Theresa W Guilbert
Affiliation: University of Wisconsin
- Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroidsRobert F Lemanske
University of Wisconsin School of Medicine and Public Health, Madison, USA
N Engl J Med 362:975-85. 2010..For children who have uncontrolled asthma despite the use of low-dose inhaled corticosteroids (ICS), evidence to guide step-up therapy is lacking...
- Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthmaTheresa W Guilbert
Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53716, USA
J Allergy Clin Immunol 128:532-8.e1-10. 2011..Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood...
- Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasoneTheresa W Guilbert
Department of Pediatrics, University of Wisconsin Madison, Wis 53716, USA
J Allergy Clin Immunol 128:956-63.e1-7. 2011..The effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial...
- Effect of breastfeeding on lung function in childhood and modulation by maternal asthma and atopyTheresa W Guilbert
Arizona Respiratory Center, Department of Pediatrics, University of Arizona, Tucson, Arizona, USA
Am J Respir Crit Care Med 176:843-8. 2007..The protective effect of breastfeeding on early respiratory infections is well established, but its relationship to the development of subsequent asthma remains controversial...
- Asthma that is not well-controlled is associated with increased healthcare utilization and decreased quality of lifeTheresa W Guilbert
The Department of Pediatrics, University of Wisconsin, Madison, WI 53716, USA
J Asthma 48:126-32. 2011..Relationships of asthma control to other asthma outcomes have been incompletely documented...
- Role of infection in the development and exacerbation of asthmaTheresa W Guilbert
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 944, CSC 4108, Madison, WI 53792, USA
Expert Rev Respir Med 4:71-83. 2010..This review discusses these various associations as they pertain to the development and exacerbation of asthma...
- Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezingLeonard B Bacharier
Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
J Allergy Clin Immunol 122:1127-1135.e8. 2008..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...
- Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthmaRobert S Zeiger
Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
J Allergy Clin Immunol 117:45-52. 2006..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
- Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezingKatherine Rivera-Spoljaric
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
J Pediatr 154:877-81.e4. 2009..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
- Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller TrialChristine A Sorkness
Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
J Allergy Clin Immunol 119:64-72. 2007..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
- Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trialFernando D Martinez
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, AZ, USA
Lancet 377:650-7. 2011..We assessed the effectiveness of an inhaled corticosteroid (beclomethasone dipropionate) used as rescue treatment...
- Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthmaGary L Larsen
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 123:861-7.e1. 2009..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...
- Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma studyRobert C Strunk
Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
J Allergy Clin Immunol 122:1138-1144.e4. 2008..Clinical trials in children with moderate-to-severe persistent asthma are limited...
- Characterization of within-subject responses to fluticasone and montelukast in childhood asthmaStanley J Szefler
Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 115:233-42. 2005..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
- Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthmaNathan Rabinovitch
Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
J Allergy Clin Immunol 126:545-51.e1-4. 2010..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
- Long-term inhaled corticosteroids in preschool children at high risk for asthmaTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
N Engl J Med 354:1985-97. 2006..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
- Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthmaLeonard B Bacharier
Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63017, USA
J Allergy Clin Immunol 123:1077-82, 1082.e1-5. 2009..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...
- Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthmaTheresa W Guilbert
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
J Allergy Clin Immunol 114:1282-7. 2004....
- The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education networkTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
Control Clin Trials 25:286-310. 2004..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
- Diagnosis and management of early asthma in preschool-aged childrenLeonard B Bacharier
Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
J Allergy Clin Immunol 130:287-96; quiz 297-8. 2012..Finally, regular monitoring of symptom control and medication side effects is important along with titrating controllers to the minimally effective dose...
- Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescenceWayne J Morgan
Arizona Respiratory Center, P.O. Box 245030, Tucson, Arizona 85724, USA
Am J Respir Crit Care Med 172:1253-8. 2005..CONCLUSION: Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthma-like symptoms during the preschool years...
- Pediatric asthma phenotypesKelly Cowan
University of Wisconsin, Madison, Wisconsin, USA
Curr Opin Pediatr 24:344-51. 2012..This review will discuss efforts to categorize these children with recurrent wheezing and develop asthma-predictive tools...
- Prevention of asthma in childhoodZoran Danov
Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin 53716, USA
Curr Opin Allergy Clin Immunol 7:174-9. 2007..The prevalence of asthma is increasing in many parts of the world, particularly in developed countries. The present review focuses on recent literature regarding asthma prevention in childhood...
- The theory and application of UW ehealth-PHINEX, a clinical electronic health record-public health information exchangeTheresa W Guilbert
Department of Pediatrics, University of Wisconsin Madison School of Medicine and Public Health, Box 9988 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA
WMJ 111:124-33. 2012..Electronic health records (EHRs) hold the promise of improving clinical quality and population health while reducing health care costs. However, it is not clear how these goals can be achieved in practice...
- The burden of asthma in the United States: level and distribution are dependent on interpretation of the national asthma education and prevention program guidelinesAnne L Fuhlbrigge
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 166:1044-9. 2002..Inquiry into recent day or nighttime symptoms alone underestimates the burden of asthma and may lead to inadequate treatment of asthma based on national guideline recommendations...
- Innate Immunity and RSV Infection in ChildrenTheresa Guilbert; Fiscal Year: 2007..Accomplishment of these aims will allow us to begin to elucidate the immune mechanisms of the major gene-environment interactions influencing early childhood respiratory disease. ..