Jun Lin Guan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
    Jun Lin Guan
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    IUBMB Life 62:268-76. 2010
  2. pmc FIP200 is required for maintenance and differentiation of postnatal neural stem cells
    Chenran Wang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Neurosci 16:532-42. 2013
  3. pmc Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways
    Boyi Gan
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 175:121-33. 2006
  4. pmc Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway
    Y Yoo
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Oncogene 29:263-72. 2010
  5. ncbi request reprint Association of Grb7 with phosphoinositides and its role in the regulation of cell migration
    Tang Long Shen
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 277:29069-77. 2002
  6. ncbi request reprint Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation
    Lee Ann Cohen
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:8197-207. 2005
  7. ncbi request reprint Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression
    Jihe Zhao
    Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    Mol Cell 11:1503-15. 2003
  8. pmc Regulation of focal adhesion kinase by a novel protein inhibitor FIP200
    Smita Abbi
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 13:3178-91. 2002
  9. ncbi request reprint Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland
    Tamas Nagy
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 282:31766-76. 2007
  10. pmc Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
    Boyi Gan
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 170:379-89. 2005

Collaborators

Detail Information

Publications57

  1. pmc Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
    Jun Lin Guan
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    IUBMB Life 62:268-76. 2010
    ..This review discusses these recent advances and future studies into the mechanism of integrin signaling through FAK in breast cancer through regulation of MaCSCs that may lead to development of novel therapies for this deadly disease...
  2. pmc FIP200 is required for maintenance and differentiation of postnatal neural stem cells
    Chenran Wang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Neurosci 16:532-42. 2013
    ..These data reveal that FIP200-mediated autophagy contributes to the maintenance and functions of NSCs through regulation of oxidative state...
  3. pmc Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways
    Boyi Gan
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 175:121-33. 2006
    ..Together, our results reveal that FIP200 functions as a regulatory node to couple two important signaling pathways to regulate cell growth and survival during mouse embryogenesis...
  4. pmc Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway
    Y Yoo
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Oncogene 29:263-72. 2010
    ....
  5. ncbi request reprint Association of Grb7 with phosphoinositides and its role in the regulation of cell migration
    Tang Long Shen
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 277:29069-77. 2002
    ....
  6. ncbi request reprint Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation
    Lee Ann Cohen
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:8197-207. 2005
    ..Together, these data strongly suggest a role for the first FAK subdomain of the FERM domain in its normal regulation and function in the cell...
  7. ncbi request reprint Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression
    Jihe Zhao
    Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    Mol Cell 11:1503-15. 2003
    ..Transcription activation of cyclin D1 by FAK requires both Ets family and KLF8 factors in a temporally differential manner. Together, our data provide further insights into molecular mechanism for FAK to regulate cell cycle progression...
  8. pmc Regulation of focal adhesion kinase by a novel protein inhibitor FIP200
    Smita Abbi
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 13:3178-91. 2002
    ..Together, these results identify FIP200 as a novel protein inhibitor for FAK...
  9. ncbi request reprint Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland
    Tamas Nagy
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 282:31766-76. 2007
    ..Together, these results provide strong support for a role of FAK in the mammary gland development and function in vivo...
  10. pmc Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
    Boyi Gan
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 170:379-89. 2005
    ..Together, these results suggest a cellular function of FIP200 in the regulation of cell size by interaction with the TSC1-TSC2 complex...
  11. pmc Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice
    Xu Peng
    Departments of Molecular Medicine, Clinical Sciences, and Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 105:6638-43. 2008
    ..Last, we found that Src, but not PI3K, is important in mediating signal transduction for the regulation of MEF2a by FAK. Together, these results identified the role and mechanisms of FAK in embryonic cardiac development...
  12. pmc Distinct FAK activities determine progenitor and mammary stem cell characteristics
    Ming Luo
    Divisions of Molecular Medicine and Genetics and Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 73:5591-602. 2013
    ..We suggest that targeting these distinct functions may tailor therapeutic strategies to address breast cancer heterogeneity more effectively...
  13. pmc Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
    Tang Long Shen
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 169:941-52. 2005
    ..Together, these results strongly suggest a role of FAK in angiogenesis and vascular development due to its essential function in the regulation of multiple EC activities...
  14. pmc Activation of FAK and Src are receptor-proximal events required for netrin signaling
    Weiquan Li
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Neurosci 7:1213-21. 2004
    ..On the basis of our observations, we suggest a model in which DCC functions as a kinase-coupled receptor, and FAK and Src act immediately downstream of DCC in netrin signaling...
  15. pmc Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Genes Dev 25:1510-27. 2011
    ..Together, these data provide strong evidence for a protumorigenesis role of autophagy in oncogene-induced tumors in vivo and suggest FIP200 as a potential target for cancer therapy...
  16. pmc Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice
    Xu Peng
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Clin Invest 116:217-27. 2006
    ..Together, these results provide strong evidence for a role of FAK in the regulation of heart hypertrophy in vivo...
  17. pmc Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration
    Chenran Wang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:29398-405. 2010
    ..Taken together, these results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin β1 recycling and localization to lipid rafts via a specific downstream effector pathway...
  18. pmc Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction
    Lee Ann Cooper
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Cell Biol 23:8030-41. 2003
    ..Based on these and previous data, we propose a working model for activation of FAK in cell adhesion...
  19. ncbi request reprint Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice
    Xu Peng
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cardiovasc Res 64:421-30. 2004
    ..However, the functions of focal adhesion kinase in endothelial cell (EC) in vivo remain unclear. This study aims to examine the role of FAK in EC function and angiogenesis in vivo by transgenic mice approach...
  20. ncbi request reprint Mechanism of cell cycle regulation by FIP200 in human breast cancer cells
    Zara K Melkoumian
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Cancer Res 65:6676-84. 2005
    ..Both effects are critical for FIP200-induced G1 arrest and may contribute to the putative antitumor activities of FIP200 in breast cancer...
  21. pmc Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo
    Huaping Fan
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Biol Chem 288:3322-33. 2013
    ..Together, these results identify a novel role of FAK scaffolding function in breast cancer, which could serve as a new target in combination with kinase inhibition for more effective treatment strategies...
  22. ncbi request reprint EphB1 associates with Grb7 and regulates cell migration
    Dong Cho Han
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 277:45655-61. 2002
    ..Together, our results identified a novel interaction between EphB1 with the adaptor molecule Grb7 and suggested that this interaction may play a role in the regulation of cell migration by EphB1...
  23. ncbi request reprint FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation
    Xiaoyang Wu
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 9:185-96. 2005
    ..Together, these results suggest a regulatory mechanism of cell invasion whereby FAK promotes cell-surface presentation of MT1-MMP by inhibiting endophilin A2-dependent endocytosis...
  24. pmc Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
    Xiaofeng Zhao
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 189:955-65. 2010
    ..Together, our data suggest that kinase-independent functions of FAK can support EC survival in vascular development through E13.5 but are insufficient for maintaining EC function to allow for completion of embryogenesis...
  25. pmc Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration
    Chun Chi Liang
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:3499-509. 2010
    ..Taken together, these results provide strong genetic evidence for a role of FIP200 in the regulation of neuronal homeostasis through its function in autophagy in vivo...
  26. pmc Visualizing and manipulating focal adhesion kinase regulation in live cells
    Michael Ritt
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Biol Chem 288:8875-86. 2013
    ..The FERM-kinase interaction at focal adhesions is enhanced at acidic pH, with a concomitant decrease in Tyr-397 phosphorylation, providing a potential mechanism for enhanced migration of cancer cells...
  27. ncbi request reprint Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth
    Qiyu Feng
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 8:945-56. 2006
    ..These findings demonstrate that the regulated phosphorylation of Cool-1 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation...
  28. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010
    ..Our data therefore suggest that CXCR1 blockade may provide a novel means of targeting and eliminating breast CSCs...
  29. pmc Inhibition of podocyte FAK protects against proteinuria and foot process effacement
    Hong Ma
    Departments of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Soc Nephrol 21:1145-56. 2010
    ..In conclusion, FAK activation regulates podocyte foot process effacement, suggesting that pharmacologic inhibition of this signaling cascade may have therapeutic potential in the setting of glomerular injury...
  30. ncbi request reprint Focal adhesion kinase regulation of N-WASP subcellular localization and function
    Xiaoyang Wu
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 279:9565-76. 2004
    ..Together, these results suggest a novel regulatory mechanism of N-WASP by tyrosine phosphorylation and subcellular localization and its potential role in the regulation of cell migration...
  31. ncbi request reprint 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove
    Luis G Rodriguez
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Cell Physiol 202:285-94. 2005
    ....
  32. ncbi request reprint Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading
    Youngdong Yoo
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 281:15352-60. 2006
    ..Together, these results identify hnRNPK as a new negative regulator of N-WASP and suggest that hnRNPK may regulate the initial stage of cell spreading by direct association with N-WASP in the spreading initiation center...
  33. pmc Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells
    Ming Luo
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:466-74. 2009
    ..Together, these results show a novel function of FAK in maintaining the mammary cancer stem/progenitor cell population and provide a novel mechanism by which FAK may promote breast cancer development and progression...
  34. ncbi request reprint Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth
    Boyi Gan
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 281:37321-9. 2006
    ....
  35. ncbi request reprint Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners
    Xiaoyang Wu
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 8:756-63. 2006
    ..Based on these results, we propose a nuclear function for N-WASP in transcriptional regulation...
  36. ncbi request reprint Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation
    Huijun Wei
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    J Biol Chem 281:16664-71. 2006
    ..Taken together, our results demonstrated that sumoylation of KLF8 negatively regulates its transcriptional activity and cellular functions...
  37. pmc FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
    Fei Liu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 116:4806-14. 2010
    ..These data identify FIP200 as a key intrinsic regulator of fetal HSCs and implicate a potential role for autophagy in the maintenance of fetal hematopoiesis and HSCs...
  38. pmc p62/SQSTM1 synergizes with autophagy for tumor growth in vivo
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Genes Dev 28:1204-16. 2014
    ..Together, our studies demonstrate that p62 and autophagy synergize to promote tumor growth, suggesting that inhibition of both pathways could be more effective than targeting either alone for cancer therapy...
  39. pmc Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells
    Xiao Yan Li
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 195:729-38. 2011
    ....
  40. ncbi request reprint FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis
    Fei Liu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Autophagy 7:229-30. 2011
    ..Together, our data identify FIP200 as a key intrinsic regulator of fetal HSCs and suggest a role of autophagy in fetal hematopoiesis and the maintenance of fetal HSCs...
  41. ncbi request reprint Grb7 in intracellular signaling and its role in cell regulation
    Tang Long Shen
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    Front Biosci 9:192-200. 2004
    ..This review will discuss the current understanding of Grb7 mediated signal transduction pathways and their role in the regulation of various cellular functions...
  42. pmc Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Biol Chem 284:6004-13. 2009
    ..Together, these results demonstrate that ablation of FIP200, although not promoting tumorigenesis, can lead to skin inflammatory disorders, suggesting a novel function of FIP200 in the maintenance of normal skin homeostasis in vivo...
  43. ncbi request reprint Mechanisms of focal adhesion kinase regulation
    Lee Ann Cohen
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Curr Cancer Drug Targets 5:629-43. 2005
    ....
  44. pmc Autophagy in stem cells
    Jun Lin Guan
    Division of Molecular Medicine, Department of Internal Medicine and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Autophagy 9:830-49. 2013
    ..We also highlight the many unanswered questions that will help to drive further research at the intersection of autophagy and stem cell biology in the near future...
  45. ncbi request reprint Cell biology. Integrins, rafts, Rac, and Rho
    Jun Lin Guan
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Science 303:773-4. 2004
  46. pmc Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents
    Heekyong Bae
    Department of Internal Medicine, University of Michigan Medical School, 3027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Mol Cancer Res 9:1232-41. 2011
    ....
  47. pmc Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
    Xiaofeng Zhao
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Adv Drug Deliv Rev 63:610-5. 2011
    ....
  48. pmc Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis
    Ming Luo
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Lett 289:127-39. 2010
    ..The wealth of knowledge accumulated over almost two decades of research on FAK should help to design potentially novel therapies for breast cancer...
  49. pmc Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity
    Huaping Fan
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:18573-82. 2011
    ....
  50. pmc Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer
    Song Chen
    1Divisions of Molecular Medicine and Genetics, Department of Internal Medicine, and 2Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan
    Cancer Discov 3:1225-7. 2013
    ..Importantly, they identify a critical role of glutamine dependency in the suppression of BrafV600E-induced cancer, thus revealing an important mechanism by which autophagy may promote tumor progression in different cellular contexts...
  51. ncbi request reprint In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
    Chun Chi Liang
    Division of Molecular Medicine and Genetics and Cell and Developmental Biology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Protoc 2:329-33. 2007
    ..Not taking into account the time for transfection of cells, in vitro scratch assay per se usually takes from several hours to overnight...
  52. ncbi request reprint Using microfluidic channel networks to generate gradients for studying cell migration
    Daniel S Rhoads
    Department of Molecular Medicine, Cornell University, Ithaca, USA
    Methods Mol Biol 294:347-57. 2005
    ..This method is highly useful because of the ability with which we can control, manipulate and analyze chemical gradients and cells' chemotactic behavior in a quantitative manner...
  53. pmc Pro-tumorigenic function of autophagy in mammary oncogenesis
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Autophagy 8:129-31. 2012
    ....
  54. pmc Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules
    Daniel S Rhoads
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Exp Cell Res 313:3859-67. 2007
    ....
  55. ncbi request reprint A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription
    Youngdong Yoo
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 282:7616-23. 2007
    ....
  56. pmc Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone
    Jianjun Xie
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Mol Endocrinol 22:2322-35. 2008
    ..Furthermore, association of Pyk2 and Cam may be required to mediate the effects of calcium on Pyk2 phosphorylation and subsequent activation of ERKs by GnRH...
  57. pmc Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation
    Fei Liu
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Bone Miner Res 28:2414-30. 2013
    ..Taken together, these data identify FIP200 as an important regulator of bone development and reveal a novel role of autophagy in osteoblast function through its positive role in supporting osteoblast nodule formation and differentiation...

Research Grants40

  1. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2007
    ..They will provide potentially novel therapeutic targets for diseases such as cancer. ..
  2. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2007
    ..abstract_text> ..
  3. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2006
    ..These studies will enhance our understanding of the molecular mechanisms of signal transduction in cell migration and invasion which are critical factors in biological processes such as embryonic development, wound healing and cancer. ..
  4. Focal adhesion kinase in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2006
    ..abstract_text> ..
  5. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2006
    ..They will provide potentially novel therapeutic targets for diseases such as cancer. ..
  6. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2005
    ..They will provide potentially novel therapeutic targets for diseases such as cancer. ..
  7. Focal adhesion kinase in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2005
    ..abstract_text> ..
  8. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2004
    ....
  9. Analysis of FAK and FIP200 in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2007
    ....
  10. Molecular Analysis of Signal Transduction in Cancer Development and Progression
    Jun Lin Guan; Fiscal Year: 2010
    ....
  11. Analysis of FAK and FIP200 in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2010
    ....
  12. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2009
    ....
  13. Analysis of FAK and FIP200 in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2009
    ....
  14. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2009
    ..abstract_text> ..
  15. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2007
    ..They will provide potentially novel therapeutic targets for diseases such as cancer. ..
  16. Focal adhesion kinase in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2004
    ..abstract_text> ..
  17. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2003
    ....
  18. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 1992
    ..In particular, it might establish an important link between cell surface adhesion receptors and cytoplasmic tyrosine kinases: transmembrane protein integrins as regulators for cytoplasmic tyrosine kinases...
  19. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 1993
    ..In particular, it might establish an important link between cell surface adhesion receptors and cytoplasmic tyrosine kinases: transmembrane protein integrins as regulators for cytoplasmic tyrosine kinases...
  20. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 1999
    ..These studies will enhance our understanding of the molecular mechanisms of signal transduction by integrins, which are critical factors in cell migration and invasiveness. ..
  21. SIGNAL TRANSDUCTION BY FAK AND ITS ASSOCIATED PROTEINS
    Jun Lin Guan; Fiscal Year: 2003
    ..The investigators hope that these studies will provide new insights into the mechanisms by which cell adhesion to extracellular matrix regulate cell cycle progression. ..
  22. Focal adhesion kinase in the cardiovascular system
    Jun Lin Guan; Fiscal Year: 2003
    ..abstract_text> ..
  23. SIGNAL TRANSDUCTION BY FAK AND ITS ASSOCIATED PROTEINS
    Jun Lin Guan; Fiscal Year: 2002
    ..The investigators hope that these studies will provide new insights into the mechanisms by which cell adhesion to extracellular matrix regulate cell cycle progression. ..
  24. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2002
    ....
  25. SIGNAL TRANSDUCTION BY FAK AND ITS ASSOCIATED PROTEINS
    Jun Lin Guan; Fiscal Year: 2001
    ..The investigators hope that these studies will provide new insights into the mechanisms by which cell adhesion to extracellular matrix regulate cell cycle progression. ..
  26. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2001
    ....
  27. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2000
    ..These studies will enhance our understanding of the molecular mechanisms of signal transduction by integrins, which are critical factors in cell migration and invasiveness. ..
  28. SIGNAL TRANSDUCTION BY FAK AND ITS ASSOCIATED PROTEINS
    Jun Lin Guan; Fiscal Year: 2000
    ..The investigators hope that these studies will provide new insights into the mechanisms by which cell adhesion to extracellular matrix regulate cell cycle progression. ..
  29. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2010
    ....