Lisa M Guay-Woodford

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Renal cystic diseases: diverse phenotypes converge on the cilium/centrosome complex
    Lisa M Guay-Woodford
    Departments of Medicine, Pediatrics, and Genetics, Division of Genetic and Translational Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South 19th Street, Birmingham, AL 35294, USA
    Pediatr Nephrol 21:1369-76. 2006
  2. ncbi request reprint Autosomal recessive polycystic kidney disease: the clinical experience in North America
    Lisa M Guay-Woodford
    Division of Genetic and Translational Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Pediatrics 111:1072-80. 2003
  3. ncbi request reprint Murine models of polycystic kidney disease: molecular and therapeutic insights
    Lisa M Guay-Woodford
    Division of Genetic and Translational Medicine, Department of Medicine, University of Alabama at Birmingham, Kaul 740, 1530 3rd Ave South 19th St, Birmingham, AL 35294, USA
    Am J Physiol Renal Physiol 285:F1034-49. 2003
  4. ncbi request reprint Overview: the genetics of renal disease
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, USA
    Semin Nephrol 19:312-8. 1999
  5. ncbi request reprint Germline and somatic loss of function of the mouse cpk gene causes biliary ductal pathology that is genetically modulated
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Hum Mol Genet 9:769-78. 2000
  6. pmc RIP-ed and ready to dance: new mechanisms for polycystin-1 signaling
    Lisa M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Clin Invest 114:1404-6. 2004
  7. ncbi request reprint Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    J Am Soc Nephrol 11:1253-60. 2000
  8. pmc PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats
    Luiz F Onuchic
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Hum Genet 70:1305-17. 2002
  9. ncbi request reprint The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0024, USA
    J Am Soc Nephrol 13:2508-16. 2002
  10. ncbi request reprint Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort
    Arlene B Chapman
    Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 64:1035-45. 2003

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Renal cystic diseases: diverse phenotypes converge on the cilium/centrosome complex
    Lisa M Guay-Woodford
    Departments of Medicine, Pediatrics, and Genetics, Division of Genetic and Translational Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South 19th Street, Birmingham, AL 35294, USA
    Pediatr Nephrol 21:1369-76. 2006
    ....
  2. ncbi request reprint Autosomal recessive polycystic kidney disease: the clinical experience in North America
    Lisa M Guay-Woodford
    Division of Genetic and Translational Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Pediatrics 111:1072-80. 2003
    ....
  3. ncbi request reprint Murine models of polycystic kidney disease: molecular and therapeutic insights
    Lisa M Guay-Woodford
    Division of Genetic and Translational Medicine, Department of Medicine, University of Alabama at Birmingham, Kaul 740, 1530 3rd Ave South 19th St, Birmingham, AL 35294, USA
    Am J Physiol Renal Physiol 285:F1034-49. 2003
    ....
  4. ncbi request reprint Overview: the genetics of renal disease
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, USA
    Semin Nephrol 19:312-8. 1999
    ..This review summarizes the role of genetics in renal disease, the different modes of inheritance of disease-susceptibility genes, the strategies for gene discovery, and the clinical impact of disease gene identification...
  5. ncbi request reprint Germline and somatic loss of function of the mouse cpk gene causes biliary ductal pathology that is genetically modulated
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Hum Mol Genet 9:769-78. 2000
    ..Expression of the biliary lesion is modulated by genetic background, and the specific biliary phenotype is determined by whether loss of function of the cpk gene occurs as a germline or a somatic event...
  6. pmc RIP-ed and ready to dance: new mechanisms for polycystin-1 signaling
    Lisa M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Clin Invest 114:1404-6. 2004
    ....
  7. ncbi request reprint Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    J Am Soc Nephrol 11:1253-60. 2000
    ..It is hypothesized that the gene encoding the polycystin-binding partner RGS7 is a candidate for the Chr 1 genetic modifier...
  8. pmc PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats
    Luiz F Onuchic
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Hum Genet 70:1305-17. 2002
    ....
  9. ncbi request reprint The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0024, USA
    J Am Soc Nephrol 13:2508-16. 2002
    ..These data add to a growing body of evidence that suggests that primary cilium plays a key role in normal physiologic functions of renal epithelia and that defects in ciliary function contribute to the pathogenesis of PKD...
  10. ncbi request reprint Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort
    Arlene B Chapman
    Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 64:1035-45. 2003
    ....
  11. pmc Cystin localizes to primary cilia via membrane microdomains and a targeting motif
    Binli Tao
    Departments of Medicine and Genetics, University of Alabama at Birmingham, 720 20th Street South, Birmingham, AL 35294, USA
    J Am Soc Nephrol 20:2570-80. 2009
    ..Analysis of deletion and chimeric constructs identified an AxEGG motif that is necessary to target and retain cystin in the cilium. Derangement of these localization motifs may lead to cystic kidney disease...
  12. ncbi request reprint Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: the consortium of radiologic imaging studies of polycystic kidney disease cohort
    Andrew D Rule
    Division of Nephrology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, and University of Alabama, Birmingham, USA
    J Am Soc Nephrol 17:854-62. 2006
    ..Misclassification from changes in non-GFR factors (e.g., creatinine production, tubular secretion) conservatively biased associations with eGFR. Misclassification from method imprecision attenuated associations with creatinine clearance...
  13. pmc Renal CD14 expression correlates with the progression of cystic kidney disease
    Juling Zhou
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 78:550-60. 2010
    ..But the association was significant when the analysis was confined to males. Clearly more studies need to be done to evaluate the utility of CD14 as a marker for outcomes in ADPKD...
  14. pmc Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
    Xiaoying Hou
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, USA
    J Clin Invest 109:533-40. 2002
    ..We therefore propose that the single epithelial cilium is important in the functional differentiation of polarized epithelia and that ciliary dysfunction underlies the PKD phenotype in cpk mice...
  15. pmc Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway
    Miguel A Garcia-Gonzalez
    Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 16:1940-50. 2007
    ..These studies are the first to show genetic interaction between the major loci responsible for human renal cystic disease in a common PKD pathway...
  16. ncbi request reprint Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse
    Michal Mrug
    Department of Medicine, University of Alabama at Birmingham, 740 Kaul Human Genetics Building, 720 20th Street South, Birmingham, AL 35294, USA
    J Am Soc Nephrol 16:905-16. 2005
    ..Therefore, the positional candidate gene, Kif12, fulfills the major criteria for QTL gene discovery established by the Complex Trait Consortium, and, thus, it is proposed that Kif12 is a cpk modifier gene...
  17. pmc Polyductin undergoes notch-like processing and regulated release from primary cilia
    Jun Ya Kaimori
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 16:942-56. 2007
    ..Regulated release from the primary cilium into the lumen may be a mechanism to distribute signal to down-stream targets using flow...
  18. ncbi request reprint Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)
    W CHARLES O'NEILL
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Kidney Dis 46:1058-64. 2005
    ..The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown...
  19. ncbi request reprint Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys
    Erik M Schwiebert
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F763-75. 2002
    ..Therefore, we hypothesize that autocrine purinergic signaling may augment detrimentally cyst volume expansion in ADPKD or tubule dilation in ARPKD, accelerating disease progression...
  20. ncbi request reprint Renal cystic disease: the role of the primary cilium/centrosome complex in pathogenesis
    Brian J Siroky
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Chronic Kidney Dis 13:131-7. 2006
    ....
  21. ncbi request reprint Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate gene
    Luiz F Onuchic
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Med Genet 110:346-52. 2002
    ..This further refinement of the PKHD1 interval will facilitate efforts to identify the PKHD1 gene by positional cloning. These data also provide additional, highly polymorphic markers for haplotype-based diagnostic testing for ARPKD...
  22. ncbi request reprint Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells
    Brian J Siroky
    Department of Physiology, Univ of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Renal Physiol 290:F1320-8. 2006
    ....
  23. pmc The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
    Maoqing Wu
    Research Division, Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e83062. 2013
    ..Thus, we speculate that Myc overexpression in the cpk kidney results from the dysregulation of the cystin-necdin regulatory complex and c-Myc, in turn, contributes to cystogenesis in the cpk mouse. ..
  24. ncbi request reprint Autosomal recessive polycystic kidney disease (ARPKD): new insights from the identification of the ARPKD gene, PKHD1
    Lisa M Guay-Woodford
    Department of Medicine, Division of Genetic and Translational Medicine, University of Alabama at Birmingham, Kaul 740, 1530 3rd Avenue South 19th Street, Birmingham, AL 35294, USA
    Pediatr Res 52:830-1. 2002
  25. doi request reprint Genetic testing: considerations for pediatric nephrologists
    Lisa M Guay-Woodford
    Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Nephrol 29:338-48. 2009
    ..In addition, we describe new technical advances that are expected to be introduced into clinical practice in the coming years...
  26. ncbi request reprint Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease
    Bernard F King
    Department of Medicine Renal Division, University of Alabama, Birmingham, Alabama, USA
    Kidney Int 64:2214-21. 2003
    ..Despite evidence for the importance of nephroangiosclerosis in the progression of renal insufficiency in ADPKD, evaluation of renal blood flow (RBF) as a surrogate marker of disease severity has received little attention...
  27. ncbi request reprint Autosomal recessive PKD in the early years
    Lisa M Guay-Woodford
    University of Alabama at Birmingham, USA
    Nephrol News Issues 21:39. 2007
  28. pmc Characterization of large rearrangements in autosomal dominant polycystic kidney disease and the PKD1/TSC2 contiguous gene syndrome
    Mark B Consugar
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 74:1468-79. 2008
    ..Our assay improves detection levels and the reliability of molecular testing of patients with ADPKD...
  29. pmc Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2
    L Tsiokas
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:6965-70. 1997
    ..These interactions suggest that PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis and that PKD1 may require the presence of PKD2 for stable expression...
  30. pmc Specific association of the gene product of PKD2 with the TRPC1 channel
    L Tsiokas
    Renal Division, RW 563, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 96:3934-9. 1999
    ....
  31. ncbi request reprint [Pathogenesis of cystic kidney diseases]
    G Walz
    Medizinische Klinik IV Nephrologie und Allgemeinmedizin, Universitatsklinikum Freiburg
    Verh Dtsch Ges Pathol 86:138-44. 2002
    ..Delineating common pathways of cystogenesis may help to design therapeutic strategies that combat the development and/or progression of renal cysts...
  32. ncbi request reprint Interaction with podocin facilitates nephrin signaling
    T B Huber
    Renal Division, University Hospital Freiburg, Freiburg 79106, Germany
    J Biol Chem 276:41543-6. 2001
    ..Mutational analysis suggests that abnormal or inefficient signaling through the nephrin-podocin complex contributes to the development of podocyte dysfunction and proteinuria...
  33. pmc Interaction between RGS7 and polycystin
    E Kim
    Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:6371-6. 1999
    ..Furthermore, membranous expression of C-terminal polycystin relocalized RGS7. Our results indicate that rapid degradation and interaction with integral membrane proteins are potential means of regulating RGS proteins...
  34. ncbi request reprint 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity
    T Benzing
    Department of Medicine, University Hospital of Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Biol Chem 275:28167-72. 2000
    ..Collectively, these data indicate that phosphorylation-dependent binding of 14-3-3 may act as molecular switch that controls the GAP activity keeping a substantial fraction of RGS proteins in a dormant state...
  35. ncbi request reprint The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals
    M Horndasch
    Department of Medicine, Division of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    Oncogene 25:3397-407. 2006
    ..CHOP binds to TCF factors, thereby preventing the binding of TCF to its DNA recognition site. Our findings demonstrate a novel function of CHOP as a Wnt repressor...
  36. ncbi request reprint The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel
    D H Vandorpe
    Molecular Medicine and Renal Units, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:4093-101. 2001
    ..Dysregulation of these or similar channels in autosomal dominant polycystic kidney disease may contribute to cyst formation or expansion...
  37. ncbi request reprint Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins
    R Schreiber
    Department of Physiology and Pharmacology, University of Queensland, St. Lucia, Queensland, 4072, Australia
    Biochem Biophys Res Commun 281:917-23. 2001
    ..Because RGS proteins interfere with the G protein-dependent regulation of CFTR, this may offer new potential pathways for pharmacological intervention in cystic fibrosis...
  38. pmc Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2
    T Benzing
    Renal Division, University Hospital Freiburg, 79106 Freiburg, Germany and Children s Hospital, and Molecular Medicine, University of Freiburg, 79106 Freiburg, Germany
    Proc Natl Acad Sci U S A 98:9784-9. 2001
    ..A lack of functional nephrocystin may compromise Pyk2 signaling in a subset of renal epithelial cells...
  39. ncbi request reprint Polycystic kidney disease: cell division without a c(l)ue?
    M Simons
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    Kidney Int 70:854-64. 2006
    ..Failure to communicate this spatial information may condemn the tubular epithelial cells to proliferate and to form cysts...
  40. ncbi request reprint [Pathogenetic aspectics of nephrotic syndrome]
    G Walz
    Medizinische Klinik IV, Universitatsklinikum, Freiburg, Germany
    Internist (Berl) 44:1075-82. 2003
    ..The familiar forms are rare; however, the identification of the relevant gene defects has greatly advanced our understanding of podocyte function as well as the pathogenesis of nephrotic syndrome...

Research Grants16

  1. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2000
    ..As already mentioned a more detailed experimental protocol is required to confirm or refute the speculations. Thus, it would be better to concentrate on the cloning of cpk gene. ..
  2. Genetics and Pharmacogenetics in FSGS (PPG Project 4)
    Lisa Guay Woodford; Fiscal Year: 2007
    ....
  3. Molecular networks: programming normal renal development and modeling disease pat
    Lisa Guay Woodford; Fiscal Year: 2007
    ..The meeting will be held in Pecs, Hungary from August 27-30, 2007, immediately preceding the 14th IPNA Congress in Budapest, Hungary (August 31- September 4, 2007). ..
  4. Cystin, a lipid raft and cilia-associated protein in PKD
    Lisa Guay Woodford; Fiscal Year: 2007
    ..Therefore, primary apical cilium represents a new focal point for dissecting the complex mechanisms involved in renal cystic disease and ultimately, perhaps a new target for therapeutic interventions. ..
  5. Cystin, a lipid raft and cilia-associated protein in PKD
    Lisa Guay Woodford; Fiscal Year: 2006
    ..Therefore, primary apical cilium represents a new focal point for dissecting the complex mechanisms involved in renal cystic disease and ultimately, perhaps a new target for therapeutic interventions. ..
  6. FASEB Conference -PKD Mechanisms and Clinical Impact
    Lisa Guay Woodford; Fiscal Year: 2005
    ..By allowing ample time for scientific exchanges and critical discussion, the conference will serve as a conduit for exploring new experimental ideas and fostering new research collaborations. ..
  7. Cystin, a lipid raft and cilia-associated protein in PKD
    Lisa Guay Woodford; Fiscal Year: 2005
    ..Therefore, primary apical cilium represents a new focal point for dissecting the complex mechanisms involved in renal cystic disease and ultimately, perhaps a new target for therapeutic interventions. ..
  8. Cystin, a lipid raft and cilia-associated protein in PKD
    Lisa Guay Woodford; Fiscal Year: 2004
    ..Therefore, primary apical cilium represents a new focal point for dissecting the complex mechanisms involved in renal cystic disease and ultimately, perhaps a new target for therapeutic interventions. ..
  9. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2003
    ..As already mentioned a more detailed experimental protocol is required to confirm or refute the speculations. Thus, it would be better to concentrate on the cloning of cpk gene. ..
  10. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2002
    ..As already mentioned a more detailed experimental protocol is required to confirm or refute the speculations. Thus, it would be better to concentrate on the cloning of cpk gene. ..
  11. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2001
    ..As already mentioned a more detailed experimental protocol is required to confirm or refute the speculations. Thus, it would be better to concentrate on the cloning of cpk gene. ..