Jun Lin Guan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
    Jun Lin Guan
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    IUBMB Life 62:268-76. 2010
  2. pmc Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo
    Huaping Fan
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Biol Chem 288:3322-33. 2013
  3. pmc Distinct FAK activities determine progenitor and mammary stem cell characteristics
    Ming Luo
    Divisions of Molecular Medicine and Genetics and Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 73:5591-602. 2013
  4. pmc FIP200 is required for maintenance and differentiation of postnatal neural stem cells
    Chenran Wang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Neurosci 16:532-42. 2013
  5. pmc Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Genes Dev 25:1510-27. 2011
  6. pmc Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
    Xiaofeng Zhao
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Adv Drug Deliv Rev 63:610-5. 2011
  7. pmc Autophagy in stem cells
    Jun Lin Guan
    Division of Molecular Medicine, Department of Internal Medicine and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Autophagy 9:830-49. 2013
  8. pmc Visualizing and manipulating focal adhesion kinase regulation in live cells
    Michael Ritt
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Biol Chem 288:8875-86. 2013
  9. pmc Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells
    Xiao Yan Li
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 195:729-38. 2011
  10. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010

Collaborators

Detail Information

Publications21

  1. pmc Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
    Jun Lin Guan
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    IUBMB Life 62:268-76. 2010
    ..This review discusses these recent advances and future studies into the mechanism of integrin signaling through FAK in breast cancer through regulation of MaCSCs that may lead to development of novel therapies for this deadly disease...
  2. pmc Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo
    Huaping Fan
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Biol Chem 288:3322-33. 2013
    ..Together, these results identify a novel role of FAK scaffolding function in breast cancer, which could serve as a new target in combination with kinase inhibition for more effective treatment strategies...
  3. pmc Distinct FAK activities determine progenitor and mammary stem cell characteristics
    Ming Luo
    Divisions of Molecular Medicine and Genetics and Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 73:5591-602. 2013
    ..We suggest that targeting these distinct functions may tailor therapeutic strategies to address breast cancer heterogeneity more effectively...
  4. pmc FIP200 is required for maintenance and differentiation of postnatal neural stem cells
    Chenran Wang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Neurosci 16:532-42. 2013
    ..These data reveal that FIP200-mediated autophagy contributes to the maintenance and functions of NSCs through regulation of oxidative state...
  5. pmc Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Genes Dev 25:1510-27. 2011
    ..Together, these data provide strong evidence for a protumorigenesis role of autophagy in oncogene-induced tumors in vivo and suggest FIP200 as a potential target for cancer therapy...
  6. pmc Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
    Xiaofeng Zhao
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Adv Drug Deliv Rev 63:610-5. 2011
    ....
  7. pmc Autophagy in stem cells
    Jun Lin Guan
    Division of Molecular Medicine, Department of Internal Medicine and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Autophagy 9:830-49. 2013
    ..We also highlight the many unanswered questions that will help to drive further research at the intersection of autophagy and stem cell biology in the near future...
  8. pmc Visualizing and manipulating focal adhesion kinase regulation in live cells
    Michael Ritt
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Biol Chem 288:8875-86. 2013
    ..The FERM-kinase interaction at focal adhesions is enhanced at acidic pH, with a concomitant decrease in Tyr-397 phosphorylation, providing a potential mechanism for enhanced migration of cancer cells...
  9. pmc Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells
    Xiao Yan Li
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 195:729-38. 2011
    ....
  10. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010
    ..Our data therefore suggest that CXCR1 blockade may provide a novel means of targeting and eliminating breast CSCs...
  11. pmc Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents
    Heekyong Bae
    Department of Internal Medicine, University of Michigan Medical School, 3027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Mol Cancer Res 9:1232-41. 2011
    ....
  12. pmc Pro-tumorigenic function of autophagy in mammary oncogenesis
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Autophagy 8:129-31. 2012
    ....
  13. pmc Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity
    Huaping Fan
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:18573-82. 2011
    ....
  14. pmc Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation
    Fei Liu
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Bone Miner Res 28:2414-30. 2013
    ..2013 American Society for Bone and Mineral Research...
  15. pmc Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer
    Song Chen
    1Divisions of Molecular Medicine and Genetics, Department of Internal Medicine, and 2Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan
    Cancer Discov 3:1225-7. 2013
    ..Importantly, they identify a critical role of glutamine dependency in the suppression of BrafV600E-induced cancer, thus revealing an important mechanism by which autophagy may promote tumor progression in different cellular contexts...
  16. pmc Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration
    Chenran Wang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:29398-405. 2010
    ..Taken together, these results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin β1 recycling and localization to lipid rafts via a specific downstream effector pathway...
  17. pmc Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
    Xiaofeng Zhao
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 189:955-65. 2010
    ..Together, our data suggest that kinase-independent functions of FAK can support EC survival in vascular development through E13.5 but are insufficient for maintaining EC function to allow for completion of embryogenesis...
  18. pmc Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis
    Ming Luo
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Lett 289:127-39. 2010
    ..The wealth of knowledge accumulated over almost two decades of research on FAK should help to design potentially novel therapies for breast cancer...
  19. pmc Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells
    Ming Luo
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:466-74. 2009
    ..Together, these results show a novel function of FAK in maintaining the mammary cancer stem/progenitor cell population and provide a novel mechanism by which FAK may promote breast cancer development and progression...
  20. pmc Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Biol Chem 284:6004-13. 2009
    ..Together, these results demonstrate that ablation of FIP200, although not promoting tumorigenesis, can lead to skin inflammatory disorders, suggesting a novel function of FIP200 in the maintenance of normal skin homeostasis in vivo...
  21. pmc Activation of FAK and Src are receptor-proximal events required for netrin signaling
    Weiquan Li
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Neurosci 7:1213-21. 2004
    ..On the basis of our observations, we suggest a model in which DCC functions as a kinase-coupled receptor, and FAK and Src act immediately downstream of DCC in netrin signaling...

Research Grants40

  1. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2006
    ..These studies will enhance our understanding of the molecular mechanisms of signal transduction in cell migration and invasion which are critical factors in biological processes such as embryonic development, wound healing and cancer. ..
  2. Focal adhesion kinase in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2006
    ..abstract_text> ..
  3. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2004
    ....
  4. Analysis of FAK and FIP200 in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2007
    ....
  5. Molecular Analysis of Signal Transduction in Cancer Development and Progression
    Jun Lin Guan; Fiscal Year: 2010
    ....
  6. Analysis of FAK and FIP200 in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2010
    ....
  7. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2009
    ..abstract_text> ..
  8. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2007
    ..They will provide potentially novel therapeutic targets for diseases such as cancer. ..
  9. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 1993
    ..In particular, it might establish an important link between cell surface adhesion receptors and cytoplasmic tyrosine kinases: transmembrane protein integrins as regulators for cytoplasmic tyrosine kinases...
  10. SIGNAL TRANSDUCTION BY FAK AND ITS ASSOCIATED PROTEINS
    Jun Lin Guan; Fiscal Year: 2003
    ..The investigators hope that these studies will provide new insights into the mechanisms by which cell adhesion to extracellular matrix regulate cell cycle progression. ..
  11. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2000
    ..These studies will enhance our understanding of the molecular mechanisms of signal transduction by integrins, which are critical factors in cell migration and invasiveness. ..
  12. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2010
    ....