MURRAY E GROSSMAN

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
    Johanna I Busch
    Departments of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol Commun 1:36. 2013
  2. pmc Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania Philadelphia, PA, USA Department of Neurology, Center for Frontotemporal Dementia, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA
    Front Aging Neurosci 5:6. 2013
  3. pmc Disruption of large-scale neural networks in non-fluent/agrammatic variant primary progressive aphasia associated with frontotemporal degeneration pathology
    Murray Grossman
    Department of Neurology, University of Pennsylvania, United States Electronic address
    Brain Lang 127:106-20. 2013
  4. pmc Multimodal comparative studies of neurodegenerative diseases
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Alzheimers Dis 33:S379-83. 2013
  5. pmc Category-specific semantic memory: converging evidence from bold fMRI and Alzheimer's disease
    Murray Grossman
    Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Neuroimage 68:263-74. 2013
  6. pmc Self-appraisal in behavioural variant frontotemporal degeneration
    Lauren Massimo
    Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Gates Building, Philadelphia, PA 19104, USA
    J Neurol Neurosurg Psychiatry 84:148-53. 2013
  7. pmc Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 84:163-9. 2013
  8. pmc The non-fluent/agrammatic variant of primary progressive aphasia
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Lancet Neurol 11:545-55. 2012
  9. pmc Difficulty processing temporary syntactic ambiguities in Lewy body spectrum disorder
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, United States
    Brain Lang 120:52-60. 2012
  10. ncbi Object recognition difficulty in visual apperceptive agnosia
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Brain Cogn 33:306-42. 1997

Research Grants

  1. Cognitive Impairments in Parkinson's Disease and Aging
    Murray Grossman; Fiscal Year: 2006
  2. Conceptual Processing in Alzheimer's Disease
    Murray Grossman; Fiscal Year: 2010

Detail Information

Publications108 found, 100 shown here

  1. pmc Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
    Johanna I Busch
    Departments of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol Commun 1:36. 2013
    ..Indeed, TMEM106B expression levels, which correlate with TMEM106B genotype, may play a role in the pathogenesis of disease...
  2. pmc Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania Philadelphia, PA, USA Department of Neurology, Center for Frontotemporal Dementia, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA
    Front Aging Neurosci 5:6. 2013
    ..To achieve these goals it will be of the utmost importance to view neurodegenerative disease, including FTLD, as a clinicopathological entity, rather than exclusively a clinical syndrome...
  3. pmc Disruption of large-scale neural networks in non-fluent/agrammatic variant primary progressive aphasia associated with frontotemporal degeneration pathology
    Murray Grossman
    Department of Neurology, University of Pennsylvania, United States Electronic address
    Brain Lang 127:106-20. 2013
    ..These findings emphasize the role of large-scale neural networks in language, and demonstrate associated language deficits in naPPA. ..
  4. pmc Multimodal comparative studies of neurodegenerative diseases
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Alzheimers Dis 33:S379-83. 2013
    ..Our goal is to determine the specific histopathologic abnormalities contributing to an individual's neurodegenerative condition...
  5. pmc Category-specific semantic memory: converging evidence from bold fMRI and Alzheimer's disease
    Murray Grossman
    Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Neuroimage 68:263-74. 2013
    ....
  6. pmc Self-appraisal in behavioural variant frontotemporal degeneration
    Lauren Massimo
    Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Gates Building, Philadelphia, PA 19104, USA
    J Neurol Neurosurg Psychiatry 84:148-53. 2013
    ..We examined whether a domain-specific versus multi-domain model best explains degraded self-appraisal in bvFTD...
  7. pmc Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 84:163-9. 2013
    ..To clarify this issue, we compared a large C9P cohort with carefully matched non-expansion (C9N) cases with a known or highly-suspected underlying TAR DNA-binding protein 43 (TDP-43) proteinopathy...
  8. pmc The non-fluent/agrammatic variant of primary progressive aphasia
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Lancet Neurol 11:545-55. 2012
    ..Knowledge of these unique clinical-pathological associations should advance care for patients with this important class of neurodegenerative diseases while supplementing our knowledge of human cognitive neuroscience...
  9. pmc Difficulty processing temporary syntactic ambiguities in Lewy body spectrum disorder
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, United States
    Brain Lang 120:52-60. 2012
    ..These findings emphasize the role of prefrontal disease in the executive limitations that interfere with processing ambiguous sentences in LBSD...
  10. ncbi Object recognition difficulty in visual apperceptive agnosia
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Brain Cogn 33:306-42. 1997
    ....
  11. ncbi Semantic memory in Alzheimer's disease: representativeness, ontologic category, and material
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Neuropsychology 12:34-42. 1998
    ..The similarity process for relating coordinate members of a taxonomic category contributes to the normal appreciation of word and picture meaning, and this process is compromised in AD patients with semantic difficulty...
  12. ncbi Sentence comprehension in Alzheimer's disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104 4283, USA
    Brain Lang 62:186-201. 1998
    ..These findings are consistent with the hypothesis that impaired sentence comprehension in AD is multifactorial in nature, including difficulty processing cognitive resource and semantic aspects of sentences...
  13. ncbi Sentence processing in Parkinson's disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelpha 19104 4283, USA
    Brain Cogn 40:387-413. 1999
    ..The physiological basis for this deficit appears to be associated with the disruption of a fronto-striatal cerebral network that is compromised following degradation of the DA projection system...
  14. ncbi Cognitive resource limitations during sentence comprehension in Parkinson's disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Brain Lang 73:1-16. 2000
    ..The sensitivity of PD patients' sentence comprehension accuracy to secondary task resource demands is most consistent with the hypothesis that limited cognitive resources contribute to sentence comprehension difficulty in PD...
  15. ncbi Progressive peripheral agraphia
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurocase 7:339-49. 2001
    ..This disruption of grapheme retrieval is associated with interruption of a superior frontal-parietal system in the left hemisphere...
  16. ncbi Cognitive resources during sentence processing in Alzheimer's disease
    M Grossman
    Department of Neurology 3 Gates, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neuropsychologia 39:1419-31. 2001
    ....
  17. ncbi Neural basis for sentence comprehension: grammatical and short-term memory components
    Ayanna Cooke
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Hum Brain Mapp 15:80-94. 2002
    ....
  18. ncbi Neural representation of verb meaning: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Hum Brain Mapp 15:124-34. 2002
    ..We suggest that left posterolateral temporal activation supports aspects of lexical semantic processing concerned with the neural representation of propositional knowledge contributing to COGNITION verbs...
  19. ncbi Sentence processing strategies in healthy seniors with poor comprehension: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Brain Lang 80:296-313. 2002
    ..Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension...
  20. ncbi Assessing resource demands during sentence processing in Parkinson's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Brain Lang 80:603-16. 2002
    ....
  21. ncbi Information processing speed and sentence comprehension in Parkinson's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neuropsychology 16:174-81. 2002
    ..Findings suggest that slowed information processing speed contributes to sentence comprehension difficulty in PD...
  22. ncbi Progressive aphasic syndromes: clinical and theoretical advances
    Murray Grossman
    Department of Neurology 2 Gibson, University Hospital, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Curr Opin Neurol 15:409-13. 2002
    ..Knowledge of the neural basis for language and related aspects of cognition has been advanced through detailed studies of patients with primary progressive aphasia. This brief review highlights some recent work...
  23. ncbi The neural basis for categorization in semantic memory
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA
    Neuroimage 17:1549-61. 2002
    ..The caudate may support resource demands that are not specific for a particular categorization process. These findings associate partially distinct large-scale neural networks with different forms of categorization in semantic memory...
  24. ncbi Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Brain 126:292-311. 2003
    ..Components of the large-scale neural network underlying semantic memory may modify themselves to maintain performance in the face of a neurodegenerative disease...
  25. ncbi Categorization of object descriptions in Alzheimer's disease and frontotemporal dementia: limitation in rule-based processing
    Murray Grossman
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Cogn Affect Behav Neurosci 3:120-32. 2003
    ..These findings suggest that semantic memory difficulty in AD is due in part to a deficit in executive processes that are central to rule-based categorization in semantic memory...
  26. ncbi Neural basis for verb processing in Alzheimer's disease: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 17:658-74. 2003
    ..These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing...
  27. ncbi What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
    Murray Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain 127:628-49. 2004
    ..These findings are consistent with the hypothesis that a large-scale neural network supports naming, and that this network is interrupted in several distinct ways in patients with neurodegenerative diseases...
  28. pmc A longitudinal study of sentence comprehension difficulty in primary progressive aphasia
    M Grossman
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Neurol Neurosurg Psychiatry 76:644-9. 2005
    ..Patients with primary progressive aphasia have sentence comprehension difficulty, but the longitudinal course of this deficit has not been investigated...
  29. ncbi Primary progressive aphasia: a review
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Neurocase 10:3-18. 2004
    ..Testing hypotheses about finer-grained syndromes such as progressive dysarthria or progressive anomia has important consequences for improving our understanding of language organization and the neural basis for language...
  30. ncbi Frontotemporal dementia: introduction
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Alzheimer Dis Assoc Disord 19:S1-2. 2005
  31. ncbi Sentence processing in frontotemporal dementia
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Cortex 41:764-77. 2005
    ....
  32. ncbi Category-specific effects in semantic memory: category-task interactions suggested by fMRI
    Murray Grossman
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neuroimage 30:1003-9. 2006
    ....
  33. pmc How necessary are the stripes of a tiger? Diagnostic and characteristic features in an fMRI study of word meaning
    Murray Grossman
    Department of Neurology 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neuropsychologia 45:1055-64. 2007
    ....
  34. pmc Verb acquisition and representation in Alzheimer's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, USA
    Neuropsychologia 45:2508-18. 2007
    ....
  35. ncbi TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, 2 Gibson, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1449-54. 2007
    ..TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  36. ncbi Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia
    Murray Grossman
    Department of Neurology, 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1601-9. 2007
    ..Clinical-pathologic studies are crucial to understanding brain-behavior relations and improving diagnostic accuracy in neurodegenerative diseases...
  37. pmc Longitudinal decline in autopsy-defined frontotemporal lobar degeneration
    M Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neurology 70:2036-45. 2008
    ..The natural history of patients with pathologically proven frontotemporal lobar degeneration (FTLD) is important from clinical and biologic perspectives, but is not well documented quantitatively...
  38. pmc Impaired action knowledge in amyotrophic lateral sclerosis
    M Grossman
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurology 71:1396-401. 2008
    ..This study examined performance on measures requiring knowledge of actions, and related performance to MRI cortical atrophy in ALS...
  39. pmc Primary progressive aphasia: clinicopathological correlations
    Murray Grossman
    Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Nat Rev Neurol 6:88-97. 2010
    ....
  40. pmc The role of ventral medial prefrontal cortex in social decisions: converging evidence from fMRI and frontotemporal lobar degeneration
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychologia 48:3505-12. 2010
    ..These converging results support the role of vmPFC in social decision-making where potentially negative consequences must be considered...
  41. pmc Biomarkers in frontotemporal lobar degeneration
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Curr Opin Neurol 23:643-8. 2010
    ..Recent findings assessing the utility of neuroimaging and biofluid biomarkers are reviewed that help identify patients with frontotemporal lobar degeneration (FTLD) spectrum abnormality...
  42. pmc Biomarkers to identify the pathological basis for frontotemporal lobar degeneration
    Murray Grossman
    Department of Neurology 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Mol Neurosci 45:366-71. 2011
    ..While progress has been made in developing biomarkers for FTLD, additional work is needed to extend these advances so that the histopathologic abnormality causing FTLD can be specified in an individual patient...
  43. ncbi Quantifier comprehension in corticobasal degeneration
    Corey T McMillan
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Cogn 62:250-60. 2006
    ..29; p<.001]. An important implication of these findings is that the meaning of generalized quantifiers appears to involve two dissociable components, number knowledge and working memory, which are supported by distinct brain regions...
  44. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders...
  45. pmc Neuropsychological decline in frontotemporal lobar degeneration: a longitudinal analysis
    David J Libon
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychology 23:337-46. 2009
    ..These data indicate that distinct patterns of neuropsychological impairment are maintained longitudinally, reflecting the unique anatomic distribution of relative disease burden in AD and FTLD...
  46. ncbi Large-scale neural network for sentence processing
    Ayanna Cooke
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Lang 96:14-36. 2006
    ....
  47. pmc Clinical and pathological continuum of multisystem TDP-43 proteinopathies
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 66:180-9. 2009
    ....
  48. ncbi Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 57:721-9. 2005
    ..We conclude that CSF tau levels are significantly reduced in many patients with FTD...
  49. ncbi Resolving sentence ambiguity with planning and working memory resources: Evidence from fMRI
    Susana Novais-Santos
    Department of Bioengineering, University of Pennsylvania, USA
    Neuroimage 37:361-78. 2007
    ..These findings are consistent with a large-scale neural network for sentence processing that recruits distinct planning and working memory processing resources as needed to support the comprehension of sentences...
  50. pmc Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia
    John Listerud
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Int Neuropsychol Soc 15:459-70. 2009
    ..We conclude that classifying patients with degenerative dementia by specific pattern of cortical atrophy has the potential to predict individual patterns of cognitive deficits...
  51. pmc Too much to count on: impaired very small numbers in corticobasal degeneration
    Casey Halpern
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Cogn 64:144-9. 2007
    ..Difficulty judging very small numbers is impaired in CBD, suggesting degraded representation of precise number knowledge that does not depend on language functioning...
  52. ncbi Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations
    Vivianna M Van Deerlin
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1148-53. 2007
    ..Patients with frontotemporal dementia due to mutation of progranulin may have a distinct phenotype...
  53. pmc Knowledge of natural kinds in semantic dementia and Alzheimer's disease
    Katy Cross
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Lang 105:32-40. 2008
    ..We suggest that SD patients may be impaired in part at identifying the features critical to diagnosing membership in a semantic category, while AD patients' performance is consistent with their semantic categorization deficit...
  54. pmc Numerosity impairment in corticobasal syndrome
    Shira Koss
    Department of Neurology, University of Pennsylvania, PA, USA
    Neuropsychology 24:476-92. 2010
    ..We assessed the representation of numerosity in corticobasal syndrome (CBS), a neurodegenerative condition affecting the parietal lobe...
  55. ncbi Frontotemporal dementia: a review
    Murray Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    J Int Neuropsychol Soc 8:566-83. 2002
    ..The clinical, neuroimaging and neuropathological profiles associated with these clinically defined subgroups are examined...
  56. ncbi Neural basis for sentence comprehension deficits in frontotemporal dementia
    Ayanna Cooke
    Department of Neurology 2 Gibson, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Lang 85:211-21. 2003
    ..We conclude that FTD subgroups have distinct patterns of sentence comprehension difficulty in part because of selective interruptions of a large-scale neural network for sentence processing...
  57. ncbi Verbal mediation of number knowledge: evidence from semantic dementia and corticobasal degeneration
    Casey Halpern
    Department of Neurology, University of Pennsylvania, USA
    Brain Cogn 56:107-15. 2004
    ..CBD patients' impairment with larger numbers despite minimal aphasia, and SD patients' intact performance despite an aphasia, challenge the proposal that understanding larger numbers depends on verbal mediation...
  58. pmc Shape-based alignment of hippocampal subfields: evaluation in postmortem MRI
    Paul A Yushkevich
    Department of Radiology, University of Pennsylvania, USA
    Med Image Comput Comput Assist Interv 11:510-7. 2008
    ....
  59. doi Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease
    Casey H Halpern
    Department of Neurosurgery, Neurology and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Int J Geriatr Psychiatry 24:443-51. 2009
    ..The following review sought to provide a clearer understanding of the various cognitive sequelae of bilateral subthalamic nucleus (STN) DBS while taking into account corresponding neuroanatomy and potential confounding variables...
  60. pmc Neural processing during older adults' comprehension of spoken sentences: age differences in resource allocation and connectivity
    Jonathan E Peelle
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cereb Cortex 20:773-82. 2010
    ..We conclude that decreased activation of specialized processing regions, and limited ability to coordinate activity between regions, contribute to older adults' difficulty with sentence comprehension under difficult listening conditions...
  61. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  62. ncbi The neural basis for category-specific knowledge: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neuroimage 15:936-48. 2002
    ....
  63. ncbi Calculation impairment in neurodegenerative diseases
    Casey Halpern
    Department of Neurology 3 Gates, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia 19104 4283, USA
    J Neurol Sci 208:31-8. 2003
    ..FTD had more difficulty relative to AD in their performance of reverse digit span, consistent with our hypothesis that FTD patients' executive resource limitation contributes to their pattern of calculation impairment...
  64. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  65. ncbi Reversal of the concreteness effect for verbs in patients with semantic dementia
    Hyon Ah Yi
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 21:9-19. 2007
    ..Second, visual feature knowledge is degraded in patients with SD because of the anatomic distribution of the disease in visual association cortex, causing relatively greater difficulty for concrete verbs compared to abstract verbs...
  66. ncbi Left inferior parietal representations for skilled hand-object interactions: evidence from stroke and corticobasal degeneration
    Laurel J Buxbaum
    Moss Rehabilitation Research Institute, Philadelphia, PA 19141, USA
    Cortex 43:411-23. 2007
    ....
  67. pmc Is it logical to count on quantifiers? Dissociable neural networks underlying numerical and logical quantifiers
    Vanessa Troiani
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Neuropsychologia 47:104-11. 2009
    ....
  68. pmc Interaction between process and content in semantic memory: an fMRI study of noun feature knowledge
    Jonathan E Peelle
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuropsychologia 47:995-1003. 2009
    ..Together, these results support the hypothesis that various classes of nouns are represented differently in semantic memory, and emphasize the dynamic interaction of process and content in semantic memory...
  69. pmc Hierarchical organization of scripts: converging evidence from FMRI and frontotemporal degeneration
    Christine Farag
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cereb Cortex 20:2453-63. 2010
    ..Our findings suggest that frontal cortex contributes to clustering events during script comprehension, underlining the role of frontal cortex in the hierarchical organization of a script...
  70. ncbi Attentional resource and processing speed limitations during sentence processing in Parkinson's disease
    Christine Lee
    Department of Neurology, Hospital of the University of Pennsylvania, 3 Gates Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Lang 85:347-56. 2003
    ..Our findings are consistent with the claim that limited executive resources for strategic attention and processing speed contribute to the sentence comprehension difficulties of PD patients...
  71. ncbi TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 66:177-83. 2007
    ..Taken together, these results expand the spectrum of TDP-43 pathology in FTLD-U, suggesting that white matter pathology might contribute to the neurodegenerative process and clinical symptoms in FTLD-U...
  72. ncbi Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  73. pmc TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
    Vivianna M Van Deerlin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Lancet Neurol 7:409-16. 2008
    ..Our aim was to investigate whether TARDBP is a candidate disease gene for familial ALS that is not associated with mutations in superoxide dismutase 1 (SOD1)...
  74. ncbi Lexical acquisition in progressive aphasia and frontotemporal dementia
    Ryan Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cogn Neuropsychol 24:48-69. 2007
    ....
  75. pmc Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies
    Kunihiro Uryu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 67:555-64. 2008
    ..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis...
  76. pmc Impaired information integration contributes to communication difficulty in corticobasal syndrome
    Rachel G Gross
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cogn Behav Neurol 23:1-7. 2010
    ..To investigate the cognitive and neural correlates of discourse impairment in corticobasal syndrome (CBS)...
  77. ncbi The correlation of cognitive decline with frontotemporal dementia induced annualized gray matter loss using diffeomorphic morphometry
    Brian Avants
    University of Pennsylvania School of Medicine, Philadelphia, 19104 6389, USA
    Alzheimer Dis Assoc Disord 19:S25-8. 2005
    ..This study gives insight into the relationship between FTD-related progressive cortical atrophy and loss in cognitive function...
  78. pmc Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies
    Deepak M Sampathu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney Bldg, Philadelphia, PA 19104, USA
    Am J Pathol 169:1343-52. 2006
    ..Identification of the disease proteins recognized by these mAbs will further advance understanding of molecular substrates of FTLD-U neurodegenerative pathways...
  79. pmc Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Lionel M Igaz
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor, Maloney Bldg, Philadelphia, PA 19104, USA
    Am J Pathol 173:182-94. 2008
    ..Therefore, regionally different pathogenic processes may underlie the development of abnormal TDP-43 proteinopathies...
  80. pmc Survival profiles of patients with frontotemporal dementia and motor neuron disease
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Arch Neurol 66:1359-64. 2009
    ..Frontotemporal dementia and amyotrophic lateral sclerosis are neurodegenerative diseases associated with TAR DNA-binding protein 43- and ubiquitin-immunoreactive pathologic lesions...
  81. pmc Speech errors in progressive non-fluent aphasia
    Sharon Ash
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Brain Lang 113:13-20. 2010
    ..We conclude that the speech errors produced by PNFA patients are mainly errors at the phonemic level of language processing and are not caused by a motor planning impairment...
  82. pmc Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:1349-62. 2008
    ..In addition, these data from a large number of human brains provide a valuable resource for future testing of disease hypotheses...
  83. ncbi Disturbed visual processing contributes to impaired reading in Alzheimer's disease
    Guila Glosser
    Department of Neurology Gates 3 West, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neuropsychologia 40:902-9. 2002
    ....
  84. ncbi Memory encoding and retrieval in frontotemporal dementia and Alzheimer's disease
    Guila Glosser
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neuropsychology 16:190-6. 2002
    ..FTD patients' retained capacity for encoding new information into long-term declarative memory is likely due to relatively spared medial temporal lobe involvement...
  85. ncbi Visual perceptual functions predict instrumental activities of daily living in patients with dementia
    Guila Glosser
    Department of Neurology, University of Pennsylvannia School of Medicine, Philadelphia 19104 4283, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:198-206. 2002
    ..To assess relations between discrete visual perceptual functions commonly affected in patients with neurodegenerative dementia and the performance of instrumental activities of daily living (IADL)...
  86. ncbi Novel concepts mediate word retrieval from human episodic associative memory: evidence from event-related potentials
    John Kounios
    Institute for Research in Cognitive Science, University of Pennsylvania, 3401 Walnut Street, Suite 400A, Philadelphia, PA 19104 6228, USA
    Neurosci Lett 345:157-60. 2003
    ..Estimates of current source density at the cortical surface showed that fusion-mediated retrieval elicited left inferior-prefrontal/anterior-temporal activity not typically observed in episodic memory retrieval studies...
  87. ncbi Alzheimer's disease and frontotemporal dementia exhibit distinct atrophy-behavior correlates: a computer-assisted imaging study
    James Gee
    Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 370, Philadelphia, PA 19104 2644, USA
    Acad Radiol 10:1392-401. 2003
    ..The purpose of this study was to test the hypothesis that distinct patterns of gray matter atrophy are responsible for unique interruptions of the naming process in Alzheimer's disease (AD) and frontotemporal dementia (FTD)...
  88. ncbi The neural basis for novel semantic categorization
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania 19104 4283, USA
    Neuroimage 24:369-83. 2005
    ..These findings suggest that large-scale networks support relatively distinct categorization processes during the acquisition and judgment of semantic category knowledge...
  89. ncbi Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual
    Vivianna M Van Deerlin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research and Institute on Aging, University of Pennsylvania, 3600 Spruce St, 3 Maloney Bldg, Philadelphia, PA, 19104, USA
    Acta Neuropathol 113:471-9. 2007
    ..This is also the first reported case of any MAPT mutation in an individual of African American ethnicity...
  90. ncbi Categorization of novel animals by patients with Alzheimer's disease and corticobasal degeneration
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 21:193-206. 2007
    ..Moreover, AD patients' impaired categorization correlated with performance on a measure of semantic memory, implicating this categorization deficit in AD patients' semantic memory difficulty...
  91. ncbi Spatiotemporal normalization for longitudinal analysis of gray matter atrophy in frontotemporal dementia
    Brian Avants
    Dept of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
    Med Image Comput Comput Assist Interv 10:303-10. 2007
    ..This paper shows the statistical power of symmetric diffeomorphic normalization for performing deformation-based studies of longitudinal atrophy...
  92. ncbi Motor neuron disease and frontotemporal lobar degeneration: a tale of two disorders linked to TDP-43
    Lauren B Elman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosignals 16:85-90. 2008
    ..Moreover, biochemical studies of ubiquinated histopathologic abnormalities in MND and FTLD reveal identical inclusions of TDP-43. These findings underline a fundamental link between MND and FTLD. This paper reviews this body of work...
  93. ncbi Neuropsychiatric features of amyotrophic lateral sclerosis
    Lauren B Elman
    Department of Neurology, Neuromuscular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    NeuroRehabilitation 22:425-9. 2007
  94. pmc Medial temporal lobe involvement in an implicit memory task: evidence of collaborating implicit and explicit memory systems from FMRI and Alzheimer's disease
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cereb Cortex 18:2831-43. 2008
    ..These findings suggest that implicit and explicit memory systems collaborate in neurologically intact individuals performing an ostensibly implicit memory task...
  95. pmc Patient care and management of frontotemporal lobar degeneration
    Lauren Massimo
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Am J Alzheimers Dis Other Demen 23:125-31. 2008
    ..Nonpharmacologic management such as behavioral interventions and environmental engineering are also efficacious in optimizing quality of life...
  96. doi Deep brain stimulation in the treatment of obesity
    Casey H Halpern
    Department of Neurosurgery, Center for Weight and Eating Disorders, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg 109:625-34. 2008
    ..The authors conclude that deep brain stimulation should be strongly considered as a promising therapeutic option for patients suffering from refractory obesity...
  97. pmc A high-resolution computational atlas of the human hippocampus from postmortem magnetic resonance imaging at 9.4 T
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 44:385-98. 2009
    ..An example application examining subfield-level hippocampal atrophy in temporal lobe epilepsy demonstrates the application of the atlas to in vivo studies...
  98. pmc Registration based cortical thickness measurement
    Sandhitsu R Das
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuroimage 45:867-79. 2009
    ..Evaluation of this method is presented on synthetic images. As an application to brain images, a longitudinal study of thickness change in frontotemporal dementia (FTD) spectrum disorder is reported...
  99. pmc Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 119:111-22. 2010
    ....
  100. ncbi TDP-43 and frontotemporal dementia
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19106, USA
    Curr Neurol Neurosci Rep 9:353-8. 2009
    ....
  101. pmc Categorization of novel tools by patients with Alzheimer's disease: category-specific content and process
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, United States
    Neuropsychologia 48:1877-85. 2010
    ..The results suggest that categorization processes are sensitive to category content, which influences AD patients' success at acquiring a new category...

Research Grants2

  1. Cognitive Impairments in Parkinson's Disease and Aging
    Murray Grossman; Fiscal Year: 2006
    ..Our data support a componential neurocognitive architecture consisting of dynamically interactive networks modified to process sentences depending on available resources and relative demand. ..
  2. Conceptual Processing in Alzheimer's Disease
    Murray Grossman; Fiscal Year: 2010
    ..This work will help facilitate communication in the day-to-day care of patients with AD, and advance our understanding of a fundamental aspect of cognition. ..