Li Qun Gu

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Nanopore-based detection of circulating microRNAs in lung cancer patients
    Yong Wang
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    Nat Nanotechnol 6:668-74. 2011
  2. pmc Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination
    Qiulin Tan
    Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    J Gen Physiol 139:295-304. 2012
  3. pmc Designing DNA interstrand lock for locus-specific methylation detection in a nanopore
    Insoon Kang
    Department of Bioengineering and Dalton Cardiovascular Research Center
    Sci Rep 3:2381. 2013
  4. pmc Detection of miRNAs with a nanopore single-molecule counter
    Li Qun Gu
    Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    Expert Rev Mol Diagn 12:573-84. 2012
  5. pmc Single molecule sensing by nanopores and nanopore devices
    Li Qun Gu
    Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park, Columbia, Missouri 65211, USA
    Analyst 135:441-51. 2010
  6. pmc Aptamer-encoded nanopore for ultrasensitive detection of bioterrorist agent ricin at single-molecule resolution
    Li Qun Gu
    Dalton Cardiovascular Research Center and Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6699-702. 2009
  7. pmc Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating
    Qiulin Tan
    Department of Biological Engineering, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    FEBS Lett 584:1602-8. 2010
  8. pmc Plasma microRNAs as novel biomarkers for early detection of lung cancer
    Dali Zheng
    Department of Pathology and Anatomical Sciences, Ellis Fischel Cancer Center, University of Missouri School of Medicine, 115 Business Loop 70 West, Columbia, MO 65203, USA
    Int J Clin Exp Pathol 4:575-86. 2011
  9. pmc Method of creating a nanopore-terminated probe for single-molecule enantiomer discrimination
    Changlu Gao
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri Columbia, Missouri 65211, USA
    Anal Chem 81:80-6. 2009
  10. doi request reprint Nanopore single-molecule detection of circulating microRNAs
    Li Qun Gu
    Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
    Methods Mol Biol 1024:255-68. 2013

Collaborators

Detail Information

Publications18

  1. pmc Nanopore-based detection of circulating microRNAs in lung cancer patients
    Yong Wang
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    Nat Nanotechnol 6:668-74. 2011
    ..This approach is potentially useful for quantitative microRNA detection, the discovery of disease markers and non-invasive early diagnosis of cancer...
  2. pmc Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination
    Qiulin Tan
    Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    J Gen Physiol 139:295-304. 2012
    ..This study may give insight into the mechanism for the interaction between the potassium channel and its inhibitor...
  3. pmc Designing DNA interstrand lock for locus-specific methylation detection in a nanopore
    Insoon Kang
    Department of Bioengineering and Dalton Cardiovascular Research Center
    Sci Rep 3:2381. 2013
    ..This single-molecule assay may have potential in detection of epigenetic cancer biomarkers in biofluids, with an ultimate goal for early diagnosis of cancer...
  4. pmc Detection of miRNAs with a nanopore single-molecule counter
    Li Qun Gu
    Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    Expert Rev Mol Diagn 12:573-84. 2012
    ..In the next 5 years, the nanopore-based miRNA techniques will be improved and validated for noninvasive and early diagnosis of diseases...
  5. pmc Single molecule sensing by nanopores and nanopore devices
    Li Qun Gu
    Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park, Columbia, Missouri 65211, USA
    Analyst 135:441-51. 2010
    ....
  6. pmc Aptamer-encoded nanopore for ultrasensitive detection of bioterrorist agent ricin at single-molecule resolution
    Li Qun Gu
    Dalton Cardiovascular Research Center and Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6699-702. 2009
    ..Here we will review our recent discoveries with a lab-in-hand glass nanopore: single-molecule discrimination of chiral enantiomers with a trapped cyclodextrin, and sensing of bioterrorist agent ricin...
  7. pmc Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating
    Qiulin Tan
    Department of Biological Engineering, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    FEBS Lett 584:1602-8. 2010
    ....
  8. pmc Plasma microRNAs as novel biomarkers for early detection of lung cancer
    Dali Zheng
    Department of Pathology and Anatomical Sciences, Ellis Fischel Cancer Center, University of Missouri School of Medicine, 115 Business Loop 70 West, Columbia, MO 65203, USA
    Int J Clin Exp Pathol 4:575-86. 2011
    ..05) and were significantly decreased in responsive patients during chemotherapy (P<0.001). These results indicate that miR-155, miR-197, and miR-182 can be potential non-invasive biomarkers for early detection of lung cancer...
  9. pmc Method of creating a nanopore-terminated probe for single-molecule enantiomer discrimination
    Changlu Gao
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri Columbia, Missouri 65211, USA
    Anal Chem 81:80-6. 2009
    ..5 nm). The small pore size allows entrapment of a single cyclodextrin molecule. The glass nanopore with a trapped cyclodextrin proves useful in single-molecule discrimination of chiral enantiomers...
  10. doi request reprint Nanopore single-molecule detection of circulating microRNAs
    Li Qun Gu
    Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
    Methods Mol Biol 1024:255-68. 2013
    ..This concise protocol describes how to device a protein nanopore to quantify target miRNAs in RNA extraction, and discusses at the end the advantages, challenges, and broad impact of the nanopore approach for miRNA detection...
  11. pmc Capturing single molecules of immunoglobulin and ricin with an aptamer-encoded glass nanopore
    Shu Ding
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri Columbia, Missouri 65211, USA
    Anal Chem 81:6649-55. 2009
    ..The functional nanopore also probed sequence-dependent aptamer-protein interactions. These findings will facilitate the development of a universal nanopore for multitarget detection...
  12. ncbi request reprint Single molecule investigation of ag(+) interactions with single Cytosine-, methylcytosine- and hydroxymethylcytosine-Cytosine mismatches in a nanopore
    Yong Wang
    1 Department of Biological Engineering and Dalton Cardiovascular Research Center University of Missouri, Columbia, MO 65211, USA 2
    Sci Rep 4:5883. 2014
    ..Our experimental method provides a novel platform to study the metal ion-DNA interactions and could also serve as a direct detection method for nucleobase modifications. ..
  13. pmc Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity
    Ji Wook Shim
    Department of Biological Engineering, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
    Nucleic Acids Res 37:972-82. 2009
    ..The methodology in this work can be used for studying other quadruplexes and protein-aptamer interactions...
  14. ncbi request reprint In vitro synthesis, tetramerization and single channel characterization of virus-encoded potassium channel Kcv
    Ji Wook Shim
    Department of Biological Engineering, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
    FEBS Lett 581:1027-34. 2007
    ....
  15. pmc Designing a polycationic probe for simultaneous enrichment and detection of microRNAs in a nanopore
    Kai Tian
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, United States
    ACS Nano 7:3962-9. 2013
    ..This highly sensitive and selective nanodielectrophoresis approach can be applied to the detection of clinically relevant nucleic acid fragments in complex samples...
  16. pmc Encapsulating a single G-quadruplex aptamer in a protein nanocavity
    Ji Wook Shim
    Department of Biological Engineering and Dalton Cardiovascular Research Center University of Missouri, Columbia, Missouri 65211, USA
    J Phys Chem B 112:8354-60. 2008
    ..This guest-nanocavity supramolecular system has potential for helping to understand single-molecule folding and unfolding kinetics...
  17. pmc Programming nanopore ion flow for encoded multiplex microRNA detection
    Xinyue Zhang
    Department of Bioengineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, United States
    ACS Nano 8:3444-50. 2014
    ..The principle of this approach was verified by using a panel of cancer-derived microRNAs as the target, a type of biomarker for cancer detection. ..
  18. pmc Stochastic sensing on a modular chip containing a single-ion channel
    Ji Wook Shim
    Department of Biological Engineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, USA
    Anal Chem 79:2207-13. 2007
    ..This pluggable biochip could be incorporated with many applicable devices, such as a microfluidic system, and be made into a microarray for both biomedical detection and membrane protein research...

Research Grants4

  1. Programmable Multi-Target Detection Using an Aptamer-Integrated Nanopore
    Li Qun Gu; Fiscal Year: 2007
    ..Fashioning such tools is significant in nanomedicine for the quantitative characterization and precise control of molecular scale components (or nanomachinery) of living cells. ..
  2. Programmable Multi-Target Detection Using an Aptamer-Integrated Nanopore
    Li Qun Gu; Fiscal Year: 2010
    ..Fashioning such tools is significant in nanomedicine for the quantitative characterization and precise control of molecular scale components (or nanomachinery) of living cells. ..
  3. Programmable Multi-Target Detection Using an Aptamer-Integrated Nanopore
    Li Qun Gu; Fiscal Year: 2009
    ..Fashioning such tools is significant in nanomedicine for the quantitative characterization and precise control of molecular scale components (or nanomachinery) of living cells. ..