M M Grumbach

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Estrogen, bone, growth and sex: a sea change in conventional wisdom
    M M Grumbach
    Department of Pediatrics, School of Medicine, University of California, San Francisco 94143 0434, USA
    J Pediatr Endocrinol Metab 13:1439-55. 2000
  2. ncbi The neuroendocrinology of human puberty revisited
    Melvin M Grumbach
    Department of Pediatrics, University of California San Francisco, Calif 94143 0434, USA
    Horm Res 57:2-14. 2002
  3. ncbi A window of opportunity: the diagnosis of gonadotropin deficiency in the male infant
    Melvin M Grumbach
    Department of Pediatrics, S 672, University of California, San Francisco, San Francisco, California 94143 0434, USA
    J Clin Endocrinol Metab 90:3122-7. 2005
  4. ncbi Mutations in the synthesis and action of estrogen: the critical role in the male of estrogen on pubertal growth, skeletal maturation, and bone mass
    Melvin M Grumbach
    Department of Pediatrics, 513 Parnassus Ave, S 672, University of California, San Francisco, San Francisco, California 94143 0434, USA
    Ann N Y Acad Sci 1038:7-13. 2004
  5. ncbi Estrogen: consequences and implications of human mutations in synthesis and action
    M M Grumbach
    Department of Pediatrics, School of Medicine, University of California, San Francisco 94143 0434, USA
    J Clin Endocrinol Metab 84:4677-94. 1999
  6. ncbi The growth hormone cascade: progress and long-term results of growth hormone treatment in growth hormone deficiency
    M M Grumbach
    Department of Pediatrics, School of Medicine, University of California San Francisco 94143 0434, Calif, USA
    Horm Res 49:41-57. 1998
  7. ncbi A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom)
    F A Conte
    Department of Pediatrics, University of California, San Francisco 94143 0106
    J Clin Endocrinol Metab 78:1287-92. 1994
  8. ncbi Acute N-methyl-D,L-aspartate administration stimulates the luteinizing hormone releasing hormone pulse generator in the ovine fetus
    M Bettendorf
    Department of Pediatrics, University of California, San Francisco, Calif
    Horm Res 51:25-30. 1999
  9. ncbi Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    J C Lo
    Department of Medicine, University of California, San Francisco 94143, USA
    J Clin Endocrinol Metab 84:930-6. 1999
  10. ncbi Pregnancy outcomes in women with congenital virilizing adrenal hyperplasia
    J C Lo
    Department of Medicine, University of California, San Francisco, USA
    Endocrinol Metab Clin North Am 30:207-29. 2001

Collaborators

Detail Information

Publications11

  1. ncbi Estrogen, bone, growth and sex: a sea change in conventional wisdom
    M M Grumbach
    Department of Pediatrics, School of Medicine, University of California, San Francisco 94143 0434, USA
    J Pediatr Endocrinol Metab 13:1439-55. 2000
    ....
  2. ncbi The neuroendocrinology of human puberty revisited
    Melvin M Grumbach
    Department of Pediatrics, University of California San Francisco, Calif 94143 0434, USA
    Horm Res 57:2-14. 2002
    ..The application of these advances provides a framework for the described classification of sexual precocity and delayed puberty.1 GnRH is synonymous with LHRH...
  3. ncbi A window of opportunity: the diagnosis of gonadotropin deficiency in the male infant
    Melvin M Grumbach
    Department of Pediatrics, S 672, University of California, San Francisco, San Francisco, California 94143 0434, USA
    J Clin Endocrinol Metab 90:3122-7. 2005
    ..The molecular basis for certain developmental disorders associated with hypogonadotropic hypogonadism and micropenis is considered and the management and treatment of congenital hypopituitarism discussed...
  4. ncbi Mutations in the synthesis and action of estrogen: the critical role in the male of estrogen on pubertal growth, skeletal maturation, and bone mass
    Melvin M Grumbach
    Department of Pediatrics, 513 Parnassus Ave, S 672, University of California, San Francisco, San Francisco, California 94143 0434, USA
    Ann N Y Acad Sci 1038:7-13. 2004
    ..This presentation focuses on the crucial role of estradiol in the human male on the pubertal growth spurt, skeletal maturation and the cessation of linear growth, and the accrual of bone mass...
  5. ncbi Estrogen: consequences and implications of human mutations in synthesis and action
    M M Grumbach
    Department of Pediatrics, School of Medicine, University of California, San Francisco 94143 0434, USA
    J Clin Endocrinol Metab 84:4677-94. 1999
    ..Finally, the structural consequences of missense mutations in CYP19 are described in accordance with a model of the structure of human aromatase...
  6. ncbi The growth hormone cascade: progress and long-term results of growth hormone treatment in growth hormone deficiency
    M M Grumbach
    Department of Pediatrics, School of Medicine, University of California San Francisco 94143 0434, Calif, USA
    Horm Res 49:41-57. 1998
    ..The rhGH is not an added risk for leukemia in the US and Europe in the absence of coexisting risk factors, nor is there a higher risk of recurrence of b..
  7. ncbi A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom)
    F A Conte
    Department of Pediatrics, University of California, San Francisco 94143 0106
    J Clin Endocrinol Metab 78:1287-92. 1994
    ..Familial P450arom deficiency, although rare, may be more common than previously suspected.(ABSTRACT TRUNCATED AT 400 WORDS)..
  8. ncbi Acute N-methyl-D,L-aspartate administration stimulates the luteinizing hormone releasing hormone pulse generator in the ovine fetus
    M Bettendorf
    Department of Pediatrics, University of California, San Francisco, Calif
    Horm Res 51:25-30. 1999
    ..It appears that central neural inhibition in addition to sex steroid negative feedback contributes to the decrease in fetal gonadotropin concentrations in late gestation. NMDA did not affect fetal oGH or oPRL secretion...
  9. ncbi Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    J C Lo
    Department of Medicine, University of California, San Francisco 94143, USA
    J Clin Endocrinol Metab 84:930-6. 1999
    ..Recommendations for the management of pregnancy and delivery in these patients are discussed...
  10. ncbi Pregnancy outcomes in women with congenital virilizing adrenal hyperplasia
    J C Lo
    Department of Medicine, University of California, San Francisco, USA
    Endocrinol Metab Clin North Am 30:207-29. 2001
    ..In most cases, successful gestational management requires the close coordination of care between the obstetrician and endocrinologist...
  11. ncbi Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    A Morishima
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Endocrinol Metab 80:3689-98. 1995
    ..Hyperinsulinemia, increased serum total and low density lipoprotein cholesterol, and triglycerides and decreased high density lipoprotein cholesterol were detected.(ABSTRACT TRUNCATED AT 400 WORDS)..