S B Gruber

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
  2. ncbi request reprint Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome
    S B Gruber
    Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor 48109, USA
    Cancer Res 58:5267-70. 1998
  3. ncbi request reprint The value of small observations in the era of big science
    Stephen B Gruber
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, Epidemiology, and Human Genetics, 4301 MSRBIII, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Cancer Epidemiol Biomarkers Prev 14:2472-3. 2005
  4. ncbi request reprint New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing
    Stephen B Gruber
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, 48109, USA
    Gastroenterology 130:577-87. 2006
  5. ncbi request reprint The genetics of hereditary non-polyposis colorectal cancer
    Stephen B Gruber
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Natl Compr Canc Netw 1:137-44. 2003
  6. ncbi request reprint Population stratification in epidemiologic studies of founder populations
    Stephen B Gruber
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Cancer Biomark 3:123-8. 2007
  7. doi request reprint Risk of pancreatic cancer in families with Lynch syndrome
    Fay Kastrinos
    Department of Internal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    JAMA 302:1790-5. 2009
  8. ncbi request reprint Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability
    Joel K Greenson
    Department of Pathology, Universit of Michigan Health System, Ann Arbor, 48109, USA
    Am J Surg Pathol 27:563-70. 2003
  9. ncbi request reprint Health behaviors of head and neck cancer patients the first year after diagnosis
    Sonia A Duffy
    VA HSR and D Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA
    Head Neck 30:93-102. 2008
  10. ncbi request reprint BRAF and NRAS mutations in melanoma and melanocytic nevi
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Melanoma Res 16:267-73. 2006

Research Grants

  1. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Stephen Gruber; Fiscal Year: 2003
  2. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Stephen Gruber; Fiscal Year: 2007

Detail Information

Publications90

  1. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
    ....
  2. ncbi request reprint Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome
    S B Gruber
    Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor 48109, USA
    Cancer Res 58:5267-70. 1998
    ..Additional somatic mutational events underlie the progression of hamartomas to adenocarcinomas, and some of these somatic mutations are common to the later stages of tumor progression seen in the majority of colorectal carcinomas...
  3. ncbi request reprint The value of small observations in the era of big science
    Stephen B Gruber
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, Epidemiology, and Human Genetics, 4301 MSRBIII, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Cancer Epidemiol Biomarkers Prev 14:2472-3. 2005
  4. ncbi request reprint New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing
    Stephen B Gruber
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, 48109, USA
    Gastroenterology 130:577-87. 2006
  5. ncbi request reprint The genetics of hereditary non-polyposis colorectal cancer
    Stephen B Gruber
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Natl Compr Canc Netw 1:137-44. 2003
    ....
  6. ncbi request reprint Population stratification in epidemiologic studies of founder populations
    Stephen B Gruber
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Cancer Biomark 3:123-8. 2007
    ..Examples from studies of colorectal cancer in Ashkenazi Jewish populations, and studies of smoking behavior in Caucasians of European origin, Mexican-Americans, Japanese and Han Chinese illustrate these principles...
  7. doi request reprint Risk of pancreatic cancer in families with Lynch syndrome
    Fay Kastrinos
    Department of Internal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    JAMA 302:1790-5. 2009
    ..A number of extracolonic tumors have been associated with the disorder, including pancreatic cancer; however, the risk of pancreatic cancer in Lynch syndrome is uncertain and not quantified...
  8. ncbi request reprint Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability
    Joel K Greenson
    Department of Pathology, Universit of Michigan Health System, Ann Arbor, 48109, USA
    Am J Surg Pathol 27:563-70. 2003
    ..The combination of >2 tumor infiltrating lymphocytes per high power field and/or any mucinous differentiation and/or the absence of dirty necrosis identified all MSI-H tumors in this study...
  9. ncbi request reprint Health behaviors of head and neck cancer patients the first year after diagnosis
    Sonia A Duffy
    VA HSR and D Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA
    Head Neck 30:93-102. 2008
    ..This prospective, cohort study is the first to describe 5 health behaviors of head and neck cancer patients the first year after diagnosis...
  10. ncbi request reprint BRAF and NRAS mutations in melanoma and melanocytic nevi
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Melanoma Res 16:267-73. 2006
    ..We suggest that BRAF mutations contribute to benign melanocytic hyperplasia, but are likely to contribute to invasive melanoma only in conjunction with other mutations...
  11. ncbi request reprint APC I1307K and the risk of prostate cancer
    Jenny N Poynter
    Division of Molecular Medicine and Genetics, University of Michigan, 4301 MSRB III, Ann Arbor, MI 48109 0638, USA
    Cancer Epidemiol Biomarkers Prev 15:468-73. 2006
    ..Overall, the evidence for an association between APC I1307K and prostate cancer is not compelling. APC I1307K is unlikely to play a clinically meaningful role in susceptibility to prostate cancer...
  12. ncbi request reprint BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer
    Bethany L Niell
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    J Natl Cancer Inst 96:15-21. 2004
    ..We investigated BRCA1/2 founder mutations and a family history of breast cancer as potential risk factors for colorectal cancer...
  13. pmc Adiponectin gene and risk of colorectal cancer
    M C Gornick
    Department of Human Genetics, University of Michigan School of Medicine, 1524 BSRB, 109 Zina Pitcher, Ann Arbor, MI, USA
    Br J Cancer 105:562-4. 2011
    ..However, variants of the adiponectin gene (ADIPOQ) have been demonstrated to be inconsistently associated with risk of colorectal cancer...
  14. doi request reprint FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations
    Leon Raskin
    Department of of Internal Medicine, University of Michigan Medical School and School of Public Health, Ann Arbor, MI 48109, USA
    Cancer Epidemiol Biomarkers Prev 17:1060-5. 2008
    ..The identification of population-specific risk haplotypes in FGFR2 is likely to help identify causal variants for breast cancer...
  15. doi request reprint FOXP3 germline polymorphisms are not associated with risk of breast cancer
    Leon Raskin
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Genet Cytogenet 190:40-2. 2009
    ..Although FOXP3 is a biologically relevant gene in the pathogenesis of breast cancer, germline variation was not meaningfully associated with risk of the disease...
  16. ncbi request reprint Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers
    Kimberly A Zuhlke
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0946, USA
    Clin Cancer Res 10:5975-80. 2004
    ..To examine the possibility that germ-line BRCA1 mutations were associated with hereditary prostate cancer, individuals from 93 families with evidence of linkage to chromosome 17q were screened for germ-line BRCA1 mutations...
  17. pmc Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles
    T J Giordano
    Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Am J Pathol 159:1231-8. 2001
    ....
  18. pmc Pretreatment health behaviors predict survival among patients with head and neck squamous cell carcinoma
    Sonia A Duffy
    VA Health Services Research and Development Center of Excellence, VA Ann Arbor Healthcare System 11H, PO Box 130170, Ann Arbor, MI 48113 0170, USA
    J Clin Oncol 27:1969-75. 2009
    ..Our prior work has shown that the health behaviors of head and neck cancer patients are interrelated and are associated with quality of life; however, other than smoking, the relationship between health behaviors and survival is unclear...
  19. ncbi request reprint The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study
    Marianne Berwick
    University of New Mexico, Department of Internal Medicine, New Mexico Cancer Research Facility, MSC08 4630, Room 103A, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Cancer Epidemiol Biomarkers Prev 15:1520-5. 2006
    ..The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma...
  20. pmc Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population
    Tuan A Dinh
    Archimedes, Inc, San Francisco, California, USA
    Cancer Prev Res (Phila) 4:9-22. 2011
    ....
  21. ncbi request reprint BRAF and NRAS mutations in spitzoid melanocytic lesions
    Douglas R Fullen
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Mod Pathol 19:1324-32. 2006
    ..Therefore, the BRAF mutational status does not separate all Spitz nevi from spitzoid melanomas and non-Spitz types of melanocytic proliferations, contrary to previous reports...
  22. doi request reprint Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers
    Kurt D Christensen
    Department of Health Behavior and Health Education, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Cancer Epidemiol Biomarkers Prev 20:522-9. 2011
    ..Whether to return individual research results from cancer genetics studies is widely debated, but little is known about how participants respond to results disclosure or about its time and cost burdens on investigators...
  23. ncbi request reprint Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
    Lin Lin
    Department of Surgery Thoracic Section, University of Michigan Medical School, B560 MSRB2, Box 0686, Ann Arbor, MI 48109, USA
    Genes Chromosomes Cancer 45:319-31. 2006
    ..Thus, the fine dissection of a 2-Mb amplified DNA segment in 3q26.3-q27 in EA revealed multiple genetic alterations that had occurred sequentially and/or concurrently during EA development...
  24. pmc AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome
    Monica L Marvin
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Am J Med Genet A 155:898-902. 2011
    ..Our report provides additional evidence supporting an autosomal dominant AXIN2-associated ectodermal dysplasia and neoplastic syndrome...
  25. pmc Returning individual research results: development of a cancer genetics education and risk communication protocol
    J Scott Roberts
    Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
    J Empir Res Hum Res Ethics 5:17-30. 2010
    ....
  26. ncbi request reprint Incidence of initial local therapy among men with lower-risk prostate cancer in the United States
    David C Miller
    Department of Urology, University of Michigan, Ann Arbor, MI, USA
    J Natl Cancer Inst 98:1134-41. 2006
    ....
  27. pmc Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer
    Laura S Rozek
    Environmental Health Sciences, School of Public Health, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Epidemiol Biomarkers Prev 19:838-43. 2010
    ..Epidemiologic studies of CRC should incorporate somatic characteristics to fully appreciate risk factors for this disease...
  28. pmc Case-control studies of gene-environment interaction: Bayesian design and analysis
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 66:934-48. 2010
    ..The Bayesian design and analysis strategies are compared with their corresponding frequentist counterparts...
  29. doi request reprint Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Genet Epidemiol 32:615-26. 2008
    ....
  30. doi request reprint Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis
    Amy E Rothberg
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5354, USA
    Thyroid 19:651-5. 2009
    ..This is a report of a patient with a novel genotype-phenotype relationship of a c804 mutation of the RET proto-oncogene manifesting as medullary thyroid carcinoma (MTC) and cutaneous lichen amyloidosis (CLA)...
  31. pmc Pathologic predictors of microsatellite instability in colorectal cancer
    Joel K Greenson
    Department of Pathology, The University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 33:126-33. 2009
    ..Although this model is not perfect in predicting microsatellite instability, its use could improve the efficiency of expensive diagnostic testing...
  32. pmc First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome
    James C Sisson
    Department of Radiology, Division of Nuclear Medicine, University of Michigan Health System, UH B1 G505D, Ann Arbor, MI 48109 0028, USA
    Endocr Pathol 19:289-93. 2008
    ..The initial report of the proband preceded the publications defining both MTC and MEN 2A. The values of in-depth family histories and genetic analyses are exemplified...
  33. pmc Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway
    Eduardo Vilar
    Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 15:2829-39. 2009
    ..Our objective was to identify low molecular weight compounds with preferential activity against MSI colorectal cancers using combined gene expression data sets...
  34. doi request reprint Pediatric duodenal cancer and biallelic mismatch repair gene mutations
    Sumita Roy
    Division of Pediatric Hematology Oncology, Dept of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan 48109 0238, USA
    Pediatr Blood Cancer 53:116-20. 2009
    ..We report the case of a 16-year-old female with duodenal adenocarcinoma and past history of medulloblastoma found to have a novel germline bialleleic truncating mutation (c.[949C>T]+[949C>T]) of the PMS2 gene...
  35. ncbi request reprint History and molecular genetics of Lynch syndrome in family G: a century later
    Julie A Douglas
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    JAMA 294:2195-202. 2005
    ..Described today as a Lynch syndrome family, family G was last documented in 1971, prior to the modern era of molecular diagnostics...
  36. ncbi request reprint Genetic variation in 8q24 associated with risk of colorectal cancer
    Stephen B Gruber
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA
    Cancer Biol Ther 6:1143-7. 2007
    ..2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies...
  37. ncbi request reprint EGF gene polymorphism and the risk of incident primary melanoma
    Kandace L Amend
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 64:2668-72. 2004
    ..Additional independent studies will be required to elucidate relationships between genetic variation in the EGF gene and risk of melanoma...
  38. ncbi request reprint Use of complementary and alternative medicine in men with family history of prostate cancer: a pilot study
    Jennifer L Beebe-Dimmer
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0946, USA
    Urology 63:282-7. 2004
    ..To describe the use of complementary and alternative medicines (CAMs) among men with a family history of prostate cancer and to evaluate the relationship between selected sociodemographic and behavioral characteristics and the use of CAMs...
  39. ncbi request reprint Staging workup, sentinel node biopsy, and follow-up tests for melanoma: update of current concepts
    Timothy M Johnson
    Department of Dermatology, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor 48109 0314, USA
    Arch Dermatol 140:107-13. 2004
    ..To clarify and update workup and follow-up strategies based on fundamental principles and current data, and to discuss new and current concepts regarding sentinel lymph node biopsy (SLNB), particularly in relation to the staging workup...
  40. ncbi request reprint Risk perception and concern among brothers of men with prostate carcinoma
    Jennifer L Beebe-Dimmer
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer 100:1537-44. 2004
    ....
  41. ncbi request reprint CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  42. ncbi request reprint Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta
    Julie A Douglas
    Department of Human Genetics, University of Michigan, Room 5912, Buhl Building, Ann Arbor, MI 48109 0618, USA
    Cancer Epidemiol Biomarkers Prev 14:2035-9. 2005
    ....
  43. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...
  44. pmc Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use
    N Jewel Samadder
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Cancer 117:1640-8. 2011
    ..The objective of this study was to quantify the relative risk of inflammatory bowel disease (IBD) as a risk factor for CRC and to estimate whether this risk may be modified by long-term use of NSAIDs or statins...
  45. pmc Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim
    Bethany L Niell
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Am J Hum Genet 73:1250-60. 2003
    ..This research underscores the importance of the migratory patterns of ancestral populations in the ethnic and geographic distribution of APC I1307K...
  46. ncbi request reprint APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel
    Laura S Rozek
    Division of Molecular Medicine and Genetics, University of Michigan, 1524 BSRB, 109 Zina Pitcher, Box 2200, Ann Arbor, MI 48109 2200, USA
    Cancer Epidemiol Biomarkers Prev 15:2325-7. 2006
    ..Given the substantial size of our study and the consistency of our findings with the results of our meta-analyses, we conclude that it is unlikely that APC E1317Q is associated with a clinically meaningful risk of colorectal cancer...
  47. ncbi request reprint Statins and the risk of colorectal cancer
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor 48109 0638, USA
    N Engl J Med 352:2184-92. 2005
    ..Statins inhibit the growth of colon-cancer cell lines, and secondary analyses of some, but not all, clinical trials suggest that they reduce the risk of colorectal cancer...
  48. pmc Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer
    Alexandros D Polydorides
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 32:1661-6. 2008
    ..Therefore, increased numbers of AILs and decreased numbers of apoptoses in colorectal adenomas are simple and inexpensive markers that raise the possibility of HNPCC...
  49. doi request reprint Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome
    L Raskin
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Clin Genet 79:512-22. 2011
    ..Together with other AJ founder mutations, they contribute substantially to the incidence of CRC and EnCa and are important tools for the early diagnosis and appropriate management of AJ Lynch syndrome patients...
  50. doi request reprint Human papillomavirus is not associated with colorectal cancer in a large international study
    Michele C Gornick
    Department of Human Genetics, School of Medicine, University of Michigan, 109 Zina Pitcher, Ann Arbor, MI 48109 2200, USA
    Cancer Causes Control 21:737-43. 2010
    ..Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer...
  51. ncbi request reprint BLM heterozygosity and the risk of colorectal cancer
    Stephen B Gruber
    Departments of Internal Medicine and Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA
    Science 297:2013. 2002
  52. pmc Common variation in ISL1 confers genetic susceptibility for human congenital heart disease
    Kristen N Stevens
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 5:e10855. 2010
    ..Our results demonstrate that two different ISL1 haplotypes contribute to risk of CHD in white and black/African American populations...
  53. pmc Microsatellite instability in colorectal cancer-the stable evidence
    Eduardo Vilar
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Nat Rev Clin Oncol 7:153-62. 2010
    ..Transcriptome expression profiles of MSI tumors and systems biology approaches are providing the opportunity to develop targeted therapeutics for MSI CRC...
  54. ncbi request reprint Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies
    J A Douglas
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 28:361-4. 2001
    ..We show that, particularly when phenotyping is expensive, conversion-based haplotyping can be more efficient and cost-effective than standard genotyping...
  55. pmc Endometrial cancer: socioeconomic status and racial/ethnic differences in stage at diagnosis, treatment, and survival
    Terri Madison
    School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Am J Public Health 94:2104-11. 2004
    ..We evaluated the association between socioeconomic status and racial/ ethnic differences in endometrial cancer stage at diagnosis, treatment, and survival...
  56. doi request reprint Diagnosis and management of hereditary paraganglioma syndrome due to the F933>X67 SDHD mutation
    Monica L Marvin
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA
    Head Neck 31:689-94. 2009
    ..The recognition of patients with hereditary PGL and identification of the responsible gene are important for the management of index patients and family members...
  57. doi request reprint Quality of life scores predict survival among patients with head and neck cancer
    Carrie A Karvonen-Gutierrez
    Veterans Affairs VA Health Services Research and Development Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System 11H, Ann Arbor, MI 48113 0170, USA
    J Clin Oncol 26:2754-60. 2008
    ..The purpose of this study was to examine whether quality of life (QOL) scores predict survival among patients with head and neck cancer, controlling for demographic, health behavior, and clinical variables...
  58. ncbi request reprint Genetics of colorectal cancer
    Joanne M Jeter
    University of Michigan, Ann Arbor, USA
    Oncology (Williston Park) 20:269-76; discussion 285-6, 288-9. 2006
    ..In this review, we will describe the phenotypes, genotypes, diagnosis, and management of hereditary colon cancer syndromes...
  59. ncbi request reprint CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium
    Takao Hinoi
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Gastroenterology 128:946-61. 2005
    ..To enhance knowledge of CDX2 function, we sought to define CDX2-regulated genes...
  60. ncbi request reprint Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
    Christophe Denoyelle
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan, 1500E Medical Center Drive, 4217 CCGC, Ann Arbor, MI 48109, USA
    Nat Cell Biol 8:1053-63. 2006
    ..These results argue against premature senescence as a converging mechanism of response to activating oncogenes and support a direct role of the ER as a gatekeeper of tumour control...
  61. ncbi request reprint R726L androgen receptor mutation is uncommon in prostate cancer families in the united states
    Stephen B Gruber
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Prostate 54:306-9. 2003
    ..We set out to determine the incidence of this mutation in a sample of men with either early-onset and/or familial prostate cancer in the United States...
  62. ncbi request reprint Rescue of fatal neonatal hemorrhage in factor V deficient mice by low level transgene expression
    T L Yang
    Department of Human Genetics, University of Michigan, Ann Arbor, USA
    Thromb Haemost 83:70-7. 2000
    ....
  63. ncbi request reprint Vulvar melanoma: a report of 20 cases and review of the literature
    Mary Ellen Wechter
    Department of Obstetrics and Gynecology, University of Michigan Health System, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0314, USA
    J Am Acad Dermatol 50:554-62. 2004
    ..Vulvar melanoma is the second most common vulvar malignancy and represents a significant women's health issue...
  64. ncbi request reprint The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
    Steven M Lipkin
    Division of Oncology, Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Nat Genet 36:694-9. 2004
    ..These studies suggest that variants of mismatch repair proteins with attenuated function may account for a higher proportion of susceptibility to sporadic microsatellite-stable CRC than previously assumed...
  65. doi request reprint Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation
    Ofer Lavie
    Division of Gynecology and Oncology, Carmel Medical Center, B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Am J Obstet Gynecol 199:148.e1-3. 2008
    ..Although the incidence of colorectal cancer in carriers is relatively well established, the frequency of other tumors is less clear...
  66. ncbi request reprint Prostate cancer early detection practices among men with a family history of disease
    Cathryn H Bock
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109 0946, USA
    Urology 62:470-5. 2003
    ....
  67. ncbi request reprint Colorectal Cancer Screening Clinical Practice Guidelines
    Bernard Levin
    J Natl Compr Canc Netw 4:384-420. 2006
  68. ncbi request reprint Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients
    Brian Y Shin
    Division of Hematology Oncology, Department of Medicine, University of California Irvine, 92697, USA
    Dis Colon Rectum 48:1723-7. 2005
    ....
  69. ncbi request reprint A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Epidemiol 35:756-64. 2006
    ..The use of a novel case-control design in which cases have second primaries and controls are cancer survivors has been proposed for this purpose...
  70. pmc Prediction of germline mutations and cancer risk in the Lynch syndrome
    Sining Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    JAMA 296:1479-87. 2006
    ..Current clinical guidelines are effective but limited by applicability and cost...
  71. ncbi request reprint CDKN2A germline mutations in individuals with cutaneous malignant melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 127:1234-43. 2007
    ..With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk...
  72. ncbi request reprint Familial aggregation of melanoma risks in a large population-based sample of melanoma cases
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Causes Control 15:957-65. 2004
    ..In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases...
  73. ncbi request reprint Network modeling links breast cancer susceptibility and centrosome dysfunction
    Miguel Angel Pujana
    Center for Cancer Systems Biology CCSB, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney St, Boston, Massachusetts 02115, USA
    Nat Genet 39:1338-49. 2007
    ..Our network modeling strategy should be useful for the discovery of additional cancer-associated genes...
  74. pmc Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility
    Xavier Sole
    Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    BMC Genomics 9:12. 2008
    ..Variation at 8q24 has also recently been associated with risk of breast and colorectal cancer. However, none of the risk variants map at or relatively close to known genes, with c-MYC mapping a few hundred kilobases distally...
  75. ncbi request reprint Statins and cancer prevention
    Marie France Demierre
    Department of Dermatology, Boston University School of Medicine, 720 Harrison Avenue DOB 801A, Boston, MA 02118, USA
    Nat Rev Cancer 5:930-42. 2005
    ..This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways...
  76. ncbi request reprint Colorectal polyps in carriers of the APC I1307K polymorphism
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
    Dis Colon Rectum 48:2317-21. 2005
    ..The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared...
  77. ncbi request reprint Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 97:1507-15. 2005
    ..In this study, we examined lifetime melanoma risk among CDKN2A mutation carriers using carriers who were identified in a population-based study of melanoma...
  78. ncbi request reprint Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:610-8. 2006
    ..ORs for XPD and XPC genotypes were stronger for melanoma diagnosed at an early age, but tests for interaction were not statistically significant. The results provide further evidence for a role of XPD in the etiology of melanoma...
  79. ncbi request reprint Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus
    Lorraine L Rosamilia
    J Am Acad Dermatol 54:S52-3. 2006
  80. ncbi request reprint Small changes in expression affect predisposition to tumorigenesis
    Hai Yan
    The Howard Hughes Medical Institute, The Oncology Center, and the Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Genet 30:25-6. 2002
    ....
  81. ncbi request reprint Cancer risks in BRCA1 carriers: time for the next generation of studies
    Stephen B Gruber
    J Natl Cancer Inst 94:1344-5. 2002
  82. ncbi request reprint Relative frequency and morphology of cancers in STK11 mutation carriers
    Wendy Lim
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Gastroenterology 126:1788-94. 2004
    ..There is limited data on the spectrum and risk for cancer associated with germline serine/threonine protein kinase 11 (STK11) mutations that cause Peutz-Jeghers syndrome (PJS)...
  83. ncbi request reprint Hyperglycemia, obesity, and cancer risks on the horizon
    Kathleen A Cooney
    JAMA 293:235-6. 2005
  84. ncbi request reprint Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 66:9330-7. 2006
    ....
  85. ncbi request reprint Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer
    Kirsten N Kangelaris
    JAMA 297:2410-1. 2007
  86. ncbi request reprint Merkel cell carcinoma and the controversial role of adjuvant radiation therapy: clinical choices in the absence of statistical evidence
    Lynn D Wilson
    Departments of Therapeutic Radiology and Dermatology, Yale University School of Medicine, HRT 136, 333 Cedar Street, New Haven, CT 06520, USA
    J Am Acad Dermatol 50:435-7; discussion 437-8. 2004
  87. pmc Sharing genetic test results in Lynch syndrome: communication with close and distant relatives
    Elena M Stoffel
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Gastroenterol Hepatol 6:333-8. 2008
    ..Clinical genetic testing can help direct cancer screening for members of Lynch syndrome families; however, there is limited information about family communication of genetic test results...
  88. pmc Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    Albert Tenesa
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Nat Genet 40:631-7. 2008
    ..008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology...
  89. doi request reprint Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)
    Elizabeth C Chao
    Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, California, USA
    Hum Mutat 29:852-60. 2008
    ..MAPP-MMR is an effective bioinformatic tool for missense variant interpretation that accurately distinguishes MLH1/MSH2 deleterious variants from neutral variants...
  90. ncbi request reprint Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas
    Wendy W J de Leng
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Cancer Res 9:3065-72. 2003
    ..DNA was studied for loss of heterozygosity (LOH) at 19p (STK11), 5q (APC), and 17p (TP53); mutations in beta-catenin, APC, and K-RAS; and microsatellite instability...

Research Grants8

  1. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Stephen Gruber; Fiscal Year: 2003
    ..abstract_text> ..
  2. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Stephen Gruber; Fiscal Year: 2007
    ..abstract_text> ..