Richard Guerrant

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Enteric pathogens through life stages
    Glynis Kolling
    Department of Internal Medicine, Division of Infectious Diseases and International Health, Center for Global Health, University of Virginia Charlottesville, VA, USA
    Front Cell Infect Microbiol 2:114. 2012
  2. pmc Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment
    Yuesheng Li
    Division of Infectious Diseases and International Health, Carter Harrison Bldg, Charlottesville, VA 22908, USA
    BMC Infect Dis 12:342. 2012
  3. pmc Higher frequency of cagA EPIYA-C phosphorylation sites in H. pylori strains from first-degree relatives of gastric cancer patients
    Dulciene M M Queiroz
    Laboratory of Research in Bacteriology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    BMC Gastroenterol 12:107. 2012
  4. pmc The impoverished gut--a triple burden of diarrhoea, stunting and chronic disease
    Richard L Guerrant
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Nat Rev Gastroenterol Hepatol 10:220-9. 2013
  5. pmc Effects of adenosine A₂A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice
    Cirle Alcantara Warren
    Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    BMC Infect Dis 12:13. 2012
  6. pmc Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis
    Orleâncio Gomes R Azevedo
    Center for Global Health, School of Medicine, University of Virginia, Carter Harrison Bldg MR 6, 625 Crispell Drive, Charlottesville, VA 22908, USA
    BMC Gastroenterol 12:35. 2012
  7. pmc Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice
    Manuel B Braga Neto
    Institute of Biomedicine and Clinical Research Unit University Hospital, Federal University of Ceara, Fortaleza, Brazil
    BMC Gastroenterol 10:90. 2010
  8. ncbi request reprint Global impact of diarrheal diseases that are sampled by travelers: the rest of the hippopotamus
    Richard L Guerrant
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Clin Infect Dis 41:S524-30. 2005
  9. ncbi request reprint Cholera, diarrhea, and oral rehydration therapy: triumph and indictment
    Richard L Guerrant
    Center for Global Health, School of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Clin Infect Dis 37:398-405. 2003
  10. pmc Cryptosporidiosis: an emerging, highly infectious threat
    R L Guerrant
    Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Emerg Infect Dis 3:51-7. 1997

Collaborators

Detail Information

Publications68

  1. pmc Enteric pathogens through life stages
    Glynis Kolling
    Department of Internal Medicine, Division of Infectious Diseases and International Health, Center for Global Health, University of Virginia Charlottesville, VA, USA
    Front Cell Infect Microbiol 2:114. 2012
    ....
  2. pmc Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment
    Yuesheng Li
    Division of Infectious Diseases and International Health, Carter Harrison Bldg, Charlottesville, VA 22908, USA
    BMC Infect Dis 12:342. 2012
    ..We investigated whether A2AAR activation improves and A2AAR deletion worsens outcomes in a murine model of C. difficile (strain VPI10463) infection (CDI)...
  3. pmc Higher frequency of cagA EPIYA-C phosphorylation sites in H. pylori strains from first-degree relatives of gastric cancer patients
    Dulciene M M Queiroz
    Laboratory of Research in Bacteriology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    BMC Gastroenterol 12:107. 2012
    ..To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer...
  4. pmc The impoverished gut--a triple burden of diarrhoea, stunting and chronic disease
    Richard L Guerrant
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Nat Rev Gastroenterol Hepatol 10:220-9. 2013
    ....
  5. pmc Effects of adenosine A₂A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice
    Cirle Alcantara Warren
    Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    BMC Infect Dis 12:13. 2012
    ..difficile toxin A-induced epithelial injury...
  6. pmc Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis
    Orleâncio Gomes R Azevedo
    Center for Global Health, School of Medicine, University of Virginia, Carter Harrison Bldg MR 6, 625 Crispell Drive, Charlottesville, VA 22908, USA
    BMC Gastroenterol 12:35. 2012
    ..Experiments were also conducted in C57BL6J ApoE knock-out mice to assess the effects of apoE peptide treatment...
  7. pmc Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice
    Manuel B Braga Neto
    Institute of Biomedicine and Clinical Research Unit University Hospital, Federal University of Ceara, Fortaleza, Brazil
    BMC Gastroenterol 10:90. 2010
    ..This study aims to investigate the effects of selected antiretroviral agents on intestinal histopathology and function in vivo and on cell proliferation and death in vitro...
  8. ncbi request reprint Global impact of diarrheal diseases that are sampled by travelers: the rest of the hippopotamus
    Richard L Guerrant
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Clin Infect Dis 41:S524-30. 2005
    ..New diagnostic methods hold promise for improved recognition and, hopefully, control of enteric infections worldwide...
  9. ncbi request reprint Cholera, diarrhea, and oral rehydration therapy: triumph and indictment
    Richard L Guerrant
    Center for Global Health, School of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Clin Infect Dis 37:398-405. 2003
    ..New advances in oral rehydration and nutrition therapy and new methods to recognize its costs are discussed in this review...
  10. pmc Cryptosporidiosis: an emerging, highly infectious threat
    R L Guerrant
    Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Emerg Infect Dis 3:51-7. 1997
    ..Although treatment is very limited, new approaches that may reduce secretion or enhance repair of the damaged intestinal mucosa are under study...
  11. pmc Age-specific Helicobacter pylori seropositivity rates of children in an impoverished urban area of northeast Brazil
    Anastasia Mitchell
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Microbiol 41:1326-8. 2003
    ..1% at 0 to 11 months of age to only 39.3% by 96 to 131 months of age and were 82.1% at maturity. We observed no correlation between the seropositivity of the mothers and the seropositivity of their children...
  12. ncbi request reprint How intestinal bacteria cause disease
    R L Guerrant
    Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Infect Dis 179:S331-7. 1999
    ..An improved understanding of pathogenesis not only opens new approaches to treatment and control but may also suggest improved simple means of diagnosis and even vaccine development...
  13. ncbi request reprint Threats to global health and survival: the growing crises of tropical infectious diseases--our "unfinished agenda"
    R L Guerrant
    School of Medicine, Division of Geographic and International Medicine, University of Virginia, Charlottesville 22908, USA
    Clin Infect Dis 28:966-86. 1999
    ....
  14. ncbi request reprint AIDS-associated diarrhea and wasting in Northeast Brazil is associated with subtherapeutic plasma levels of antiretroviral medications and with both bovine and human subtypes of Cryptosporidium parvum
    Richard K Brantley
    Division of Geographic and International Medicine, Department of Internal Medicine, University of Virginia School of Medicine, Virginia 22908, USA
    Braz J Infect Dis 7:16-22. 2003
    ..We conclude that severe diarrhea and wasting in this population is associated with both protozoal pathogens and subtherapeutic levels of antiretroviral medications...
  15. ncbi request reprint Early childhood diarrhea predicts impaired school performance
    Breyette Lorntz
    Center for Global Health, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Pediatr Infect Dis J 25:513-20. 2006
    ..Recently, early childhood diarrhea (ECD) has been associated with impaired physical fitness, growth and cognitive function 6 to 9 years later. We studied the effects of ECD on school functioning in a shantytown in northeastern Brazil...
  16. ncbi request reprint Limitations in verbal fluency following heavy burdens of early childhood diarrhea in Brazilian shantytown children
    Peter D Patrick
    Kluge Children s Rehabilitation Center, Division of Neuropsychology, University of Virginia, USA
    Child Neuropsychol 11:233-44. 2005
    ....
  17. pmc Role of apolipoprotein E4 in protecting children against early childhood diarrhea outcomes and implications for later development
    Reinaldo B Oriá
    Center for Global Health, School of Medicine, University of Virginia, United States
    Med Hypotheses 68:1099-107. 2007
    ....
  18. pmc Detection and quantification of Cryptosporidium in HCT-8 cells and human fecal specimens using real-time polymerase chain reaction
    Jonathan B Parr
    University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Trop Med Hyg 76:938-42. 2007
    ..hominis and C. parvum in clinical specimens. This assay is useful in a variety of samples in the research laboratory and will likely prove to be a useful tool in the clinical laboratory...
  19. ncbi request reprint Short report: asymptomatic Cryptosporidium hominis infection among human immunodeficiency virus-infected patients in Tanzania
    Eric R Houpt
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Am J Trop Med Hyg 73:520-2. 2005
    ..parvum-infected patients (P < 0.05). This study suggests there may be important differences in the natural history of Cryptosporidium infection in HIV-infected persons depending on parasite species...
  20. pmc Giardia duodenalis assemblage, clinical presentation and markers of intestinal inflammation in Brazilian children
    Anita Kohli
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Trans R Soc Trop Med Hyg 102:718-25. 2008
    ..Additionally, second and third infections had decreasing faecal lactoferrin, suggesting some protection against severity, albeit not against infection, by prior infection...
  21. pmc Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of cryptosporidiosis
    Cirle Alcantara Warren
    Center for Global Health, University of Virginia, Charlottesville, VA 22901, USA
    J Infect Dis 198:143-9. 2008
    ..Intestinal cells grown in microgravity produce a three-dimensional tissue assembly, or "organoid," similar to the human intestinal mucosa, making it an ideal model for enteric infections such as cryptosporidiosis...
  22. ncbi request reprint APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil
    Reinaldo B Oriá
    Center for Global Health, School of Medicine, Kluge s Children Rehabilitation Center, University of Virginia, Charlottesville, VA 22908, USA
    Pediatr Res 57:310-6. 2005
    ..Our findings show that APOE4 is relatively common in favela children and suggest a protective role of the APOE4 allele in children with a history of heavy burdens of diarrhea in their first 2 y of life...
  23. ncbi request reprint Magnitude and impact of diarrheal diseases
    Richard L Guerrant
    Department of Medicine, Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Arch Med Res 33:351-5. 2002
    ....
  24. pmc Semantic fluency: a sensitive marker for cognitive impairment in children with heavy diarrhea burdens?
    Reinaldo B Oriá
    Center for Global Health, Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Med Hypotheses 73:682-6. 2009
    ..In addition, they suggest that semantic fluency could provide a simple mean to assess cognitive impairment in impoverished settings so as to determine preventive measures...
  25. pmc High early mortality in patients with chronic acquired immunodeficiency syndrome diarrhea initiating antiretroviral therapy in Haiti: a case-control study
    Rebecca A Dillingham
    University of Virginia, Charlottesville, Virginia 22903, USA
    Am J Trop Med Hyg 80:1060-4. 2009
    ..At six weeks, mortality was 10% in the patients with diarrhea and 5% in the patients without diarrhea (P = 0.009). Chronic diarrhea in patients requesting ART in Haiti is associated with increased early mortality...
  26. pmc Technology in global health: the need for essential diagnostics
    Eric R Houpt
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Lancet 372:873-4. 2008
  27. pmc Malnutrition as an enteric infectious disease with long-term effects on child development
    Richard L Guerrant
    Department of Medicine, University of Virginia, Charlottesville 22901, USA
    Nutr Rev 66:487-505. 2008
    ..Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea-malnutrition cycle so children may develop their full potential...
  28. ncbi request reprint Diarrhea and reduced levels of antiretroviral drugs: improvement with glutamine or alanyl-glutamine in a randomized controlled trial in northeast Brazil
    Oluma Y Bushen
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Clin Infect Dis 38:1764-70. 2004
    ....
  29. ncbi request reprint Heavy cryptosporidial infections in children in northeast Brazil: comparison of Cryptosporidium hominis and Cryptosporidium parvum
    Oluma Y Bushen
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA
    Trans R Soc Trop Med Hyg 101:378-84. 2007
    ..01). Cryptosporidium hominis is more common than C. parvum in favela children and is associated with heavier infections and greater growth shortfalls, even in the absence of symptoms...
  30. pmc Enteroaggregative Escherichia coli (EAEC) impairs growth while malnutrition worsens EAEC infection: a novel murine model of the infection malnutrition cycle
    James K Roche
    Center for Global Health, Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Infect Dis 202:506-14. 2010
    ....
  31. pmc Faecal contamination of drinking water in a Brazilian shanty town: importance of household storage and new human faecal marker testing
    Curtis C Copeland
    University of Virginia Center for Global Health, Charlottesville, VA 22908, USA
    J Water Health 7:324-31. 2009
    ....
  32. ncbi request reprint Real-time PCR detection and speciation of Cryptosporidium infection using Scorpion probes
    Suzanne E Stroup
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA, and Department of Gastrointestinal Sciences and Haematology, Christian Medical College and Hospital, Vellore, India
    J Med Microbiol 55:1217-22. 2006
    ..These Scorpion probe qPCR assays are simpler to perform than existing nested PCR and RFLP methods for diagnosis and epidemiological investigation of cryptosporidiosis...
  33. pmc The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000
    Margaret Kosek
    Division of Geographic and International Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Bull World Health Organ 81:197-204. 2003
    ..There has not been a concurrent decrease in morbidity rates attributable to diarrhoea. As population growth is focused in the poorest areas, the total morbidity component of the disease burden is greater than previously...
  34. ncbi request reprint Clinical practice. Acute infectious diarrhea
    Nathan M Thielman
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 350:38-47. 2004
  35. ncbi request reprint Childhood stunting: measuring and stemming the staggering costs of inadequate water and sanitation
    Rebecca Dillingham
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Lancet 363:94-5. 2004
  36. pmc Persistent G. lamblia impairs growth in a murine malnutrition model
    Luther A Bartelt
    Division of Infectious Diseases and Center for Global Health, University of Virginia, Charlottesville, Virginia 22903, USA
    J Clin Invest 123:2672-84. 2013
    ..These findings add insight into the potential role of G. lamblia as a "stunting" pathogen and suggest that, similarly, malnourished children may be at increased risk of G. lamblia– potentiated growth decrements...
  37. pmc Diarrhea, clostridium difficile, and intestinal inflammation in residents of a long-term care facility
    Laurie Archbald-Pannone
    University of Virginia, Department of Internal Medicine, Division of General Medicine, Section of Geriatrics, Charlottesville, VA 22908, USA
    J Am Med Dir Assoc 11:263-7. 2010
    ....
  38. pmc Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae
    Eliah R Shamir
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia 22908, USA
    Antimicrob Agents Chemother 54:1526-33. 2010
    ..Antimicrobial agents that inhibit the assembly or function of fimbrial filaments should be good candidates for the prevention of infection...
  39. pmc Cryptosporidium infection causes undernutrition and, conversely, weanling undernutrition intensifies infection
    Bruna P Coutinho
    Center for Blobal Health, School of Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Parasitol 94:1225-32. 2008
    ..Taken together, these findings show that Cryptosporidium infection can cause undernutrition and, conversely, that weanling undernutrition intensifies infection and mucosal damage...
  40. ncbi request reprint Pathophysiology and impact of enteric bacterial and protozoal infections: new approaches to therapy
    Gerly A C Brito
    Division of Geographic Medicine, Department of Internal Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Chemotherapy 51:23-35. 2005
    ..This article provides an overview of the epidemiological impact, pathogenesis and new approaches to the management of enteric infections...
  41. ncbi request reprint A trans-university center for global health
    Breyette Lorntz
    University of Virginia School of Medicine, Center for Global Health, Charlottesville, Virginia 22908, USA
    Acad Med 83:165-72. 2008
    ..A university that actively supports global health becomes increasingly internationalized, grounded in scientific excellence, and committed to addressing the most pressing issues humanity faces today...
  42. pmc Diagnosis and treatment of acute or persistent diarrhea
    Sean W Pawlowski
    Division of Infectious Disease and International Health, Center for Global Health, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Gastroenterology 136:1874-86. 2009
    ..These studies have led to practical approaches for prevention, diagnosis, and treatment...
  43. pmc AIDS diarrhea and antiretroviral drug concentrations: a matched-pair cohort study in Port au Prince, Haiti
    Rebecca Dillingham
    University of Virginia School of Medicine, Center for Global Health, Charlottesville, VA 22903, USA
    Am J Trop Med Hyg 84:878-82. 2011
    ..Diarrhea at ART initiation does not influence plasma concentrations of the medications evaluated. Virologic outcome at Week 24 does correlate with efavirenz concentrations early in therapy but not with the presence of chronic diarrhea...
  44. ncbi request reprint Cryptosporidiosis: epidemiology and impact
    Rebecca A Dillingham
    Division of Geographic and International Medicine, University of Virginia School of Medicine, Health Sciences Center, P O Box 801379, Charlottesville, VA 22908 1379, USA
    Microbes Infect 4:1059-66. 2002
    ....
  45. ncbi request reprint Clostridium difficile toxin A induces intestinal epithelial cell apoptosis and damage: role of Gln and Ala-Gln in toxin A effects
    Gerly A C Brito
    Center for Global Health, Department of Intemal Medicine, School of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Dig Dis Sci 50:1271-8. 2005
    ..In conclusion, both peptides reduced toxin-induced epithelial damage and thus might play an adjunctive role in C. difficile-induced colitis therapy...
  46. ncbi request reprint Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis
    Cirle S Alcantara
    Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Trop Med Hyg 68:325-8. 2003
    ..Although considered relatively non-inflammatory. cryptosporidiosis is often associated with mild inflammation, especially in children in an endemic area...
  47. ncbi request reprint Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis
    Mônica C Façanha
    Clinical Research Unit and Institute of Biomedicine, Center for Global Health, Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Fortaleza
    Braz J Infect Dis 13:210-7. 2009
    ..The results demonstrated a marked decrease on intestinal paracellular transport in patients with active pulmonary tuberculosis and reduced serum concentrations of rifampin and isoniazid in both groups...
  48. doi request reprint Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion
    Aldo A M Lima
    Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Appl Toxicol 28:849-57. 2008
    ..The data suggest that PLA2 is involved in the major pathway of toxin A-induced histologic inflammatory damage and hemorrhagic fluid secretion...
  49. ncbi request reprint Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil
    Ping Chen
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville 22908, USA
    J Health Popul Nutr 21:309-15. 2003
    ..001) and HAZ scores (p = 0.007) improved with supplementation. It is concluded that impaired intestinal barrier function and linear growth shortfalls improve following supplementation of vitamin A and zinc in this setting...
  50. pmc Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro
    Benedito A Carneiro
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, MR4, Lane Road, Room 3148, Charlottesville, VA 22908, USA
    Infect Immun 74:81-7. 2006
    ..Glutamine and alanyl-glutamine inhibited the apoptosis of T84 cells by preventing caspase 8 activation and reduced TxA-induced intestinal secretion and disruption...
  51. pmc Enteric infections, diarrhea, and their impact on function and development
    William A Petri
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 118:1277-90. 2008
    ..We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding...
  52. ncbi request reprint Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin
    Aldo A M Lima
    Institute of Biomedicine, Clinical Research Unit, Dept of Physiology and Pharmacology, Federal University of Ceara, Avenida José Bastos 3990, C P 3229, Porangabusso, Fortaleza, Ceara, Brazil CEP 60 436 160
    Nutrition 18:458-62. 2002
    ..We investigated the effect of an AlaGln-ORNT solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin...
  53. ncbi request reprint Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown
    Mark D Niehaus
    Brown University, Providence, Rhode Island, USA
    Am J Trop Med Hyg 66:590-3. 2002
    ..These findings have important implications for the importance of interventions that may reduce early childhood diarrheal illnesses or their consequences...
  54. ncbi request reprint Prevalence and species distribution of E. Histolytica and E. Dispar in the Venda region, Limpopo, South Africa
    Amidou Samie
    Department of Microbiology, University of Venda, Thohoyandou, South Africa
    Am J Trop Med Hyg 75:565-71. 2006
    ..12%) of the 31 HIV-positive individuals and in 33 (15.5%) of the 213 HIV-negative individuals. E. histolytica infections are common in the Venda region and are associated with diarrhea and intestinal inflammation...
  55. ncbi request reprint Updating the DALYs for diarrhoeal disease
    Richard L Guerrant
    Trends Parasitol 18:191-3. 2002
    ..Recent studies into the long-term consequences of diarrhoeal diseases on physical and mental development suggest that the disability adjusted life year calculations for these conditions could require updating...
  56. ncbi request reprint Criterion-related validity of a diarrhea questionnaire in HIV-infected patients
    Nathan M Thielman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dig Dis Sci 47:1421-6. 2002
    ..8069-0.8792). In demonstrating the concurrent, criterion-related validity of this survey, we found it helpful for evaluating HIV-related diarrhea and suggest its utility for HIV-seronegative subjects as well...
  57. ncbi request reprint Common infectious diseases and skin test anergy in children from an urban slum in northeast Brazil
    Melânia X Castro
    Clinical Research Unit, University Hospital Walter Cantídio, Fortaleza, Brazil
    Braz J Infect Dis 7:387-94. 2003
    ..Objectives: (a) to evaluate the morbidity of ARI, DD and ID; and (b) to determine their association with cellular immunity in poor urban children from Fortaleza, Brazil...
  58. ncbi request reprint Strategies to reduce the devastating costs of early childhood diarrhea and its potential long-term impact: imperatives that we can no longer afford to ignore
    Aldo A M Lima
    Clin Infect Dis 38:1552-4. 2004
  59. ncbi request reprint Cholera--still teaching hard lessons
    Richard L Guerrant
    N Engl J Med 354:2500-2. 2006
  60. ncbi request reprint Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula
    Noélia L Lima
    Clinical Research Unit and Institute of Biomedicine Center for Global Health, School of Medicine, Federal University of Ceara, Fortaleza, Brazil
    J Pediatr Gastroenterol Nutr 44:365-74. 2007
    ..We examined the effect of a diet supplemented with alanyl-glutamine (AG) or placebo glycine (G) on intestinal barrier function and growth in children in northeastern Brazil...
  61. ncbi request reprint Enteroaggregative Escherichia coli in Venda, South Africa: distribution of virulence-related genes by multiplex polymerase chain reaction in stool samples of human immunodeficiency virus (HIV)-positive and HIV-negative individuals and primary school child
    Amidou Samie
    Department of Microbiology, University of Venda, Thohoyandou, South Africa
    Am J Trop Med Hyg 77:142-50. 2007
    ..543, P < 0.0001) in the stool samples. This study suggests that the clinical presentation of EAEC infection may be directly related to the bacterial load as well as to the genetic characteristics of the strains involved...
  62. ncbi request reprint Reducing stunting among children: the potential contribution of diagnostics
    Karen A Ricci
    RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90407 2138, USA
    Nature 444:29-38. 2006
  63. ncbi request reprint Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis
    Valéria G F Pinheiro
    Clinical Research Unit and Institute of Biomedicine Center for Global Health, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil
    Braz J Infect Dis 10:374-9. 2006
    ..There is a need for new approaches to improve drug bioavailability in TB patients...
  64. pmc Role of retinol in protecting epithelial cell damage induced by Clostridium difficile toxin A
    Andressa A F L Maciel
    Clinical Research Unit and Institute of Biomedicine, School of Medicine, Federal University of Ceara, Brazil
    Toxicon 50:1027-40. 2007
    ..difficile TxA challenge in a glutamine-free medium. These results suggest the role of retinol in protecting intestinal epithelial barrier function from C. difficile TxA enterotoxic damage...
  65. ncbi request reprint PCR detection of Clostridium difficile triose phosphate isomerase (tpi), toxin A (tcdA), toxin B (tcdB), binary toxin (cdtA, cdtB), and tcdC genes in Vhembe District, South Africa
    Amidou Samie
    AIDS Virus Research Laboratory, Department of Microbiology, University of Venda, Thohoyandou, South Africa
    Am J Trop Med Hyg 78:577-85. 2008
    ..difficile and suggests that C. difficile is responsible for a small, but underappreciated, proportion of diarrheal cases in the region, and further study is warranted in this area...
  66. pmc Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea
    Alexander Y Kots
    Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler Street, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:8440-5. 2008
    ..Thus, BPIPP may be a promising lead compound for treatment of diarrhea and other diseases...
  67. ncbi request reprint Infectious diarrhea: new pathogens and new challenges in developed and developing areas
    Theodore S Steiner
    Clin Infect Dis 43:408-10. 2006
  68. ncbi request reprint Risk factors for adverse outcomes in developing countries
    Sean R Moore
    Lancet 369:824-5. 2007

Research Grants11

  1. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2007
    ....
  2. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard L Guerrant; Fiscal Year: 2010
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  3. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard Guerrant; Fiscal Year: 2009
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  4. Tailoring Novel Therapeutics for Emerging Drug-Resistant C. Difficile Colitis
    Richard Guerrant; Fiscal Year: 2007
    ..Our fourth aim involves discovery efforts towards developing more highly absorbed AaR agonists and the synthesis of the proposed A2A, agonists and A2B antagonists necessary to support this grant. ..
  5. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard Guerrant; Fiscal Year: 2007
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  6. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2006
    ..abstract_text> ..
  7. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard Guerrant; Fiscal Year: 2006
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  8. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard Guerrant; Fiscal Year: 2009
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..