Louis J Guillette

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife
    L J Guillette
    Department of Zoology, University of Florida, Gainesville 32611, USA
    Environ Health Perspect 103:157-64. 1995
  2. ncbi request reprint Affinity of the alligator estrogen receptor for serum pesticide contaminants
    Louis J Guillette
    Department of Zoology, 223 Bartram Hall, University of Florida, Gainesville, FL 32611, USA
    Toxicology 181:151-4. 2002
  3. ncbi request reprint Contaminant-induced endocrine disruption in wildlife
    L J Guillette
    Department of Zoology, University of Florida, Gainesville, USA
    Growth Horm IGF Res 10:S45-50. 2000
  4. ncbi request reprint Organochlorine pesticides as endocrine disruptors in wildlife
    L J Guillette
    Department of Zoology, University of Florida, Gainesville 32611, USA
    Cent Eur J Public Health 8:34-5. 2000
  5. pmc Endocrine disrupting contaminants--beyond the dogma
    Louis J Guillette
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Environ Health Perspect 114:9-12. 2006
  6. ncbi request reprint Environmental contaminants, fertility, and multioocytic follicles: a lesson from wildlife?
    Louis J Guillette
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Semin Reprod Med 24:134-41. 2006
  7. ncbi request reprint Environmental contaminants and reproductive abnormalities in wildlife: implications for public health?
    L J Guillette
    Department of Zoology, University of Florida, Gainesville 32611, USA
    Toxicol Ind Health 12:537-50. 1996
  8. ncbi request reprint Alligators, contaminants and steroid hormones
    Louis J Guillette
    Department of Zoology, 223 Bartram Hall, Box 118525, University of Florida, Gainesville, FL 32611 8525, USA
    Environ Sci 14:331-47. 2007
  9. ncbi request reprint Variation in sex steroids and phallus size in juvenile American alligators (Alligator mississippiensis) collected from 3 sites within the Kissimmee-Everglades drainage in Florida (USA)
    Mark P Gunderson
    Department of Zoology, University of Florida, 221 Bartram Hall, P O Box 118525, Gainesville, FL 32611 8525, USA
    Chemosphere 56:335-45. 2004
  10. doi request reprint Birth defects in wildlife: the role of environmental contaminants as inducers of reproductive and developmental dysfunction
    Heather J Hamlin
    Department of Biology, University of Florida, Gainesville, FL 32611 8525, USA
    Syst Biol Reprod Med 56:113-21. 2010

Research Grants

Detail Information

Publications94

  1. pmc Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife
    L J Guillette
    Department of Zoology, University of Florida, Gainesville 32611, USA
    Environ Health Perspect 103:157-64. 1995
    ..Additionally, this model helps explain evolutionary adaptations to naturally occurring estrogenic compounds, such as phytoestrogens...
  2. ncbi request reprint Affinity of the alligator estrogen receptor for serum pesticide contaminants
    Louis J Guillette
    Department of Zoology, 223 Bartram Hall, University of Florida, Gainesville, FL 32611, USA
    Toxicology 181:151-4. 2002
    ..Two compounds, aldrin and Mirex showed little affinity for the aER. These data suggest that additional compounds are capable of acting as aER agonists or antagonists, but future research is needed to confirm in vivo actions, if any...
  3. ncbi request reprint Contaminant-induced endocrine disruption in wildlife
    L J Guillette
    Department of Zoology, University of Florida, Gainesville, USA
    Growth Horm IGF Res 10:S45-50. 2000
    ....
  4. ncbi request reprint Organochlorine pesticides as endocrine disruptors in wildlife
    L J Guillette
    Department of Zoology, University of Florida, Gainesville 32611, USA
    Cent Eur J Public Health 8:34-5. 2000
    ....
  5. pmc Endocrine disrupting contaminants--beyond the dogma
    Louis J Guillette
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Environ Health Perspect 114:9-12. 2006
    ..Without this broader approach, research into endocrine disruption will become dominated by a narrow dogma, focusing on a few end points and mechanisms...
  6. ncbi request reprint Environmental contaminants, fertility, and multioocytic follicles: a lesson from wildlife?
    Louis J Guillette
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Semin Reprod Med 24:134-41. 2006
    ....
  7. ncbi request reprint Environmental contaminants and reproductive abnormalities in wildlife: implications for public health?
    L J Guillette
    Department of Zoology, University of Florida, Gainesville 32611, USA
    Toxicol Ind Health 12:537-50. 1996
    ..We suggest that wildlife are excellent sentinels of ecosystem health. Data from these wildlife studies present models and methodologies for examining human health...
  8. ncbi request reprint Alligators, contaminants and steroid hormones
    Louis J Guillette
    Department of Zoology, 223 Bartram Hall, Box 118525, University of Florida, Gainesville, FL 32611 8525, USA
    Environ Sci 14:331-47. 2007
    ....
  9. ncbi request reprint Variation in sex steroids and phallus size in juvenile American alligators (Alligator mississippiensis) collected from 3 sites within the Kissimmee-Everglades drainage in Florida (USA)
    Mark P Gunderson
    Department of Zoology, University of Florida, 221 Bartram Hall, P O Box 118525, Gainesville, FL 32611 8525, USA
    Chemosphere 56:335-45. 2004
    ..E. associated with these endpoints exists among the 3 sites with the patterns matching the patterns of organochlorine contamination, although S.E. patterns were opposite to what was predicted...
  10. doi request reprint Birth defects in wildlife: the role of environmental contaminants as inducers of reproductive and developmental dysfunction
    Heather J Hamlin
    Department of Biology, University of Florida, Gainesville, FL 32611 8525, USA
    Syst Biol Reprod Med 56:113-21. 2010
    ....
  11. ncbi request reprint Altered neonatal development and endocrine function in Alligator mississippiensis associated with a contaminated environment
    Matthew R Milnes
    Department of Zoology, University of Florida, Gainesville, Florida 32611 8525, USA
    Biol Reprod 73:1004-10. 2005
    ..These results should begin to help separate developmental abnormalities resulting from in ovo exposure, presumably of maternal origin, from physiological alterations induced through environmental exposure to contaminants...
  12. pmc Gonadotropin-induced changes in oviducal mRNA expression levels of sex steroid hormone receptors and activin-related signaling factors in the alligator
    Brandon C Moore
    Department of Biology, 220 Bartram Hall, P O Box 118525, University of Florida, Gainesville, FL 32611 8525, USA
    Gen Comp Endocrinol 175:251-8. 2012
    ..These results demonstrate that five-month-old female alligators display an endocrine-responsive ovarian-oviducal axis and environmental pollution exposure may alter these physiological responses...
  13. pmc Posthatching development of Alligator mississippiensis ovary and testis
    Brandon C Moore
    Department of Biology, University of Florida, Gainesville, Florida 32611 8525, USA
    J Morphol 271:580-95. 2010
    ..Additionally, we predict the morphological maturation observed in these gonads is concomitant with increased endocrine activities...
  14. doi request reprint Altered gonadal expression of TGF-β superfamily signaling factors in environmental contaminant-exposed juvenile alligators
    Brandon C Moore
    Department of Biology, University of Florida, Gainesville, FL 32611 8525, USA
    J Steroid Biochem Mol Biol 127:58-63. 2011
    ..Our study suggests that embryonic exposure to environmental contaminants can affect future non-steroidal signaling patterns in the gonads of a long-lived species...
  15. ncbi request reprint Reproductive characteristics of male mosquitofish (Gambusia holbrooki) from nitrate-contaminated springs in Florida
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, FL 32611, USA
    Aquat Toxicol 85:40-7. 2007
    ..We conclude that male mosquitofish reproduction is not the same among the eight springs tested, and that elevated aquatic nitrate concentrations may explain some of the observed variation...
  16. ncbi request reprint Altered development and reproduction in mosquitofish exposed to pulp and paper mill effluent in the Fenholloway River, Florida USA
    Edward F Orlando
    University of Florida, Department of Zoology, 223 Bartram Hall, Gainesville, FL 32611, USA
    Aquat Toxicol 84:399-405. 2007
    ..The importance of this study is that we have documented masculinized development and decreased embryo production in PME-exposed mosquitofish and that these site effects are generally consistent across seasons and between years...
  17. doi request reprint Increased posthatching mortality and loss of sexually dimorphic gene expression in alligators (Alligator mississippiensis) from a contaminated environment
    Matthew R Milnes
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Biol Reprod 78:932-8. 2008
    ..Because these animals were raised under similar laboratory conditions, the differences are most likely of embryonic origin and organizational in nature...
  18. pmc Influences of sex, incubation temperature, and environmental quality on gonadal estrogen and androgen receptor messenger RNA expression in juvenile American alligators (Alligator mississippiensis)
    Brandon C Moore
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Biol Reprod 82:194-201. 2010
    ..These findings demonstrate that the mRNA expression of receptors required for steroid hormone signaling are modified by exposure to environmental factors, including temperature and contaminants...
  19. pmc Gene-environment interactions: the potential role of contaminants in somatic growth and the development of the reproductive system of the American alligator
    Brandon C Moore
    Department of Biology, 220 Bartram Hall, P O Box 118525, University of Florida, Gainesville, FL 32611 8525, USA
    Mol Cell Endocrinol 354:111-20. 2012
    ..We posit that these differences predispose these animals to increased risks of disease and reproductive dysfunction at adulthood...
  20. doi request reprint Gene expression patterns in juvenile American alligators (Alligator mississippiensis) exposed to environmental contaminants
    Satomi Kohno
    Department of Zoology, 223 Bartram Hall, PO Box 118525, University of Florida, Gainesville, FL 32611 8525, USA
    Aquat Toxicol 88:95-101. 2008
    ..The investigation of these genes also helps clarify normal endocrine and reproductive system function in the American alligator...
  21. ncbi request reprint Contaminant-induced feminization and demasculinization of nonmammalian vertebrate males in aquatic environments
    Matthew R Milnes
    Department of Zoology, 223 Bartram Hall, P O Box 118525, University of Florida, Gainesville, FL 32611, USA
    Environ Res 100:3-17. 2006
    ....
  22. pmc Water quality influences reproduction in female mosquitofish (Gambusia holbrooki) from eight Florida springs
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Environ Health Perspect 114:69-75. 2006
    ..Specifically, we provide evidence that maternal support of the embryo occurs at least during the first two thirds of gestation and that female fecundity is affected by an apparent tradeoff between embryo size and embryo number...
  23. doi request reprint Altered sex hormone concentrations and gonadal mRNA expression levels of activin signaling factors in hatchling alligators from a contaminated Florida lake
    Brandon C Moore
    Department of Biology, University of Florida, Bartram Hall, Gainesville, Florida, USA
    J Exp Zool A Ecol Genet Physiol 313:218-30. 2010
    ..In hatchling alligators, ovarian follicles have not yet formed; therefore, these endocrine differences are likely to affect subsequent ovarian development, including ovarian follicle assembly...
  24. ncbi request reprint Seasonal variation in plasma thyroxine concentrations in juvenile alligators (Alligators mississippiensis) from three Florida Lakes
    Dieldrich S Bermudez
    Department of Zoology, 223 Bartram Hall, University of Florida, Gainesville, FL 32611, USA
    Comp Biochem Physiol A Mol Integr Physiol 141:8-14. 2005
    ..Comparing the seasonal pattern in plasma T(4) with plasma concentrations of sex steroids (testosterone and estradiol-17beta) or corticosterone could provide important information on the peripubescent life stage of the American alligator...
  25. ncbi request reprint Developmental alterations as a result of in ovo exposure to the pesticide metabolite p,p'-DDE in Alligator mississippiensis
    Matthew R Milnes
    Department of Zoology, University of Florida, 223 Bartram Hall, Gainesville, FL 32611 8525, USA
    Gen Comp Endocrinol 144:257-63. 2005
    ....
  26. doi request reprint Environmental influence on yolk steroids in American alligators (Alligator mississippiensis)
    Heather J Hamlin
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Biol Reprod 83:736-41. 2010
    ....
  27. ncbi request reprint Towards an understanding of the evolution of the chorioallantoic placenta: steroid biosynthesis and steroid hormone signaling in the chorioallantoic membrane of an oviparous reptile
    Lori Cruze
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Biol Reprod 87:71. 2012
    ....
  28. pmc Agriculture alters gonadal form and function in the toad Bufo marinus
    Krista A McCoy
    School of Natural Resources and Environment, University of Florida, Gainesville, Florida, USA
    Environ Health Perspect 116:1526-32. 2008
    ..However, evidence of endocrine disruption in wild amphibians living in agricultural areas has been controversial. Typically, studies on the effects of pollutants on wildlife attempt to compare polluted with unpolluted sites...
  29. ncbi request reprint Gonadotropin-induced testosterone response in peripubertal male alligators
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, 32611, USA
    Gen Comp Endocrinol 135:372-80. 2004
    ..These peripubertal animals are not juveniles but sub-adults capable of responding to the seasonal signals associated with reproductive timing in adults...
  30. pmc Organizational changes to thyroid regulation in Alligator mississippiensis: evidence for predictive adaptive responses
    Ashley S P Boggs
    School of Natural Resources and Environment and Department of Biology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e55515. 2013
    ..This work supports the hypothesis that embryonic EDC exposure or iodide imbalance could induce adult metabolic disease states, thereby stressing the need to consider the multiple environmental variables present during development...
  31. doi request reprint Seasonal variation in plasma thyroid hormone concentrations in coastal versus inland populations of juvenile American alligators (Alligator mississippiensis): influence of plasma iodide concentrations
    Ashley S P Boggs
    Department of Biology, 220 Bartram Hall, P O Box 118525, University of Florida, Gainesville, FL 32611, USA
    Gen Comp Endocrinol 174:362-9. 2011
    ..Differences in thyroid hormone concentrations between the populations could be due to differences in dietary iodide, which need to be further evaluated...
  32. ncbi request reprint Tradeoffs between somatic and gonadal investments during development in the African clawed frog (Xenopus laevis)
    Krista A McCoy
    Department of Zoology, University of Florida, Gainesville, Florida 32611 8525, USA
    J Exp Zool A Ecol Genet Physiol 307:637-46. 2007
    ..These tradeoffs may contribute to phenotypic correlations between small size and reduced fitness...
  33. ncbi request reprint Reproductive seasonality of the female Florida gar, Lepisosteus platyrhincus
    Edward F Orlando
    University of Florida, Department of Zoology, 223 Bartram Hall, Gainesville, FL 32611, USA
    Gen Comp Endocrinol 151:318-24. 2007
    ..Moreover, it increases our understanding of basic reproductive biology of semitropical fishes in general, and nonteleost, bony fishes in particular...
  34. ncbi request reprint Environmental context determines nitrate toxicity in Southern toad (Bufo terrestris) tadpoles
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, FL 32611, USA
    Aquat Toxicol 78:50-8. 2006
    ..However, we suggest that, in spring water, tadpoles were exposed to additional stressors that decreased growth rate and thyroxine concentrations, and that this effect was modified by nitrate...
  35. ncbi request reprint Altered histology of the thymus and spleen in contaminant-exposed juvenile American alligators
    Andrew A Rooney
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    J Morphol 256:349-59. 2003
    ..The results point to alterations in the histology of the thymus and spleen. Further studies are required to examine the functional significance of these observations...
  36. doi request reprint Sex steroid and thyroid hormone receptor expressions in the thyroid of the American alligator (Alligator mississippiensis) during different life stages
    Dieldrich S Bermudez
    Department of Biology, 220 Bartram Hall, University of Florida, Gainesville, FL 32611, USA
    J Morphol 272:698-703. 2011
    ..No sexual dimorphism was observed in ERα immunostaining. No statistical analysis across life stages were performed due to confounding factor of season...
  37. ncbi request reprint Cellular bioavailability of natural hormones and environmental contaminants as a function of serum and cytosolic binding factors
    D A Crain
    Department of Zoology, University of Florida, Gainesville, USA
    Toxicol Ind Health 14:261-73. 1998
    ..Therefore, such contaminants may be more hormonally active than previously hypothesized...
  38. pmc Aromatase activity in the ovary and brain of the eastern mosquitofish (Gambusia holbrooki) exposed to paper mill effluent
    Edward F Orlando
    Department of Zoology, University of Florida, Gainesville, Florida, USA
    Environ Health Perspect 110:429-33. 2002
    ..Future studies should examine the relationship between aromatase enzyme activity and exposure to environmental androgens...
  39. ncbi request reprint Developmental morphology of the neonatal alligator (Alligator mississippiensis) ovary
    Brandon C Moore
    Department of Zoology, University of Florida, Gainesville, Florida 32611 8525, USA
    J Morphol 269:302-12. 2008
    ..Diplotene oocytes are observed at hatching in chickens, but not until 3 months in alligators. Folliculogenesis is completed at 3 weeks in chickens whereas it is still progressing at 3 months in alligators...
  40. doi request reprint Renal pathologies in giant toads (Bufo marinus) vary with land use
    Krista A McCoy
    School of Natural Resources and Environment, 103 Black Hall, PO Box 116455, Gainesville, Florida 32611 6455, USA
    Sci Total Environ 407:348-57. 2008
    ....
  41. ncbi request reprint Reproductive dysgenesis in wildlife: a comparative view
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, 32611, USA
    Int J Androl 29:109-21. 2006
    ..These tissues can develop as either male or female and their ultimate direction depends on the environment in which they develop...
  42. ncbi request reprint Seasonal variation in plasma sex steroid concentrations in juvenile American alligators
    Andrew A Rooney
    Department of Zoology, University of Florida, 223 Bartram Hall, P O Box 118525, Gainesville, FL 32611 8525, USA
    Gen Comp Endocrinol 135:25-34. 2004
    ....
  43. ncbi request reprint Reproductive seasonality of the male Florida gar, Lepisosteus platyrhincus
    Edward F Orlando
    Department of Zoology, University of Florida, 223 Bartram Hall, Gainesville, FL 32611, USA
    Gen Comp Endocrinol 131:365-71. 2003
    ..Furthermore, it increases our understanding of the reproductive biology of semitropical fishes...
  44. ncbi request reprint Developmental effects of embryonic exposure to toxaphene in the American alligator (Alligator mississippiensis)
    Matthew R Milnes
    Department of Zoology, University of Florida, 223 Bartram Hall, Gainesville, FL 32611 8525, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:81-7. 2004
    ..Future studies should consider the effects of embryonic exposure to a mixture of chemicals, including toxaphene metabolites, on development in alligators to better evaluate the consequences of environmental contamination...
  45. doi request reprint Morphology and histochemistry of juvenile male American alligator (Alligator mississippiensis) phallus
    Brandon C Moore
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Anat Rec (Hoboken) 295:328-37. 2012
    ..These results better characterize the complexity of the alligator phallus and predict later reproductive functions during adulthood...
  46. doi request reprint Seasonal androgen cycles in adult male American alligators (Alligator mississippiensis) from a barrier island population
    Heather J Hamlin
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Biol Reprod 85:1108-13. 2011
    ....
  47. pmc Endocrine-disrupting effects of cattle feedlot effluent on an aquatic sentinel species, the fathead minnow
    Edward F Orlando
    Department of Zoology, University of Florida, Gainesville, Florida, USA
    Environ Health Perspect 112:353-8. 2004
    ..Future studies are needed to further investigate the effects of agricultural runoff and to identify the biologically active agents, whether natural or pharmaceutical in origin...
  48. ncbi request reprint Temporal and spatial variation in plasma thyroxine (T4) concentrations in juvenile alligators collected from Lake Okeechobee and the northern Everglades, Florida, USA
    Mark P Gunderson
    Department of Zoology, University of Florida, Gainesville 32611 8525, USA
    Environ Toxicol Chem 21:914-21. 2002
    ..We concluded that mean plasma T4 concentrations did not match the sediment contaminant mixture data presently available to us, whereas variance seems to be a more reliable indicator of contaminant exposure...
  49. ncbi request reprint The functional and structural observations of the neonatal reproductive system of alligators exposed in ovo to atrazine, 2,4-D, or estradiol
    D A Crain
    Department of Zoology, University of Florida, Gainesville, USA
    Toxicol Ind Health 15:180-5. 1999
    ..e., steroidogenic enzyme activity) and the structure (i.e., histological analysis) of the reproductive system. Structural assessment alone may be insufficient for detecting subtle endocrine alterations...
  50. doi request reprint Androgens modulate song effort and aggression in Neotropical singing mice
    Bret Pasch
    Department of Biology, University of Florida, Gainesville, Florida 32611, USA
    Horm Behav 59:90-7. 2011
    ..The extensive effects of androgens on a suite of phenotypes highlight their role in linking gonadal status with decisions about investment in reproductive behaviors...
  51. doi request reprint Sublethal effects of methylmercury on fecal metabolites of testosterone, estradiol, and corticosterone in captive juvenile white ibises (Eudocimus albus)
    Evan M Adams
    Department of Wildlife Ecology and Conservation, P O Box 110430, University of Florida, Gainesville, Florida 32611, USA
    Environ Toxicol Chem 28:982-9. 2009
    ..The evidence presented here suggests that endocrine effects of MeHg exposure could behave similarly...
  52. doi request reprint Environmental influences on fertility: can we learn lessons from studies of wildlife?
    Louis J Guillette
    Department of Zoology, University of Florida, Gainesville, Florida 32611 8525
    Fertil Steril 89:e21-4. 2008
    ....
  53. pmc Altered breast development in young girls from an agricultural environment
    Elizabeth A Guillette
    Department of Anthropology, University of Florida, Gainesville, Florida 02611, USA
    Environ Health Perspect 114:471-5. 2006
    ..These data suggest that future in-depth studies examining mammary tissue growth and fat deposition in breast tissue are required if we are to understand environmental influences on these phenomena...
  54. ncbi request reprint Alterations in development of reproductive and endocrine systems of wildlife populations exposed to endocrine-disrupting contaminants
    L J Guillette
    Department of Zoology, 223 Bartram Hall, University of Florida, Gainesville, FL 32611, USA
    Reproduction 122:857-64. 2001
    ..The possible role of contaminants in altering sex determination mechanisms is also examined...
  55. ncbi request reprint Phase I and II liver enzyme activities in juvenile alligators (Alligator mississippiensis) collected from three sites in the Kissimmee-Everglades drainage, Florida (USA)
    M P Gunderson
    Department of Zoology, University of Florida, Gainesville, FL 32611 8525, USA
    Comp Biochem Physiol C Toxicol Pharmacol 139:39-46. 2004
    ..No correlation was observed in this study between plasma steroid concentrations (estradiol-17 beta or testosterone) and hepatic EROD, MROD, or GST activities...
  56. ncbi request reprint Effect of acute stress on plasma beta-corticosterone, estradiol-17 beta and testosterone concentrations in juvenile American alligators collected from three sites within the Kissimmee-Everglades drainage basin in Florida (USA)
    M P Gunderson
    Department of Zoology, University of Florida, P O Box 118525, Gainesville, FL 32611 8525, USA
    Comp Biochem Physiol C Toxicol Pharmacol 135:365-74. 2003
    ..We concluded that the environmental contaminants could be acting as stressors, leading to the observed differences...
  57. pmc Alterations in sexually dimorphic biotransformation of testosterone in juvenile American alligators (alligator mississippiensis) from contaminated lakes
    M P Gunderson
    Department of Zoology, University of Florida, Gainesville, Florida 32611 8525, USA
    Environ Health Perspect 109:1257-64. 2001
    ..These data demonstrate different patterns of hepatic androgen biotransformation in animals living in contaminated environments...
  58. pmc Effects of incubation temperature and estrogen exposure on aromatase activity in the brain and gonads of embryonic alligators
    Matthew R Milnes
    Department of Zoology, University of Florida, Gainesville, FL 32611, USA
    Environ Health Perspect 110:393-6. 2002
    ..This study indicates the need to examine multiple end points and to determine the persistence of developmental alterations in contaminant-exposed wildlife populations...
  59. pmc Endocrine activity of extraembryonic membranes extends beyond placental amniotes
    Lori C Albergotti
    Department of Biology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 4:e5452. 2009
    ..In this study, we ask whether the oviparous chorioallantoic membrane (CAM) of chicken (Gallus gallus) has the capability to synthesize and receive signaling of progesterone, a major placental steroid hormone...
  60. ncbi request reprint Nitrate-induced goiter in captive whitespotted bamboo sharks Chilosryllium plagiosum
    Alexis L Morris
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Post Office Box 100136, Gainesville, Florida 32610, USA
    J Aquat Anim Health 23:92-9. 2011
    ..Goiter is one of the most common health problems in captive elasmobranchs, and this study suggests that nitrate exposure is an important factor in the etiology of this disease...
  61. ncbi request reprint Novel approaches for the study of vertebrate steroid hormone receptors
    Satomi Kohno
    Department of Zoology, 223 Bartram Hall, University of Florida, Gainesville, FL 32611, USA Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences and Department of Basic Biology, School of Life Science, Graduate University for Advanced Studies, Okazaki, Aichi 444 8787, Japan
    Integr Comp Biol 48:527-34. 2008
    ....
  62. ncbi request reprint Up-regulation of the alligator CYP3A77 gene by toxaphene and dexamethasone and its short term effect on plasma testosterone concentrations
    M P Gunderson
    Department of Zoology, University of Florida, P O Box 118525, Gainesville, FL 32611 8525, United States
    Aquat Toxicol 78:272-83. 2006
    ....
  63. doi request reprint Morphology and histochemistry of juvenile American alligator (Alligator mississippiensis) nephrons
    Brandon C Moore
    Department of Biology, 220 Bartram Hall, PO Box 118525, University of Florida, Gainesville, Florida, 32611 8525, USA
    Anat Rec (Hoboken) 292:1670-6. 2009
    ..Through the techniques described here, we have identified a series of distinct markers to be used by pathologists, veterinarians, and researchers to easily identify alligator nephron segments. Anat Rec, 2009. (c) 2009 Wiley-Liss, Inc...
  64. ncbi request reprint Plasma steroid concentrations in relation to size and age in juvenile alligators from two Florida lakes
    Matthew R Milnes
    Department of Zoology, 223 Bartram Hall, University of Florida, Gainesville, FL 32611 8525, USA
    Comp Biochem Physiol A Mol Integr Physiol 131:923-30. 2002
    ..We suggest both factors should be considered when conducting physiological studies where there is evidence to suggest growth rates may differ among populations...
  65. pmc Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator
    S Kohno
    Department of Biology, University of Florida, Gainesville, FL 32611 8525, USA
    Sex Dev 4:73-87. 2010
    ..These findings provide new insights on TSD and suggest that further studies examining the role of HSPs during gonadal development are needed...
  66. doi request reprint Animal-Borne Imaging Reveals Novel Insights into the Foraging Behaviors and Diel Activity of a Large-Bodied Apex Predator, the American Alligator (Alligator mississippiensis)
    James C Nifong
    Department of Biology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e83953. 2014
    ....
  67. ncbi request reprint Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes
    Jena L Chojnowski
    Department of Zoology, University of Florida, Gainesville, FL 32611, USA
    J Mol Evol 65:259-66. 2007
    ..Falsification of these models places fundamental constraints upon the plausible pathways for the evolution of isochores...
  68. pmc Gonadal mRNA expression levels of TGFbeta superfamily signaling factors correspond with post-hatching morphological development in American alligators
    B C Moore
    Department of Biology, Bartram Hall, University of Florida, Gainesville, FL, USA bmoore2 tulane edu
    Sex Dev 4:62-72. 2010
    ..We propose that the mRNA expression levels and concomitant morphological changes observed here affect the establishment of alligator reproductive health and later fertility...
  69. ncbi request reprint Decreased sperm count and sexual behavior in mosquitofish exposed to water from a pesticide-contaminated lake
    Gunnar Toft
    Institute of Biological Sciences, University of Aarhus, Building 135, DK 8000 Aarhus C, Denmark
    Ecotoxicol Environ Saf 60:15-20. 2005
    ..We hypothesize that the presence of contaminants with antiandrogenic and estrogenic action in the water from Lake Apopka are the likely cause of the observed decrease in sperm count and impaired sexual behavior...
  70. ncbi request reprint Microsatellite DNA analyses support an east-west phylogeographic split of American alligator populations
    Lisa M Davis
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    J Exp Zool 294:352-72. 2002
    ....
  71. ncbi request reprint Thyroid status in juvenile alligators (Alligator mississippiensis) from contaminated and reference sites on Lake Okeechobee, Florida, USA
    Elizabeth A Hewitt
    Department of Biology, Maryville College, TN 37804, USA
    Chemosphere 47:1129-35. 2002
    ..0001). It is proposed that the disruptions seen in Lake Okeechobee alligators are due to disruptions at both the thyroid and extra-thyroidal tissues...
  72. pmc Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a lake contaminated with endocrine disruptors
    Gunnar Toft
    Institute of Biological Sciences, University of Aarhus, Aarhus, Denmark
    Environ Health Perspect 111:695-701. 2003
    ....
  73. ncbi request reprint Effects of an androgenic growth promoter 17beta-trenbolone on masculinization of Mosquitofish (Gambusia affinis affinis)
    Kiyoaki Sone
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Gen Comp Endocrinol 143:151-60. 2005
    ..TB also induced differentiation of the anal fin into a gonopodium in fry of both sexes, stimulated precocious spermatogenesis in the testes of males and the formation of ovotestes in females...
  74. ncbi request reprint Occurrence and biological effect of exogenous steroids in the Elkhorn River, Nebraska, USA
    Alan S Kolok
    Department of Biology, University of Nebraska at Omaha, Omaha, NE 68182 0040, USA
    Sci Total Environ 388:104-15. 2007
    ....
  75. ncbi request reprint Reproductive physiology of free-living White Ibises (Eudocimus albus) in the Florida Everglades
    Julie A Heath
    Department of Biology, Hofstra University, Hempstead, NY 11549, USA
    Gen Comp Endocrinol 133:118-31. 2003
    ..White Ibises showed similar patterns in reproductive physiology to other monogamous, seasonally breeding bird species in which both sexes incubate and care for the young...
  76. ncbi request reprint Interembryonic regions of the uterus of the viviparous lizard Mabuya brachypoda (Squamata: Scincidae)
    Mari Carmen Uribe-Aranzábal
    Laboratorio de Biología de la Reproducción Animal, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, D F Mexico
    J Morphol 267:404-14. 2006
    ..The presence of abundant uterine glands and extraembryonic membranes in the interembryonic regions during gestation suggests uterine secretory activity and histotrophic transfer of nutrients to embryos in these regions...
  77. ncbi request reprint Altered social behavior and sexual characteristics in mosquitofish (Gambusia holbrooki) living downstream of a paper mill
    Gunnar Toft
    Institute of Biological Sciences, Department of Zoophysiology, University of Aarhus, Building 131, DK 8000 Aarhus C, Denmark
    Aquat Toxicol 70:213-22. 2004
    ..We conclude that a number of sexual characteristics were affected in mosquitofish living in the paper mill contaminated Fenholloway River, with possible adverse effects on the reproduction of this population...
  78. ncbi request reprint Isolation of the alligator (Alligator mississippiensis) thyroid hormone receptor alpha and beta transcripts and their responsiveness to thyroid stimulating hormone
    Caren C Helbing
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Gen Comp Endocrinol 149:141-50. 2006
    ..These data demonstrate that alligator tissues are differentially responsive to TSH by regulation of TR expression and provide an important comparative framework among vertebrates...
  79. ncbi request reprint Characterization of Inhibitor of Growth 2 tumor suppressor in Alligator mississippiensis, its conservation in Archosauria, and response to thyroid stimulating hormone
    Caren C Helbing
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Comp Biochem Physiol B Biochem Mol Biol 146:279-88. 2007
    ..ING2 expression in the thyroid gland, gonad, and heart was unaffected by TSH treatment. These data indicate that control of ING2 expression by the thyroid axis may be conserved among species and is tissue-dependent...
  80. ncbi request reprint An ecological assessment of bisphenol-A: evidence from comparative biology
    D Andrew Crain
    Department of Biology, Maryville College, 502 E Lamar Alexander Parkway, Maryville, TN 37804 5907, USA
    Reprod Toxicol 24:225-39. 2007
    ..Further studies should examine the most vulnerable vertebrate and invertebrate species...
  81. ncbi request reprint In vitro assessment of transcriptional activation of the estrogen and androgen receptors of mosquitofish, Gambusia affinis affinis
    Yoshinao Katsu
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Mol Cell Endocrinol 276:10-7. 2007
    ..These data provide a basic tool allowing future studies examining the receptor-ligand interactions and endocrine disrupting mechanisms in mosquitofish and also expands our knowledge of estrogen and androgen receptor evolution...
  82. pmc Abnormal bone composition in female juvenile American alligators from a pesticide-polluted lake (Lake Apopka, Florida)
    P Monica Lind
    Institute of Environmental Medicine, Karolinska Institutet, Institute of Environmental Medicine, PO Box 210, Nobels vag 13, plan 3, S 171 77 Stockholm, Sweden
    Environ Health Perspect 112:359-62. 2004
    ....
  83. pmc Molecular cloning and characterization of estrogen, androgen, and progesterone nuclear receptors from a freshwater turtle (Pseudemys nelsoni)
    Yoshinao Katsu
    Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Aichi 444 8787, Japan
    Endocrinology 149:161-73. 2008
    ..This is the first report of the full coding regions of a reptilian AR and PR and the examination of their transactivation by steroid hormones...
  84. ncbi request reprint Protecting embryos from stress: corticosterone effects and the corticosterone response to capture and confinement during pregnancy in a live-bearing lizard (Hoplodactylus maculatus)
    Alison Cree
    Department of Zoology, University of Otago, Box 56, Dunedin, New Zealand
    Gen Comp Endocrinol 134:316-29. 2003
    ....
  85. ncbi request reprint Molecular cloning of the estrogen and progesterone receptors of the American alligator
    Yoshinao Katsu
    Center for Integrative Bioscience, National Institute for Basic Biology, Okazaki National Research Institutes, Higashiyama, Myodaiji, Okazaki, Japan
    Gen Comp Endocrinol 136:122-33. 2004
    ..These results provide tools that will allow future studies examining the regulation and ontogenic expression of steroid receptors in alligators and expand our knowledge of vertebrate steroid receptor evolution...
  86. pmc Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in Eastern Nebraska, USA
    Ana M Soto
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Health Perspect 112:346-52. 2004
    ..Tap water was devoid of hormonal activity. We conclude that feedlot effluents contain sufficient levels of hormonally active agents to warrant further investigation of possible effects on aquatic ecosystem health...
  87. ncbi request reprint Timing of parturition in two species of viviparous lizard: influences of beta-adrenergic stimulation and temperature upon uterine responses to arginine vasotocin (AVT)
    Natalia Atkins
    School of Zoology, University of Tasmania, Private Bag 5, Hobart, TAS, 7001, Australia
    J Comp Physiol B 176:783-92. 2006
    ....
  88. doi request reprint Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
    D Andrew Crain
    Maryville College, Maryville, Tennessee, USA
    Fertil Steril 90:911-40. 2008
    ..Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health...
  89. ncbi request reprint Sexual dimorphic responses in wildlife exposed to endocrine disrupting chemicals
    Edward F Orlando
    Harbor Branch Oceanographic Institution Campus, Florida Atlantic University, 5600 US 1, North, Ft Pierce, FL 34946, USA
    Environ Res 104:163-73. 2007
    ....
  90. ncbi request reprint Molecular cloning of estrogen receptor alpha (ERalpha; ESR1) of the Japanese giant salamander, Andrias japonicus
    Yoshinao Katsu
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Aichi, Japan
    Mol Cell Endocrinol 257:84-94. 2006
    ..This is the first isolation of an estrogen receptor from a salamander and also is the first functional cDNA obtained from the Japanese giant salamander, an endangered species considered a special natural monument of Japan...
  91. ncbi request reprint Evaluation of androstenedione as an androgenic component of river water downstream of a pulp and paper mill effluent
    Eth J Durhan
    US Environmental Protection Agency, National Health and Environmental Effects Laboratory, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 21:1973-6. 2002
    ..We conclude that, although androstenedione was present at easily detectable concentrations in the river water (> 100 ng/L), this compound is not associated with androgenic activity of water from the site...
  92. ncbi request reprint Stress and its relation to endocrine function in captive female Siberian sturgeon (Acipenser baeri)
    Heather J Hamlin
    Mote Marine Laboratory, Center for Aquaculture Research and Development, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA
    Environ Sci 14:129-39. 2007
    ..This is the first study to define the relationship between stress and possible changes in sex steroid concentration in this threatened and commercially important species...
  93. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  94. ncbi request reprint Molecular cloning of estrogen receptor alpha of the Nile crocodile
    Yoshinao Katsu
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Comp Biochem Physiol A Mol Integr Physiol 143:340-6. 2006
    ..These data provide a novel tool allowing future studies examining the regulation and ontogenic expression of ERalpha in crocodiles and expands our knowledge of estrogen receptor evolution...

Research Grants1

  1. Inhibins and Environmental Estrogens in Ovarian Disease
    Louis Guillette; Fiscal Year: 2007
    ..Understanding and documenting the conserved mechanisms of induction of MOFs among vertebrates will strengthen the causal and mechanistic relationships, allowing a better understanding of this phenomenon in human populations. ..