Research Topics
| David R GuaySummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Cranberry and urinary tract infectionsDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Drugs 69:775-807. 2009..However, in light of the heterogeneity of clinical study designs and the lack of consensus regarding the dosage regimen and formulation to use, cranberry products cannot be recommended for the prophylaxis of recurrent UTIs at this time...
Vilazodone hydrochloride, a combined SSRI and 5-HT1A receptor agonist for major depressive disorderDavid R P Guay
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA
Consult Pharm 27:857-67. 2012..This paper will review the chemistry, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, drug-drug interaction potential, dosing, and administration of this agent...
Antimicrobial prophylaxis in noncardiac prosthetic device recipientsDavid R Guay
College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
Hosp Pract (Minneap) 40:44-74. 2012..However, secondary antimicrobial prophylaxis in recipients of other types of prosthetic devices has been the subject of much controversy, with a wide variety of recommendations being made...
Topical clindamycin in the management of acne vulgarisDavid R P Guay
University of Minnesota, College of Pharmacy, Department of Experimental and Clinical Pharmacology, Weaver Densford Hall 7 148, 308 Harvard Street SE, Minneapolis, MN, 55455, USA
Expert Opin Pharmacother 8:2625-64. 2007..e., handwashing between seeing patients in the clinic) can both clindamycin's and erythromycin's widespread utility be preserved in this disorder...
Newer antiepileptic drugs in the management of agitation/aggression in patients with dementia or developmental disabilityDavid R P Guay
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Consult Pharm 22:1004-34. 2007..To assess the potential role of newer antiepileptic drugs (AEDs) in the management of agitation/aggression in patients with dementia or developmental disability...
Are there alternatives to the use of quinine to treat nocturnal leg cramps?David R Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Consult Pharm 23:141-56. 2008..To review the efficacy and tolerability profiles of quinine in nocturnal and dialysis-associated leg cramps and to examine potential alternative agents...
Contemporary management of uncomplicated urinary tract infectionsDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Drugs 68:1169-205. 2008..It can be anticipated that the optimal approach to the management of uUTIs will change substantially in the future as a consequence of antimicrobial resistance...
Rivastigmine transdermal patch: role in the management of Alzheimer's diseaseDavid R Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA
Consult Pharm 23:598-609. 2008..To assess the potential role of a new transdermal (TD) formulation of rivastigmine in the management of Alzheimer's disease...
Inappropriate sexual behaviors in cognitively impaired older individualsDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Geriatr Pharmacother 6:269-88. 2008..Substantial mental and physical harm can occur secondary to these behaviors. The common perception is that such behavior cannot be treated...
Drug treatment of paraphilic and nonparaphilic sexual disordersDavid R P Guay
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
Clin Ther 31:1-31. 2009..These fantasies, urges, and behaviors produce clinically significant distress or impairments in social, occupational, and other important areas of functioning...
Methylnaltrexone methobromide: the first peripherally active, centrally inactive opioid receptor-antagonistDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneanpolis, MN 55455, USA
Consult Pharm 24:210-26. 2009..To review the chemistry, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, indications, and dosing and administration of methylnaltrexone methobromide, the first approved peripherally selective opioid receptor-antagonist...
Is tapentadol an advance on tramadol?David R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
Consult Pharm 24:833-40. 2009....
Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disordersDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Geriatr Pharmacother 8:331-73. 2010..Tetrabenazine (TBZ) is a monoamine-depleting agent initially studied in the 1950s and currently approved by the US Food and Drug Administration for the treatment of chorea in Huntington's disease...
Oral hydromorphone extended-releaseDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Consult Pharm 25:816-28. 2010..To review the chemistry, pharmacodynamics, pharmacokinetics, efficacy, tolerability, dosing, and role of the Osmotic-controlled Release Oral delivery System (OROS) hydromorphone extended-release (ER) tablets...
Dabigatran etexilate: a possible replacement for heparinoids and vitamin K antagonists?David R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
Hosp Pract (Minneap) 39:105-25. 2011..Dabigatran etexilate appears to be a valuable addition to our anticoagulant armamentarium...
Update on clindamycin in the management of bacterial, fungal and protozoal infectionsDavid Guay
University of Minnesota, College of Pharmacy, Weaver Densford Hall 7 148, 308 Harvard Street SE, Minneapolis, MN 55455, USA
Expert Opin Pharmacother 8:2401-44. 2007....
Use of oral oxymorphone in the elderlyDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, MN 55455, USA
Consult Pharm 22:417-30. 2007..To review the pharmacodynamics, pharmacokinetics, efficacy, tolerability, dosing, and role of oral oxymorphone immediate-release (IR) and extended-release (ER)...
Rasagiline (TVP-1012): a new selective monoamine oxidase inhibitor for Parkinson's diseaseDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Geriatr Pharmacother 4:330-46. 2006....
Trandolapril: a newer angiotensin-converting enzyme inhibitorDavid R P Guay
Institute for the Study of Geriatric Pharmacotherapy, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Clin Ther 25:713-75. 2003..The fixed-dose combination of trandolapril and verapamil extended release (ER) is approved for the treatment of hypertension only...
Update on fenofibrateDavid R P Guay
University of Minnesota, College of Pharmacy, Weaver Densford Hall 7 115C, 308 Harvard Street SE, Minneapolis, MN 55455, USA
Cardiovasc Drug Rev 20:281-302. 2002..The results of other ongoing outcome trials are eagerly awaited. These results will help to establish the overall place of fenofibrate in the hypolipidemic armamentarium...
Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic painDavid R P Guay
Department of Experimental and Clinical Pharmacology, Institute for the Study of Geriatric Pharmacotherapy, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
Am J Geriatr Pharmacother 1:18-37. 2003..Based on the experience with carbamazepine, gabapentin, and lamotrigine, these newer AEDs are being investigated for the management of neuropathic pain...
Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasiaDavid R P Guay
Department of Experimental and Clinical Pharmacology, Institute for the Study of Geriatric Pharmacotherapy, College of Pharmacy, University of Minnesota, MN 55455, USA
Am J Geriatr Pharmacother 2:14-23. 2004..Although new to the United States, alfuzosin has been available in immediate-release (IR) and sustained-release (SR) formulations in other countries for many years...
Dalbavancin: an investigational glycopeptideDavid R P Guay
University of Minnesota, College of Pharmacy, Weaver Densford Hall 7 115C, 308 Harvard Street SE, Minneapolis, MN 55455, USA
Expert Rev Anti Infect Ther 2:845-52. 2004....
Duloxetine for management of stress urinary incontinenceDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis 55455, USA
Am J Geriatr Pharmacother 3:25-38. 2005....
Pregabalin in neuropathic pain: a more "pharmaceutically elegant" gabapentin?David R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis 55455, USA
Am J Geriatr Pharmacother 3:274-87. 2005..Pregabalin was provisionally approved by the US Food and Drug Administration in December 2004 and was granted final approval after controlled substance scheduling (Schedule V) by the US Drug Enforcement Agency in August 2005...
Ibandronate, an experimental intravenous bisphosphonate for osteoporosis, bone metastases, and hypercalcemia of malignancyDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, 55455, USA
Pharmacotherapy 26:655-73. 2006..Whether intravenous ibandronate will be a therapeutic advance is best answered by randomized, controlled trials. These are ongoing and should provide data with which to make better-informed choices concerning intravenous bisphosphonates...
Guidelines for the management of adults with health care-associated pneumonia: implications for nursing facility residentsDavid R Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Menneapolis, MN 55455, USA
Consult Pharm 21:719-25. 2006..To review the implications for nursing facility residents of the 2005 American Thoracic Society (ATS)/Infectious Diseases Society of America (IDSA) guidelines for the Management of Adults with Health Care-Associated Pneumonia...
Treatment of bacterial skin and skin structure infectionsDavid R P Guay
College of Pharmacy, University of Minnesota, Weaver Densford Hall 7 115C, 308 Harvard Street SE, Minneapolis, MN 55455, USA
Expert Opin Pharmacother 4:1259-75. 2003..Perhaps this assessment will change if the penetrance of the antimicrobial resistance patterns described above reach a critical threshold and clinical failures become more widespread...
Pneumococcal polysaccharide revaccination: immunoglobulin g seroconversion, persistence, and safety in frail, chronically ill older subjectsThomas E Lackner
Institute for the Study of Geriatric Pharmacotherapy, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Am Geriatr Soc 51:240-5. 2003..To determine the 1-month postpneumococcal polysaccharide-revaccination immunoglobulin G (IgG) antibody response, its persistence at 1 year, and tolerability of revaccination in frail, chronically ill older nursing facility residents...
Clinical pharmacokinetics of drugs used to treat urge incontinenceDavid R P Guay
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
Clin Pharmacokinet 42:1243-85. 2003....
Oritavancin and tigecycline: investigational antimicrobials for multidrug-resistant bacteriaDavid R P Guay
Institute for the Study of Geriatric Pharmacotherapy, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
Pharmacotherapy 24:58-68. 2004....
Cefdinir: an advanced-generation, broad-spectrum oral cephalosporinDavid R P Guay
Institute for the Study of Geriatric Pharmacotherapy, College of Pharmacy, University of Minnesota, Minneapolis 55455, USA
Clin Ther 24:473-89. 2002....
Use of antibacterial drugs in community-dwelling older personsDavid R P Guay
J Am Geriatr Soc 51:1819-21. 2003
