P O Gubbins

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. doi request reprint Triazole antifungal agents drug-drug interactions involving hepatic cytochrome P450
    Paul O Gubbins
    University of Arkansas for Medical Sciences, College of Pharmacy, Department of Pharmacy Practice, Little Rock, AR 72205, USA
    Expert Opin Drug Metab Toxicol 7:1411-29. 2011
  2. pmc Pharmacokinetics and safety of oral posaconazole in neutropenic stem cell transplant recipients
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Antimicrob Agents Chemother 50:1993-9. 2006
  3. ncbi request reprint Mould-active azoles: pharmacokinetics, drug interactions in neutropenic patients
    Paul O Gubbins
    University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Curr Opin Infect Dis 20:579-86. 2007
  4. ncbi request reprint Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
    Pharmacotherapy 24:460-7. 2004
  5. doi request reprint Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7122, USA
    Eur J Clin Pharmacol 64:293-301. 2008
  6. ncbi request reprint Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes
    P O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 522, Little Rock, AR 7225 7122, USA
    Pharmacology 67:195-201. 2003
  7. ncbi request reprint Characterizing and predicting amphotericin B-associated nephrotoxicity in bone marrow or peripheral blood stem cell transplant recipients
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
    Pharmacotherapy 22:961-71. 2002
  8. pmc Pharmacokinetics and buccal mucosal concentrations of a 15 milligram per kilogram of body weight total dose of liposomal amphotericin B administered as a single dose (15 mg/kg), weekly dose (7.5 mg/kg), or daily dose (1 mg/kg) in peripheral stem cell tran
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Antimicrob Agents Chemother 53:3664-74. 2009
  9. doi request reprint Clinically relevant drug interactions of current antifungal agents
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham 522, Little Rock, AR 72205, USA
    Mycoses 53:95-113. 2010
  10. ncbi request reprint Drug-drug interactions of antifungal agents and implications for patient care
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Expert Opin Pharmacother 6:2231-43. 2005

Detail Information

Publications19

  1. doi request reprint Triazole antifungal agents drug-drug interactions involving hepatic cytochrome P450
    Paul O Gubbins
    University of Arkansas for Medical Sciences, College of Pharmacy, Department of Pharmacy Practice, Little Rock, AR 72205, USA
    Expert Opin Drug Metab Toxicol 7:1411-29. 2011
    ..Therefore, clinicians must understand the drug interaction profile of this class...
  2. pmc Pharmacokinetics and safety of oral posaconazole in neutropenic stem cell transplant recipients
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Antimicrob Agents Chemother 50:1993-9. 2006
    ..1483). Moreover, this reduction could be overcome by increasing the total dose and dosing frequency. Posaconazole was safe and well tolerated...
  3. ncbi request reprint Mould-active azoles: pharmacokinetics, drug interactions in neutropenic patients
    Paul O Gubbins
    University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Curr Opin Infect Dis 20:579-86. 2007
    ....
  4. ncbi request reprint Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
    Pharmacotherapy 24:460-7. 2004
    ....
  5. doi request reprint Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7122, USA
    Eur J Clin Pharmacol 64:293-301. 2008
    ..To explore whether sex-related differences in intestinal itraconazole metabolism exist in healthy adults using grapefruit juice (GFJ) as a selective enteric cytochrome P450 3A4 (CYP3A4) inhibitor...
  6. ncbi request reprint Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes
    P O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 522, Little Rock, AR 7225 7122, USA
    Pharmacology 67:195-201. 2003
    ..Human hepatocytes in primary culture can metabolize ITZ. However, IL-6 did not inhibit hydroxyitraconazole formation, but it may inhibit its subsequent metabolism...
  7. ncbi request reprint Characterizing and predicting amphotericin B-associated nephrotoxicity in bone marrow or peripheral blood stem cell transplant recipients
    Paul O Gubbins
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
    Pharmacotherapy 22:961-71. 2002
    ..To characterize amphotericin B-associated nephrotoxicity and to determine the variables associated with it that can be used to identify, a priori, at-risk patients...
  8. pmc Pharmacokinetics and buccal mucosal concentrations of a 15 milligram per kilogram of body weight total dose of liposomal amphotericin B administered as a single dose (15 mg/kg), weekly dose (7.5 mg/kg), or daily dose (1 mg/kg) in peripheral stem cell tran
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Antimicrob Agents Chemother 53:3664-74. 2009
    ..5 mg/kg) or a single L-AMB dose (15 mg/kg) produced sufficient concentrations in plasma and highly vascular tissue to warrant further studies of the safety, efficacy, and practicality of the weekly prophylactic administration of L-AMB...
  9. doi request reprint Clinically relevant drug interactions of current antifungal agents
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham 522, Little Rock, AR 72205, USA
    Mycoses 53:95-113. 2010
    ..However, certain interactions produce significant toxicity or compromise efficacy to such an extent that they cannot be managed and the particular combination of antifungal and interacting medicine should be avoided...
  10. ncbi request reprint Drug-drug interactions of antifungal agents and implications for patient care
    Paul O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Expert Opin Pharmacother 6:2231-43. 2005
    ..This article reviews drug interactions involving antifungal agents that affect other agents and implications for patient care are highlighted...
  11. ncbi request reprint Current management of funguria
    P O Gubbins
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Health Syst Pharm 56:1929-35; quiz 1936. 1999
    ..Studies are needed to determine whether intravesical amphotericin B still has a role in the treatment of funguria and to refine strategies involving fluconazole...
  12. ncbi request reprint Relative bioavailability of itraconazole from an extemporaneously prepared suspension and from the marketed capsules
    K J Christensen
    Critical Care and Internal Medicine, University of Arkansas for Medical Sciences Medical Center, Little Rock 72205, USA
    Am J Health Syst Pharm 55:261-5. 1998
    ..19 (0.13-0.28), 0.95 (0.81-1.12), and 0.13 (0.07-0.23), respectively. The bioavailability of itraconazole from the extemporaneously prepared suspension is much lower than that from capsules...
  13. ncbi request reprint Incidence of imipenem hypersensitivity reactions in febrile neutropenic bone marrow transplant patients with a history of penicillin allergy
    S A McConnell
    College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Clin Infect Dis 31:1512-4. 2000
    ..The findings of this study indicate the incidence of cross-reactivity between imipenem/cilastatin and penicillin among patients with a history of penicillin allergy may be lower than previously reported...
  14. ncbi request reprint Rapid and sensitive high performance liquid chromatographic method for the determination of itraconazole and its hydroxy-metabolite in human serum
    P O Gubbins
    Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Pharm Biomed Anal 16:1005-12. 1998
    ..999). Intra-assay relative standard deviations (R.S.D.) were below 12%. Inter-assay R.S.D. were below 14%. This method provides a rapid means for the accurate and precise determination of both OH-ITZ and ITZ concentrations in human serum...
  15. ncbi request reprint Tick-borne bacterial, rickettsial, spirochetal, and protozoal infectious diseases in the United States: a comprehensive review
    Jarrett R Amsden
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Pharmacotherapy 25:191-210. 2005
    ..Because pharmacists are the most accessible health care providers, they are often asked how to treat tick-borne diseases. Thus, practitioners should be familiar with the ticks that inhabit their locale...
  16. ncbi request reprint Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt
    Elias J Anaissie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Clin Infect Dis 43:1031-9. 2006
  17. ncbi request reprint Renal interaction between itraconazole and cimetidine
    Chetan S Karyekar
    Renal Clinical Pharmacology Laboratory, School of Pharmacy, and the Department of Medicine, Division of Nephrology, School of Medicine, University of Maryland, Baltimore 21201, USA
    J Clin Pharmacol 44:919-27. 2004
    ..Further evaluation of renal P-gp-modulating drugs such as itraconazole that may alter the renal excretion of coadministered drugs is warranted...
  18. ncbi request reprint Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model
    Chetan S Karyekar
    Pharmacokinetics Biopharmaceutics Laboratory, School of Pharmacy, University of Maryland, Baltimore 21201, USA
    Pharmacotherapy 23:436-42. 2003
    ..To evaluate P-glycoprotein (P-gp)-mediated renal drug interactions in an in vitro model of tubular secretion...
  19. ncbi request reprint Are antimicrobial-impregnated catheters effective? Replace the water and grab your washcloth, because we have a baby to wash
    Scott A McConnell
    School of Pharmacy and Health Related Professions, Creighton University Medical Center, Omaha, NE, USA
    Clin Infect Dis 39:1829-33. 2004
    ....