A Guidotti

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi Epigenetic GABAergic targets in schizophrenia and bipolar disorder
    A Guidotti
    Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Psychiatric Institute, 1601 Taylor, Chicago, IL 60612, USA
    Neuropharmacology 60:1007-16. 2011
  2. ncbi The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders
    A Guidotti
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, MC 912, Chicago, IL 60612, USA
    Brain Res Brain Res Rev 37:110-5. 2001
  3. doi A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009)
    Alessandro Guidotti
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor, Chicago, IL 60612, United States
    Pharmacol Res 64:344-9. 2011
  4. ncbi Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
    A Guidotti
    Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Room 256, Chicago, IL 60612, USA
    Arch Gen Psychiatry 57:1061-9. 2000
  5. ncbi New neurochemical markers for psychosis: a working hypothesis of their operation
    A Guidotti
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    Neurochem Res 25:1207-18. 2000
  6. doi Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
    Alessandro Guidotti
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor Street, Chicago, IL 60612, USA
    Trends Pharmacol Sci 30:55-60. 2009
  7. ncbi Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability
    E Costa
    Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Neurobiol Dis 8:723-42. 2001
  8. pmc Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia
    E Dong
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:12578-83. 2005
  9. pmc An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
    L Tremolizzo
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 99:17095-100. 2002
  10. ncbi Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
    Lucio Tremolizzo
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 57:500-9. 2005

Research Grants

  1. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
  2. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2007
  3. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
  4. NEUROSTEROIDS: PHYSIOLOGICAL RELEVANCE
    Alessandro Guidotti; Fiscal Year: 1999
  5. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009

Collaborators

Detail Information

Publications84

  1. doi Epigenetic GABAergic targets in schizophrenia and bipolar disorder
    A Guidotti
    Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Psychiatric Institute, 1601 Taylor, Chicago, IL 60612, USA
    Neuropharmacology 60:1007-16. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  2. ncbi The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders
    A Guidotti
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, MC 912, Chicago, IL 60612, USA
    Brain Res Brain Res Rev 37:110-5. 2001
    ..The results of these studies may enable us to design drugs that specifically affect neurosteroidogenic enzymatic activities and may provide an efficacious treatment for the psychopathologies associated with psychiatric disorders...
  3. doi A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009)
    Alessandro Guidotti
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor, Chicago, IL 60612, United States
    Pharmacol Res 64:344-9. 2011
    ..As you know, Dr. Costa was an eclectic scientist and in his 15 years of studies at UIC, he touched many other aspects of neuroscience research that are not discussed in this overview...
  4. ncbi Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
    A Guidotti
    Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Room 256, Chicago, IL 60612, USA
    Arch Gen Psychiatry 57:1061-9. 2000
    ....
  5. ncbi New neurochemical markers for psychosis: a working hypothesis of their operation
    A Guidotti
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    Neurochem Res 25:1207-18. 2000
    ..This downregulation of neuropile plasticity may be a factor to be considered in the etiology of the disintegration of consciousness, which is one of the primary signs of psychosis...
  6. doi Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
    Alessandro Guidotti
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor Street, Chicago, IL 60612, USA
    Trends Pharmacol Sci 30:55-60. 2009
    ..This remodeling might contribute to reelin- and GAD(67)-promoter demethylation and might reverse the GABAergic-gene-expression downregulation associated with SZ morbidity...
  7. ncbi Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability
    E Costa
    Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Neurobiol Dis 8:723-42. 2001
    ..This hypothesis is supported by a genetic mouse model of reelin haploinsufficiency that replicates the above-described dendritic and presynaptic GABAergic defects documented in schizophrenia brains...
  8. pmc Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia
    E Dong
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:12578-83. 2005
    ....
  9. pmc An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
    L Tremolizzo
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 99:17095-100. 2002
    ..Hence the inhibition of histone deacetylases could represent a pharmacological intervention mitigating epigenetically induced vulnerability to schizophrenia in individuals at risk...
  10. ncbi Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
    Lucio Tremolizzo
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 57:500-9. 2005
    ..We studied whether MET-induced epigenetic reelin promoter hypermethylation and the associated behavioral alterations can be reduced by valproate in doses that inhibit histone deacetylases (HDACs)...
  11. pmc Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters
    E Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:4676-81. 2007
    ....
  12. pmc The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases
    M V Simonini
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:1587-92. 2006
    ..Hence, some benzamide derivatives may express a greater efficacy than VPA as an adjunctive to antipsychotics in the treatment of epigenetically induced psychiatric disorders...
  13. pmc Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex
    M A Rodriguez
    Psychiatric Institute, Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 97:3550-5. 2000
    ....
  14. pmc DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains
    M Veldic
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 101:348-53. 2004
    ....
  15. pmc Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats
    C Pesold
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 95:3221-6. 1998
    ..The translated product of this mRNA is readily exported from the granule cell somata to the parallel fibers, where it has been detected by electron microscopy in axon terminals located presynaptically to Purkinje cell dendrites...
  16. ncbi REELIN and schizophrenia: a disease at the interface of the genome and the epigenome
    E Costa
    Psychiatric Institute Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Interv 2:47-57. 2002
    ..Such inhibitors could thus be of therapeutic value in mitigating vulnerability to schizophrenia among high-risk individuals...
  17. ncbi A GABAergic cortical deficit dominates schizophrenia pathophysiology
    E Costa
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor St, Chicago IL 60612, USA
    Crit Rev Neurobiol 16:1-23. 2004
    ..Hence, imidazenil should be appropriately studied as a prospective candidate for a pharmacological intervention in schizophrenia...
  18. pmc In psychosis, cortical interneurons overexpress DNA-methyltransferase 1
    Marin Veldic
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:2152-7. 2005
    ..Interestingly, the DNMT1 increase failed to occur when patients with psychosis received a combination of valproate and APS treatment but not APS monotherapy...
  19. pmc Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse
    W S Liu
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 98:3477-82. 2001
    ..These findings are interesting because the brain neurochemical and neuroanatomical phenotypic traits exhibited by the HRM are in several ways similar to those found in postmortem brains of psychotic patients...
  20. pmc Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression
    C Pesold
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago IL, 60612, USA
    Proc Natl Acad Sci U S A 96:3217-22. 1999
    ....
  21. ncbi Epigenetic targets in GABAergic neurons to treat schizophrenia
    E Costa
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Adv Pharmacol 54:95-117. 2006
  22. pmc Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
    E Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:13614-9. 2008
    ..By activating a DNA demethylase, the association of CLZ or SULP with VPA may facilitate a chromatin remodeling that normalizes the GABAergic gene expression down-regulation detected in the telencephalic regions of SZ and BP patients...
  23. ncbi Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation
    G Carboni
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor, Chicago, IL 60612, USA
    Neuropharmacology 46:1070-81. 2004
    ....
  24. pmc Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells
    N R Smalheiser
    Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, M C 912, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 97:1281-6. 2000
    ..Liver appears to be a prime candidate to produce and maintain the circulating reelin pool. It now becomes relevant to ask whether circulating reelin has a physiologic role on one or more peripheral target tissues...
  25. ncbi Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection
    W B Ruzicka
    1Department of Psychiatry, College of Medicine, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Psychiatry 12:385-97. 2007
    ..These findings implicate an epigenetically mediated layer I GABAergic dysfunction in the pathogenesis of schizophrenia, and suggest novel strategies for treatment of the disease...
  26. ncbi GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs
    E Costa
    University of Illinois at Chicago, Department of Psychiatry, Psychiatric Institute, 1601 W Taylor St, Chicago, IL 60612, USA
    Neuropharmacology 43:925-37. 2002
    ..New analytic procedures may foster progress in the understanding of tolerance to and withdrawal from benzodiazepines...
  27. ncbi The phenotypic characteristics of heterozygous reeler mouse
    P Tueting
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    Neuroreport 10:1329-34. 1999
    ..Possible analogies between these rl+/- phenotypic traits and signs of psychosis vulnerability are discussed...
  28. pmc Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines
    E Izzo
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 98:3483-8. 2001
    ....
  29. pmc Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
    R Satta
    Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:16356-61. 2008
    ..Nicotine is not effective in striatal medium spiny GABAergic neurons that primarily express muscarinic receptors...
  30. pmc DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures
    Jai Sung Noh
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:1749-54. 2005
    ..These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters...
  31. ncbi GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
    Alessandro Guidotti
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor St, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 180:191-205. 2005
    ..Indirectly, this GABAergic neuron downregulation may play a key role in the expression of positive and negative symptoms of SZ and BP disorders...
  32. pmc The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes
    Marija Kundakovic
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Pharmacol 75:342-54. 2009
    ..These data provide a mechanistic rationale for the use of epigenetic drugs, individually or in combination, as a potential novel therapeutic strategy to alleviate deficits associated with schizophrenia...
  33. pmc Reelin function in neural stem cell biology
    H M Kim
    Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 60612, USA
    Proc Natl Acad Sci U S A 99:4020-5. 2002
    ..We suggest that a possible inhibition of NSC migration in psychiatric patients with a reelin deficit may be a potential problem in successful NSC transplantation in these patients...
  34. pmc An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes
    A Zhubi
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, IL, USA
    Schizophr Res 111:115-22. 2009
    ..Hence, PBL studies may become useful to investigate a diagnostic epigenetic marker of SZ morbidity...
  35. pmc Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation
    E Dong
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 98:2849-54. 2001
    ....
  36. ncbi S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis
    Alessandro Guidotti
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, Illinois, USA
    Neuroreport 18:57-60. 2007
    ....
  37. pmc Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance
    J Auta
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, M C 912, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 97:2314-9. 2000
    ..Using patas monkeys and a multiple schedule with repeated acquisition and performance of chain responses, we report that IMD administration for 17 days antagonized without showing tolerance ALP-induced disruption of acquisition...
  38. ncbi On the putative physiological role of allopregnanolone on GABA(A) receptor function
    G Puia
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor St MC912, Chicago, IL 60612, USA
    Neuropharmacology 44:49-55. 2003
    ....
  39. ncbi In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas
    Miguel A Rodriguez
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Comp Neurol 451:279-88. 2002
    ..2000])...
  40. doi Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage
    Bashkim Kadriu
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
    Toxicology 256:164-74. 2009
    ....
  41. pmc Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression
    Ekrem Maloku
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 107:4407-11. 2010
    ..This finding suggests that lack of reelin impairs GABAergic Purkinje neuron expression and/or positioning during cerebellar development...
  42. doi DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients
    J Auta
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, United States Electronic address
    Schizophr Res 150:312-8. 2013
    ....
  43. ncbi Neurochemical basis for an epigenetic vision of synaptic organization
    E Costa
    Psychiatric Institute Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int Rev Neurobiol 59:73-91. 2004
  44. pmc Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder
    Fabio Pibiri
    Psychiatric Institute, Department of Psychiatry, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:5567-72. 2008
    ....
  45. ncbi Changes in AMPA receptor-spliced variant expression and shift in AMPA receptor spontaneous desensitization pharmacology during cerebellar granule cell maturation in vitro
    P Longone
    Department of Psychiatry, University of Illinois College of Medicine, Chicago 60612, USA
    J Mol Neurosci 11:23-41. 1998
    ....
  46. pmc Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography
    D P Uzunov
    Department of Psychiatry, University of Illinois at Chicago 60612, USA
    Proc Natl Acad Sci U S A 93:12599-604. 1996
    ..A fluoxetine stimulation of brain 3 alpha, 5 alpha-TH PROG biosynthesis might be operative in the anxiolytic and antidysphoric actions of this drug...
  47. pmc Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice
    Roberto C Agis-Balboa
    Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:18736-41. 2007
    ..In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders such as anxiety, aggression, and cognitive dysfunction...
  48. ncbi From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia
    Dennis R Grayson
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA
    Epigenetics 4:144-9. 2009
    ..We suggest that to expand our knowledge of epigenetically-responsive promoters using MET might allow for a better appreciation of global methylation changes occurring in selected brain regions...
  49. pmc In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:2035-40. 2003
    ..We conclude that Allo brain content normalization is a better candidate than 5-HT reuptake inhibition to explain the reduction of aggressiveness elicited by S-FLX and S-NFLX...
  50. pmc Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 101:6222-5. 2004
    ..We conclude that normalization of PTB action elicited by the S-isomers of FLX and NFLX is related to the reversal of the down-regulation of brain Allo content and is independent of selective serotonin reuptake inhibitor activity...
  51. pmc Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
    Roberto C Agis-Balboa
    Department of Psychiatry, Psychiatric Institute, University of Illinois, 1601 Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:14602-7. 2006
    ....
  52. doi Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum
    A Zhubi
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Transl Psychiatry 4:e349. 2014
    ..These data are consistent with the hypothesis that an increase of 5-hmC (relative to 5-mC) at specific gene domains enhances the binding of MeCP2 to 5-hmC and reduces expression of the corresponding target genes in ASD cerebella. ..
  53. ncbi Moving up or moving down? Malpositioned cerebellar unipolar brush cells in reeler mouse
    E Ilijic
    Northwestern University Institute for Neuroscience, Searle 5 470, 320 East Superior Street, Chicago, IL 60611, USA
    Neuroscience 136:633-47. 2005
    ..The observed displacement of UBCs in the reeler suggests that they originate from the ventricular zone...
  54. ncbi The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    Dennis R Grayson
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
    Pharmacol Ther 111:272-86. 2006
    ....
  55. doi GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability
    Erminio Costa
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor, Chicago, IL 60612, USA
    Expert Rev Neurother 9:87-98. 2009
    ....
  56. ncbi Brain neurosteroids in gender-related aggression induced by social isolation
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Crit Rev Neurobiol 16:75-82. 2004
    ..g., by treatment with MET) or by direct administration of Allo or of agents (e.g., fluoxetine) that upregulate brain Allo content in SI mice...
  57. ncbi Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
    Erminio Costa
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Mol Interv 3:220-9. 2003
  58. ncbi Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam
    James Auta
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St, Chicago, IL 60612, USA
    Neuropharmacology 49:425-9. 2005
    ..Thus, we suggest that imidazenil might be more effective than FLU at alleviating the withdrawal syndrome associated with long-term BZ administration...
  59. ncbi GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability
    Erminio Costa
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Crit Rev Neurobiol 15:121-42. 2003
    ....
  60. ncbi Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity
    James Auta
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Neuropharmacology 46:397-403. 2004
    ..In contrast, diazepam was effective at doses (5 and 2.5 mg/kg) that produce sedation, amnesia, and ataxia. Furthermore, the combination of imidazenil with atropine was more potent and efficacious than that with diazepam...
  61. doi Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives
    James Auta
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Pharmacol Biochem Behav 95:383-9. 2010
    ..In contrast, none of the IMD derivatives studied shows any similarity to BTZ, which elicits anticonflict, anti-proconflict actions and suppresses locomotor activity but is virtually inactive against BIC-induced tonic-clonic convulsions...
  62. pmc L-methionine decreases dendritic spine density in mouse frontal cortex
    Patricia Tueting
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, USA
    Neuroreport 21:543-8. 2010
    ....
  63. doi Valproate induces DNA demethylation in nuclear extracts from adult mouse brain
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL, USA
    Epigenetics 5:730-5. 2010
    ....
  64. pmc A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:5479-84. 2003
    ..We conclude that reelin binds with high affinity to integrin receptors expressed in SNSs and thereby activates Arc protein synthesis...
  65. ncbi Olfactory discrimination learning deficit in heterozygous reeler mice
    John Larson
    Department of Psychiatry, College of Medicine, University of Illinois, 1601 W Taylor St, Chicago, IL 60612, USA
    Brain Res 971:40-6. 2003
    ..Whether or not the olfactory learning deficit observed in HR mice is related to the low dendritic spine density or GAD67 reduction observed in hippocampus and cortex are currently under investigation...
  66. ncbi The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics
    Erminio Costa
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, College of Medicine, 1601 West Taylor Street, Chicago, Illinois 60612, USA
    Curr Opin Pharmacol 2:56-62. 2002
    ..An understanding of the epigenetic regulation of reelin gene expression and of the possible pathogenetic role of reelin deficiency in schizophrenia, may become a major focus that will open new avenues for the treatment of this disease...
  67. pmc Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:2135-40. 2005
    ..Our results support the view that TP-induced aggressive behavior is the result of a TP-mediated neurosteroid biosynthesis down-regulation that can be reversed by the S-NFLX-induced increase of brain Allo content...
  68. pmc The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice
    Fabio Pibiri
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:14169-74. 2008
    ..Our data show that a combination of HUP with IMI is a prophylactic, potent, and safe therapeutic strategy to overcome DFP toxicity...
  69. pmc Reelin promoter hypermethylation in schizophrenia
    Dennis R Grayson
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:9341-6. 2005
    ..Collectively, the data show that this promoter region has positive and negative properties and that the function of this complex cis element relates to its methylation status...
  70. ncbi Reelin down-regulation in mice and psychosis endophenotypes
    Patricia Tueting
    Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street Chicago, IL 60612, USA
    Neurosci Biobehav Rev 30:1065-77. 2006
    ..Thus, an animal model that combines genetic heterozygocity with epigenesis holds promise for understanding the role of Reelin down-regulation in psychosis...
  71. pmc Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:4275-80. 2006
    ..Benzodiazepine response mediated by alpha1-containing GABA(A)-Rs is expected to be silent or reduced...
  72. ncbi Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Schizophr Res 88:227-31. 2006
    ..The authors consider these results in the context of future application of HDAC inhibitors to the treatment of psychiatric disorders...
  73. ncbi Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 186:362-72. 2006
    ..Therefore, the term "SSRI" may be misleading in defining the pharmacological profile of fluoxetine and its congeners. To this extent, the term "selective brain steroidogenic stimulants" (SBSSs) could be proposed...
  74. pmc SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States
    Curr Opin Pharmacol 9:24-30. 2009
    ..Thus, fluoxetine and related congeners facilitate GABA(A) receptor neurotransmission and effectively ameliorate emotional and anxiety disorders and depression by acting as selective brain steroidogenic stimulants (SBSSs)...
  75. pmc Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder
    Marin Veldic
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, United States
    Schizophr Res 91:51-61. 2007
    ..This suggests that different epigenetic mechanisms must exist in the pathogenesis underlying SZ and BDP and implies that these disorders might involve two separate entities that are characterized by a well-defined neuropathology...
  76. pmc Chromatin, DNA methylation and neuron gene regulation--the purpose of the package
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Psychiatry Neurosci 30:257-63. 2005
    ..Because chromatin structure can be modified by conventional pharmacologic therapy, a novel approach to the regulation of neuronal gene expression in clinical populations is possible...
  77. ncbi Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability
    Erminio Costa
    University of Illinois, Department of Psychiatry, Chicago, Illinois 60612, USA
    Epigenetics 2:29-36. 2007
    ..The results encourage the view that promoter hypermethylation in GABAergic neurons that occurs in SZ represents a testable target for novel therapeutic strategies to treat this disorder...
  78. doi Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601W Taylor Street, Chicago, IL 60612, USA
    Neurochem Res 33:1990-2007. 2008
    ....
  79. pmc Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem
    James Auta
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 W Taylor St, Chicago, IL 60612, USA
    Neuropharmacology 55:148-53. 2008
    ..These findings suggest that long-term activation of GABA(A) receptors containing the alpha1 or other subunits but not the alpha5 receptor subunit is essential for the induction of anticonvulsant tolerance...
  80. ncbi Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder
    Ann M Rasmusson
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 60:704-13. 2006
    ..Alterations in the gamma-amino-butyric acid (GABA) neurotransmitter system have been identified in some populations with posttraumatic stress disorder (PTSD)...
  81. ncbi Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis
    Kinzo Matsumoto
    Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama, 930 0194, Japan
    Stress 8:85-93. 2005
    ....
  82. ncbi Should allosteric positive modulators of GABA(A) receptors be tested in the treatment of schizophrenia?
    Erminio Costa
    Schizophr Res 73:367-8. 2005
  83. ncbi Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function
    Elisabetta Cagetti
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California, Room CHS 23 120, 650 Young Drive South, Los Angeles, CA 90095 1735, USA
    Neuropharmacology 46:570-9. 2004
    ..These results suggest that changes in neurosteroids level and in vivo sensitivity to these compounds are involved in the development of ethanol dependence in the CIE model...
  84. ncbi [Stress and sleep/emotional disorder: possible involvement of neurosteroid allopregnanolone]
    Kinzo Matsumoto
    Nihon Yakurigaku Zasshi 126:107-12. 2005

Research Grants25

  1. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
    ....
  2. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2007
    ..abstract_text> ..
  3. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
    ....
  4. NEUROSTEROIDS: PHYSIOLOGICAL RELEVANCE
    Alessandro Guidotti; Fiscal Year: 1999
    ....
  5. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009
    ..abstract_text> ..