R Gruetter

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint A mathematical model of compartmentalized neurotransmitter metabolism in the human brain
    R Gruetter
    Department of Radiology, Center for Magnetic Resonance Research and General Clinical Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Endocrinol Metab 281:E100-12. 2001
  2. ncbi request reprint In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
    Rolf Gruetter
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Neurochem Int 41:143-54. 2002
  3. ncbi request reprint Glycogen: the forgotten cerebral energy store
    Rolf Gruetter
    Departments of Radiology and Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurosci Res 74:179-83. 2003
  4. pmc Localized in vivo 13C NMR spectroscopy of the brain
    Rolf Gruetter
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    NMR Biomed 16:313-38. 2003
  5. ncbi request reprint Field mapping without reference scan using asymmetric echo-planar techniques
    R Gruetter
    Department of Radiology, University of Minnesota, Minneapolis, USA
    Magn Reson Med 43:319-23. 2000
  6. ncbi request reprint In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus
    Lakshmi Raman
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res Dev Brain Res 156:202-9. 2005
  7. ncbi request reprint Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla
    R Gruetter
    Departments of Radiology, Medicine, Psychiatry and Biochemistry, University of Minnesota, Minneapolis, Minn, USA
    Dev Neurosci 20:380-8. 1998
  8. ncbi request reprint In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia
    I Y Choi
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Cereb Blood Flow Metab 21:653-63. 2001
  9. ncbi request reprint Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity
    GULIN OZ
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 24:11273-9. 2004
  10. ncbi request reprint Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using (1)H-[(13)C] MRS and fMRI
    W Chen
    Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 45:349-55. 2001

Detail Information

Publications63

  1. ncbi request reprint A mathematical model of compartmentalized neurotransmitter metabolism in the human brain
    R Gruetter
    Department of Radiology, Center for Magnetic Resonance Research and General Clinical Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Endocrinol Metab 281:E100-12. 2001
    ..The study underlines the importance of assumptions made in modeling 13C labeling data in brain...
  2. ncbi request reprint In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
    Rolf Gruetter
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Neurochem Int 41:143-54. 2002
    ....
  3. ncbi request reprint Glycogen: the forgotten cerebral energy store
    Rolf Gruetter
    Departments of Radiology and Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurosci Res 74:179-83. 2003
    ....
  4. pmc Localized in vivo 13C NMR spectroscopy of the brain
    Rolf Gruetter
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    NMR Biomed 16:313-38. 2003
    ..We conclude that the unique and novel insights provided by (13)C NMR spectroscopy have opened many new research areas that are likely to improve the understanding of brain carbohydrate metabolism in health and disease...
  5. ncbi request reprint Field mapping without reference scan using asymmetric echo-planar techniques
    R Gruetter
    Department of Radiology, University of Minnesota, Minneapolis, USA
    Magn Reson Med 43:319-23. 2000
    ..1 Hz. With adiabatic low flip-angle excitation, the time required for field mapping was below 1 second...
  6. ncbi request reprint In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus
    Lakshmi Raman
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res Dev Brain Res 156:202-9. 2005
    ..The altered hippocampal neurochemistry during its development may underlie some of the cognitive deficits present in human infants at risk of chronic hypoxia...
  7. ncbi request reprint Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla
    R Gruetter
    Departments of Radiology, Medicine, Psychiatry and Biochemistry, University of Minnesota, Minneapolis, Minn, USA
    Dev Neurosci 20:380-8. 1998
    ....
  8. ncbi request reprint In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia
    I Y Choi
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Cereb Blood Flow Metab 21:653-63. 2001
    ..At this point, CBF increased sharply by 57% +/- 22%, suggesting that brain glucose concentration is the signal that triggers defense mechanisms aimed at improving glucose delivery to the brain during hypoglycemia...
  9. ncbi request reprint Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity
    GULIN OZ
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 24:11273-9. 2004
    ..We postulate that the high rate of anaplerosis in awake brain is linked to brain activity by maintaining glial glutamine concentrations during increased neurotransmission...
  10. ncbi request reprint Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using (1)H-[(13)C] MRS and fMRI
    W Chen
    Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 45:349-55. 2001
    ..Magn Reson Med 45:349-355, 2001...
  11. ncbi request reprint The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans
    E R Seaquist
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Diabetes 50:2203-9. 2001
    ..These data support the hypothesis that the majority of cerebral glucose uptake/metabolism is an insulin-independent process in humans...
  12. ncbi request reprint Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo (1)H NMR spectroscopy
    I Tkac
    Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    J Neurosci Res 66:891-8. 2001
    ....
  13. ncbi request reprint In vivo 1H NMR spectroscopy of the human brain at 7 T
    I Tkac
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 46:451-6. 2001
    ..Characteristic spectral patterns of metabolites, e.g., myo-inositol and taurine, were discernible in the in vivo spectra, which facilitated an unambiguous signal assignment...
  14. ncbi request reprint Detecting natural abundance carbon signal of NAA metabolite within 12-cm3 localized volume of human brain using 1H-[13C] NMR spectroscopy
    W Chen
    Radiology Department, University of Minnesota, School of Medicine, Minneapolis 55455, USA
    Magn Reson Med 40:180-4. 1998
    ....
  15. ncbi request reprint Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra
    Melissa Terpstra
    University of Minnesota, Department of Radiology, Center for MR Research Minneapolis, Minnesota
    Magn Reson Med 50:19-23. 2003
    ..GSH concentration was estimated from the in vivo spectra as 1.3 +/- 0.2 micro mol/g (mean +/- SD, n = 12)...
  16. ncbi request reprint In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time
    I Tkac
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis 55455, USA
    Magn Reson Med 41:649-56. 1999
    ..At 9.4 T, peaks close to the water were observed, including the H-1 of alpha-D-glucose at 5.23 ppm and a tentative H-1 resonance of glycogen at 5.35 ppm...
  17. ncbi request reprint Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients
    G Oz
    Center for MR Research, University of Minnesota, Minneapolis, MN 55455, USA
    Neurology 64:434-41. 2005
    ....
  18. ncbi request reprint Human brain glycogen content and metabolism: implications on its role in brain energy metabolism
    GULIN OZ
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th St SE, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 292:E946-51. 2007
    ..We conclude that the brain stores a substantial amount of glycogen relative to free glucose and metabolizes this store very slowly under normal physiology...
  19. pmc Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia
    Raghavendra Rao
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurochem 114:728-38. 2010
    ..Compensatory neurochemical changes maintain energy homeostasis during prolonged hypoglycemia in the developing hippocampus...
  20. ncbi request reprint Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy
    Elizabeth R Seaquist
    Department of Medicine, University of Minnesota Medical School, MN 55455, USA
    Metabolism 54:1008-13. 2005
    ..1 micromol/g wet wt; P = .1). Our sample size gave 80% power to detect a difference as small as 1.1 micromol/g wet wt. We conclude that chronic hyperglycemia in diabetes does not alter brain glucose concentrations in human subjects...
  21. pmc In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T
    Ivan Tkac
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 62:868-79. 2009
    ....
  22. ncbi request reprint Validation of glutathione quantitation from STEAM spectra against edited 1H NMR spectroscopy at 4T: application to schizophrenia
    Melissa Terpstra
    Center for Magnetic Resonance Research, Department of Radiology, University of MN, Minneapolis, MN 55455, USA
    MAGMA 18:276-82. 2005
    ..A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control...
  23. ncbi request reprint Proton-observed carbon-edited NMR spectroscopy in strongly coupled second-order spin systems
    Pierre Gilles Henry
    Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Magn Reson Med 55:250-7. 2006
    ..This effect is demonstrated theoretically with density matrix calculations and simulations, and experimentally with measured POCE spectra of [3-13C]glutamate...
  24. ncbi request reprint Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla: detection of high GABA concentrations
    GULIN OZ
    Center for MR Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 55:296-301. 2006
    ..These findings establish the feasibility of obtaining a neurochemical profile of the unilateral human SN by single-voxel spectroscopy in small volumes...
  25. pmc Biochemical quantification of total brain glycogen concentration in rats under different glycemic states
    Florence D Morgenthaler
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, USA
    Neurochem Int 48:616-22. 2006
    ..Finally we also conclude that previous interpretation of (13)C NMR spectroscopy data accurately reflected the changes in total brain glycogen content...
  26. ncbi request reprint Quantification of vitamin C in the rat brain in vivo using short echo-time 1H MRS
    Melissa Terpstra
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 55:979-83. 2006
    ..Ascorbate concentrations measured using STEAM decreased with increasing postnatal rat age, in agreement with published brain ascorbate concentrations measured in vitro using high-performance liquid chromatography (HPLC)...
  27. doi request reprint Editing through multiple bonds: threonine detection
    Malgorzata Marjanska
    Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Magn Reson Med 59:245-51. 2008
    ..A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain...
  28. ncbi request reprint Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T
    Silvia Mangia
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Magn Reson Imaging 24:343-8. 2006
    ..Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz...
  29. ncbi request reprint In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective
    Pierre Gilles Henry
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA
    Magn Reson Imaging 24:527-39. 2006
    ..The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues...
  30. ncbi request reprint Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli
    Silvia Mangia
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci Res 85:3340-6. 2007
    ..Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed...
  31. pmc Perinatal iron deficiency predisposes the developing rat hippocampus to greater injury from mild to moderate hypoxia-ischemia
    Raghavendra Rao
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:729-40. 2007
    ....
  32. ncbi request reprint Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo (1)H MRS study of a hibernating mammal
    Pierre Gilles Henry
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurochem 101:1505-15. 2007
    ....
  33. ncbi request reprint Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex
    Silvia Mangia
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:1055-63. 2007
    ....
  34. ncbi request reprint Detection of an antioxidant profile in the human brain in vivo via double editing with MEGA-PRESS
    Melissa Terpstra
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 56:1192-9. 2006
    ..GSSG contributions to the DEW MEGA-PRESS GSH resonance (3.0 ppm) are negligible under physiologic conditions, and would be evidenced by a distinct GSSG resonance (3.3 ppm) at exceptionally high concentrations...
  35. pmc Uncovering hidden in vivo resonances using editing based on localized TOCSY
    Malgorzata Marjanska
    Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Magn Reson Med 53:783-9. 2005
    ..63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform...
  36. ncbi request reprint Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness
    Amy B Criego
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Neurosci Res 79:42-7. 2005
    ..5 +/- 0.3 vs. 4.7 +/- 0.1 micromol/g wet weight, P = 0.016). These data suggest that changes in brain glucose transport or metabolism may occur as a result of recurrent hypoglycemia...
  37. ncbi request reprint Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy
    Ivan Tkac
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 50:24-32. 2003
    ..The current data may serve as a reference for studies focused on developmental defects and pathologies using neonatal rat models...
  38. ncbi request reprint Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus
    Raghavendra Rao
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    J Nutr 133:3215-21. 2003
    ..An altered neurochemical profile of the developing hippocampus may underlie some of the cognitive deficits observed in human infants with perinatal iron deficiency...
  39. ncbi request reprint Toward dynamic isotopomer analysis in the rat brain in vivo: automatic quantitation of 13C NMR spectra using LCModel
    Pierre Gilles Henry
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
    NMR Biomed 16:400-12. 2003
    ..The possibility of measuring in vivo a wealth of information that was hitherto accessible only in extracts is likely to expand the scope of metabolic studies in the intact brain...
  40. ncbi request reprint Ultrahigh field magnetic resonance imaging and spectroscopy
    Kamil Ugurbil
    Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Magn Reson Imaging 21:1263-81. 2003
  41. ncbi request reprint 1H NMR detection of vitamin C in human brain in vivo
    Melissa Terpstra
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 51:225-9. 2004
    ..This study represents the first in vivo detection of vitamin C in the human brain using 1H MRS. A concentration of 1.3 +/- 0.3 micromol/g (mean +/- SD, N = 4) was estimated...
  42. ncbi request reprint Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T
    Ivan Tkac
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis 55455, USA
    Magn Reson Med 52:478-84. 2004
    ..4 T can provide precise biochemical information from distinct regions of the mouse brain noninvasively that can be used for monitoring of disease progression and treatment as well as phenotyping in transgenic mice models...
  43. ncbi request reprint Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism
    In Young Choi
    Departments of RadiologyBiochemistry, Molecular Biology and Biophysics Neuroscience University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Eur J Biochem 269:4418-26. 2002
    ..These observations provide a key to understanding the mechanisms by which elevated hepatic Fru-2,6-P2 levels promote reduced hepatic glucose production and lower blood glucose in diabetes mellitus...
  44. ncbi request reprint Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action
    In Young Choi
    Department of Radiology, University of Minnesota, Center for MR Research, Minneapolis 55455, USA
    J Cereb Blood Flow Metab 22:1343-51. 2002
    ..However, the rates of cerebral oxidative glucose metabolism and glutamatergic neurotransmission, CMRglc(ox)/V(NT), did not correlate with a 1:1 stoichiometry...
  45. ncbi request reprint Brain glucose concentrations in healthy humans subjected to recurrent hypoglycemia
    Amy B Criego
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
    J Neurosci Res 82:525-30. 2005
    ..1 +/- 0.8 vs. 4.5 +/- 0.5 mumol/g wet weight, respectively, P = 0.05). These observations suggest that brain glucose transport or metabolism is not altered following short episodes of recurrent hypoglycemia in healthy human volunteers...
  46. pmc Effect of chronic hypoglycaemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study
    Hongxia Lei
    Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurochem 99:260-8. 2006
    ..Such increased brain glucose concentrations can result in a lowered glycaemic threshold of counter-regulation observed in chronic hypoglycaemia...
  47. pmc Direct validation of in vivo localized 13C MRS measurements of brain glycogen
    Hongxia Lei
    Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA
    Magn Reson Med 57:243-8. 2007
    ..79). The results are consistent with the notion that localized 13C MRS measurements closely reflect 13C glycogen content in the brain...
  48. pmc Effect of hypoglycemia on brain glycogen metabolism in vivo
    In Young Choi
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci Res 72:25-32. 2003
    ....
  49. ncbi request reprint Brain glycogen: an insulin-sensitive carbohydrate store
    E R Seaquist
    Department of Medicine, University of Minnesota, USA
    Diabetes Nutr Metab 15:285-9; discussion 289-90. 2002
  50. ncbi request reprint Water diffusion in rat brain in vivo as detected at very large b values is multicompartmental
    J Pfeuffer
    Department of Radiology, University of Minnesota Medical School, Center for Magnetic Resonance Research, Minneapolis 55455, USA
    MAGMA 8:98-108. 1999
    ..e. the relative volume fractions and the extracellular tortuosity, while the intrinsic intracellular diffusion constant and the exchange time are predicted to have minor influence...
  51. ncbi request reprint Direct, noninvasive measurement of brain glycogen metabolism in humans
    GULIN OZ
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th St S E, Minneapolis, MN 55455, USA
    Neurochem Int 43:323-9. 2003
    ..The noninvasive detection of human brain glycogen opens the prospect of understanding the role and function of this important energy reserve under various physiological and pathophysiological conditions...
  52. ncbi request reprint Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla
    Melissa Terpstra
    Center for MR Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 47:1009-12. 2002
    ....
  53. ncbi request reprint In vivo 13C NMR assessment of brain glycogen concentration and turnover in the awake rat
    In Young Choi
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Neurochem Int 43:317-22. 2003
    ..Absolute quantification of the total concentration of brain glycogen in the awake, normoglycemic rat yielded 3.3+/-0.8 micromol/g (n=6, mean+/-S.D.)...
  54. pmc Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy
    Ivan Tkac
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurochem 100:1397-406. 2007
    ..Longitudinal monitoring of changes in these metabolites may provide quantifiable measures of disease progression and treatment effects in both mouse models of HD and patients...
  55. ncbi request reprint 1H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 T
    Pierre Gilles Henry
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis Minnesota
    Magn Reson Med 50:684-92. 2003
    ..This unprecedented amount of information will be useful for metabolic modeling studies aimed at understanding brain energy metabolism and neurotransmission in the rodent brain...
  56. ncbi request reprint Evaluation of brain mitochondrial glutamate and alpha-ketoglutarate transport under physiologic conditions
    Deborah A Berkich
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Neurosci Res 79:106-13. 2005
    ..The alpha-ketoglutarate pool is far smaller than the glutamate pool and will therefore approach steady state faster than will glutamate at the metabolite transport rates measured...
  57. doi request reprint Comparison of three commercially available radio frequency coils for human brain imaging at 3 Tesla
    Ralf Mekle
    Centre d Imagerie BioMedicale, Ecole Polytechnique Federale de Lausanne, EPFL SB IPMC LIFMET, CH F0 572 Batiment CH, Station 6, 1015 Lausanne, Switzerland
    MAGMA 21:53-61. 2008
    ....
  58. ncbi request reprint Mathematical modeling of (13)C label incorporation of the TCA cycle: the concept of composite precursor function
    Kai Uffmann
    Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Neurosci Res 85:3304-17. 2007
    ..This approach allows one to determine metabolic rates by fitting explicit mathematical functions to measured time courses...
  59. ncbi request reprint Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T
    Lijing Xin
    Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    NMR Biomed 21:396-401. 2008
    ..The T2 values of J-coupled metabolites ranged from 89 +/- 8 ms (glutamate) to 148 +/- 14 ms (myo-inositol)...
  60. ncbi request reprint Localized short-echo-time proton MR spectroscopy with full signal-intensity acquisition
    Vladimir Mlynarik
    Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Magn Reson Med 56:965-70. 2006
    ....
  61. pmc Dynamic or inert metabolism? Turnover of N-acetyl aspartate and glutathione from D-[1-13C]glucose in the rat brain in vivo
    In Young Choi
    The Nathan Kline Institute, Medical Physics, Orangeburg, New York 10962, USA
    J Neurochem 91:778-87. 2004
    ..8 micromol/g, comparable to the cortical glutathione concentration. We conclude that NAA and GSH are completely turned over and that the metabolism is extremely slow (< 0.05% of the glucose metabolic rate)...
  62. pmc Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions
    Ruud B van Heeswijk
    Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Magn Reson Imaging 25:821-5. 2007
    ..1- to 10-microM contrast agents should be detectable, provided sufficient sensitivity is available, such as that afforded by hyperpolarization, recently introduced to in vivo imaging...
  63. pmc Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times
    Vladimir Mlynarik
    Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Magn Reson Med 59:52-8. 2008
    ..We conclude that it is feasible to achieve a sensitivity that is sufficient for quantitative mapping of the neurochemical profile at microliter spatial resolution...