Research Topics
| P O GubbinsSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
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Detail Information
Publications
Triazole antifungal agents drug-drug interactions involving hepatic cytochrome P450Paul O Gubbins
University of Arkansas for Medical Sciences, College of Pharmacy, Department of Pharmacy Practice, Little Rock, AR 72205, USA
Expert Opin Drug Metab Toxicol 7:1411-29. 2011....
Pharmacokinetics and safety of oral posaconazole in neutropenic stem cell transplant recipientsPaul O Gubbins
College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
Antimicrob Agents Chemother 50:1993-9. 2006..1483). Moreover, this reduction could be overcome by increasing the total dose and dosing frequency. Posaconazole was safe and well tolerated...
Mould-active azoles: pharmacokinetics, drug interactions in neutropenic patientsPaul O Gubbins
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Curr Opin Infect Dis 20:579-86. 2007....- Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteersPaul O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
Pharmacotherapy 24:460-7. 2004.... - Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juicePaul O Gubbins
College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7122, USA
Eur J Clin Pharmacol 64:293-301. 2008..To explore whether sex-related differences in intestinal itraconazole metabolism exist in healthy adults using grapefruit juice (GFJ) as a selective enteric cytochrome P450 3A4 (CYP3A4) inhibitor... - Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytesP O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 522, Little Rock, AR 7225 7122, USA
Pharmacology 67:195-201. 2003..Human hepatocytes in primary culture can metabolize ITZ. However, IL-6 did not inhibit hydroxyitraconazole formation, but it may inhibit its subsequent metabolism... - Characterizing and predicting amphotericin B-associated nephrotoxicity in bone marrow or peripheral blood stem cell transplant recipientsPaul O Gubbins
College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205 7122, USA
Pharmacotherapy 22:961-71. 2002..To characterize amphotericin B-associated nephrotoxicity and to determine the variables associated with it that can be used to identify, a priori, at-risk patients... - Pharmacokinetics and buccal mucosal concentrations of a 15 milligram per kilogram of body weight total dose of liposomal amphotericin B administered as a single dose (15 mg/kg), weekly dose (7.5 mg/kg), or daily dose (1 mg/kg) in peripheral stem cell tranPaul O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Antimicrob Agents Chemother 53:3664-74. 2009..5 mg/kg) or a single L-AMB dose (15 mg/kg) produced sufficient concentrations in plasma and highly vascular tissue to warrant further studies of the safety, efficacy, and practicality of the weekly prophylactic administration of L-AMB... - Clinically relevant drug interactions of current antifungal agentsPaul O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham 522, Little Rock, AR 72205, USA
Mycoses 53:95-113. 2010..However, certain interactions produce significant toxicity or compromise efficacy to such an extent that they cannot be managed and the particular combination of antifungal and interacting medicine should be avoided... - Drug-drug interactions of antifungal agents and implications for patient carePaul O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Expert Opin Pharmacother 6:2231-43. 2005..This article reviews drug interactions involving antifungal agents that affect other agents and implications for patient care are highlighted... - Current management of funguriaP O Gubbins
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Am J Health Syst Pharm 56:1929-35; quiz 1936. 1999..Studies are needed to determine whether intravesical amphotericin B still has a role in the treatment of funguria and to refine strategies involving fluconazole... - Relative bioavailability of itraconazole from an extemporaneously prepared suspension and from the marketed capsulesK J Christensen
Critical Care and Internal Medicine, University of Arkansas for Medical Sciences Medical Center, Little Rock 72205, USA
Am J Health Syst Pharm 55:261-5. 1998..19 (0.13-0.28), 0.95 (0.81-1.12), and 0.13 (0.07-0.23), respectively. The bioavailability of itraconazole from the extemporaneously prepared suspension is much lower than that from capsules... - Incidence of imipenem hypersensitivity reactions in febrile neutropenic bone marrow transplant patients with a history of penicillin allergyS A McConnell
College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Clin Infect Dis 31:1512-4. 2000..The findings of this study indicate the incidence of cross-reactivity between imipenem/cilastatin and penicillin among patients with a history of penicillin allergy may be lower than previously reported... - Rapid and sensitive high performance liquid chromatographic method for the determination of itraconazole and its hydroxy-metabolite in human serumP O Gubbins
Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock 72205, USA
J Pharm Biomed Anal 16:1005-12. 1998..999). Intra-assay relative standard deviations (R.S.D.) were below 12%. Inter-assay R.S.D. were below 14%. This method provides a rapid means for the accurate and precise determination of both OH-ITZ and ITZ concentrations in human serum... - Tick-borne bacterial, rickettsial, spirochetal, and protozoal infectious diseases in the United States: a comprehensive reviewJarrett R Amsden
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Pharmacotherapy 25:191-210. 2005..Because pharmacists are the most accessible health care providers, they are often asked how to treat tick-borne diseases. Thus, practitioners should be familiar with the ticks that inhabit their locale... - Clinical research in the lay press: irresponsible journalism raises a huge dose of doubtElias J Anaissie
Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Clin Infect Dis 43:1031-9. 2006 - Renal interaction between itraconazole and cimetidineChetan S Karyekar
Renal Clinical Pharmacology Laboratory, School of Pharmacy, and the Department of Medicine, Division of Nephrology, School of Medicine, University of Maryland, Baltimore 21201, USA
J Clin Pharmacol 44:919-27. 2004..Further evaluation of renal P-gp-modulating drugs such as itraconazole that may alter the renal excretion of coadministered drugs is warranted... - Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK modelChetan S Karyekar
Pharmacokinetics-Biopharmaceutics Laboratory, School of Pharmacy, University of Maryland, Baltimore 21201, USA
Pharmacotherapy 23:436-42. 2003.... - Are antimicrobial-impregnated catheters effective? Replace the water and grab your washcloth, because we have a baby to washScott A McConnell
School of Pharmacy and Health Related Professions, Creighton University Medical Center, Omaha, NE, USA
Clin Infect Dis 39:1829-33. 2004....