Research Topics
Species | Clinton GrubbsSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targetsRuisheng Yao
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Carcinogenesis 27:1420-31. 2006..Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs...
Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene)PETER T VEDELL
Medical College of Wisconsin, Cancer Center, Department of Pharmacology Toxicology, Milwaukee, Wisconsin, USA
Mol Pharmacol 83:698-708. 2013..Different patterns of gene expression among the agonists provided insight into molecular differences and allowed one to predict certain physiologic consequences of agonist treatment...- Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkersClinton J Grubbs
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
Carcinogenesis 27:1232-9. 2006..In summary, a short-term in vivo method has been identified for screening newly synthesized retinoids both for chemopreventive efficacy and for their adverse effect on serum triglycerides... - 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancersClinton J Grubbs
Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cancer Lett 201:17-24. 2003..6; and controls, 6.0. Thus, the combination of the agents resulted in an increased effect in preventing mammary cancers; suggesting that cancer cell proliferation was inhibited by the compounds blocking different pathways... - Proteomics analysis of rat brain protein modulations by grape seed extractJessy Deshane
Department of Pharmacology and Toxicology, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama 35294, USA
J Agric Food Chem 52:7872-83. 2004..This is the first identification and quantitation of specific proteins in mammalian tissues modulated by a dietary supplement, as well as the first to demonstrate links of such proteins with any disease... - Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependentHelen Kim
Departments of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Nutr 134:3445S-3452S. 2004.... - Prevention of methylnitrosourea-induced mammary cancers by 9-cis-retinoic acid and/or vitamin D3Mark B Cope
University of Alabama at Birmingham, Nutrition Sciences Department, Birmingham, AL 35294, USA
Oncol Rep 9:533-7. 2002..Possible interactions between the retinoic acid receptors and vitamin D receptor may be responsible for the observed inhibition of mammary carcinogenesis... 
Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changesRonald A Lubet
National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
Mol Cancer Ther 7:972-9. 2008..Finally, combining suboptimal doses of Iressa with suboptimal doses of vorozole (an aromatase inhibitor) or targretin (a retinoid X receptor agonist) yielded greater chemopreventive efficacy than any of these agents given alone...- Short-term modulation of cell proliferation and apoptosis and preventive/therapeutic efficacy of various agents in a mammary cancer modelKonstantin Christov
Department of Surgical Oncology, University of Illinois at Chicago, Chicago, Illinois, USA
Clin Cancer Res 13:5488-96. 2007.... - Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutationsRonald A Lubet
National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
Mol Cancer Ther 5:1073-8. 2006..Thus, R115777 was active in the prevention and therapy of these chemically induced mammary cancers, but was strikingly more effective in cancers with HaRas mutations... - Hypermethylation patterns in the Fhit regulatory region are tissue specificGulnur Guler
Department of Microbiology Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Mol Carcinog 43:175-81. 2005..The specific patterns of hypermethylated CpGs in the Fhit regulatory regions thus appear to be tissue-specific... - Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancerLaundette P Jones
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
Oncogene 24:3554-62. 2005.... - Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphologyCristina Rodriguez-Burford
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Nutr Cancer 43:67-75. 2002..It would appear that the observed decrease in mammary cancers observed with moderate reductions in body weight gain might be due to multiple related factors different from those related to 4-HPR treatment... - Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosisRonald A Lubet
Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
Carcinogenesis 26:441-8. 2005..Determination of serum IGF1 levels showed that treatment of rats with highly effective doses of Targretin at 272 mg/kg diet or at 60 or 20 mg/kg body wt/day by gavage caused significantly decreased serum IGF1 levels... - Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30)Venkatram R Atigadda
Department of Chemistry, University of Alabama at Birmingham, 901 South 14th Street, Birmingham, AL 35294, USA
J Med Chem 46:3766-9. 2003..Here, we describe a modified synthesis that yields up to 100 g of 1. We further demonstrate that 1 is very effective in the prevention of N-methyl-N-nitrosourea induced mammary cancers in rats without signs of toxicity... - The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trialRonald D Alvarez
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233 7333, USA
Cancer Epidemiol Biomarkers Prev 12:114-9. 2003..The rate of histological regression in biopsied CIN 2/3 patients is high even over a short time interval, and emphasizes the importance of having a placebo arm and an adequate sample size in cervical dysplasia chemoprevention studies... - Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer preventionMark B Cope
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Oncol Rep 11:465-9. 2004..In both experiments, the two retinoids in combination produced an additive effect, suggesting that they may inhibit mammary cancers by different mechanisms... - Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamideYian Wang
Department of Surgery and The Alvin J. Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South, Euclid Avenue, St. Louis, MO 63110, USA
Mol Cancer Ther 5:1060-72. 2006..These expression signatures could provide useful pharmacodynamic biomarkers for retinoid treatment and chemoprevention... - Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor modelsZhongqiu Zhang
Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Oncogene 23:3841-50. 2004..Furthermore, ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas... - Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenolsRonald A Lubet
National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
Mol Cancer Ther 6:2022-8. 2007..The bioavailability of these tea polyphenols to different organ sites may contribute to the differing preventive efficacy of Polyphenon E against urinary bladder and mammary cancers... - Paradigms for primary prevention of ovarian carcinomaMack N Barnes
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA
CA Cancer J Clin 52:216-25. 2002..Continued research efforts toward identification of novel compounds will accelerate the progress of clinical trials in this neglected area of investigation... - 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacinRonald A Lubet
Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
Carcinogenesis 26:571-8. 2005..The anti-apoptotic protein survivin was not expressed in normal bladder epithelium, but was variably expressed in cancers. FHIT and survivin expressions were similar in cancers from indomethacin-treated and non-treated mice... - Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancersRonald A Lubet
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
Int J Cancer 123:2254-9. 2008..In summary, rosiglitazone over a wide dose range enhanced urinary bladder carcinogenesis in the OH-BBN model in rats... - Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activityMinglin Li
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
Oncogene 22:2568-72. 2003..Alterations in cyclin D1 activity in preneoplastic cells could represent an early biomarker of chemopreventive action and are consistent with a mechanistic role for cyclin D1 in progression of mammary cancer...
Research Grants
- Chemoprevention of Chemically-Induced Bladder CancersClinton Grubbs; Fiscal Year: 2004..Depending on the results in the FTI treated rats, additional profiles can be assessed in the celecoxib and esculetin treated animals. ..
- Prevention of Urinary Bladder Carcinogenesis in MiceClinton Grubbs; Fiscal Year: 2005..Examination of altered RNA levels in cancers and preneoplastic lesions in an animal model will facilitate the development of relevant surrogate biomarkers for cancer chemoprevention studies (one of the stated goals of this RFA). ..