Kunliang Guan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase
    Joyce H Hurley
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Neurosci 4:10. 2003
  2. ncbi request reprint TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    Nat Cell Biol 4:648-57. 2002
  3. ncbi request reprint Signalling mechanisms mediating neuronal responses to guidance cues
    Kun Liang Guan
    Life Sciences Institute, Department of Biological Chemistry and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 4:941-56. 2003
  4. pmc Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
    Yong Li
    Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606, USA
    Mol Cell Biol 24:7965-75. 2004
  5. ncbi request reprint The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
    Yong Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 278:13663-71. 2003
  6. ncbi request reprint Regulation of TSC2 by 14-3-3 binding
    Yong Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:44593-6. 2002
  7. pmc Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1829-34. 2003
  8. ncbi request reprint Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb
    Yong Li
    Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 282:35803-13. 2007
  9. ncbi request reprint The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop
    Fan Yang
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 172:2446-52. 2004
  10. pmc Signaling by target of rapamycin proteins in cell growth control
    Ken Inoki
    Life Science Institute, University of Michigan Medical School, 5450 Medical Science I Bldg, Ann Arbor, MI 48109 0606, USA
    Microbiol Mol Biol Rev 69:79-100. 2005

Collaborators

Detail Information

Publications23

  1. pmc Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase
    Joyce H Hurley
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Neurosci 4:10. 2003
    ..In particular it is not clear whether GPCRs are modulated by tyrosine kinase receptor-MAP kinase pathways...
  2. ncbi request reprint TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    Nat Cell Biol 4:648-57. 2002
    ..Our data indicate a molecular mechanism for TSC2 in insulin signalling, tumour suppressor functions and in the inhibition of cell growth...
  3. ncbi request reprint Signalling mechanisms mediating neuronal responses to guidance cues
    Kun Liang Guan
    Life Sciences Institute, Department of Biological Chemistry and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 4:941-56. 2003
    ..Studies of neuronal guidance mechanisms have shed light not only on neural development, but also on other processes that involve the extracellular regulation of the cytoskeleton...
  4. pmc Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
    Yong Li
    Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606, USA
    Mol Cell Biol 24:7965-75. 2004
    ..Our data further demonstrate that GAP activity is essential for the cellular function of TSC2 to inhibit S6K phosphorylation...
  5. ncbi request reprint The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
    Yong Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 278:13663-71. 2003
    ..Phosphorylation of TSC2 by MK2 creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein...
  6. ncbi request reprint Regulation of TSC2 by 14-3-3 binding
    Yong Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:44593-6. 2002
    ..Phosphorylation of Ser(1210) in TSC2 is required for its association with 14-3-3. Our data indicate that 14-3-3 association may inhibit the function of TSC2 and represents a possible mechanism of TSC2 regulation...
  7. pmc Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1829-34. 2003
    ..Our data demonstrate that Rheb acts downstream of TSC1/TSC2 and upstream of mTOR to regulate cell growth...
  8. ncbi request reprint Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb
    Yong Li
    Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 282:35803-13. 2007
    ..Moreover, Bnip3 inhibits cell growth in vivo by suppressing the mTOR pathway. These observations demonstrate that Bnip3 mediates the inhibition of the mTOR pathway in response to hypoxia...
  9. ncbi request reprint The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop
    Fan Yang
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 172:2446-52. 2004
    ..The anhydrotic ectodermal dysplasia with immunodeficiency patients' immunodeficiency may be associated with NF-kappaB defect in response to bacterial stimulation...
  10. pmc Signaling by target of rapamycin proteins in cell growth control
    Ken Inoki
    Life Science Institute, University of Michigan Medical School, 5450 Medical Science I Bldg, Ann Arbor, MI 48109 0606, USA
    Microbiol Mol Biol Rev 69:79-100. 2005
    ..Here we review the current understanding of the regulation of TOR signaling and discuss its function as a signaling nexus to control cell growth during normal development and tumorigenesis...
  11. pmc Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer
    J Chad Brenner
    Michigan Center for Translational Pathology, University of Michigan, 1400 E Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA
    Cancer Cell 19:664-78. 2011
    ..Finally, overexpression of the TMPRSS2:ERG fusion induces DNA damage, which is potentiated by PARP1 inhibition in a manner similar to that of BRCA1/2 deficiency...
  12. ncbi request reprint TSC2: filling the GAP in the mTOR signaling pathway
    Yong Li
    Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Biochem Sci 29:32-8. 2004
    ..Thus, TSC1/2 and Rheb have pivotal roles in mediating growth factors, nutrient and energy sensing signals to mTOR-dependent targets. These discoveries lend new insight into TSC pathogenesis...
  13. pmc Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth
    Stefan W Stoll
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 130:2031-40. 2010
    ....
  14. ncbi request reprint Measurements of TSC2 GAP activity toward Rheb
    Yong Li
    Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA
    Methods Enzymol 407:46-54. 2006
    ..The last method is to determine the phosphorylation of S6K1 (ribosomal S6 kinase), which is a downstream target of mTOR, as an indirect assay for TSC2 GAP activity in vivo...
  15. pmc Coordinated regulation of polycomb group complexes through microRNAs in cancer
    Qi Cao
    Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA
    Cancer Cell 20:187-99. 2011
    ..Taken together, our data have uncovered a coordinate regulation of PRC1 and PRC2 activities that is mediated by miRNAs...
  16. ncbi request reprint TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
    Huira Chong-Kopera
    Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:8313-6. 2006
    ..Furthermore, these data reveal a possible biochemical basis of how certain disease mutations inactivate TSC2...
  17. doi request reprint UV irradiation induces Snail expression by AP-1 dependent mechanism in human skin keratinocytes
    Yong Li
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 5609, USA
    J Dermatol Sci 60:105-13. 2010
    ..Ultraviolet (UV) irradiation from the sun is the major cause of keratinocyte skin cancer. Transcription factor Snail plays an important role in epithelial-to-mesenchymal transition and epithelial tumor formation...
  18. pmc Therapeutic targeting of SPINK1-positive prostate cancer
    Bushra Ateeq
    Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA
    Sci Transl Med 3:72ra17. 2011
    ..Our results provide a rationale for both the development of humanized mAbs to SPINK1 and evaluation of EGFR inhibition in SPINK1+/ETSā» prostate cancers...
  19. pmc Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin
    Laure Rittie
    Department of Dermatology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0932, USA
    Am J Pathol 170:2089-99. 2007
    ..Our results suggest that targeting ErbB1 signaling might be of benefit in the treatment of SCC...
  20. ncbi request reprint IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide
    Fan Yang
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 170:5630-5. 2003
    ..In summary, our results demonstrate that IKK beta plays an essential role in the LPS-induced p65 phosphorylation on serine 536, which may represent a mechanism to regulate the NF-kappa B transcription activity by LPS...
  21. doi request reprint Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiation
    Yong Li
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 0932, USA
    Arch Dermatol Res 301:205-17. 2009
    ..022). This finding was confirmed in an independent set of mice analyzed by quantitative RT-PCR (8.8-fold vs. 1.2-fold, n = 4, P = 0.001). The finding of persistent dermal DNA damage after suberythemal doses of SSR merits further study...
  22. ncbi request reprint Amelogenin: a potential regulator of cementum-associated genes
    Hema L Viswanathan
    Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Periodontol 74:1423-31. 2003
    ..Amelogenins have been reported to induce expression of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate the activity of mesenchyme-derived cells...
  23. ncbi request reprint PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2
    Yong Li
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0676, USA
    Am J Physiol Renal Physiol 282:F1129-39. 2002
    ..These results suggest that the interaction of podocalyxin with NHERF-2 may function to efficiently retain podocalyxin at the apical surface of the podocyte and provide a mechanism linking podocalyxin to the actin cytoskeleton...