Andrew M Gulick
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Acta Crystallogr D Biol Crystallogr 58:306-9. 2002
    ..A further benefit of this precipitant for crystallization is its ability to function as a cryoprotectant, allowing the crystals to be transferred directly from the mother liquor to the nitrogen stream at 113 K...

Research Grants7

  1. STRUCTURE OF PEPTIDE SYNTHETASES AND RELATED ENZYMES
    ANDREW GULICK; Fiscal Year: 2004
    ....
  2. STRUCTURE OF PEPTIDE SYNTHETASES AND RELATED ENZYMES
    ANDREW GULICK; Fiscal Year: 2005
    ....
  3. STRUCTURE OF PEPTIDE SYNTHETASES AND RELATED ENZYMES
    ANDREW GULICK; Fiscal Year: 2006
    ....
  4. STRUCTURE OF PEPTIDE SYNTHETASES AND RELATED ENZYMES
    ANDREW GULICK; Fiscal Year: 2007
    ....
  5. Structures of Peptide Synthetases and Related Enzymes
    Andrew M Gulick; Fiscal Year: 2010
    ....
  6. STRUCTURE OF PEPTIDE SYNTHETASES AND RELATED ENZYMES
    ANDREW GULICK; Fiscal Year: 2009
    ....