Jose A Guevara Patino

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Optimization of a self antigen for presentation of multiple epitopes in cancer immunity
    Jose A Guevara-Patino
    Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 116:1382-90. 2006
  2. ncbi request reprint CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
    Polly D Gregor
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Vaccine 22:1700-8. 2004
  3. ncbi request reprint CD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma
    Maria Lia Palomba
    Department of Medicine and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:370-9. 2005
  4. ncbi request reprint Autoimmunity and tumor immunity induced by immune responses to mutations in self
    Manuel E Engelhorn
    Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Med 12:198-206. 2006
  5. ncbi request reprint DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation
    Miguel Angel Perales
    Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 177:4159-67. 2006
  6. ncbi request reprint Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles
    Stacie M Goldberg
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:8114-21. 2005
  7. ncbi request reprint Immunological validation of the EpitOptimizer program for streamlined design of heteroclitic epitopes
    Colin S B Houghton
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, United States
    Vaccine 25:5330-42. 2007
  8. doi request reprint Mechanisms of immunization against cancer using chimeric antigens
    Manuel E Engelhorn
    The Swim Across America Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Ther 16:773-81. 2008
  9. ncbi request reprint Identification of cancer-testis genes expressed by melanoma and soft tissue sarcoma using bioinformatics
    Neil H Segal
    Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immun 5:2. 2005
  10. pmc Immune recognition of self in immunity against cancer
    Alan N Houghton
    The Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Invest 114:468-71. 2004

Collaborators

Detail Information

Publications12

  1. pmc Optimization of a self antigen for presentation of multiple epitopes in cancer immunity
    Jose A Guevara-Patino
    Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 116:1382-90. 2006
    ....
  2. ncbi request reprint CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
    Polly D Gregor
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Vaccine 22:1700-8. 2004
    ..Based on these pre-clinical studies, we suggest that anti-CTLA-4 should be tested with xenogeneic DNA vaccines against cancer and that special attention should be given to sequence and schedule of administration...
  3. ncbi request reprint CD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma
    Maria Lia Palomba
    Department of Medicine and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:370-9. 2005
    ..These results show that active immunization with xenogeneic DNA vaccines can induce CD8+ T cell-dependent immunity against CD20...
  4. ncbi request reprint Autoimmunity and tumor immunity induced by immune responses to mutations in self
    Manuel E Engelhorn
    Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Med 12:198-206. 2006
    ..Thus, presentation of a vast repertoire of antigen variants to the immune system can enhance the generation of adaptive immune responses to self...
  5. ncbi request reprint DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation
    Miguel Angel Perales
    Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 177:4159-67. 2006
    ..These results demonstrate that DNA immunization against tissue-restricted Ags after allogeneic T cell-depleted HSCT can induce potent antitumor effects without causing GVHD...
  6. ncbi request reprint Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles
    Stacie M Goldberg
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:8114-21. 2005
    ..The purpose of this study was to compare viral and plasmid DNA in combination vaccination strategies in the context of a tumor antigen...
  7. ncbi request reprint Immunological validation of the EpitOptimizer program for streamlined design of heteroclitic epitopes
    Colin S B Houghton
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, United States
    Vaccine 25:5330-42. 2007
    ..These data demonstrate that this approach can serve as the basis of epitope-engineering against cancer and intracellular pathogens...
  8. doi request reprint Mechanisms of immunization against cancer using chimeric antigens
    Manuel E Engelhorn
    The Swim Across America Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Ther 16:773-81. 2008
    ..Therefore large fusion vector panels such as those presented here can provide information to promote the successful advancement of gene-based vaccines...
  9. ncbi request reprint Identification of cancer-testis genes expressed by melanoma and soft tissue sarcoma using bioinformatics
    Neil H Segal
    Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immun 5:2. 2005
    ....
  10. pmc Immune recognition of self in immunity against cancer
    Alan N Houghton
    The Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Invest 114:468-71. 2004
  11. pmc Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
    Mary Jo Turk
    The Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 200:771-82. 2004
    ..These results show that regulatory T cells are the major regulators of concomitant tumor immunity against this weakly immunogenic tumor...
  12. ncbi request reprint Immunity to cancer through immune recognition of altered self: studies with melanoma
    Jose A Guevara-Patino
    Memorial Sloan Kettering Cancer Center and the Weill Graduate School of Medical Sciences and Medical School of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Adv Cancer Res 90:157-77. 2003
    ..Studies examining the molecular basis for immunogenicity of conserved paralogues are facilitating the development of new strategies to rationally design vaccines that trigger adaptive immune responses to cancer...