S M Grundy

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Waist circumference as measure of abdominal fat compartments
    Scott M Grundy
    Departments of Internal Medicine, Clinical Nutrition and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Obes 2013:454285. 2013
  2. doi request reprint Treatment targets in the management of dyslipidemias: which targets in whom?
    Scott M Grundy
    Center for Human Nutrition, Dallas, TX 75390 9052, USA
    Curr Cardiol Rep 14:692-700. 2012
  3. doi request reprint Cardiorespiratory fitness and metabolic risk
    Scott M Grundy
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Am J Cardiol 109:988-93. 2012
  4. doi request reprint Pre-diabetes, metabolic syndrome, and cardiovascular risk
    Scott M Grundy
    Center for Human Nutrition and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    J Am Coll Cardiol 59:635-43. 2012
  5. ncbi request reprint Cardiovascular and metabolic risk factors: how can we improve outcomes in the high-risk patient?
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Am J Med 120:S3-8; discussion S9. 2007
  6. doi request reprint Metabolic syndrome pandemic
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3 206, Dallas, TX 75390 9052, USA
    Arterioscler Thromb Vasc Biol 28:629-36. 2008
  7. ncbi request reprint Metabolic syndrome: a multiplex cardiovascular risk factor
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3 206, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 92:399-404. 2007
  8. ncbi request reprint Does a diagnosis of metabolic syndrome have value in clinical practice?
    Scott M Grundy
    Center for Human Nutrition and the Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9052, USA
    Am J Clin Nutr 83:1248-51. 2006
  9. ncbi request reprint Metabolic syndrome: part II
    Scott M Grundy
    Center for Human Nutrition University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard Dallas, TX 75390 9052, USA
    Endocrinol Metab Clin North Am 33:xi-xiii. 2004
  10. pmc Variable contributions of fat content and distribution to metabolic syndrome risk factors
    Scott M Grundy
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, Center for Human Nutrition, Dallas, Texas 75390 9052, USA
    Metab Syndr Relat Disord 6:281-8. 2008

Research Grants

  1. CARDIOVASCULAR NUTRITION IN MEDICAL EDUCATION
    Scott Grundy; Fiscal Year: 2002

Detail Information

Publications106 found, 100 shown here

  1. pmc Waist circumference as measure of abdominal fat compartments
    Scott M Grundy
    Departments of Internal Medicine, Clinical Nutrition and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Obes 2013:454285. 2013
    ..353 (men) and 0.348 (women)) and HOMA2-IR (r = 0.290 (men) and 0.221 (women)). WC measures TAF reliably, but its association with IPF depends on IPF/ASF ratios that vary by gender and ethnicity...
  2. doi request reprint Treatment targets in the management of dyslipidemias: which targets in whom?
    Scott M Grundy
    Center for Human Nutrition, Dallas, TX 75390 9052, USA
    Curr Cardiol Rep 14:692-700. 2012
    ..At the same time, there are dangers of overuse and turning society into a "drug culture". To abandon the benefits of healthy lifestyles for excessive drug intervention would be unfortunate...
  3. doi request reprint Cardiorespiratory fitness and metabolic risk
    Scott M Grundy
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Am J Cardiol 109:988-93. 2012
    ..The mechanisms responsible for this enrichment in subjects with a low CRF represent a challenge for future research...
  4. doi request reprint Pre-diabetes, metabolic syndrome, and cardiovascular risk
    Scott M Grundy
    Center for Human Nutrition and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    J Am Coll Cardiol 59:635-43. 2012
    ..When drug therapy is contemplated and when the metabolic syndrome is present, the primary consideration is prevention of cardiovascular disease. The major targets are elevations of cholesterol and blood pressure...
  5. ncbi request reprint Cardiovascular and metabolic risk factors: how can we improve outcomes in the high-risk patient?
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Am J Med 120:S3-8; discussion S9. 2007
    ..g., smoking cessation, weight reduction, increased physical activity, and "heart-healthy" dietary modifications) and blood pressure control can be used across all categories of risk...
  6. doi request reprint Metabolic syndrome pandemic
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3 206, Dallas, TX 75390 9052, USA
    Arterioscler Thromb Vasc Biol 28:629-36. 2008
    ..On the other hand, in parts of developing world in which young adults predominate, the prevalence is lower; but with increasing affluence and aging of the population, the prevalence undoubtedly with rise...
  7. ncbi request reprint Metabolic syndrome: a multiplex cardiovascular risk factor
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3 206, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 92:399-404. 2007
    ..The metabolic syndrome (MetS) is a multiplex risk factor for cardiovascular disease. The syndrome develops through interplay of obesity and metabolic susceptibility...
  8. ncbi request reprint Does a diagnosis of metabolic syndrome have value in clinical practice?
    Scott M Grundy
    Center for Human Nutrition and the Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9052, USA
    Am J Clin Nutr 83:1248-51. 2006
    ..Treating the underlying causes does not rule out the management of individual risk factors, but it will add strength to the control of multiple risk factors...
  9. ncbi request reprint Metabolic syndrome: part II
    Scott M Grundy
    Center for Human Nutrition University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard Dallas, TX 75390 9052, USA
    Endocrinol Metab Clin North Am 33:xi-xiii. 2004
  10. pmc Variable contributions of fat content and distribution to metabolic syndrome risk factors
    Scott M Grundy
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, Center for Human Nutrition, Dallas, Texas 75390 9052, USA
    Metab Syndr Relat Disord 6:281-8. 2008
    ..However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined...
  11. pmc Should women be offered cholesterol lowering drugs to prevent cardiovascular disease? Yes
    Scott M Grundy
    Center for Human Nutrition, Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9052, USA
    BMJ 334:982. 2007
  12. ncbi request reprint Metabolic syndrome: part I
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
    Endocrinol Metab Clin North Am 33:ix-xi. 2004
  13. ncbi request reprint What is the contribution of obesity to the metabolic syndrome?
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
    Endocrinol Metab Clin North Am 33:267-82, table of contents. 2004
    ....
  14. doi request reprint Promise of low-density lipoprotein-lowering therapy for primary and secondary prevention
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Ste Y3 206, Dallas, TX 75390 9052, USA
    Circulation 117:569-73; discussion 573. 2008
  15. pmc Thyroid mimetic as an option for lowering low-density lipoprotein
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
    Proc Natl Acad Sci U S A 105:409-10. 2008
  16. ncbi request reprint Alternative approaches to cholesterol-lowering therapy
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3 206, Dallas, TX 75290 9052, USA
    Am J Cardiol 90:1135-8. 2002
  17. ncbi request reprint Approach to lipoprotein management in 2001 National Cholesterol Guidelines
    Scott M Grundy
    Center for Human Nutrition and Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    Am J Cardiol 90:11i-21i. 2002
    ..Diabetes was identified as a CHD risk equivalent, requiring more intensive LDL-lowering therapy. Finally, the report placed more emphasis on the metabolic syndrome as a major, multiplex risk factor requiring increased clinical attention...
  18. doi request reprint Correlation of non-high-density lipoprotein cholesterol and low-density lipoprotein cholesterol with apolipoprotein B during simvastatin + fenofibrate therapy in patients with combined hyperlipidemia (a subanalysis of the SAFARI trial)
    Scott M Grundy
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 104:548-53. 2009
    ....
  19. ncbi request reprint Stanol esters as a component of maximal dietary therapy in the National Cholesterol Education Program Adult Treatment Panel III report
    Scott M Grundy
    Center for Human Nutrition, and the Department of Clinical Nutrition, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    Am J Cardiol 96:47D-50D. 2005
    ..The time has come, however, to reassert the importance of maximal dietary therapy as a cost-effective means for treatment of elevated LDL concentrations and for lifetime prevention of coronary heart disease...
  20. ncbi request reprint A constellation of complications: the metabolic syndrome
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75390 9052, USA
    Clin Cornerstone 7:36-45. 2005
    ..This review also discusses issues that require additional research and new drugs that are considered promising for treatment of the metabolic syndrome itself...
  21. ncbi request reprint Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds
    Scott M Grundy
    Center for Human Nutrition and Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    J Am Coll Cardiol 47:1093-100. 2006
    ..Ultimately, it might be possible to develop drugs that will simultaneously modify all of the risk factors. At present such drugs are in development but so far have not reached the level of clinical practice...
  22. ncbi request reprint Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial)
    Scott M Grundy
    UT Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 95:462-8. 2005
    ..Thus, this combination therapy is a beneficial therapeutic option for managing combined hyperlipidemia...
  23. ncbi request reprint Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy
    Scott M Grundy
    Center for Human Nutrition and Department of Clinical Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Y3 206, Dallas, Texas 75390 9052, USA
    Nat Rev Drug Discov 5:295-309. 2006
    ....
  24. ncbi request reprint Does the metabolic syndrome exist?
    Scott M Grundy
    Department of Clinical Nutrition, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Y3 206, Dallas, 75390 9052, USA
    Diabetes Care 29:1689-92; discussion 1693-6. 2006
  25. ncbi request reprint Coronary plaque as a replacement for age as a risk factor in global risk assessment
    S M Grundy
    Department of Clinical Nutrition, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    Am J Cardiol 88:8E-11E. 2001
    ..This article describes a technique whereby such a replacement can be made...
  26. ncbi request reprint United States Cholesterol Guidelines 2001: expanded scope of intensive low-density lipoprotein-lowering therapy
    S M Grundy
    Center for Human Nutrition and the Departments of Internal Medicine and Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Cardiol 88:23J-27J. 2001
    ..This expansion derives from a conclusive demonstration of efficacy, safety, and cost-effectiveness of therapies. This article will review briefly the major features of ATP III...
  27. doi request reprint Comparisons of apolipoprotein B levels estimated by immunoassay, nuclear magnetic resonance, vertical auto profile, and non-high-density lipoprotein cholesterol in subjects with hypertriglyceridemia (SAFARI Trial)
    Scott M Grundy
    Center for Human Nutrition, Departments of Internal Medicine and Clinical Nutrition, University of Texas Southwestern Medical Center, and Metabolic Unit, Veterans Affairs Medical Center, Dallas, Texas, USA
    Am J Cardiol 108:40-6. 2011
    ..Non-HDL cholesterol is also useful to predict total apolipoprotein B and some improvement may be attained by taking into account the ratio of triglyceride/HDL cholesterol as a measurement of LDL particle size...
  28. ncbi request reprint Atherogenic dyslipidemia associated with metabolic syndrome and insulin resistance
    Scott M Grundy
    Center for Human Nutrition University of Texas Southwestern Medical Center Dallas, Texas 75390 9052, USA
    Clin Cornerstone 8:S21-7. 2006
    ..Patients with atherogenic dyslipidemia and metabolic syndrome should undergo global risk assessment for cardiovascular disease and future cardiovascular events to determine an overall treatment strategy...
  29. ncbi request reprint Point: the metabolic syndrome still lives
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Y3 206, Dallas, TX 75390 9052, USA
    Clin Chem 51:1352-4. 2005
  30. ncbi request reprint Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC)
    Ralph V Shohet
    Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Hum Mutat 19:536-42. 2002
    ..Three novel LIPC polymorphisms were identified in the study (-1596insC, -2740A>G, and -2880G>C)...
  31. ncbi request reprint Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol
    G L Vega
    Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, USA
    J Intern Med 246:1-9. 1999
    ..This finding raises the possibility that lifibrol activates the LDL-receptor pathway through a different mechanisms which remains to be determined...
  32. ncbi request reprint Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial
    Scott M Grundy
    The University of Texas Southwestern Medical Center, Room Y3206, 5323 Harry Hines Blvd, Dallas, TX 75390 9052
    Arch Intern Med 162:1568-76. 2002
    ..We evaluated the efficacy and safety of once-daily extended-release (ER) niacin in patients with diabetic dyslipidemia...
  33. ncbi request reprint Effect of hydroxymethyl glutaryl coenzyme a reductase inhibitor therapy on high sensitive C-reactive protein levels
    I Jialal
    University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Circulation 103:1933-5. 2001
    ....
  34. ncbi request reprint Combination drug therapy for familial combined hyperlipidemia
    C East
    University of Texas Southwestern Medical Center, Dallas
    Ann Intern Med 109:25-32. 1988
    ..To compare the efficacy of gemfibrozil and colestipol with gemfibrozil and lovastatin in patients with familial combined hyperlipidemia...
  35. ncbi request reprint Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:3773-6. 2003
    ....
  36. doi request reprint Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study
    Karen Chen
    The School of Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 5:96-101. 2008
    ..In conclusion, both MetS and DM are independently associated with an increased prevalence of atherosclerosis, with the highest observed prevalence in subjects with both DM and MetS...
  37. ncbi request reprint Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
    ..In conclusion, the significant ethnic and sex differences in the prevalence of hepatic steatosis documented in this study may have a profound impact on susceptibility to steatosis-related liver disease...
  38. pmc Ethnic differences in hepatic steatosis: an insulin resistance paradox?
    Richard Guerrero
    Department of Internal Medicine, Dallas, TX, USA
    Hepatology 49:791-801. 2009
    ....
  39. ncbi request reprint Metabolic complications of obesity
    S M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 75390 9052, USA
    Endocrine 13:155-65. 2000
    ..In addition, understanding at the clinical level will lead to improved management of these complications...
  40. pmc Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21
    S B Patel
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9052, USA
    J Clin Invest 102:1041-4. 1998
    ..By studying 10 well-characterized families with this disorder, we have localized the genetic defect to chromosome 2p21, between microsatellite markers D2S1788 and D2S1352 (maximum lodscore 4.49, theta = 0.0)...
  41. ncbi request reprint African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas Heart Study
    Tulika Jain
    Donald W Reynolds Cardiovascular Clinical Research Center and the Department of Internal Medicine, Dallas, Texas, USA
    J Am Coll Cardiol 44:1011-7. 2004
    ..We sought to compare the prevalence of coronary atherosclerosis in a cohort of middle-age African American (black) and non-Hispanic Caucasian (white) men and women from a population-based probability sample...
  42. ncbi request reprint Multifactorial causation of obesity: implications for prevention
    S M Grundy
    Department of Clinical Nutrition, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 75235 9052, USA
    Am J Clin Nutr 67:563S-72S. 1998
    ..A major public health effort is urgently needed to counter the increasing frequency of moderate obesity in the United States and throughout the world...
  43. pmc Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
    Proc Natl Acad Sci U S A 103:1810-5. 2006
    ....
  44. ncbi request reprint Relationship between C-reactive protein and subclinical atherosclerosis: the Dallas Heart Study
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circulation 113:38-43. 2006
    ..However, less is known regarding the relationship between CRP levels and atherosclerotic burden...
  45. ncbi request reprint Race and gender differences in C-reactive protein levels
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 46:464-9. 2005
    ..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
  46. pmc Insulin resistance and body fat distribution in South Asian men compared to Caucasian men
    Manisha Chandalia
    Departments of Internal Medicine, Endocrinology and Metabolism, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 2:e812. 2007
    ..South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians...
  47. doi request reprint Prevalence of the metabolic syndrome as influenced by the measure of obesity employed
    Gloria Lena Vega
    Departments of Clinical Nutrition, Internal Medicine, and Clinical Science and Center for Human Nutrition and Clinical and Translational Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Cardiol 105:1306-12. 2010
    ..In conclusion, abridged ATP III MS appears to be preferable to ATP III MS for the detection of candidates for intensive cardiovascular risk reduction...
  48. ncbi request reprint Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes
    Meena Shah
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Diabetes Care 30:2993-8. 2007
    ..The objective of this study was to study the effect of fatty acids on postprandial insulin, glucose, and triglyceride responses...
  49. doi request reprint Effects of N-3 fatty acids on hepatic triglyceride content in humans
    Gloria Lena Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
    J Investig Med 56:780-5. 2008
    ..Because dietary N-3 fatty acids reduce plasma triglycerides, they may also decrease hepatic triglyceride content. If so, N-3 fatty acids might constitute a therapy for fatty liver...
  50. ncbi request reprint Metabolic correlates of nonalcoholic fatty liver in women and men
    Gloria Lena Vega
    The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Hepatology 46:716-22. 2007
    ..Obese subjects with hepatic steatosis had higher ratios of truncal-to-lower body fat and other indicators of adipose tissue dysfunction compared with obese subjects without steatosis...
  51. ncbi request reprint Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort
    Manisha Chandalia
    Division of Endocrinology and Metabolism and The Center for Human Nutrition, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:143-8. 2007
    ..Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups...
  52. doi request reprint Impaired hepatic ketogenesis in moderately obese men with hypertriglyceridemia
    Gloria Lena Vega
    Department of Clinical Nutrition, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, TX 75390 9052, USA
    J Investig Med 57:590-4. 2009
    ..Several studies suggest that increased nonesterified fatty acid flux and increased de novo lipogenesis may contribute to hypertriglyceridemia, but few studies have examined fatty acid oxidation as a factor...
  53. ncbi request reprint Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors
    Nicola Abate
    University of Texas Southwestern Medical Center, Dallas 75390 9169, USA
    Nat Clin Pract Endocrinol Metab 2:694-701. 2006
    ..Understanding the mechanisms that regulate E-NPP1 expression and/or function might render this protein a new target for strategies to treat and prevent type 2 diabetes and cardiovascular disease...
  54. pmc Evaluation of coronary artery calcium screening strategies focused on risk categories: the Dallas Heart Study
    Mahesh J Patel
    Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am Heart J 157:1001-9. 2009
    ..A strategy using coronary artery calcium (CAC) screening to refine coronary heart disease risk assessment in moderately high risk (MHR) subjects (10-year risk 10%-20%) has been suggested. The potential impact of this strategy is unknown...
  55. pmc Sex differences in the relationship between C-reactive protein and body fat
    Amit Khera
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Boulevard, Dallas, Texas 75390 9047, USA
    J Clin Endocrinol Metab 94:3251-8. 2009
    ..C-reactive protein (CRP) levels are significantly influenced by adiposity and are higher in women compared with men. We postulated that there may be sex differences in the relationship between CRP and body fat...
  56. ncbi request reprint Influence of body fat content and distribution on variation in metabolic risk
    Gloria Lena Vega
    Donald W Reynolds Cardiovascular Clinical Research Center and Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 91:4459-66. 2006
    ..The objective of the study was to determine whether this can be confirmed and generalized throughout the population...
  57. ncbi request reprint Sex differences in the association between leptin and CRP: results from the Dallas Heart Study
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Atherosclerosis 195:404-10. 2007
    ..Higher C-reactive protein (CRP) levels in women compared with men may reflect sex differences in the relationship between obesity and inflammation. We evaluated how the adipokine leptin influenced these relationships...
  58. ncbi request reprint Hyperhomocysteinemia in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:1089-95. 2003
    ..Lower plasma concentrations of vitamin B-12 and lower insulin sensitivity may contribute to this finding but only partially explained the ethnic-related hyperhomocysteinemia of the Asian Indians...
  59. ncbi request reprint Obesity, metabolic syndrome, and cardiovascular disease
    Scott M Grundy
    Center for Human Nutrition, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 89:2595-600. 2004
  60. ncbi request reprint Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Clin Endocrinol Metab 89:2750-5. 2004
    ..These differences may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease in nonobese Asian Indians...
  61. ncbi request reprint Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome
    Gloria Lena Vega
    The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
    Am J Cardiol 91:956-60. 2003
    ..Therefore, a combination of simvastatin 10 mg/day and fenofibrate 200 mg/day appears to be effective and safe for the treatment of atherogenic dyslipidemia in combined hyperlipidemia...
  62. ncbi request reprint Free fatty acid metabolism during fenofibrate treatment of the metabolic syndrome
    Gloria Lena Vega
    Department of Clinical Nutrition, and Center for Human Nutrition, University of Texas Southwest Medical Center, and Metabolic Unit, Veterans Affairs Medical Center, Dallas, Texas 75390 9052, USA
    Clin Pharmacol Ther 74:236-44. 2003
    ..Our objective was to determine whether fenofibrate modifies the metabolism of nonesterified (free) fatty acids as a component of its triglyceride-lowering action in male patients with the metabolic syndrome...
  63. ncbi request reprint ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    Nicola Abate
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    Diabetes 54:1207-13. 2005
    ....
  64. ncbi request reprint Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia
    Gloria Lena Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center, and Veterans Affair Medical Center, Dallas, Texas 75390 9052, USA
    Am J Cardiol 95:1309-13. 2005
    ....
  65. doi request reprint Oxandrolone enhances hepatic ketogenesis in adult men
    Gloria Lena Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Investig Med 56:920-4. 2008
    ..Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein...
  66. ncbi request reprint Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance
    Nicola Abate
    Center for Human Nutrition and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:5927-34. 2003
    ..This finding indicates the need for expanded studies on the association between PC-1 K121Q and insulin resistance in a representative sample of the Asian Indian population...
  67. ncbi request reprint Sex steroid hormones, upper body obesity, and insulin resistance
    Nicola Abate
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:4522-7. 2002
    ..Low plasma levels of bioavailable testosterone do not independently predict excessive insulin resistance, beta-cell dysfunction, or hepatic glucose output in normogonadal men...
  68. doi request reprint Adipose tissue mass and location affect circulating adiponectin levels
    A T Turer
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8521, USA
    Diabetologia 54:2515-24. 2011
    ..Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels...
  69. ncbi request reprint Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100
    X Li
    Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 9052, USA
    J Lipid Res 38:1277-88. 1997
    ..Total apoB secreted, however, was not increased. Our data further suggest that the predominant cause of the dyslipidemia under these conditions is a defect in removal of VLDL from the circulation...
  70. ncbi request reprint Effects of combined therapy with lovastatin and colestipol in heterozygous familial hypercholesterolemia. Effects on kinetics of apolipoprotein B
    G L Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75235
    Arteriosclerosis 9:I135-44. 1989
    ....
  71. pmc Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin
    Susan G Lakoski
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9046, USA
    J Clin Endocrinol Metab 95:800-9. 2010
    ..Responsiveness to simvastatin and ezetimibe were highly correlated, suggesting that factors downstream of the primary sites of action of these drugs are a major determinant of response...
  72. ncbi request reprint Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8
    Knut E Berge
    The Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390 9052, USA
    J Lipid Res 43:486-94. 2002
    ....
  73. ncbi request reprint Hepatic lipase: new insights from genetic and metabolic studies
    J C Cohen
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, USA
    Curr Opin Lipidol 10:259-67. 1999
    ..Association studies using these polymorphisms are elucidating the effects of variation in hepatic lipase activity on plasma lipoprotein concentrations and susceptibility to coronary atherosclerosis...
  74. ncbi request reprint Responsiveness of plasma lipids and lipoproteins to plant stanol esters
    Nilo B Cater
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
    Am J Cardiol 96:23D-28D. 2005
    ..This makes plant stanols an attractive dietary component to help to achieve the goals of LDL-lowering therapy in patients requiring an LDL-lowering drug...
  75. ncbi request reprint The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study
    Raphael See
    Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9037, USA
    J Am Coll Cardiol 50:752-9. 2007
    ..This study sought to evaluate the associations between different measures of obesity and prevalent atherosclerosis in a large population-based cohort...
  76. ncbi request reprint Diet composition and the metabolic syndrome: what is the optimal fat intake?
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Am J Med 113:25S-29S. 2002
    ....
  77. ncbi request reprint Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans
    Surekha Mathur
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    J Nutr 132:3663-7. 2002
    ..In conclusion, cocoa products supplementation in humans affects LDL oxidizability, but not urinary F(2) isoprostanes or markers of inflammation...
  78. ncbi request reprint Atherosclerosis imaging for risk assessment and primary prevention of cardiovascular disease
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 75390 9052, USA
    Prog Cardiovasc Dis 46:115-21. 2003
    ....
  79. ncbi request reprint No association between plasma levels of plant sterols and atherosclerosis in mice and men
    Kenneth R Wilund
    Donald W Reynolds Cardiovascular Clinical Research Center at Dallas, University of Texas Southwestern Medical Center at Dallas, Tex 75390 9046, USA
    Arterioscler Thromb Vasc Biol 24:2326-32. 2004
    ..We tested whether elevated plasma levels of plant sterols (sitosterol and campesterol) were associated with atherosclerosis in genetically modified mice and in middle-aged men and women...
  80. ncbi request reprint Immunotoxicity of polyunsaturated fatty acids in serum-free medium
    B U Tezabwala
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas 75235, USA
    Immunopharmacol Immunotoxicol 17:365-83. 1995
    ..Thus, linoleic and linolenic acids appear to directly inhibit immune and tumor cells, at least under these conditions...
  81. ncbi request reprint The metabolic syndrome: practical guide to origins and treatment: Part I
    Peter W F Wilson
    Framingham Heart Study of the National Heart, Blood, and Lung Institute, Boston, Mass, USA
    Circulation 108:1422-4. 2003
  82. ncbi request reprint Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    Martijn B Katan
    Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Mayo Clin Proc 78:965-78. 2003
    ..However, present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease...
  83. ncbi request reprint Inflammation, metabolic syndrome, and diet responsiveness
    Scott M Grundy
    Circulation 108:126-8. 2003
  84. ncbi request reprint Atherosclerosis imaging and the future of lipid management
    Scott M Grundy
    Circulation 110:3509-11. 2004
  85. ncbi request reprint Low-density lipoprotein, non-high-density lipoprotein, and apolipoprotein B as targets of lipid-lowering therapy
    Scott M Grundy
    Circulation 106:2526-9. 2002
  86. ncbi request reprint HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    Philip Barter
    Heart Research Institute, Sydney, Australia
    N Engl J Med 357:1301-10. 2007
    ..High-density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events. However, it is not clear whether this association is maintained at very low levels of low-density lipoprotein (LDL) cholesterol...
  87. ncbi request reprint Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003
    Richard W Nesto
    Circulation 108:2941-8. 2003
  88. ncbi request reprint Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study
    Prakash Deedwania
    Veterans Affairs Central California Healthcare System and University of California San Francisco School of Medicine, San Francisco, CA, USA
    Lancet 368:919-28. 2006
    ....
  89. ncbi request reprint Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Arterioscler Thromb Vasc Biol 24:e149-61. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  90. ncbi request reprint Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    Scott M Grundy
    J Am Coll Cardiol 44:720-32. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  91. ncbi request reprint Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Circulation 110:227-39. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  92. ncbi request reprint Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary
    Scott M Grundy
    Cardiol Rev 13:322-7. 2005
  93. ncbi request reprint Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity
    Venkatesan Radha
    Department of Molecular Genetics, Madras Diabetes Research Foundation, Dr Mohan s Diabetes Specialties Centre, No 4, Conran Smith Road, Gopalapuram, Chennai 86, India
    Diabetes Care 29:1046-51. 2006
    ..To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians...
  94. ncbi request reprint Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  95. ncbi request reprint Trends in serum lipids and lipoproteins of adults, 1960-2002
    Margaret D Carroll
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 294:1773-81. 2005
    ....
  96. ncbi request reprint Metabolic syndrome and hyperglycemia: congruence and divergence
    Charles M Alexander
    Outcomes Research and Management, Merck and Co, Inc, West Point, Pennsylvania, USA
    Am J Cardiol 98:982-5. 2006
  97. ncbi request reprint A summary of implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Arterioscler Thromb Vasc Biol 24:1329-30. 2004
  98. ncbi request reprint Inflammation, hypertension, and the metabolic syndrome
    Scott M Grundy
    JAMA 290:3000-2. 2003
  99. ncbi request reprint Ten-year cardiovascular disease risk of metabolic syndrome without central obesity in middle-aged chinese
    Dong Zhao
    Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
    Am J Cardiol 100:835-9. 2007
    ..In conclusion, MS with or without central obesity has a significantly increased 10-year risk of CVD in middle-aged Chinese...
  100. ncbi request reprint Safety and efficacy of Atorvastatin-induced very low-density lipoprotein cholesterol levels in Patients with coronary heart disease (a post hoc analysis of the treating to new targets [TNT] study)
    John C LaRosa
    State University of New York Health Science Center, New York, New York, USA
    Am J Cardiol 100:747-52. 2007
    ....
  101. ncbi request reprint Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management
    Scott M Grundy
    Circulation 109:551-6. 2004

Research Grants1

  1. CARDIOVASCULAR NUTRITION IN MEDICAL EDUCATION
    Scott Grundy; Fiscal Year: 2002
    ..The long term goal is to produce graduates who routinely address nutrition and exercise for cardiovascular health with their patients. ..