Chad E Grueter
Affiliation: University of Iowa
Minerath R, Hall D, Grueter C. Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure. Heart Fail Rev. 2019;: pubmed publisher
..Therefore, pharmacological inhibition of transcriptional machinery that integrates pro-hypertrophic TFs may represent a promising alternative therapeutic approach to limit pathological remodeling associated with the development of HF. ..
Minerath R, Dewey C, Hall D, Grueter C. Regulation of cardiac transcription by thyroid hormone and Med13. J Mol Cell Cardiol. 2019;129:27-38 pubmed publisher
..Collectively, these studies reveal cardiac transcriptional pathways regulated in response to hypothyroidism and re-establishment of a euthyroid state and define molecular pathways that are regulated by Med13 in response to TH signaling. ..
Grueter C. Mediator complex dependent regulation of cardiac development and disease. Genomics Proteomics Bioinformatics. 2013;11:151-7 pubmed publisher
..Enhanced understanding of the role of this core transcriptional regulatory complex in the heart will help us gain further insights into CVD. ..
Spitler K, Ponce J, Oudit G, Hall D, Grueter C. Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming. Am J Physiol Heart Circ Physiol. 2017;312:H768-H780 pubmed publisher
..Med1 deletion disrupted cardiac mitochondrial and metabolic gene expression patterns. ..