Research Topics
Genomes and Genes
| Kunliang GuanSummaryAffiliation: University of Michigan Country: USA Publications
| Collaborators
|
Detail Information
Publications
Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinaseJoyce H Hurley
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
BMC Neurosci 4:10. 2003..In particular it is not clear whether GPCRs are modulated by tyrosine kinase receptor-MAP kinase pathways...
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingKen Inoki
Department of Biological Chemistry, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
Nat Cell Biol 4:648-57. 2002..Our data indicate a molecular mechanism for TSC2 in insulin signalling, tumour suppressor functions and in the inhibition of cell growth...- Signalling mechanisms mediating neuronal responses to guidance cuesKun Liang Guan
Life Sciences Institute, Department of Biological Chemistry and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Rev Neurosci 4:941-56. 2003..Studies of neuronal guidance mechanisms have shed light not only on neural development, but also on other processes that involve the extracellular regulation of the cytoskeleton... 
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityYong Li
Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606, USA
Mol Cell Biol 24:7965-75. 2004..Our data further demonstrate that GAP activity is essential for the cellular function of TSC2 to inhibit S6K phosphorylation...- The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3Yong Li
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA
J Biol Chem 278:13663-71. 2003..Phosphorylation of TSC2 by MK2 creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein... - Regulation of TSC2 by 14-3-3 bindingYong Li
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 277:44593-6. 2002..Phosphorylation of Ser(1210) in TSC2 is required for its association with 14-3-3. Our data indicate that 14-3-3 association may inhibit the function of TSC2 and represents a possible mechanism of TSC2 regulation... - Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingKen Inoki
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Genes Dev 17:1829-34. 2003..Our data demonstrate that Rheb acts downstream of TSC1/TSC2 and upstream of mTOR to regulate cell growth... - The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loopFan Yang
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 172:2446-52. 2004..The anhydrotic ectodermal dysplasia with immunodeficiency patients' immunodeficiency may be associated with NF-kappaB defect in response to bacterial stimulation... - Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with RhebYong Li
Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
J Biol Chem 282:35803-13. 2007..Moreover, Bnip3 inhibits cell growth in vivo by suppressing the mTOR pathway. These observations demonstrate that Bnip3 mediates the inhibition of the mTOR pathway in response to hypoxia... - Signaling by target of rapamycin proteins in cell growth controlKen Inoki
Life Science Institute, University of Michigan Medical School, 5450 Medical Science I Bldg, Ann Arbor, MI 48109 0606, USA
Microbiol Mol Biol Rev 69:79-100. 2005..Here we review the current understanding of the regulation of TOR signaling and discuss its function as a signaling nexus to control cell growth during normal development and tumorigenesis... - Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancerJ Chad Brenner
Michigan Center for Translational Pathology, University of Michigan, 1400 E Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA
Cancer Cell 19:664-78. 2011..Finally, overexpression of the TMPRSS2:ERG fusion induces DNA damage, which is potentiated by PARP1 inhibition in a manner similar to that of BRCA1/2 deficiency... - TSC2: filling the GAP in the mTOR signaling pathwayYong Li
Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Trends Biochem Sci 29:32-8. 2004..Thus, TSC1/2 and Rheb have pivotal roles in mediating growth factors, nutrient and energy sensing signals to mTOR-dependent targets. These discoveries lend new insight into TSC pathogenesis... - Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growthStefan W Stoll
Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Invest Dermatol 130:2031-40. 2010.... - Measurements of TSC2 GAP activity toward RhebYong Li
Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA
Methods Enzymol 407:46-54. 2006..The last method is to determine the phosphorylation of S6K1 (ribosomal S6 kinase), which is a downstream target of mTOR, as an indirect assay for TSC2 GAP activity in vivo... - Coordinated regulation of polycomb group complexes through microRNAs in cancerQi Cao
Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA
Cancer Cell 20:187-99. 2011..Taken together, our data have uncovered a coordinate regulation of PRC1 and PRC2 activities that is mediated by miRNAs... - TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligaseHuira Chong-Kopera
Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 281:8313-6. 2006..Furthermore, these data reveal a possible biochemical basis of how certain disease mutations inactivate TSC2... 
UV irradiation induces Snail expression by AP-1 dependent mechanism in human skin keratinocytesYong Li
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 5609, USA
J Dermatol Sci 60:105-13. 2010..Ultraviolet (UV) irradiation from the sun is the major cause of keratinocyte skin cancer. Transcription factor Snail plays an important role in epithelial-to-mesenchymal transition and epithelial tumor formation...- Therapeutic targeting of SPINK1-positive prostate cancerBushra Ateeq
Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA
Sci Transl Med 3:72ra17. 2011..Our results provide a rationale for both the development of humanized mAbs to SPINK1 and evaluation of EGFR inhibition in SPINK1+/ETSā» prostate cancers... - Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skinLaure Rittie
Department of Dermatology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0932, USA
Am J Pathol 170:2089-99. 2007..Our results suggest that targeting ErbB1 signaling might be of benefit in the treatment of SCC... - IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharideFan Yang
Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 170:5630-5. 2003..In summary, our results demonstrate that IKK beta plays an essential role in the LPS-induced p65 phosphorylation on serine 536, which may represent a mechanism to regulate the NF-kappa B transcription activity by LPS... - Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiationYong Li
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 0932, USA
Arch Dermatol Res 301:205-17. 2009..022). This finding was confirmed in an independent set of mice analyzed by quantitative RT-PCR (8.8-fold vs. 1.2-fold, n = 4, P = 0.001). The finding of persistent dermal DNA damage after suberythemal doses of SSR merits further study... - Amelogenin: a potential regulator of cementum-associated genesHema L Viswanathan
Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
J Periodontol 74:1423-31. 2003..Amelogenins have been reported to induce expression of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate the activity of mesenchyme-derived cells... - PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2Yong Li
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0676, USA
Am J Physiol Renal Physiol 282:F1129-39. 2002..These results suggest that the interaction of podocalyxin with NHERF-2 may function to efficiently retain podocalyxin at the apical surface of the podocyte and provide a mechanism linking podocalyxin to the actin cytoskeleton...