B J Guglielmo
Affiliation: University of California
- Pharmacokinetics of quinacrine in the treatment of prion diseaseLotus Yung
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, San Francisco, California 94143 0622, USA
BMC Infect Dis 4:53. 2004..If quinacrine penetrates brain tissue in concentrations exceeding that demonstrated for in vitro inhibition of PrPSc, it may be useful in the treatment of prion disease...
- Prevention of adverse events in hospitalized patients using an antimicrobial review programB J Guglielmo
Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco 94143 0622, USA
West J Med 171:159-62. 1999..To evaluate whether an antimicrobial review system is associated with a reduction in antimicrobial-associated adverse events...
- Ceftriaxone therapy for staphylococcal osteomyelitis: a reviewB J Guglielmo
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143 0622, USA
Clin Infect Dis 30:205-7. 2000..It is concluded that ceftriaxone is effective in the ambulatory treatment of S. aureus osteomyelitis...
- Impact of a series of interventions in vancomycin prescribing on use and prevalence of vancomycin-resistant enterococciB Joseph Guglielmo
Department of Clinical Pharmacy, University of California San Francisco, USA
Jt Comm J Qual Patient Saf 31:469-75. 2005..In response to vancomycin-resistant bacteria, particularly vancomycin-resistant enterococci (VRE), measures have been recommended to improve on the appropriate use of vancomycin...
- Voriconazole is safe and effective as prophylaxis for early and late fungal infections following allogeneic hematopoietic stem cell transplantationT Martin
Division of Hematology Oncology, University of California San Francisco, San Francisco, California, USA
Transpl Infect Dis 12:45-50. 2010..No Candida infections were seen in either period. These data suggest that fungal prophylaxis with VOR following allogeneic transplantation is safe and effective...
- Antimicrobial selection for hospitalized patients with presumed community-acquired pneumonia: a survey of nonteaching US community hospitalsV Dudas
University of California, San Francisco 94143, USA
Ann Pharmacother 34:446-52. 2000..Secondary outcomes included length of stay (LOS) and mortality associated with the choice of therapy...
- Impact of an intravenous fluconazole restriction policy on patient outcomesJ S Burkiewicz
School of Pharmacy, University of California, San Francisco, CA, USA
Ann Pharmacother 35:9-13. 2001..To evaluate both the economic and clinical impact of an intravenous fluconazole restriction policy in a university teaching hospital...
- Patient education for H pylori: who benefits?Katherine Yang
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 521 Parnassus Ave, Room C 152 San Francisco, CA 94143 0622, USA
West J Med 176:97. 2002
- In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4Jean Paul A Nicandro
Dept of Clinical Pharmacy, University of California, San Francisco, CA 94143, USA
J Herb Pharmacother 7:39-56. 2007..However, it is still unknown whether interactions exist between I'm-Yunity and other medications metabolized by other CYP450 isozymes or enzyme/transporter systems...
- Diagnosis and treatment of extended-spectrum and AmpC beta-lactamase-producing organismsKatherine Yang
Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco, San Francisco, CA 94143, USA
Ann Pharmacother 41:1427-35. 2007..To review the laboratory diagnosis of extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase-producing bacteria and evaluate potential treatment options...
- Antimicrobial stewardship programs: interventions and associated outcomesDimple Patel
University of California, San Francisco School of Pharmacy, 521 Parnassus Avenue, C 152, San Francisco, CA 94143, USA
Expert Rev Anti Infect Ther 6:209-22. 2008..Antimicrobial stewardship programs are becoming increasingly associated with clear benefits and will be integral in the in-patient healthcare setting...
- Impact of a piperacillin-tazobactam shortage on antimicrobial prescribing and the rate of vancomycin-resistant enterococci and Clostridium difficile infectionsMarisa N Mendez
Department of Clinical Pharmacy, School of Pharmacy, School of Medicine, University of California--San Francisco, San Francisco, California 94143, USA
Pharmacotherapy 26:61-7. 2006..difficile infections.Conclusion: The piperacillin-tazobactam shortage was associated with significant changes in antimicrobial prescribing, which resulted in a significant reduction in the rate of C. difficile but not VRE infections...
- Daptomycin treatment failure for vancomycin-resistant Enterococcus faecium infective endocarditis: impact of protein binding?Brian S Schwartz
Ann Pharmacother 42:289-90. 2008
- Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoproteinYong Huang
Department of Biopharmaceutical Sciences, School of Pharmacy, University of California San Francisco, CA 94143-0446, USA
Drug Metab Dispos 34:1136-44. 2006..v. dose and <2 times greater after 10 mg/kg oral doses in MDR1-KO mice compared with WT mice. These results indicate that P-gp plays a critical role in transporting QA from the brain...
- Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and toleranceTim Frenzel
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Cerebrovasc Dis 25:157-63. 2008..Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations...
- Pharmacological advances in the treatment of invasive candidiasisDaniel H Deck
San Francisco General Hospital, San Francisco, CA, USA
Expert Rev Anti Infect Ther 4:137-49. 2006..The availability of new agents, future adoption of diagnostic tests for candidiasis, and susceptibility testing will have a major impact in the management of invasive candidiasis...
- Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulationChanhung Z Lee
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
J Cereb Blood Flow Metab 26:1157-64. 2006..This study provided the evidence that the tetracyclines inhibit stimulated cerebral MMP-9 at multiple levels and are effective at very low doses, offering great potential for therapeutic use...
- Antimicrobial drug prescribing for pneumonia in ambulatory careConan MacDougall
University of California School of Pharmacy, San Francisco, California, USA
Emerg Infect Dis 11:380-4. 2005..Clear and consistent guidelines are needed to address the role of fluoroquinolones in treatment of outpatient community-acquired pneumonia...
- Antimicrobial therapy of gram-negative bacteremia at two university-affiliated medical centersLarissa R Graff
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, California 94143, USA
Am J Med 112:204-11. 2002..CONCLUSION: Prescribing practices for the treatment of gram-negative bacteremia differed significantly in the two institutions despite similar patients and pathogens...
- Compliance in two medical centers with criteria for use of caspofungin and lipid-based amphotericin BAmy N Bower
School of Pharmacy, University of California at San Francisco, 94143-0622, USA
Am J Health Syst Pharm 61:915-20. 2004..CONCLUSION: Compliance with criteria for use of LBA and caspofungin at two medical centers was inconsistent, probably because the initial criteria were insufficient in defining the conditions that justified the drugs' use...
- Risk factors for community-acquired ciprofloxacin-resistant Escherichia coli urinary tract infectionKarla M Killgore
Department of Clinical Pharmacy, University of California, San Francisco, CA 94143-0622, USA
Ann Pharmacother 38:1148-52. 2004..Nitrofurantoin or a cephalosporin may be better choices in patients with recurrent lower UTI and/or previous fluoroquinolone use...
- Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitorDana D Phan
School of Pharmacy, University of California, San Francisco, California 94143, USA
Antimicrob Agents Chemother 47:2351-3. 2003..These results suggest a stable valacyclovir absorption phenotype, significant interindividual variability, and minimal interaction between these hPEPT1 substrates...
- Pharmacy-based intervention to reduce antibiotic use for acute bronchitisDavid E Hickman
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94143-0622, USA
Ann Pharmacother 37:187-91. 2003..While a significant decrease in antibiotic use was realized, other interventions are required to further reduce the prevalence of antibiotic use in acute bronchitis...
- Blood culture and susceptibility results and allergy history do not influence fluoroquinolone use in the treatment of community-acquired pneumoniaNancy N Chang
Department of Clinical Pharmacy, School of Pharmacy, University of California-San Francisco, San Francisco, California 94143, USA
Pharmacotherapy 25:59-66. 2005..These prescribing patterns may contribute to selection pressure associated with fluoroquinolone-resistant gram-positive and gram-negative bacteria...